{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:36:43Z","timestamp":1785818203747,"version":"3.56.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.healun.2014.05.008","type":"journal-article","created":{"date-parts":[[2014,6,7]],"date-time":"2014-06-07T14:46:47Z","timestamp":1402152407000},"page":"1083-1092","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Transplantation of SIRT1-engineered aged mesenchymal stem cells improves cardiac function in a rat myocardial infarction model"],"prefix":"10.1016","volume":"33","author":[{"given":"Xianbao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinchuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengxun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunchao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u05f3an","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2014.05.008_bib1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/stem.430","article-title":"A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke","volume":"28","author":"Lee","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.healun.2014.05.008_bib2","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1161\/CIRCRESAHA.111.243147","article-title":"Mesenchymal stem cells biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease","volume":"109","author":"Williams","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.healun.2014.05.008_bib3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1474-4422(11)70305-2","article-title":"Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study","volume":"11","author":"Connick","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.healun.2014.05.008_bib4","first-page":"e6","article-title":"Heart disease and stroke statistics\u20132013 update a report from the American Heart Association","volume":"127","author":"Go","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2014.05.008_bib5","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.yjmcc.2007.11.014","article-title":"Transcriptional profiling of young and old mesenchymal stem cells in response to oxygen deprivation and reparability of the infarcted myocardium","volume":"44","author":"Jiang","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.healun.2014.05.008_bib6","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/j.1582-4934.2009.00998.x","article-title":"Repair of senescent myocardium by mesenchymal stem cells is dependent on the age of donor mice","volume":"15","author":"Khan","year":"2011","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.healun.2014.05.008_bib7","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jtcvs.2009.07.053","article-title":"Impaired angiogenic potency of bone marrow cells from patients with advanced age, anemia, and renal failure","volume":"139","author":"Li","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.healun.2014.05.008_bib8","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1474-9726.2010.00646.x","article-title":"Age-related changes in mesenchymal stem cells derived from rhesus macaque bone marrow","volume":"10","author":"Yu","year":"2011","journal-title":"Aging Cell"},{"key":"10.1016\/j.healun.2014.05.008_bib9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1474-9726.2006.00213.x","article-title":"Age-related impairment of mesenchymal progenitor cell function","volume":"5","author":"Stolzing","year":"2006","journal-title":"Aging Cell"},{"key":"10.1016\/j.healun.2014.05.008_bib10","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1089\/scd.2010.0280","article-title":"Effects of donor age, gender, and in vitro cellular aging on the phenotypic, functional, and molecular characteristics of mouse bone marrow-derived mesenchymal stem cells","volume":"20","author":"Katsara","year":"2011","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.healun.2014.05.008_bib11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1479-5876-9-10","article-title":"Angiogenic properties of aged adipose derived mesenchymal stem cells after hypoxic conditioning","volume":"9","author":"Efimenko","year":"2011","journal-title":"J Transl Med"},{"key":"10.1016\/j.healun.2014.05.008_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.mad.2007.12.002","article-title":"Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies","volume":"129","author":"Stolzing","year":"2008","journal-title":"Mech Ageing Devel"},{"key":"10.1016\/j.healun.2014.05.008_bib13","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1474-9726.2008.00377.x","article-title":"Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts","volume":"7","author":"Zhou","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/j.healun.2014.05.008_bib14","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1001\/jama.2012.25321","article-title":"Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy. The POSEIDON Randomized Trial. Mesenchymal Stem Cells and Ischemic Cardiomyopathy","volume":"308","author":"Hare","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.healun.2014.05.008_bib15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.tcm.2011.12.002","article-title":"Challenges in allogeneic mesenchymal stem cell-mediated cardiac repair","volume":"20","author":"Dhingra","year":"2010","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.healun.2014.05.008_bib16","first-page":"1173","article-title":"Translating cell survival and cell longevity into treatment strategies with SIRT1","volume":"52","author":"Maiese","year":"2011","journal-title":"Rom J Morphol Embryol"},{"key":"10.1016\/j.healun.2014.05.008_bib17","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1359\/jbmr.060415","article-title":"Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells","volume":"21","author":"B\u00e4ckesj\u00f6","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.healun.2014.05.008_bib18","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/emmm.201201606","article-title":"SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating \u03b2-catenin","volume":"5","author":"Simic","year":"2013","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.healun.2014.05.008_bib19","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00109-011-0825-4","article-title":"SIRT1 is required for long-term growth of human mesenchymal stem cells","volume":"90","author":"Yuan","year":"2012","journal-title":"J Mol Med"},{"key":"10.1016\/j.healun.2014.05.008_bib20","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/jbmr.5650100320","article-title":"Bone marrow cells are targets for the anabolic actions of prostaglandin E2 on bone: induction of a transition from nonadherent to adherent osteoblast precursors","volume":"10","author":"Scutt","year":"1995","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.healun.2014.05.008_bib21","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1089\/scd.2008.0324","article-title":"In vitro senescence of rat mesenchymal stem cells is accompanied by downregulation of stemness-related and DNA damage repair genes","volume":"18","author":"Galderisi","year":"2009","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.healun.2014.05.008_bib22","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1161\/01.RES.0000258460.41160.ef","article-title":"Pharmacologically preconditioned skeletal myoblasts are resistant to oxidative stress and promote angiomyogenesis via release of paracrine factors in the infarcted heart","volume":"100","author":"Niagara","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.healun.2014.05.008_bib23","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1111\/jcmm.12100","article-title":"Human endometrial stem cells confer enhanced myocardial salvage and regeneration by paracrine mechanisms","volume":"17","author":"Jiang","year":"2013","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.healun.2014.05.008_bib24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/j.1939-4640.1997.tb01921.x","article-title":"Use of a rat cDNA probe specific for the Y chromosome to detect male-derived cells","volume":"18","author":"An","year":"1997","journal-title":"J Androl"},{"key":"10.1016\/j.healun.2014.05.008_bib25","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1016\/j.biomaterials.2010.12.051","article-title":"An assessment of the risks of carcinogenicity associated with polyhydroxyalkanoates through an analysis of DNA aneuploid and telomerase activity","volume":"32","author":"Peng","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.healun.2014.05.008_bib26","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/jgm.1362","article-title":"Combining angiogenic gene and stem cell therapies for myocardial infarction","volume":"11","author":"Pons","year":"2009","journal-title":"J Gene Med"},{"key":"10.1016\/j.healun.2014.05.008_bib27","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1002\/stem.153","article-title":"Mesenchymal stem cells pretreated with delivered Hph-1-Hsp70 protein are protected from hypoxia-mediated cell death and rescue heart functions from myocardial injury","volume":"27","author":"Chang","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.healun.2014.05.008_bib28","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1002\/stem.230","article-title":"Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors","volume":"27","author":"Wang","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.healun.2014.05.008_bib29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.scr.2011.11.002","article-title":"Aging alters tissue resident mesenchymal stem cell properties","volume":"8","author":"Alt","year":"2012","journal-title":"Stem Cell Res"},{"key":"10.1016\/j.healun.2014.05.008_bib30","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1146\/annurev-physiol-030212-183653","article-title":"Aging, cellular senescence, and cancer","volume":"75","author":"Campisi","year":"2013","journal-title":"Ann Rev Physiol"},{"key":"10.1016\/j.healun.2014.05.008_bib31","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cvr\/cvm025","article-title":"Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium","volume":"77","author":"Pasha","year":"2008","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.healun.2014.05.008_bib32","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1111\/j.1582-4934.2012.01568.x","article-title":"Mesenchymal stem cells conditioned with glucose depletion augments their ability to repair-infarcted myocardium","volume":"16","author":"Choudhery","year":"2012","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.healun.2014.05.008_bib33","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.arr.2009.10.003","article-title":"Caloric restriction: from soup to nuts","volume":"9","author":"Spindler","year":"2010","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.healun.2014.05.008_bib34","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1093\/eurheartj\/ehr131","article-title":"Increased expression of pigment epithelium-derived factor in aged mesenchymal stem cells impairs their therapeutic efficacy for attenuating myocardial infarction injury","volume":"34","author":"Liang","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.healun.2014.05.008_bib35","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.1021\/pr300539b","article-title":"Resveratrol-induced changes of the human adipocyte secretion profile","volume":"11","author":"Rosenow","year":"2012","journal-title":"J Proteome Res"},{"key":"10.1016\/j.healun.2014.05.008_bib36","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cytogfr.2009.10.002","article-title":"Mechanisms involved in the therapeutic properties of mesenchymal stem cells","volume":"20","author":"da Silva Meirelles","year":"2009","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.healun.2014.05.008_bib37","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1161\/CIRCULATIONAHA.109.864629","article-title":"MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1","volume":"120","author":"Menghini","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2014.05.008_bib38","doi-asserted-by":"crossref","first-page":"E110","DOI":"10.1152\/ajpendo.00192.2010","article-title":"MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1","volume":"299","author":"Zhao","year":"2010","journal-title":"Am J Physiol Endocrinol Metabol"},{"key":"10.1016\/j.healun.2014.05.008_bib39","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1634\/stemcells.2006-0771","article-title":"Bcl-2 engineered MSCs inhibited apoptosis and improved heart function","volume":"25","author":"Li","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.healun.2014.05.008_bib40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fncel.2012.00063","article-title":"SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells","volume":"6","author":"Khan","year":"2012","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.healun.2014.05.008_bib41","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1172\/JCI41563","article-title":"Sirt1 activation protects the mouse renal medulla from oxidative injury","volume":"120","author":"He","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.healun.2014.05.008_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00395-013-0333-5","article-title":"Rosuvastatin enhances the therapeutic efficacy of adipose-derived mesenchymal stem cells for myocardial infarction via PI3K\/Akt and MEK\/ERK pathways","volume":"108","author":"Zhang","year":"2013","journal-title":"Basic Res Cardiol"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249814011450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249814011450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:28:28Z","timestamp":1760948908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249814011450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S1053249814011450"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2014.05.008","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transplantation of SIRT1-engineered aged mesenchymal stem cells improves cardiac function in a rat myocardial infarction model","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2014.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}