{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:36:43Z","timestamp":1792661803353,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.healun.2016.04.006","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T16:47:12Z","timestamp":1462553232000},"page":"1321-1329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Right ventricular concentric hypertrophy and clinical worsening in idiopathic pulmonary arterial hypertension"],"prefix":"10.1016","volume":"35","author":[{"given":"Roberto","family":"Badagliacca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Poscia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Pezzuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Papa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pesce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Manzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Giannetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Raineri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Schina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Sciomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Parola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Francone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Fedele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine Dario","family":"Vizza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2016.04.006_bib1","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1161\/CIRCULATIONAHA.106.632208","article-title":"Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure","volume":"114","author":"Voelkel","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2016.04.006_bib2","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1378\/chest.08-1758","article-title":"Determinants of right ventricular ejection fraction in pulmonary arterial hypertension","volume":"135","author":"Kawut","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.healun.2016.04.006_bib3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.7326\/0003-4819-115-5-343","article-title":"Survival in patients with primary pulmonary hypertension. Results from a national prospective registry","volume":"115","author":"D\u2019Alonzo","year":"1991","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.healun.2016.04.006_bib4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1183\/09059180.00006511","article-title":"The role of the right ventricle in pulmonary arterial hypertension","volume":"20","author":"Vonk Noordegraaf","year":"2011","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.healun.2016.04.006_bib5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/CIRCULATIONAHA.109.911818","article-title":"Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era","volume":"122","author":"Humbert","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2016.04.006_bib6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1161\/CIRCULATIONAHA.109.898122","article-title":"Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)","volume":"122","author":"Benza","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2016.04.006_bib7","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1093\/eurheartj\/ehp297","volume":"30","author":"Gali\u00e8","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.healun.2016.04.006_bib8","doi-asserted-by":"crossref","first-page":"D73","DOI":"10.1016\/j.jacc.2013.10.034","article-title":"Treatment goals of pulmonary hypertension","volume":"62","author":"McLaughlin","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2016.04.006_bib9","doi-asserted-by":"crossref","first-page":"D22","DOI":"10.1016\/j.jacc.2013.10.027","article-title":"Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology","volume":"62","author":"Vonk-Noordegraaf","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2016.04.006_bib10","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1161\/CIRCULATIONAHA.107.653584","article-title":"Right ventricular function in cardiovascular disease, part II: pathophysiology, clinical importance and management of right ventricular failure","volume":"117","author":"Haddad","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2016.04.006_bib11","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1161\/01.RES.49.4.829","article-title":"Ventricular wall stress","volume":"49","author":"Yin","year":"1981","journal-title":"Circ Res"},{"key":"10.1016\/j.healun.2016.04.006_bib12","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.healun.2014.11.002","article-title":"Right ventricular remodeling in idiopathic pulmonary arterial hypertension: adaptive versus maladaptive morphology","volume":"34","author":"Badagliacca","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2016.04.006_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2009.04.007","article-title":"End points and clinical trial design in pulmonary arterial hypertension","volume":"54","author":"McLaughlin","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2016.04.006_bib14","first-page":"300","article-title":"Prostanoids but not oral therapies improve right ventricular function in pulmonary arterial hypertension","volume":"1","author":"Brittain","year":"2013","journal-title":"J Am Coll Cardiol HF"},{"key":"10.1016\/j.healun.2016.04.006_bib15","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.echo.2010.05.010","volume":"23","author":"Rudski","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.healun.2016.04.006_bib16","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.cct.2011.05.006","article-title":"Are propensity scores really superior to standard multivariable analysis?","volume":"32","author":"Biondi-Zoccai","year":"2011","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.healun.2016.04.006_bib17","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.healun.2016.04.006_bib18","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S0735-1097(02)02012-0","article-title":"Long-term intravenous epoprostenol infusion in primary pulmonary hypertension. Prognostic factors and survival","volume":"40","author":"Sitbon","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2016.04.006_bib19","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/01.CIR.0000029100.82385.58","article-title":"Survival in primary pulmonary hypertension. The impact of epoprostenol therapy","volume":"106","author":"McLaughlin","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2016.04.006_bib20","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/S0735-1097(02)01744-8","article-title":"Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension","volume":"39","author":"Raymond","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2016.04.006_bib21","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1378\/chest.11-0676","article-title":"The REVEAL registry risk score calculator in patients newly diagnosed with pulmonary arterial hypertension","volume":"141","author":"Benza","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.healun.2016.04.006_bib22","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1532-429X-14-40","article-title":"Diagnostic accuracy of cardiovascular magnetic resonance imaging of right ventricular morphology and function in the assessment of suspected pulmonary hypertension results from the ASPIRE registry","volume":"14","author":"Swift","year":"2012","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.healun.2016.04.006_bib23","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1183\/09031936.00139907","article-title":"Cardiac magnetic resonance imaging for the assessment of the heart and pulmonary circulation in pulmonary hypertension","volume":"33","author":"McLure","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2016.04.006_bib24","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.jacc.2008.08.033","article-title":"Role of cardiac magnetic resonance imaging in the management of patients with pulmonary arterial hypertension","volume":"52","author":"Benza","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2016.04.006_bib25","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1378\/chest.10-3277","article-title":"Progressive changes in right ventricular geometric shortening and long-term survival in pulmonary arterial hypertension","volume":"14","author":"Mauritz","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.healun.2016.04.006_bib26","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1378\/chest.14-0701","article-title":"Signs of right ventricular deterioration in clinically stable patients with pulmonary arterial hypertension","volume":"147","author":"van de Veerdonk","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.healun.2016.04.006_bib27","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1093\/eurheartj\/ehl477","article-title":"Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension","volume":"28","author":"van Wolferen","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.healun.2016.04.006_bib28","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1152\/ajplegacy.1957.192.1.148","article-title":"Hemodynamic determinants of oxygen consumption of the heart with special reference to the tension time index","volume":"192","author":"Sarnoff","year":"1958","journal-title":"Am J Physiol"},{"key":"10.1016\/j.healun.2016.04.006_bib29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1161\/01.RES.46.3.321","article-title":"The law of LaPlace, its limitations as a relation for diastolic pressure, volume, or wall stress of the left ventricle","volume":"46","author":"Moriarity","year":"1980","journal-title":"Circ Res"},{"key":"10.1016\/j.healun.2016.04.006_bib30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1161\/01.RES.33.3.303","article-title":"Evaluation of several geometric models for estimation of left ventricular circumferential wall stress","volume":"33","author":"McHale","year":"1973","journal-title":"Circ Res"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249816301097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249816301097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:32:21Z","timestamp":1760949141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249816301097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S1053249816301097"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2016.04.006","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Right ventricular concentric hypertrophy and clinical worsening in idiopathic pulmonary arterial hypertension","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2016.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc. on behalf of International Society for the Heart and Lung Transplantation","name":"copyright","label":"Copyright"}]}}