{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:08:25Z","timestamp":1777673305545,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.healun.2016.12.004","type":"journal-article","created":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T18:41:25Z","timestamp":1481913685000},"page":"640-649","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Left ventricular assist device outcomes based on flow configuration and pre-operative left ventricular dimension: An Interagency Registry for Mechanically Assisted Circulatory Support Analysis"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8175-168X","authenticated-orcid":false,"given":"Palak","family":"Shah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Birk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Maltais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Stulak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Elmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis D.","family":"Pagani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Cowger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3 Suppl","key":"10.1016\/j.healun.2016.12.004_bib1","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1016\/S0003-4975(00)02639-4","article-title":"HeartMate II left ventricular assist system: from concept to first clinical use","volume":"71","author":"Griffith","year":"2001","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.healun.2016.12.004_bib2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1525-1594.2007.00391.x","article-title":"The effect of surface roughness on activation of the coagulation system and platelet adhesion in rotary blood pumps","volume":"31","author":"Linneweber","year":"2007","journal-title":"Artif Organs"},{"key":"10.1016\/j.healun.2016.12.004_bib3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.healun.2013.12.013","article-title":"Echocardiographic markers of left ventricular unloading using a centrifugal-flow rotary pump","volume":"33","author":"Sauer","year":"2014","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2016.12.004_bib4","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/j.jacc.2012.07.052","article-title":"Development of a novel echocardiography ramp test for speed optimization and diagnosis of device thrombosis in continuous-flow left ventricular assist devices: the Columbia ramp study","volume":"60","author":"Uriel","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2016.12.004_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.healun.2012.10.001","article-title":"Axial and centrifugal continuous-flow rotary pumps: a translation from pump mechanics to clinical practice","volume":"32","author":"Moazami","year":"2013","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2016.12.004_bib6","doi-asserted-by":"crossref","first-page":"081002","DOI":"10.1115\/1.4007092","article-title":"A quantitative comparison of mechanical blood damage parameters in rotary ventricular assist devices: shear stress, exposure time and hemolysis index","volume":"134","author":"Fraser","year":"2012","journal-title":"J Biomech Eng"},{"key":"10.1016\/j.healun.2016.12.004_bib7","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.healun.2013.07.013","article-title":"Diagnosis of hemolysis and device thrombosis with lactate dehydrogenase during left ventricular assist device support","volume":"33","author":"Shah","year":"2014","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2016.12.004_bib8","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/jocs.12158","article-title":"Clinical differences between continuous flow ventricular assist devices: a comparison between HeartMate II and HeartWare HVAD","volume":"28","author":"Lalonde","year":"2013","journal-title":"J Card Surg"},{"key":"10.1016\/j.healun.2016.12.004_bib9","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.healun.2015.10.003","article-title":"Seventh INTERMACS annual report: 15,000 patients and counting","volume":"34","author":"Kirklin","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2016.12.004_bib10","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.healun.2015.01.012","article-title":"HeartWare HVAD for the treatment of patients with advanced heart failure ineligible for cardiac transplantation: results of the ENDURANCE Destination Therapy Trial","volume":"34","author":"Pagani","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2016.12.004_bib11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0899-9007(99)00293-2","article-title":"The meaning and interpretation of interaction","volume":"16","author":"Fitzmaurice","year":"2000","journal-title":"Nutrition"},{"key":"10.1016\/j.healun.2016.12.004_bib12","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.healun.2015.10.024","article-title":"Pump thrombosis in the Thoratec HeartMate II device: an update analysis of the INTERMACS Registry","volume":"34","author":"Kirklin","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2016.12.004_bib13","unstructured":"U.S. Food and Drug Administration. Premarket approval of the Thoratec HeartMate II\u00a9 Left Ventricular Assist System (LVAS). 2008. Available at: http:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf6\/p060040a.pdf."},{"key":"10.1016\/j.healun.2016.12.004_bib14","unstructured":"U.S. Food and Drug Administration. Premarket approval of the Thoratec HeartMate II\u00a9 Left Ventricular Assist System (LVAS). 2010. Available at: http:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf6\/p060040S005A.pdf."},{"key":"10.1016\/j.healun.2016.12.004_bib15","unstructured":"U.S. Food and Drug Administration. Heartware Ventricular Assist System (HVAS); 2013. Available at: www.accessdata.fda.gov\/cdrh_docs\/pdf10\/p100047b.pdf."},{"key":"10.1016\/j.healun.2016.12.004_bib16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa1313385","article-title":"Unexpected abrupt increase in left ventricular assist device thrombosis","volume":"370","author":"Starling","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.healun.2016.12.004_bib17","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.jbiomech.2013.12.031","article-title":"Intraventricular flow patterns and stasis in the LVAD-assisted heart","volume":"47","author":"Wong","year":"2014","journal-title":"J Biomech"},{"key":"10.1016\/j.healun.2016.12.004_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1742-4682-10-35","article-title":"Numerical investigation of the effect of cannula placement on thrombosis","volume":"10","author":"Ong","year":"2013","journal-title":"Theor Biol Med Model"},{"key":"10.1016\/j.healun.2016.12.004_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.healun.2007.12.007","article-title":"Influence of inflow cannula length in axial-flow pumps on neurologic adverse event rate: results from a multi-center analysis","volume":"27","author":"Schmid","year":"2008","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2016.12.004_bib20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.healun.2013.11.010","article-title":"Ambient hemolysis and activation of coagulation is different between HeartMate II and HeartWare left ventricular assist devices","volume":"33","author":"Birschmann","year":"2014","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2016.12.004_bib21","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.athoracsur.2010.04.099","article-title":"Acquired von Willebrand syndrome in continuous-flow ventricular assist device recipients","volume":"90","author":"Crow","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.healun.2016.12.004_bib22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/MAT.0000000000000055","article-title":"Do axial-flow LVADs unload better than centrifugal-flow LVADs?","volume":"60","author":"Giridharan","year":"2014","journal-title":"ASAIO J"},{"key":"10.1016\/j.healun.2016.12.004_bib23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1161\/CIRCHEARTFAILURE.112.000206","article-title":"Pulsatility and the risk of nonsurgical bleeding in patients supported with the continuous-flow left ventricular assist device HeartMate II","volume":"6","author":"Wever-Pinzon","year":"2013","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.healun.2016.12.004_bib24","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1161\/CIRCULATIONAHA.111.058412","article-title":"Use of an intrapericardial, continuous-flow, centrifugal pump in patients awaiting heart transplantation","volume":"125","author":"Aaronson","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2016.12.004_bib25","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.jacc.2013.08.1656","article-title":"Pre-operative risk factors of bleeding and stroke during left ventricular assist device support: an analysis of more than 900 HeartMate II outpatients","volume":"63","author":"Boyle","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2016.12.004_bib26","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/MAT.0000000000000074","article-title":"Stroke while on long-term left ventricular assist device support: incidence, outcome, and predictors","volume":"60","author":"Morgan","year":"2014","journal-title":"ASAIO J"},{"key":"10.1016\/j.healun.2016.12.004_bib27","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.healun.2013.11.001","article-title":"Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) analysis of pump thrombosis in the HeartMate II left ventricular assist device","volume":"33","author":"Kirklin","year":"2014","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2016.12.004_bib28","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.healun.2009.05.018","article-title":"Low thromboembolism and pump thrombosis with the HeartMate II left ventricular assist device: analysis of outpatient anti-coagulation","volume":"28","author":"Boyle","year":"2009","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2016.12.004_bib29","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.healun.2010.02.003","article-title":"Post-operative heparin may not be required for transitioning patients with a HeartMate II left ventricular assist system to long-term warfarin therapy","volume":"29","author":"Slaughter","year":"2010","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2016.12.004_bib30","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.healun.2015.03.012","article-title":"Role of ventricular assist therapy for patients with heart failure and restrictive physiology: Improving outcomes for a lethal disease","volume":"34","author":"Grupper","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2016.12.004_bib31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jacc.2012.09.055","article-title":"Predicting survival in patients receiving continuous flow left ventricular assist devices: the HeartMate II risk score","volume":"61","author":"Cowger","year":"2013","journal-title":"J Am Coll Cardiol"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249816304454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249816304454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:33:36Z","timestamp":1760949216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249816304454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S1053249816304454"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2016.12.004","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Left ventricular assist device outcomes based on flow configuration and pre-operative left ventricular dimension: An Interagency Registry for Mechanically Assisted Circulatory Support Analysis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2016.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 International Society for the Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}