{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:19:02Z","timestamp":1792016342613,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jhltonline.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.healun.2017.05.029","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T20:32:56Z","timestamp":1496176376000},"page":"1192-1200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":152,"title":["Building a tissue-based molecular diagnostic system in heart transplant rejection: The heart Molecular Microscope Diagnostic (MMDx) System"],"prefix":"10.1016","volume":"36","author":[{"given":"Philip F.","family":"Halloran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Potena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul Duong","family":"Van Huyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Bruneval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornella","family":"Leone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Jouven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Reeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Loupy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2017.05.029_bib1","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.healun.2005.03.019","article-title":"Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection","volume":"11","author":"Stewart","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib2","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/j.healun.2005.03.018","article-title":"The revised ISHLT heart biopsy grading scale","volume":"11","author":"Billingham","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.healun.2015.10.023","article-title":"The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: a 10-year update","volume":"1","author":"Mehra","year":"2016","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.carpath.2011.10.001","article-title":"2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology","volume":"4","author":"Leone","year":"2012","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.healun.2017.05.029_bib5","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1097\/TP.0b013e31826e19e2","article-title":"Concordance Among Pathologists in the Second Cardiac Allograft Rejection Gene Expression Observational Study (CARGO II)","volume":"11","author":"Crespo-Leiro","year":"2012","journal-title":"Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib6","unstructured":"Hammond EH, Yowell RL, Nunoda S. Vascular (humoral) rejection in heart transplantation: pathologic observations and clinical implications. J Heart Lung Transplant 1989430-3."},{"key":"10.1016\/j.healun.2017.05.029_bib7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.healun.2015.10.016","article-title":"Mixed cellular and antibody-mediated rejection in heart transplantation: in-depth pathologic and clinical observations","volume":"3","author":"Kfoury","year":"2016","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.healun.2008.09.012","article-title":"A clinical correlation study of severity of antibody-mediated rejection and cardiovascular mortality in heart transplantation","volume":"1","author":"Kfoury","year":"2009","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib9","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1161\/CIRCRESAHA.117.306340","article-title":"Determinants and outcomes of accelerated arteriosclerosis: major impact of circulating antibodies","volume":"5","author":"Loupy","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.healun.2017.05.029_bib10","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.healun.2011.02.015","article-title":"The ISHLT working formulation for pathologic diagnosis of antibody-mediated rejection in heart transplantation: evolution and current status (2005-2011)","volume":"6","author":"Berry","year":"2011","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib11","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.healun.2013.08.011","article-title":"The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation","volume":"12","author":"Berry","year":"2013","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/ajt.14112","article-title":"The XIIIth Banff Conference on Allograft Pathology: the Banff 2015 Heart Meeting Report: improving antibody-mediated rejection diagnostics: strengths, unmet needs, and future directions","volume":"1","author":"Bruneval","year":"2017","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib13","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/ajt.12976","article-title":"Inflammatory cell burden and phenotype in endomyocardial biopsies with antibody-mediated rejection (AMR): a multicenter pilot study from the AECVP","volume":"2","author":"Fedrigo","year":"2015","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib14","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.healun.2013.05.012","article-title":"Pathologic classification of antibody-mediated rejection correlates with donor-specific antibodies and endothelial cell activation","volume":"8","author":"Tible","year":"2013","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib15","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1111\/j.1600-6143.2011.03931.x","article-title":"A new diagnostic algorithm for antibody-mediated microcirculation inflammation in kidney transplants","volume":"5","author":"Sis","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib16","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1111\/j.1600-6143.2009.02761.x","article-title":"Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining","volume":"10","author":"Sis","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib17","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1111\/j.1600-6143.2009.02799.x","article-title":"Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure","volume":"11","author":"Einecke","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib18","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1111\/ajt.12335","article-title":"In search of perfection","volume":"8","author":"Gebel","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib19","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1097\/TP.0000000000000229","article-title":"Denatured class I human leukocyte antigen antibodies in sensitized kidney recipients: prevalence, relevance, and impact on organ allocation","volume":"98","author":"Visentin","year":"2014","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2017.05.029_bib20","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1111\/ajt.12332","article-title":"Influence of test technique on sensitization status of patients on the kidney transplant waiting list","volume":"8","author":"Gombos","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/MOT.0000000000000193","article-title":"The molecular phenotypes of rejection in kidney transplant biopsies","volume":"3","author":"Halloran","year":"2015","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/ki.2013.300","article-title":"Antibody-mediated rejection, T cell-mediated rejection, and the injury-repair response: new insights from the Genome Canada studies of kidney transplant biopsies","volume":"85","author":"Halloran","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.healun.2017.05.029_bib23","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nrneph.2016.85","article-title":"Molecular assessment of disease states in kidney transplant biopsies","volume":"9","author":"Halloran","year":"2016","journal-title":"Nat Rev Nephrology"},{"key":"10.1016\/j.healun.2017.05.029_bib24","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1111\/j.1600-6143.2010.03182.x","article-title":"The molecular phenotype of heart transplant biopsies: relationship to histopathological and clinical variables","volume":"9","author":"Mengel","year":"2010","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib25","first-page":"404","article-title":"Molecular diagnosis of rejection in endomyocardial allograft biopsies correlates with Quilty lesion but not ISHLT rejection Grades [abstract]","volume":"s4","author":"Mengel","year":"2010","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib26","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1161\/CIRCULATIONAHA.116.022907","article-title":"The molecular landscape of antibody-mediated rejection in heart transplant patients: insights for mechanisms, activity and stage","volume":"135","author":"Loupy","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2017.05.029_bib27","doi-asserted-by":"crossref","DOI":"10.1111\/ajt.14200","article-title":"Comprehensive analysis of transcript changes associated with allograft rejection: combining universal and selective features [e-pub ahead of print]","author":"Halloran","year":"2017","journal-title":"Am J Transplant"},{"issue":"Suppl 3","key":"10.1016\/j.healun.2017.05.029_bib28","article-title":"Development and validation of a Molecular Microscope Diagnostic System (MMDx) for heart transplant biopsies [abstract]","volume":"16","author":"Halloran","year":"2016","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib29","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.94197","article-title":"Assessing rejection-related disease in kidney transplant biopsies based on archetypal analysis of molecular phenotypes.","volume":"2","author":"Reeve","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.healun.2017.05.029_bib30","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1681\/ASN.2014060588","article-title":"Disappearance of T cell-mediated rejection despite continued antibody-mediated rejection in late kidney transplant recipients","volume":"7","author":"Halloran","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.healun.2017.05.029_bib31","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/00401706.1994.10485840","article-title":"Archetypal analysis","volume":"4","author":"Cutler","year":"1994","journal-title":"Technometrics"},{"key":"10.1016\/j.healun.2017.05.029_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v030.i08","article-title":"From Spider-Man to hero\u2014archetypal analysis in R","volume":"30","author":"Eugster","year":"2009","journal-title":"J Stat Software"},{"key":"10.1016\/j.healun.2017.05.029_bib33","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1111\/ajt.12465","article-title":"Microarray diagnosis of antibody-mediated rejection in kidney transplant biopsies: an international prospective study (INTERCOM)","volume":"11","author":"Halloran","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib34","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1111\/j.1600-6143.2009.02694.x","article-title":"Diagnosing rejection in renal transplants: a comparison of molecular- and histopathology-based approaches","volume":"8","author":"Reeve","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib35","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1111\/ajt.12946","article-title":"Molecular landscape of T cell-mediated rejection in human kidney transplants: prominence of CTLA4 and PD ligands","volume":"11","author":"Venner","year":"2014","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib36","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/ajt.13115","article-title":"The molecular landscape of antibody-mediated kidney transplant rejection: evidence for NK involvement through CD16a Fc receptors","volume":"5","author":"Venner","year":"2015","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib37","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/ajt.12079","article-title":"Molecular diagnosis of T cell-mediated rejection in human kidney transplant biopsies","volume":"3","author":"Reeve","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib38","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.healun.2008.12.011","article-title":"Quilty effect correlates with biopsy-proven acute cellular rejection but does not predict transplanted heart coronary artery vasculopathy","volume":"3","author":"Zakliczynski","year":"2009","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib39","first-page":"937","article-title":"\u201cQuilty effect\u201d in heart transplantation: is it related to acute rejection?","volume":"6","author":"Pardo-Mindan","year":"1991","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2017.05.029_bib40","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0046-8177(95)90252-X","article-title":"\u201cQuilty\u201d revisited: a 10-year perspective","volume":"5","author":"Joshi","year":"1995","journal-title":"Hum Pathol"},{"key":"10.1016\/j.healun.2017.05.029_bib41","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1161\/CIRCULATIONAHA.109.913921","article-title":"Identification and classification of acute cardiac rejection by intragraft transcriptional profiling","volume":"20","author":"Holweg","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2017.05.029_bib42","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/ajt.14107","article-title":"The Banff 2015 Kidney Meeting Report: current challenges in rejection classification and prospects for adopting molecular pathology","volume":"1","author":"Loupy","year":"2017","journal-title":"Am J Transplant"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249817318302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249817318302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T05:21:28Z","timestamp":1535779288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249817318302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S1053249817318302"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2017.05.029","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Building a tissue-based molecular diagnostic system in heart transplant rejection: The heart Molecular Microscope Diagnostic (MMDx) System","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2017.05.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 International Society for the Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}