{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:03:30Z","timestamp":1778565810867,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T00:00:00Z","timestamp":1499299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.healun.2017.07.003","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T05:54:49Z","timestamp":1499234089000},"page":"1322-1328","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["SERCA2a: A potential non-invasive biomarker of cardiac allograft rejection"],"prefix":"10.1016","volume":"36","author":[{"given":"Estefan\u00eda","family":"Taraz\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Gil-Cayuela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"S\u00e1nchez-Lacuesta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Mar\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca","family":"Lago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ram\u00f3n","family":"Gonz\u00e1lez-Juanatey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Mart\u00ednez-Dolz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Portol\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Rosell\u00f3-Llet\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2017.07.003_bib1","first-page":"389","article-title":"Adverse event rates in congenital cardiac catheterization\u2014a multi-center experience","volume":"75","author":"Bergersen","year":"2010","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.healun.2017.07.003_bib2","first-page":"239","article-title":"Reproducibility of the acute rejection diagnosis in human cardiac allografts. The Stanford Classification and the International Grading System","volume":"12","author":"Nielsen","year":"1993","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2017.07.003_bib3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jacc.2008.05.020","article-title":"The changing face of heart transplantation","volume":"52","author":"Hunt","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2017.07.003_bib4","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1093\/eurheartj\/ehv682","article-title":"Clinical usefulness of gene-expression profile to rule out acute rejection after heart transplantation: CARGO II","volume":"37","author":"Crespo-Leiro","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.healun.2017.07.003_bib5","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1093\/eurheartj\/ehu346","article-title":"MicroRNAs as non-invasive biomarkers of heart transplant rejection","volume":"35","author":"Duong Van Huyen","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.healun.2017.07.003_bib6","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2217\/bmm.14.56","article-title":"Biomarkers of acute rejection following cardiac transplantation","volume":"8","author":"McMinn","year":"2014","journal-title":"Biomark Med"},{"key":"10.1016\/j.healun.2017.07.003_bib7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1172\/JCI114429","article-title":"Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure","volume":"85","author":"Mercadier","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1016\/j.healun.2017.07.003_bib8","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1161\/CIRCRESAHA.113.302187","article-title":"Sarcoplasmic reticulum Ca-ATPase and heart failure 20 years later","volume":"113","author":"Eisner","year":"2013","journal-title":"Circ Res"},{"key":"10.1016\/j.healun.2017.07.003_bib9","doi-asserted-by":"crossref","first-page":"5251","DOI":"10.1073\/pnas.95.9.5251","article-title":"Modulation of ventricular function through gene transfer in vivo","volume":"95","author":"Hajjar","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.healun.2017.07.003_bib10","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/01.RES.75.3.434","article-title":"Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium","volume":"75","author":"Hasenfuss","year":"1994","journal-title":"Circ Res"},{"key":"10.1016\/j.healun.2017.07.003_bib11","doi-asserted-by":"crossref","first-page":"24060","DOI":"10.1038\/srep24060","article-title":"Human ischemic cardiomyopathy shows cardiac nos1 translocation and its increased levels are related to left ventricular performance","volume":"6","author":"Rosell\u00f3-Llet\u00ed","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.healun.2017.07.003_bib12","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1600-6143.2006.01241.x","article-title":"Diastolic dysfunction in human cardiac allografts is related with reduced SERCA2a gene expression","volume":"6","author":"St\u00fcdeli","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2017.07.003_bib13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1161\/01.CIR.95.2.423","article-title":"Physiological effects of adenoviral gene transfer of sarcoplasmic reticulum calcium ATPase in isolated rat myocytes","volume":"95","author":"Hajjar","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2017.07.003_bib14","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1161\/01.CIR.100.23.2308","article-title":"Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a","volume":"100","author":"del Monte","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2017.07.003_bib15","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1073\/pnas.97.2.793","article-title":"Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure","volume":"97","author":"Miyamoto","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.healun.2017.07.003_bib16","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1038\/gt.2008.120","article-title":"Recirculating cardiac delivery of AAV2\/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals","volume":"15","author":"Byrne","year":"2008","journal-title":"Gene Ther"},{"key":"10.1016\/j.healun.2017.07.003_bib17","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1161\/CIRCULATIONAHA.111.022889","article-title":"Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure","volume":"124","author":"Jessup","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2017.07.003_bib18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1161\/CIRCRESAHA.113.302421","article-title":"Long-term effects of AAV1\/SERCA2a gene transfer in patients with severe heart failure: analysis of recurrent cardiovascular events and mortality","volume":"114","author":"Zsebo","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.healun.2017.07.003_bib19","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/S0140-6736(16)00082-9","article-title":"Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial","volume":"387","author":"Greenberg","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.healun.2017.07.003_bib20","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.healun.2005.03.019","article-title":"Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection","volume":"24","author":"Stewart","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2017.07.003_bib21","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1513\/pats.200701-011GC","article-title":"The Council for International Organizations and Medical Sciences (CIOMS) guidelines on ethics of clinical trials","volume":"4","author":"Macrae","year":"2007","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.healun.2017.07.003_bib22","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1136\/heartjnl-2012-302759","article-title":"Non-invasive approaches for the diagnosis of acute cardiac allograft rejection","volume":"99","author":"Miller","year":"2013","journal-title":"Heart"},{"key":"10.1016\/j.healun.2017.07.003_bib23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1161\/01.CIR.100.3.287","article-title":"Discoordinate modulation of natriuretic peptides during acute cardiac allograft rejection in humans","volume":"100","author":"Masters","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2017.07.003_bib24","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S1053-2498(01)00424-7","article-title":"Bedside b-type natriuretic peptide and acute non-cellular cardiac allograft rejection","volume":"21","author":"Park","year":"2002","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2017.07.003_bib25","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1016\/j.transproceed.2005.09.150","article-title":"Value of NT-proBNP determinations in the follow-up of heart transplantation","volume":"37","author":"Cuppoletti","year":"2005","journal-title":"Transplant Proc"},{"key":"10.1016\/j.healun.2017.07.003_bib26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cca.2009.10.021","article-title":"Clinical utility of NT-proBNP levels in late heart transplantation patients","volume":"411","author":"Avello","year":"2010","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.healun.2017.07.003_bib27","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.healun.2012.02.014","article-title":"Changes in serial B-type natriuretic peptide level independently predict cardiac allograft rejection","volume":"31","author":"Damodaran","year":"2012","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2017.07.003_bib28","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.healun.2009.04.019","article-title":"The change in B-type natriuretic peptide levels over time predicts significant rejection in cardiac transplant recipients","volume":"28","author":"Kittleson","year":"2009","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2017.07.003_bib29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1010-7940(02)00293-2","article-title":"Troponin T and I are not reliable markers of cardiac transplant rejection","volume":"22","author":"Mullen","year":"2002","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.healun.2017.07.003_bib30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.5483\/BMBRep.2013.46.5.077","article-title":"SERCA2a: a prime target for modulation of cardiac contractility during heart failure","volume":"46","author":"Park","year":"2013","journal-title":"BMB Rep"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249817318879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249817318879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:34:09Z","timestamp":1760949249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249817318879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S1053249817318879"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2017.07.003","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SERCA2a: A potential non-invasive biomarker of cardiac allograft rejection","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2017.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author. Published by Elsevier Inc. on behalf of International Society for the Heart and Lung Transplantation","name":"copyright","label":"Copyright"}]}}