{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:10:58Z","timestamp":1789495858668,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK080074"],"award-info":[{"award-number":["R01 DK080074"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK109581"],"award-info":[{"award-number":["R01 DK109581"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 DK22682"],"award-info":[{"award-number":["RO1 DK22682"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 HL140470-0181"],"award-info":[{"award-number":["RO1 HL140470-0181"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.healun.2020.09.012","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T12:06:35Z","timestamp":1601294795000},"page":"1476-1490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["MicroRNA-206 antagomiR\u2012enriched extracellular vesicles attenuate lung ischemia\u2012reperfusion injury through CXCL1 regulation in alveolar epithelial cells"],"prefix":"10.1016","volume":"39","author":[{"given":"Jun","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Gehrau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxiao","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Leroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria R.","family":"Mas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Emtiazjoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Pelaez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Machuca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Gilbert R.","family":"Upchurch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2020.09.012_bib0001","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.healun.2017.07.020","volume":"36","author":"Diamond","year":"2017","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2020.09.012_bib0002","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.21037\/jtd.2017.07.85","article-title":"Outcomes after lung transplantation","volume":"9","author":"Thabut","year":"2017","journal-title":"J Thorac Dis"},{"issue":"Suppl s1","key":"10.1016\/j.healun.2020.09.012_bib0003","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/ajt.15677","article-title":"OPTN\/SRTR 2018 annual data report: lung","volume":"20","author":"Valapour","year":"2020","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2020.09.012_bib0004","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jtcvs.2010.09.009","article-title":"Short- and long-term outcomes of 1000 adult lung transplant recipients at a single center","volume":"141","author":"Kreisel","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.healun.2020.09.012_bib0005","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5628404","article-title":"Exosomes and exosomal miRNA in respiratory diseases","volume":"2016","author":"Alipoor","year":"2016","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.healun.2020.09.012_bib0006","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1161\/CIRCULATIONAHA.112.114173","article-title":"Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension","volume":"126","author":"Lee","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2020.09.012_bib0007","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12931-017-0704-9","article-title":"Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death","volume":"18","author":"Stone","year":"2017","journal-title":"Respir Res"},{"key":"10.1016\/j.healun.2020.09.012_bib0008","doi-asserted-by":"crossref","first-page":"6038","DOI":"10.1096\/fj.201701138RR","article-title":"Human mesenchymal stromal cell-derived extracellular vesicles attenuate aortic aneurysm formation and macrophage activation via microRNA-147","volume":"32","author":"Spinosa","year":"2018","journal-title":"FASEB J"},{"key":"10.1016\/j.healun.2020.09.012_bib0009","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: exosomes, microvesicles, and friends","volume":"200","author":"Raposo","year":"2013","journal-title":"J Cell Biol"},{"key":"10.1016\/j.healun.2020.09.012_bib0010","doi-asserted-by":"crossref","first-page":"8472","DOI":"10.1038\/ncomms9472","article-title":"Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs","volume":"6","author":"Phinney","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.healun.2020.09.012_bib0011","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.healun.2016.03.018","article-title":"The potential role of microRNAs in lung allograft rejection","volume":"35","author":"Ladak","year":"2016","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2020.09.012_bib0012","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1097\/TP.0000000000001595","article-title":"Role of circulating microRNAs in the immunopathogenesis of rejection after pediatric lung transplantation","volume":"101","author":"Xu","year":"2017","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2020.09.012_bib0013","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.healun.2020.09.012_bib0014","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1097\/TXD.0000000000000551","article-title":"Acute cellular rejection elicits distinct microRNA signatures in airway epithelium of lung transplant patients","volume":"1","author":"Gharib","year":"2015","journal-title":"Transplant Direct"},{"key":"10.1016\/j.healun.2020.09.012_bib0015","doi-asserted-by":"crossref","first-page":"e11803","DOI":"10.1371\/journal.pone.0011803","article-title":"Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs","volume":"5","author":"Collino","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.healun.2020.09.012_bib0016","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1164\/rccm.201007-1173OC","article-title":"Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury","volume":"183","author":"Sharma","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.healun.2020.09.012_bib0017","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1164\/rccm.201506-1253OC","article-title":"NOX2 activation of natural killer T cells is blocked by the adenosine A2a receptor to inhibit lung ischemia-reperfusion injury","volume":"193","author":"Sharma","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.healun.2020.09.012_bib0018","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2119\/molmed.2008.00110","article-title":"Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinoma","volume":"15","author":"Mas","year":"2009","journal-title":"Mol Med"},{"key":"10.1016\/j.healun.2020.09.012_bib0019","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11748-019-01181-9","article-title":"Prolonged warm ischemia exacerbated acute rejection after lung transplantation from donation after cardiac death in a mouse","volume":"68","author":"Hirano","year":"2020","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"10.1016\/j.healun.2020.09.012_bib0020","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1111\/ajt.14717","article-title":"Donor pretreatment with nebulized complement C3a receptor antagonist mitigates brain-death induced immunological injury post-lung transplant","volume":"18","author":"Cheng","year":"2018","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2020.09.012_bib0021","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1097\/TP.0000000000000830","article-title":"Ex vivo perfusion with adenosine A2a receptor agonist enhances rehabilitation of murine donor lungs after circulatory death","volume":"99","author":"Stone","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2020.09.012_bib0022","doi-asserted-by":"crossref","first-page":"L105","DOI":"10.1152\/ajplung.00470.2006","article-title":"Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury","volume":"293","author":"Sharma","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.healun.2020.09.012_bib0023","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.healun.2020.09.012_bib0024","doi-asserted-by":"crossref","first-page":"11167","DOI":"10.1038\/s41598-018-29504-5","article-title":"Lung resident mesenchymal cells isolated from patients with the bronchiolitis obliterans syndrome display a deregulated epigenetic profile","volume":"8","author":"Vella","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.healun.2020.09.012_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trim.2017.04.002","article-title":"Serum miRNAs as potential biomarkers for the bronchiolitis obliterans syndrome after lung transplantation","volume":"42","author":"Budding","year":"2017","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.healun.2020.09.012_bib0026","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2213-0802-1-12","article-title":"MicroRNAs implicated in dysregulation of gene expression following human lung transplantation","volume":"1","author":"Zhang","year":"2013","journal-title":"Transl Respir Med"},{"key":"10.1016\/j.healun.2020.09.012_bib0027","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.4049\/jimmunol.180.8.5689","article-title":"Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells","volume":"180","author":"Perry","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.healun.2020.09.012_bib0028","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cellsig.2014.10.006","article-title":"miR-206 modulates lipopolysaccharide-mediated inflammatory cytokine production in human astrocytes","volume":"27","author":"Duan","year":"2015","journal-title":"Cell Signal"},{"key":"10.1016\/j.healun.2020.09.012_bib0029","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbrc.2016.06.038","article-title":"MicroRNA-206 regulates the secretion of inflammatory cytokines and MMP9 expression by targeting TIMP3 in mycobacterium tuberculosis-infected THP-1 human macrophages","volume":"477","author":"Fu","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.healun.2020.09.012_bib0030","first-page":"296","article-title":"miR-206 regulates alveolar type II epithelial cell Cx43 expression in sepsis-induced acute lung injury","volume":"18","author":"Zhou","year":"2019","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.healun.2020.09.012_bib0031","doi-asserted-by":"crossref","first-page":"e20171","DOI":"10.1371\/journal.pone.0020171","article-title":"Expression of miRNAs miR-133b and miR-206 in the Il17a\/f locus is co-regulated with IL-17 production in \u03b1\u03b2 and \u03b3\u03b4 T cells","volume":"6","author":"Haas","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.healun.2020.09.012_bib0032","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.3390\/jcm8091345","article-title":"Exosomal miRNAs in lung diseases: from biologic function to therapeutic targets","volume":"8","author":"Guiot","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.healun.2020.09.012_bib0033","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.healun.2019.08.016","article-title":"Mesenchymal stem cell-derived extracellular vesicles improve the molecular phenotype of isolated rat lungs during ischemia\/reperfusion injury","volume":"38","author":"Lonati","year":"2019","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2020.09.012_bib0034","doi-asserted-by":"crossref","first-page":"H216","DOI":"10.1152\/ajpheart.00812.2013","article-title":"MicroRNAs associated with ischemia-reperfusion injury and cardioprotection by ischemic pre- and postconditioning: protectomiRs","volume":"307","author":"Varga","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.healun.2020.09.012_bib0035","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1096\/fj.201700488r","article-title":"Exosomes in postshock mesenteric lymph are key mediators of acute lung injury triggering the macrophage activation via toll-like receptor 4","volume":"32","author":"Kojima","year":"2018","journal-title":"FASEB J"},{"key":"10.1016\/j.healun.2020.09.012_bib0036","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejphar.2019.01.022","article-title":"Mesenchymal stromal cells-derived exosomes alleviate ischemia\/reperfusion injury in mouse lung by transporting anti-apoptotic miR-21-5p","volume":"852","author":"Li","year":"2019","journal-title":"Eur J Pharmacol"},{"issue":"Suppl","key":"10.1016\/j.healun.2020.09.012_bib0037","first-page":"S247","article-title":"Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction","volume":"120","author":"Deuse","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2020.09.012_bib0038","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/stem.1504","article-title":"Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice","volume":"32","author":"Zhu","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.healun.2020.09.012_bib0039","article-title":"Prostaglandin E2 and transforming growth factor-beta play a critical role in suppression of allergic airway inflammation by adipose-derived stem cells","volume":"10","author":"Cho","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.healun.2020.09.012_bib0040","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1097\/TP.0000000000000856","article-title":"Indoleamine 2, 3-dioxgenase transfected mesenchymal stem cells induce kidney allograft tolerance by increasing the production and function of regulatory T cells","volume":"99","author":"He","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2020.09.012_bib0041","doi-asserted-by":"crossref","first-page":"L69","DOI":"10.1152\/ajplung.00205.2013","article-title":"NADPH oxidase mediates synergistic effects of IL-17 and TNF-\u03b1 on CXCL1 expression by epithelial cells after lung ischemia-reperfusion","volume":"306","author":"Sharma","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249820317599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249820317599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:00:46Z","timestamp":1778518846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249820317599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S1053249820317599"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2020.09.012","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-206 antagomiR\u2012enriched extracellular vesicles attenuate lung ischemia\u2012reperfusion injury through CXCL1 regulation in alveolar epithelial cells","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2020.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 International Society for Heart and Lung Transplantation. All rights reserved.","name":"copyright","label":"Copyright"}]}}