{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:50:04Z","timestamp":1772131804413,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1074386"],"award-info":[{"award-number":["1074386"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.healun.2022.02.008","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T01:48:13Z","timestamp":1645235293000},"page":"829-839","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of frailty on mortality and morbidity in bridge to transplant recipients of contemporary durable mechanical circulatory support"],"prefix":"10.1016","volume":"41","author":[{"given":"Kavitha","family":"Muthiah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8542-6478","authenticated-orcid":false,"given":"Kay","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desiree","family":"Robson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0000-7520","authenticated-orcid":false,"given":"Hariharan","family":"Raju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira R.","family":"Aili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunita R.","family":"Jha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Fritis-Lamora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elyn","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Gorrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Deveza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7660-6258","authenticated-orcid":false,"given":"Bruno","family":"Schnegg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Jabbour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Kotlyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Keogh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Bart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Conellan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjun","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alasdair","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Granger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul C.","family":"Jansz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4036-1890","authenticated-orcid":false,"given":"Christopher","family":"Hayward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Macdonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2022.02.008_bib0001","first-page":"1000","article-title":"The impact of frailty status on clinical and functional outcomes after transcatheter aortic valve replacement in nonagenarians with severe aortic stenosis","volume":"90","author":"Okoh","year":"2017","journal-title":"Catheter Cardiovasc Interv Off J Soc Card Angiogr Interv"},{"key":"10.1016\/j.healun.2022.02.008_bib0002","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/TP.0000000000000991","article-title":"The prevalence and prognostic significance of frailty in patients with advanced heart failure referred for heart transplantation","volume":"100","author":"Jha","year":"2016","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2022.02.008_bib0003","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10741-015-9493-8","article-title":"Frailty in advanced heart failure: a systematic review","volume":"20","author":"Jha","year":"2015","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.healun.2022.02.008_bib0004","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.healun.2016.04.008","article-title":"Cognitive impairment improves the predictive validity of physical frailty for mortality in patients with advanced heart failure referred for heart transplantation","volume":"35","author":"Jha","year":"2016","journal-title":"J Heart Lung Transplant Off Publ Int Soc Heart Transplant"},{"key":"10.1016\/j.healun.2022.02.008_bib0005","article-title":"Validation of cognitive impairment in combination with physical frailty as a predictor of mortality in patients with advanced heart failure referred for heart transplantation","author":"Aili","year":"2021","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2022.02.008_bib0006","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/PSY.0000000000000872","article-title":"Longitudinal course of depressive, anxiety, and posttraumatic stress disorder symptoms after heart surgery: a meta-analysis of 94 studies","volume":"83","author":"Rosson","year":"2021","journal-title":"Psychosom Med"},{"key":"10.1016\/j.healun.2022.02.008_bib0007","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.healun.2013.12.014","article-title":"Frailty and outcomes after implantation of left ventricular assist device as destination therapy","volume":"33","author":"Dunlay","year":"2014","journal-title":"J Heart Lung Transplant Off Publ Int Soc Heart Transplant"},{"key":"10.1016\/j.healun.2022.02.008_bib0008","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.healun.2019.02.004","article-title":"Third annual report from the ISHLT Mechanically Assisted Circulatory Support Registry: a comparison of centrifugal and axial continuous-flow left ventricular assist devices","volume":"38","author":"Goldstein","year":"2019","journal-title":"J Heart Lung Transplant Off Publ Int Soc Heart Transplant"},{"key":"10.1016\/j.healun.2022.02.008_bib0009","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.healun.2022.02.008_bib0010","first-page":"69","article-title":"Grip and pinch strength: normative data for adults","volume":"66","author":"Mathiowetz","year":"1985","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.healun.2022.02.008_bib0011","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S0363-5023(85)80210-0","article-title":"Effect of elbow position on grip and key pinch strength","volume":"10","author":"Mathiowetz","year":"1985","journal-title":"J Hand Surg"},{"key":"10.1016\/j.healun.2022.02.008_bib0012","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.healun.2020.03.010","article-title":"Updated definitions of adverse events for trials and registries of mechanical circulatory support: a consensus statement of the mechanical circulatory support academic research consortium","volume":"39","author":"Kormos","year":"2020","journal-title":"J Heart Lung Transplant Off Publ Int Soc Heart Transplant"},{"key":"10.1016\/j.healun.2022.02.008_bib0013","doi-asserted-by":"crossref","first-page":"e167","DOI":"10.1097\/TXD.0000000000000690","article-title":"Reversibility of frailty after bridge-to-transplant ventricular assist device implantation or heart transplantation","volume":"3","author":"Jha","year":"2017","journal-title":"Transplant Direct"},{"key":"10.1016\/j.healun.2022.02.008_bib0014","article-title":"The impact of frailty on mortality after heart transplantation","author":"Macdonald","year":"2020","journal-title":"J Heart Lung Transplant Off Publ Int Soc Heart Transplant"},{"key":"10.1016\/j.healun.2022.02.008_bib0015","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/ejhf.504","article-title":"Prognostic incremental role of right ventricular function in acute decompensation of advanced chronic heart failure","volume":"18","author":"Frea","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.healun.2022.02.008_bib0016","doi-asserted-by":"crossref","first-page":"e578","DOI":"10.1161\/CIR.0000000000000560","article-title":"Evaluation and management of right-sided heart failure: a scientific statement from the American Heart Association","volume":"137","author":"Konstam","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2022.02.008_bib0017","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1161\/CIRCHEARTFAILURE.111.963215","article-title":"Frailty and the selection of patients for destination therapy left ventricular assist device","volume":"5","author":"Flint","year":"2012","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.healun.2022.02.008_bib0018","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1510\/icvts.2010.251884","article-title":"One-year follow-up of patients undergoing elective cardiac surgery assessed with the Comprehensive Assessment of Frailty test and its simplified form","volume":"13","author":"S\u00fcndermann","year":"2011","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.healun.2022.02.008_bib0019","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12877-016-0329-8","article-title":"Frailty and post-operative outcomes in older surgical patients: a systematic review","volume":"16","author":"Lin","year":"2016","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.healun.2022.02.008_bib0020","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ijcard.2019.09.064","article-title":"The hospital frailty risk score and its association with in-hospital mortality, cost, length of stay and discharge location in patients with heart failure short running title: Frailty and outcomes in heart failure","volume":"300","author":"Kwok","year":"2020","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.healun.2022.02.008_bib0021","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1056\/NEJMoa1610426","article-title":"A fully magnetically levitated circulatory pump for advanced heart failure","volume":"376","author":"Mehra","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.healun.2022.02.008_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.healun.2020.01.1330","article-title":"Understanding risk factors and predictors for stroke subtypes in the ENDURANCE trials","author":"Cho","year":"2020","journal-title":"J Heart Lung Transplant Off Publ Int Soc Heart Transplant"},{"key":"10.1016\/j.healun.2022.02.008_bib0023","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.healun.2015.12.024","article-title":"Longitudinal changes in hemostatic parameters and reduced pulsatility contribute to non-surgical bleeding in patients with centrifugal continuous-flow left ventricular assist devices","volume":"35","author":"Muthiah","year":"2016","journal-title":"J Heart Lung Transplant Off Publ Int Soc Heart Transplant"},{"key":"10.1016\/j.healun.2022.02.008_bib0024","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.healun.2015.06.015","article-title":"Right ventricular failure after left ventricular assist devices","volume":"34","author":"Lampert","year":"2015","journal-title":"J Heart Lung Transplant Off Publ Int Soc Heart Transplant"},{"key":"10.1016\/j.healun.2022.02.008_bib0025","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.cardfail.2014.02.008","article-title":"Reduced handgrip strength as a marker of frailty predicts clinical outcomes in patients with heart failure undergoing ventricular assist device placement","volume":"20","author":"Chung","year":"2014","journal-title":"J Card Fail"},{"key":"10.1016\/j.healun.2022.02.008_bib0026","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1111\/jgs.15124","article-title":"Can a left ventricular assist device in individuals with advanced systolic heart failure improve or reverse frailty?","volume":"65","author":"Maurer","year":"2017","journal-title":"J Am Geriatr Soc"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249822018150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249822018150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:45:51Z","timestamp":1760949951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249822018150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S1053249822018150"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2022.02.008","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of frailty on mortality and morbidity in bridge to transplant recipients of contemporary durable mechanical circulatory support","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2022.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society for Heart and Lung Transplantation. All rights reserved.","name":"copyright","label":"Copyright"}]}}