{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:38:37Z","timestamp":1793144317569,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.healun.2022.02.021","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T11:19:41Z","timestamp":1646479181000},"page":"780-790","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Incremental value of cardiopulmonary exercise testing in intermediate-risk pulmonary arterial hypertension"],"prefix":"10.1016","volume":"41","author":[{"given":"Roberto","family":"Badagliacca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Rischard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Lo","family":"Giudice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8653-4035","authenticated-orcid":false,"given":"Silvia","family":"Papa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Valli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0676-3132","authenticated-orcid":false,"given":"Giovanna","family":"Manzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Sciomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Palange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe G.N.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Vanderpool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3999-5298","authenticated-orcid":false,"given":"Rocco","family":"Rinaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Vigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Insel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Fedele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine Dario","family":"Vizza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2022.02.021_bib0001","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1093\/eurheartj\/ehq152","article-title":"Pulmonary arterial hypertension: from the kingdom of the near-dead to multiple clinical trial meta-analyses","volume":"31","author":"Gali\u00e8","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.healun.2022.02.021_bib0002","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01889-2018","article-title":"Risk stratification and medical therapy of pulmonary arterial hypertension","volume":"53","author":"Gali\u00e8","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.02.021_bib0003","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01353-2017","article-title":"Assessing risk in pulmonary arterial hypertension: what we know, what we don't","volume":"50","author":"Benza","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.02.021_bib0004","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00740-2017","article-title":"Mortality in pulmonary arterial hypertension: prediction by the 2015 European pulmonary hypertension guidelines risk stratification model","volume":"50","author":"Hoeper","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.02.021_bib0005","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00889-2017","article-title":"Risk assessment, prognosis and guideline implementation in pulmonary arterial hypertension","volume":"50","author":"Boucly","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.02.021_bib0006","article-title":"A comprehensive risk stratification at early follow-up determines prognosis in pulmonary arterial hypertension","author":"Kylhammar","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.healun.2022.02.021_bib0007","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.healun.2014.09.016","article-title":"Prognostic implications of serial risk score assessments in patients with pulmonary arterial hypertension: a registry to evaluate early and long-term pulmonary arterial hypertension disease management (REVEAL) analysis","volume":"34","author":"Benza","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2022.02.021_bib0008","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.chest.2019.02.004","article-title":"Predicting survival in patients with pulmonary arterial hypertension: the REVEAL risk score calculator 2.0 and comparison with ESC\/ERS-based risk assessment strategies","volume":"156","author":"Benza","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.healun.2022.02.021_bib0009","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00889-2017","article-title":"Risk assessment, prognosis and guideline implementation in pulmonary arterial hypertension","volume":"50","author":"Boucly","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.02.021_bib0010","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","volume":"37","author":"Gali\u00e8","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.healun.2022.02.021_bib0011","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1183\/13993003.01032-2015","volume":"46","author":"Gali\u00e8","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.02.021_bib0012","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01900-2018","article-title":"Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update","volume":"53","author":"Vonk Noordegraaf","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.02.021_bib0013","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.jacc.2018.12.076","article-title":"Anatomy, function, and dysfunction of the right ventricle: JACC state-of-the-art review","volume":"73","author":"Sanz","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.healun.2022.02.021_bib0014","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijcard.2019.10.043","article-title":"The importance of right ventricular evaluation in risk assessment and therapeutic strategies: raising the bar in pulmonary arterial hypertension","volume":"301","author":"Badagliacca","year":"2020","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.healun.2022.02.021_bib0015","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1161\/CIRCULATIONAHA.113.001573","article-title":"Assessment and prognostic relevance of right ventricular contractile reserve in patients with severe pulmonary hypertension","volume":"128","author":"Gr\u00fcnig","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2022.02.021_bib0016","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cardfail.2014.04.019","article-title":"Hemodynamic ranges during daily activities and exercise testing in patients with pulmonary arterial hypertension","volume":"20","author":"Kjellstr\u00f6m","year":"2014","journal-title":"J Card Fail"},{"key":"10.1016\/j.healun.2022.02.021_bib0017","doi-asserted-by":"crossref","DOI":"10.1378\/chest.14-2065","article-title":"Echocardiography of right ventriculo-arterial coupling combined to cardiopulmonary exercise testing to predict outcome in heart failure","author":"Guazzi","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.healun.2022.02.021_bib0018","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1183\/09031936.00123712","article-title":"Haemodynamics, exercise capacity and clinical events in pulmonary arterial hypertension","volume":"42","author":"Savarese","year":"2013","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.02.021_bib0019","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.chest.2016.07.036","article-title":"Echocardiography combined with cardiopulmonary exercise testing for the prediction of outcome in idiopathic pulmonary arterial hypertension","volume":"150","author":"Badagliacca","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.healun.2022.02.021_bib0020","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.chest.2019.02.004","article-title":"Predicting survival in patients with pulmonary arterial hypertension: the REVEAL risk score calculator 2.0 and comparison with ESC\/ERS-based risk assessment strategies","volume":"156","author":"Benza","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.healun.2022.02.021_bib0021","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/eurheartj\/ehu207","article-title":"Towards better clinical prediction models: seven steps for development and an ABCD for validation","volume":"35","author":"Steyerberg","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.healun.2022.02.021_bib0022","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.regpep.2004.07.021","article-title":"Increased plasma levels of adrenomedullin, a vasoactive peptide, in patients with end-stage pulmonary disease","volume":"124","author":"Vizza","year":"2005","journal-title":"Regul Pept"},{"key":"10.1016\/j.healun.2022.02.021_bib0023","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1001\/jama.2011.1966","article-title":"Prognostic indices for older adults: a systematic review","volume":"307","author":"Yourman","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.healun.2022.02.021_bib0024","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1164\/ajrccm.160.2.9811062","article-title":"Determination of cardiac output by the Fick method, thermodilution, and acetylene rebreathing in pulmonary hypertension","volume":"160","author":"Hoeper","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.healun.2022.02.021_bib0025","article-title":"Risk reduction and hemodynamics with initial combination therapy in pulmonary arterial hypertension","author":"Badagliacca","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.healun.2022.02.021_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.healun.2020.08.016","article-title":"Hemodynamics and risk assessment 2 years after the initiation of upfront ambrisentan\u2012tadalafil in pulmonary arterial hypertension","author":"D'Alto","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2022.02.021_bib0027","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00279-2018","article-title":"Risk assessment in pulmonary arterial hypertension","volume":"51","author":"Boucly","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.02.021_bib0028","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1161\/CIRCULATIONAHA.117.029254","article-title":"Prognostic value of follow-up hemodynamic variables after initial management in pulmonary arterial hypertension","volume":"137","author":"Weatherald","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2022.02.021_bib0029","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1093\/eurheartj\/ehl477","article-title":"Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension","volume":"28","author":"van Wolferen","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.healun.2022.02.021_bib0030","doi-asserted-by":"crossref","unstructured":"Gr\u00fcnig E, Tiede H, Enyimayew EO, et\u00a0al. Assessment and prognostic relevance of right ventricular contractile reserve in patients with severe pulmonary hypertension. Circulation;128:2005-15. doi:10.1161\/CIRCULATIONAHA.113.001573. Epub 2013 Sep 20. PMID: 24056689.","DOI":"10.1161\/CIRCULATIONAHA.113.001573"},{"key":"10.1016\/j.healun.2022.02.021_bib0031","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/eurjhf\/hft044","article-title":"Impact of right ventricular reserve on exercise capacity and survival in patients with pulmonary hypertension","volume":"15","author":"Blumberg","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.healun.2022.02.021_bib0032","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1183\/09031936.00153613","article-title":"Prognostic value of exercise pulmonary haemodynamics in pulmonary arterial hypertension","volume":"44","author":"Chaouat","year":"2014","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.02.021_bib0033","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.chest.2016.02.634","article-title":"Pressure-flow during exercise catheterization predicts survival in pulmonary hypertension","volume":"150","author":"Hasler","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.healun.2022.02.021_bib0034","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1249\/mss.0b013e318159d1b8","article-title":"Impaired systemic oxygen extraction at maximum exercise in pulmonary hypertension","volume":"40","author":"Tolle","year":"2008","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.healun.2022.02.021_bib0035","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.ijcard.2012.03.135","article-title":"Incremental prognostic value of cardiopulmonary exercise testing and resting haemodynamics in pulmonary arterial hypertension","volume":"167","author":"Wensel","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.healun.2022.02.021_bib0036","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0134-2017","article-title":"Right and left heart failure study group\u201d of the italian society of cardiology. The role of cardiopulmonary exercise tests in pulmonary arterial hypertension","volume":"27","author":"Farina","year":"2018","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.healun.2022.02.021_bib0037","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1183\/09031936.00217911","article-title":"Exercise testing to predict outcome in idiopathic versus associated pulmonary arterial hypertension","volume":"40","author":"Deboeck","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.02.021_bib0038","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/01.CIR.0000022687.18568.2A","article-title":"Assessment of survival in patients with primary pulmonary hypertension: importance of cardiopulmonary exercise testing","volume":"106","author":"Wensel","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2022.02.021_bib0039","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.healun.2018.11.015","article-title":"The added value of cardiopulmonary exercise testing in the follow-up of pulmonary arterial hypertension","volume":"38","author":"Badagliacca","year":"2019","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2022.02.021_bib0040","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1249\/MSS.0b013e31817c92c0","article-title":"Exercise testing to estimate survival in pulmonary hypertension","volume":"40","author":"Groepenhoff","year":"2008","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.healun.2022.02.021_bib0041","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1183\/09031936.00217911","article-title":"Exercise testing to predict outcome in idiopathic versus associated pulmonary arterial hypertension","volume":"40","author":"Deboeck","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.02.021_bib0042","doi-asserted-by":"crossref","first-page":"e72013","DOI":"10.1371\/journal.pone.0072013","article-title":"Prognostic relevance of changes in exercise test variables in pulmonary arterial hypertension","volume":"8","author":"Groepenhoff","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.healun.2022.02.021_bib0043","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.amjcard.2013.10.017","article-title":"Noninvasive cardiac output measurement by inert gas rebreathing in suspected pulmonary hypertension","volume":"113","author":"Farina","year":"2014","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.healun.2022.02.021_bib0044","article-title":"COMPERA 2.0: a refined 4-strata risk assessment model for pulmonary arterial hypertension","author":"Hoeper","year":"2021","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.02.021_bib0045","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1378\/chest.11-0676","article-title":"The REVEAL registry risk score calculator in patients newly diagnosed with pulmonary arterial hypertension","volume":"141","author":"Benza","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.healun.2022.02.021_bib0046","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1183\/09059180.00008211","article-title":"REVEAL: a contemporary US pulmonary arterial hypertension registry","volume":"21","author":"McGoon","year":"2012","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.healun.2022.02.021_bib0047","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1183\/09031936.00094112","article-title":"Survivor bias and risk assessment","volume":"40","author":"Miller","year":"2012","journal-title":"Eur Respir J"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249822018447?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249822018447?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:45:45Z","timestamp":1760949945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249822018447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S1053249822018447"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2022.02.021","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incremental value of cardiopulmonary exercise testing in intermediate-risk pulmonary arterial hypertension","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2022.02.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society for Heart and Lung Transplantation. All rights reserved.","name":"copyright","label":"Copyright"}]}}