{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:52:32Z","timestamp":1792403552548,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"am","delay-in-days":361,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.healun.2022.06.019","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T21:17:03Z","timestamp":1656451023000},"page":"1401-1413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Circulating microRNAs in cellular and antibody-mediated heart transplant rejection"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8175-168X","authenticated-orcid":false,"given":"Palak","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9380-9161","authenticated-orcid":false,"given":"Sean","family":"Agbor-Enoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-2767","authenticated-orcid":false,"given":"Pramita","family":"Bagchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0660-4943","authenticated-orcid":false,"given":"Christopher R.","family":"deFilippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Mercado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7304-9591","authenticated-orcid":false,"given":"Gouqing","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave JP","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-2963","authenticated-orcid":false,"given":"Keyur B.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-416X","authenticated-orcid":false,"given":"Samer S.","family":"Najjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Feller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabra C.","family":"Lewsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1657-2877","authenticated-orcid":false,"given":"Moon Kyoo","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6844-209X","authenticated-orcid":false,"given":"Charles","family":"Marboe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6176-2629","authenticated-orcid":false,"given":"Gerald J.","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9697-5926","authenticated-orcid":false,"given":"Kiran K.","family":"Khush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah A.","family":"Valantine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2022.06.019_bib0001","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.healun.2020.07.010","article-title":"The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 37th adult heart transplantation report-2020; focus on deceased donor characteristics","volume":"39","author":"Khush","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2022.06.019_bib0002","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1161\/CIRCULATIONAHA.120.049098","article-title":"Cell-free DNA to detect heart allograft acute rejection","volume":"143","author":"Agbor-Enoh","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2022.06.019_bib0003","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1161\/CIR.0000000000000093","article-title":"Antibody-mediated rejection in cardiac transplantation: emerging knowledge in diagnosis and management: a scientific statement from the American Heart Association","volume":"131","author":"Colvin","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2022.06.019_bib0004","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.healun.2009.01.015","article-title":"Asymptomatic antibody-mediated rejection after heart transplantation predicts poor outcomes","volume":"28","author":"Wu","year":"2009","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2022.06.019_bib0005","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.healun.2022.06.019_bib0006","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s11897-017-0362-8","article-title":"MicroRNAs in heart failure, cardiac transplantation, and myocardial recovery: biomarkers with therapeutic potential","volume":"14","author":"Shah","year":"2017","journal-title":"Curr Heart Fail Rep"},{"key":"10.1016\/j.healun.2022.06.019_bib0007","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.healun.2012.12.007","article-title":"Altered serum miRNA profiles during acute rejection after heart transplantation: potential for non-invasive allograft surveillance","volume":"32","author":"Sukma Dewi","year":"2013","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2022.06.019_bib0008","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1093\/eurheartj\/ehu346","article-title":"MicroRNAs as non-invasive biomarkers of heart transplant rejection","volume":"35","author":"Duong Van Huyen","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.healun.2022.06.019_bib0009","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.healun.2018.06.010","article-title":"MicroRNA signatures in cardiac biopsies and detection of allograft rejection","volume":"37","author":"Di Francesco","year":"2018","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2022.06.019_bib0010","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.healun.2020.05.018","article-title":"Circulating miR-181a-5p as a new biomarker for acute cellular rejection in heart transplantation","volume":"39","author":"Constanso-Conde","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2022.06.019_bib0011","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/09674845.2017.1333265","article-title":"Role of miR-29 as marker of risk of acute rejection after heart transplant","volume":"74","author":"Guo","year":"2017","journal-title":"Br J Biomed Sci"},{"key":"10.1016\/j.healun.2022.06.019_bib0012","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.healun.2005.03.019","article-title":"Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection","volume":"24","author":"Stewart","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2022.06.019_bib0013","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.healun.2013.08.011","article-title":"The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation","volume":"32","author":"Berry","year":"2013","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2022.06.019_bib0014","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1097\/TP.0b013e31826e19e2","article-title":"Concordance among pathologists in the second Cardiac Allograft Rejection Gene Expression Observational Study (CARGO II)","volume":"94","author":"Crespo-Leiro","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2022.06.019_bib0015","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3389\/fgene.2020.00442","article-title":"Red blood cells as potential repositories of microRNAs in the circulatory system","volume":"11","author":"Sun","year":"2020","journal-title":"Front Genet"},{"key":"10.1016\/j.healun.2022.06.019_bib0016","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.healun.2022.06.019_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J Stat Softw"},{"key":"10.1016\/j.healun.2022.06.019_bib0018","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/biomet\/80.1.27","article-title":"Bias reduction of maximum likelihood estimates","volume":"80","author":"Firth","year":"1993","journal-title":"Biometrika"},{"key":"10.1016\/j.healun.2022.06.019_bib0019","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/bimj.200410135","article-title":"Estimation of the Youden Index and its associated cutoff point","volume":"47","author":"Fluss","year":"2005","journal-title":"Biom J"},{"key":"10.1016\/j.healun.2022.06.019_bib0020","first-page":"D148","article-title":"miRTarBase 2020: updates to the experimentally validated microRNA-target interaction database","volume":"48","author":"Huang","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.healun.2022.06.019_bib0021","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.3892\/ijo.2012.1647","article-title":"Circulating microRNAs: new biomarkers in diagnosis, prognosis and treatment of cancer (review)","volume":"41","author":"Allegra","year":"2012","journal-title":"Int J Oncol"},{"key":"10.1016\/j.healun.2022.06.019_bib0022","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1600-6143.2005.01175.x","article-title":"Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling","volume":"6","author":"Deng","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2022.06.019_bib0023","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.healun.2009.12.015","article-title":"Benefit of immune monitoring in heart transplant patients using ATP production in activated lymphocytes","volume":"29","author":"Kobashigawa","year":"2010","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2022.06.019_bib0024","doi-asserted-by":"crossref","first-page":"6229","DOI":"10.1073\/pnas.1013924108","article-title":"Universal noninvasive detection of solid organ transplant rejection","volume":"108","author":"Snyder","year":"2011","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.healun.2022.06.019_bib0025","doi-asserted-by":"crossref","first-page":"241ra77","DOI":"10.1126\/scitranslmed.3007803","article-title":"Circulating cell-free DNA enables noninvasive diagnosis of heart transplant rejection","volume":"6","author":"De Vlaminck","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.healun.2022.06.019_bib0026","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1111\/ajt.15339","article-title":"Noninvasive detection of graft injury after heart transplant using donor-derived cell-free DNA: A prospective multicenter study","volume":"19","author":"Khush","year":"2019","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2022.06.019_bib0027","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1600-6143.2011.03958.x","article-title":"Differential expression of microRNAs during allograft rejection","volume":"12","author":"Wei","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2022.06.019_bib0028","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/TP.0000000000001345","article-title":"Absence of miR-182 augments cardiac allograft survival","volume":"101","author":"Wei","year":"2017","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2022.06.019_bib0029","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/CIRCRESAHA.111.247452","article-title":"Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease?","volume":"110","author":"Creemers","year":"2012","journal-title":"Circ Res"},{"key":"10.1016\/j.healun.2022.06.019_bib0030","doi-asserted-by":"crossref","first-page":"e615","DOI":"10.1097\/TXD.0000000000001057","article-title":"Circulating donor heart exosome profiling enables noninvasive detection of antibody-mediated rejection","volume":"6","author":"Hu","year":"2020","journal-title":"Transplant Direct"},{"key":"10.1016\/j.healun.2022.06.019_bib0031","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1186\/s12864-019-5870-3","article-title":"Comprehensive assessment of multiple biases in small RNA sequencing reveals significant differences in the performance of widely used methods","volume":"20","author":"Wright","year":"2019","journal-title":"BMC Genom"},{"key":"10.1016\/j.healun.2022.06.019_bib0032","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41374-018-0143-3","article-title":"MicroRNA amplification and detection technologies: opportunities and challenges for point of care diagnostics","volume":"99","author":"Dave","year":"2019","journal-title":"Lab Invest"},{"key":"10.1016\/j.healun.2022.06.019_bib0033","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.healun.2017.11.003","article-title":"Racial differences in the development of de-novo donor-specific antibodies and treated antibody-mediated rejection after heart transplantation","volume":"37","author":"Cole","year":"2018","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2022.06.019_bib0034","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1161\/CIRCULATIONAHA.114.011676","article-title":"Racial disparities in outcomes of adult heart transplantation","volume":"131","author":"Kilic","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2022.06.019_bib0035","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.amjcard.2009.11.015","article-title":"Socioeconomic position, ethnicity, and outcomes in heart transplant recipients","volume":"105","author":"Singh","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.healun.2022.06.019_bib0036","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.healun.2016.01.1231","article-title":"Racial and ethnic disparities in outcomes after heart transplantation: a systematic review of contributing factors and future directions to close the outcomes gap","volume":"35","author":"Morris","year":"2016","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2022.06.019_bib0037","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/HCO.0000000000000855","article-title":"Racial and ethnic disparities in heart failure: current state and future directions","volume":"36","author":"Lewsey","year":"2021","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.healun.2022.06.019_bib0038","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.healun.2015.01.987","article-title":"Gene expression profiling to study racial differences after heart transplantation","volume":"34","author":"Khush","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.healun.2022.06.019_bib0039","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/ajt.12162","article-title":"A survey of current practice for antibody-mediated rejection in heart transplantation","volume":"13","author":"Chih","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.healun.2022.06.019_bib0040","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","article-title":"Regression shrinkage and selection via the lasso","volume":"58","author":"Tibshirani","year":"1996","journal-title":"J R Stat Soc Series B (Methodological)"},{"key":"10.1016\/j.healun.2022.06.019_bib0041","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1161\/CIRCULATIONAHA.116.022907","article-title":"Gene expression profiling for the identification and classification of antibody-mediated heart rejection","volume":"135","author":"Loupy","year":"2017","journal-title":"Circulation"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249822020186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249822020186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:47:00Z","timestamp":1760950020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249822020186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S1053249822020186"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2022.06.019","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating microRNAs in cellular and antibody-mediated heart transplant rejection","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2022.06.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society for Heart and Lung Transplantation. All rights reserved.","name":"copyright","label":"Copyright"}]}}