{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:16:17Z","timestamp":1791944177477,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.healun.2022.08.019","type":"journal-article","created":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T07:31:18Z","timestamp":1661671878000},"page":"1808-1818","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Anticoagulation in pulmonary arterial hypertension - association with mortality, healthcare utilization, and quality of life: The Pulmonary Hypertension Association Registry (PHAR)"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9140-1632","authenticated-orcid":false,"given":"Jonah D.","family":"Garry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4586-959X","authenticated-orcid":false,"given":"Nicholas A.","family":"Kolaitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9897-7076","authenticated-orcid":false,"given":"Richard","family":"Kronmal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thenappan","family":"Thenappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2755-5845","authenticated-orcid":false,"given":"Anna","family":"Hemnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Grinnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Bull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murali M.","family":"Chakinala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-4704","authenticated-orcid":false,"given":"Teresa","family":"De Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2022.08.019_bib0001","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/01.CIR.70.4.580","article-title":"Primary pulmonary hypertension: Natural history and the importance of thrombosis","volume":"70","author":"Fuster","year":"1984","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2022.08.019_bib0002","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/01.CIR.80.5.1198","article-title":"Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute, Primary Pulmonary Hypertension Registry","volume":"80","author":"Pietra","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2022.08.019_bib0003","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.drudis.2014.04.001","article-title":"Thrombosis, platelets, microparticles and PAH: more than a clot","volume":"19","author":"Lannan","year":"2014","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.healun.2022.08.019_bib0004","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.amjcard.2004.09.006","article-title":"New predictors of outcome in idiopathic pulmonary arterial hypertension","volume":"95","author":"Kawut","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.healun.2022.08.019_bib0005","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1378\/chest.112.3.714","article-title":"The effect of anticoagulant therapy in primary and anorectic drug- induced pulmonary hypertension","volume":"112","author":"Frank","year":"1997","journal-title":"Chest"},{"key":"10.1016\/j.healun.2022.08.019_bib0006","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1253\/jcj.57.63","article-title":"Effects of a combination therapy of anticoagulant and vasodilator on the long-term prognosis of primary pulmonary hypertension","volume":"57","author":"Ogata","year":"1993","journal-title":"Jpn Circ J"},{"key":"10.1016\/j.healun.2022.08.019_bib0007","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1056\/NEJM199207093270203","article-title":"The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension","volume":"327","author":"Rich","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.healun.2022.08.019_bib0008","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.0954-6820.1966.tb05449.x","article-title":"Primary pulmonary hypertension with emphasis on its etiology and treatment","volume":"179","author":"Storstein","year":"1966","journal-title":"Acta Med Scand"},{"key":"10.1016\/j.healun.2022.08.019_bib0009","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1161\/CIRCULATIONAHA.113.004526","article-title":"Anticoagulation and survival in pulmonary arterial hypertension: results from the comparative, prospective registry of newly initiated therapies for pulmonary hypertension (COMPERA)","volume":"129","author":"Olsson","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2022.08.019_bib0010","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1161\/CIRCULATIONAHA.115.018435","article-title":"Effect of warfarin treatment on survival of patients with pulmonary arterial hypertension (PAH) in the registry to evaluate early and Long-Term PAH Disease Management (REVEAL)","volume":"132","author":"Preston","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2022.08.019_bib0011","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.118.004757","article-title":"Is anticoagulation beneficial in pulmonary arterial hypertension?","volume":"11","author":"Khan","year":"2018","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.healun.2022.08.019_bib0012","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.thromres.2020.08.024","article-title":"Can anticoagulants improve the survival rate for patients with idiopathic pulmonary arterial hypertension? A systematic review and meta-analysis","volume":"196","author":"Wang","year":"2020","journal-title":"Thromb Res"},{"key":"10.1016\/j.healun.2022.08.019_bib0013","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"2015 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"37","author":"Gali\u00e8","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.healun.2022.08.019_bib0014","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.chest.2018.11.030","article-title":"Therapy for pulmonary arterial hypertension in adults: update of the CHEST Guideline and Expert Panel Report","volume":"155","author":"Klinger","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.healun.2022.08.019_bib0015","doi-asserted-by":"crossref","DOI":"10.1177\/2045894019895451","article-title":"Anticoagulation in pulmonary arterial hypertension: a decision analysis","volume":"9","author":"Jose","year":"2019","journal-title":"Pulm Circ"},{"key":"10.1016\/j.healun.2022.08.019_bib0016","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.thromres.2014.02.029","article-title":"A descriptive evaluation of warfarin use in patients with pulmonary arterial hypertension","volume":"133","author":"Irwin","year":"2014","journal-title":"Thromb Res"},{"key":"10.1016\/j.healun.2022.08.019_bib0017","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1177\/2045893217721903","article-title":"Complications associated with the use of oral anticoagulation in patients with pulmonary arterial hypertension from two referral centers","volume":"7","author":"Roldan","year":"2017","journal-title":"Pulm Circ"},{"key":"10.1016\/j.healun.2022.08.019_bib0018","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.thromres.2017.10.024","article-title":"Assessment of the quality of anticoagulation management in patients with pulmonary arterial hypertension","volume":"160","author":"Roldan","year":"2017","journal-title":"Thromb Res"},{"key":"10.1016\/j.healun.2022.08.019_bib0019","article-title":"Survival and quality of life in incident systemic sclerosis-related pulmonary arterial hypertension","volume":"19","author":"Morrisroe","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.healun.2022.08.019_bib0020","doi-asserted-by":"crossref","first-page":"185","DOI":"10.21693\/1933-088X-16.4.185","article-title":"The pulmonary hypertension association registry: rationale, design, and role in quality improvement","volume":"16","author":"Gray","year":"2018","journal-title":"Adv Pulm Hypertens"},{"key":"10.1016\/j.healun.2022.08.019_bib0021","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00005650-199603000-00003","article-title":"A 12-item short-form health survey: construction of scales and preliminary tests of reliability andvalidity","volume":"34","author":"Ware","year":"1996","journal-title":"Med Care"},{"key":"10.1016\/j.healun.2022.08.019_bib0022","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1183\/09031936.00127113","article-title":"EmPHasis-10: development of a health-related quality of life measure in pulmonary hypertension","volume":"43","author":"Yorke","year":"2014","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.08.019_bib0023","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.115.019651","article-title":"Whither anticoagulation in pulmonary arterial hypertension? Conflicting evidence REVEALed","volume":"132","author":"Frantz","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2022.08.019_bib0024","doi-asserted-by":"crossref","DOI":"10.1177\/2045894018790316","article-title":"Atrial arrhythmias are associated with increased mortality in pulmonary arterial hypertension","volume":"8","author":"Smith","year":"2018","journal-title":"Pulm Circ"},{"key":"10.1016\/j.healun.2022.08.019_bib0025","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1183\/09031936.00039212","article-title":"Vonk-Noordegraaf A. Major bleeding with vitamin K antagonist anticoagulants in pulmonary hypertension","volume":"41","author":"Henkens","year":"2013","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.08.019_bib0026","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10067-019-04588-0","article-title":"Risk of bleeding events among patients with systemic sclerosis and the general population in the UK: a large population-based cohort study","volume":"39","author":"Michel","year":"2020","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.healun.2022.08.019_bib0027","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00414-2020","article-title":"EmPHasis-10 as a measure of health-related quality of life in pulmonary arterial hypertension: data from PHAR","volume":"57","author":"Borgese","year":"2021","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.08.019_bib0028","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00124-2020","article-title":"EmPHasis-10 health-related quality of life score predicts outcomes in patients with idiopathic and connective tissue disease-associated pulmonary arterial hypertension: results from a UK multicentre study","volume":"57","author":"Lewis","year":"2021","journal-title":"Eur Respir J"},{"key":"10.1016\/j.healun.2022.08.019_bib0029","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.chest.2018.04.027","article-title":"Psychometric validation of the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT) Questionnaire: Results of the SYMPHONY Trial","volume":"154","author":"Chin","year":"2018","journal-title":"Chest"},{"key":"10.1016\/j.healun.2022.08.019_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7525-6-65","article-title":"Development and validation of a preference based measure derived from the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for use in cost utility analyses","volume":"6","author":"McKenna","year":"2008","journal-title":"Health Qual Life Outcomes"},{"key":"10.1016\/j.healun.2022.08.019_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7525-11-161","article-title":"Development and validation of the living with pulmonary hypertension questionnaire in pulmonary arterial hypertension patients","volume":"11","author":"Bonner","year":"2013","journal-title":"Health Qual Life Outcomes"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105324982202085X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105324982202085X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T15:14:43Z","timestamp":1762355683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105324982202085X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S105324982202085X"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2022.08.019","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anticoagulation in pulmonary arterial hypertension - association with mortality, healthcare utilization, and quality of life: The Pulmonary Hypertension Association Registry (PHAR)","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2022.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society for Heart and Lung Transplantation. All rights reserved.","name":"copyright","label":"Copyright"}]}}