{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:33:53Z","timestamp":1793136833092,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL125303"],"award-info":[{"award-number":["R01 HL125303"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013015","name":"Cedars-Sinai Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015015","name":"Government of South Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.healun.2023.09.017","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:25:38Z","timestamp":1696483538000},"page":"387-393","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["HLA sensitization is associated with an increased risk of primary graft dysfunction after heart transplantation"],"prefix":"10.1016","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-5355","authenticated-orcid":false,"given":"Jiho","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1254-6687","authenticated-orcid":false,"given":"Josh","family":"Rushakoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasbanoo","family":"Moayedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Henricksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Luikart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Shalakhti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5945-6518","authenticated-orcid":false,"given":"Loren","family":"Gragert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Benck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Malinoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Kobashigawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8342-3222","authenticated-orcid":false,"given":"Jeffrey","family":"Teuteberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran K.","family":"Khush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jignesh","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0507-2412","authenticated-orcid":false,"given":"Evan","family":"Kransdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.healun.2023.09.017_bib1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/TP.0000000000002220","article-title":"ISHLT primary graft dysfunction risk, risk factors, and outcome: a UK national study","volume":"103","author":"Avtaar Singh","year":"2019","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2023.09.017_bib2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.healun.2018.12.007","article-title":"Validation of the International Society for Heart and Lung Transplantation primary graft dysfunction instrument in heart transplantation","volume":"38","author":"Foroutan","year":"2019","journal-title":"J Heart Lung Transpl"},{"key":"10.1016\/j.healun.2023.09.017_bib3","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.healun.2014.02.027","article-title":"Report from a consensus conference on primary graft dysfunction after cardiac transplantation","volume":"33","author":"Kobashigawa","year":"2014","journal-title":"J Heart Lung Transpl"},{"issue":"7","key":"10.1016\/j.healun.2023.09.017_bib4","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.healun.2021.03.015","article-title":"Risk and impact of primary graft dysfunction in adult heart transplant recipients: a systematic review and meta-analysis","volume":"40","author":"Buchan","year":"2021","journal-title":"J Heart Lung Transpl"},{"key":"10.1016\/j.healun.2023.09.017_bib5","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.healun.2011.01.721","article-title":"RADIAL: a novel primary graft failure risk score in heart transplantation","volume":"30","author":"Segovia","year":"2011","journal-title":"J Heart Lung Transpl"},{"key":"10.1016\/j.healun.2023.09.017_bib6","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.healun.2021.06.002","article-title":"Recipient and surgical factors trigger severe primary graft dysfunction after heart transplant","volume":"40","author":"Benck","year":"2021","journal-title":"J Heart Lung Transpl"},{"key":"10.1016\/j.healun.2023.09.017_bib7","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.healun.2017.05.025","article-title":"Dose-dependent association between amiodarone and severe primary graft dysfunction in orthotopic heart transplantation","volume":"36","author":"Wright","year":"2017","journal-title":"J Heart Lung Transpl"},{"key":"10.1016\/j.healun.2023.09.017_bib8","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1161\/CIR.0000000000000598","article-title":"Sensitization in heart transplantation: emerging knowledge: a scientific statement from the American Heart Association","volume":"139","author":"Colvin","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.healun.2023.09.017_bib9","doi-asserted-by":"crossref","first-page":"E61","DOI":"10.1111\/j.1399-0012.2010.01334.x","article-title":"The long-term outcome of treated sensitized patients who undergo heart transplantation","volume":"25","author":"Kobashigawa","year":"2011","journal-title":"Clin Transpl"},{"key":"10.1016\/j.healun.2023.09.017_bib10","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.healun.2017.02.015","article-title":"Calculated panel-reactive antibody predicts outcomes on the heart transplant waiting list","volume":"36","author":"Kransdorf","year":"2017","journal-title":"J Heart Lung Transpl"},{"key":"10.1016\/j.healun.2023.09.017_bib11","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.011124","article-title":"Human leukocyte antigen-based risk stratification in heart transplant recipients-implications for targeted surveillance","volume":"8","author":"Nilsson","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.healun.2023.09.017_bib12","unstructured":"OPTN. CPRA calculator.\u00a0Available at:\u00a0\u3008https:\/\/optn.transplant.hrsa.gov\/data\/allocation-calculators\/cpra-calculator\u3009, accessed April 14, 2023."},{"key":"10.1016\/j.healun.2023.09.017_bib13","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.healun.2022.12.022","article-title":"Donor hyperoxia is a novel risk factor for severe cardiac primary graft dysfunction","volume":"42","author":"Kransdorf","year":"2023","journal-title":"J Heart Lung Transpl"},{"key":"10.1016\/j.healun.2023.09.017_bib14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1600-6143.2009.02927.x","article-title":"Calculated PRA (cPRA): the new measure of sensitization for transplant candidates","volume":"10","author":"Cecka","year":"2010","journal-title":"Am J Transpl"},{"key":"10.1016\/j.healun.2023.09.017_bib15","unstructured":"Schlegel B, Steenbergen M. Brant: test for parallel regression\u00a0assumption. 2020. Available at:\u00a0\u3008https:\/\/CRAN.R-project.org\/package=brant\u3009, accessed August 19, 2023."},{"key":"10.1016\/j.healun.2023.09.017_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v057.i12","article-title":"Building bivariate tables: The compareGroups package for R","volume":"57","author":"Subirana","year":"2014","journal-title":"J Stat Softw"},{"key":"10.1016\/j.healun.2023.09.017_bib17","series-title":"Modern applied statistics with S","author":"Venables","year":"2002"},{"key":"10.1016\/j.healun.2023.09.017_bib18","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.jtcvs.2011.07.019","article-title":"Effect of sensitization in US heart transplant recipients bridged with a ventricular assist device: update in a modern cohort","volume":"142","author":"Arnaoutakis","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.healun.2023.09.017_bib19","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/ndt\/gfv391","article-title":"Pre-transplant donor-specific anti-human leukocyte antigen antibodies are associated with high risk of delayed graft function after renal transplantation","volume":"31","author":"Per\u00e4saari","year":"2016","journal-title":"Nephrol Dial Transpl"},{"key":"10.1016\/j.healun.2023.09.017_bib20","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1097\/TP.0b013e318209f22b","article-title":"Recipient risk factors associated with delayed graft function: a paired kidney analysis","volume":"91","author":"Doshi","year":"2011","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2023.09.017_bib21","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1093\/ndt\/gfw099","article-title":"The mode of sensitization and its influence on allograft outcomes in highly sensitized kidney transplant recipients","volume":"31","author":"Redfield","year":"2016","journal-title":"Nephrol Dial Transpl"},{"key":"10.1016\/j.healun.2023.09.017_bib22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12890-018-0606-8","article-title":"Prevalence of pre-transplant anti-HLA antibodies and their impact on outcomes in lung transplant recipients","volume":"18","author":"Park","year":"2018","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.healun.2023.09.017_bib23","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.138358","article-title":"Local complement activation is associated with primary graft dysfunction after lung transplantation","volume":"5","author":"Kulkarni","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.healun.2023.09.017_bib24","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.healun.2017.03.018","article-title":"Ventricular assist device elicits serum natural IgG that correlates with the development of primary graft dysfunction following heart transplantation","volume":"36","author":"See","year":"2017","journal-title":"J Heart Lung Transpl"},{"key":"10.1016\/j.healun.2023.09.017_bib25","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1111\/j.1600-6143.2012.04053.x","article-title":"Expansion of polyreactive B cells cross-reactive to HLA and self in the blood of a patient with kidney graft rejection","volume":"12","author":"Porcheray","year":"2012","journal-title":"Am J Transpl"},{"key":"10.1016\/j.healun.2023.09.017_bib26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/TP.0000000000000840","article-title":"Evidence to support a contribution of polyreactive antibodies to HLA serum reactivity","volume":"100","author":"Gao","year":"2016","journal-title":"Transplantation"},{"key":"10.1016\/j.healun.2023.09.017_bib27","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1111\/ajt.12394","article-title":"Polyreactive antibodies developing amidst humoral rejection of human kidney grafts bind apoptotic cells and activate complement","volume":"13","author":"Porcheray","year":"2013","journal-title":"Am J Transpl"},{"key":"10.1016\/j.healun.2023.09.017_bib28","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1164\/rccm.201312-2121LE","article-title":"Plasma complement levels are associated with primary graft dysfunction and mortality after lung transplantation","volume":"189","author":"Shah","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.healun.2023.09.017_bib29","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.healun.2012.02.006","article-title":"Association of pre-operative interleukin-6 levels with Interagency Registry for Mechanically Assisted Circulatory Support profiles and intensive care unit stay in left ventricular assist device patients","volume":"31","author":"Caruso","year":"2012","journal-title":"J Heart Lung Transpl"},{"key":"10.1016\/j.healun.2023.09.017_bib30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jtcvs.2019.03.061","article-title":"Temporal expression of cytokines and B-cell phenotypes during mechanical circulatory support","volume":"159","author":"Iyengar","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.healun.2023.09.017_bib31","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/tri.13657","article-title":"Molecular-level HLA mismatch is associated with rejection and worsened graft survival in heart transplant recipients - a retrospective study","volume":"33","author":"Osorio-Jaramillo","year":"2020","journal-title":"Transpl Int"},{"key":"10.1016\/j.healun.2023.09.017_bib32","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/TP.0b013e3181e6f1eb","article-title":"Factors associated with primary graft failure after heart transplantation","volume":"90","author":"Russo","year":"2010","journal-title":"Transplantation"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249823020302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249823020302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T15:14:57Z","timestamp":1762355697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249823020302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1053249823020302"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2023.09.017","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HLA sensitization is associated with an increased risk of primary graft dysfunction after heart transplantation","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2023.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 International Society for Heart and Lung Transplantation. All rights reserved.","name":"copyright","label":"Copyright"}]}}