{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:49:57Z","timestamp":1791229797541,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005262","name":"Ministry of Advanced Education and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005262","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018911","name":"University Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020295","name":"Natera","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020295","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013148","name":"Mendez National Institute of Transplantation Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013148","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000190","name":"University of Alberta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhltonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Heart and Lung Transplantation"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.healun.2025.11.005","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:43:10Z","timestamp":1763538190000},"page":"403-414","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Molecular biopsy features associated with baseline lung allograft dysfunction in a multicenter international cohort"],"prefix":"10.1016","volume":"45","author":[{"given":"Martina","family":"Mackova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6103-8307","authenticated-orcid":false,"given":"Patrick","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5039-2186","authenticated-orcid":false,"given":"Jessica","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6879-2345","authenticated-orcid":false,"given":"Alim","family":"Hirji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4486-4823","authenticated-orcid":false,"given":"Justin","family":"Weinkauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-556X","authenticated-orcid":false,"given":"Stephen","family":"Juvet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4547-8094","authenticated-orcid":false,"given":"Shaf","family":"Keshavjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7667-2634","authenticated-orcid":false,"given":"Jan","family":"Havlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lischke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9691-2500","authenticated-orcid":false,"given":"Andrea","family":"Zajacova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9093-3669","authenticated-orcid":false,"given":"Greg","family":"Snell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Westall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1371-1947","authenticated-orcid":false,"given":"Philip F.","family":"Halloran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5615-6974","authenticated-orcid":false,"given":"Kieran","family":"Halloran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.healun.2025.11.005_bib1","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1164\/rccm.202305-0798OC","article-title":"Higher molecular injury at diagnosis of acute cellular rejection increases the risk of lung allograft failure: a clinical trial","volume":"209","author":"Keller","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"10.1016\/j.healun.2025.11.005_bib2","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.healun.2018.02.014","article-title":"Baseline lung allograft dysfunction is associated with impaired survival after double-lung transplantation","volume":"37","author":"Liu","year":"2018","journal-title":"J Heart Lung Transpl"},{"issue":"12","key":"10.1016\/j.healun.2025.11.005_bib3","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.healun.2021.08.003","article-title":"Abnormal one-year post-lung transplant spirometry is a significant predictor of increased mortality and chronic lung allograft dysfunction","volume":"40","author":"Paraskeva","year":"2021","journal-title":"J Heart Lung Transpl"},{"issue":"2","key":"10.1016\/j.healun.2025.11.005_bib4","doi-asserted-by":"crossref","DOI":"10.1097\/TXD.0000000000001751","article-title":"Health-related quality of life and exercise capacity in double lung transplant recipients with baseline lung allograft dysfunction","volume":"11","author":"Rullay","year":"2025","journal-title":"Transpl Direct"},{"key":"10.1016\/j.healun.2025.11.005_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2021.106617","article-title":"Baseline lung allograft dysfunction in primary graft dysfunction survivors after lung transplantation","volume":"188","author":"Li","year":"2021","journal-title":"Respir Med"},{"issue":"5","key":"10.1016\/j.healun.2025.11.005_bib6","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.healun.2019.01.1317","article-title":"Molecular assessment of rejection and injury in lung transplant biopsies","volume":"38","author":"Halloran","year":"2019","journal-title":"J Heart Lung Transpl"},{"issue":"4","key":"10.1016\/j.healun.2025.11.005_bib7","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/ajt.16895","article-title":"Transcripts associated with chronic lung allograft dysfunction in transbronchial biopsies of lung transplants","volume":"22","author":"Parkes","year":"2022","journal-title":"Am J Transpl"},{"issue":"12","key":"10.1016\/j.healun.2025.11.005_bib8","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.healun.2022.08.014","article-title":"The molecular features of chronic lung allograft dysfunction in lung transplant airway mucosa","volume":"41","author":"Halloran","year":"2022","journal-title":"J Heart Lung Transpl"},{"issue":"4","key":"10.1016\/j.healun.2025.11.005_bib9","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/ajt.15685","article-title":"Molecular phenotyping of rejection-related changes in mucosal biopsies from lung transplants","volume":"20","author":"Halloran","year":"2020","journal-title":"Am J Transpl"},{"issue":"5","key":"10.1016\/j.healun.2025.11.005_bib10","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.healun.2019.03.009","article-title":"Chronic lung allograft dysfunction: definition, diagnostic criteria, and approaches to treatment-A consensus report from the Pulmonary Council of the ISHLT","volume":"38","author":"Verleden","year":"2019","journal-title":"J Heart Lung Transpl"},{"issue":"10","key":"10.1016\/j.healun.2025.11.005_bib11","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.healun.2004.11.049","article-title":"Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part II: definition. A consensus statement of the International Society for Heart and Lung Transplantation","volume":"24","author":"Christie","year":"2005","journal-title":"J Heart Lung Transpl"},{"key":"10.1016\/j.healun.2025.11.005_bib12","series-title":"Bioinformatics and Computational Biology Solutions using R and Bioconductor","first-page":"398","article-title":"limma: Linear Models for Microarray Data","author":"Smythe","year":"2005"},{"issue":"7","key":"10.1016\/j.healun.2025.11.005_bib13","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/j.1600-6143.2008.02232.x","article-title":"Expression of B cell and immunoglobulin transcripts is a feature of inflammation in late allografts","volume":"8","author":"Einecke","year":"2008","journal-title":"Am J Transpl"},{"issue":"7","key":"10.1016\/j.healun.2025.11.005_bib14","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1111\/ajt.14200","article-title":"Comprehensive analysis of transcript changes associated with allograft rejection: combining universal and selective features","volume":"17","author":"Halloran","year":"2017","journal-title":"Am J Transpl"},{"issue":"3","key":"10.1016\/j.healun.2025.11.005_bib15","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1600-6143.2007.02129.x","article-title":"The transcriptome of human cytotoxic T cells: measuring the burden of CTL-associated transcripts in human kidney transplants","volume":"8","author":"Hidalgo","year":"2008","journal-title":"Am J Transpl"},{"issue":"10","key":"10.1016\/j.healun.2025.11.005_bib16","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1111\/j.1600-6143.2010.03267.x","article-title":"The molecular phenotype of kidney transplants","volume":"10","author":"Halloran","year":"2010","journal-title":"Am J Transpl"},{"issue":"11","key":"10.1016\/j.healun.2025.11.005_bib17","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.healun.2017.05.029","article-title":"Building a tissue-based molecular diagnostic system in heart transplant rejection: The heart Molecular Microscope Diagnostic (MMDx) System","volume":"36","author":"Halloran","year":"2017","journal-title":"J Heart Lung Transpl"},{"issue":"12","key":"10.1016\/j.healun.2025.11.005_bib18","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.94197","article-title":"Assessing rejection-related disease in kidney transplant biopsies based on archetypal analysis of molecular phenotypes","volume":"2","author":"Reeve","year":"2017","journal-title":"Jci Insight"},{"issue":"5","key":"10.1016\/j.healun.2025.11.005_bib19","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/j.1600-6143.2011.03970.x","article-title":"Interpreting NK cell transcripts versus T cell transcripts in renal transplant biopsies","volume":"12","author":"Hidalgo","year":"2012","journal-title":"Am J Transpl"},{"issue":"8","key":"10.1016\/j.healun.2025.11.005_bib20","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1111\/j.1600-6143.2010.03201.x","article-title":"NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection","volume":"10","author":"Hidalgo","year":"2010","journal-title":"Am J Transpl"},{"issue":"5","key":"10.1016\/j.healun.2025.11.005_bib21","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1681\/ASN.2011090887","article-title":"Molecular phenotypes of acute kidney injury in kidney transplants","volume":"23","author":"Famulski","year":"2012","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.healun.2025.11.005_bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate - a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Ser BStat Methodol"},{"key":"10.1016\/j.healun.2025.11.005_bib23","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1309","article-title":"Super learner","volume":"6","author":"van der Laan","year":"2007","journal-title":"Stat Appl Genet Mol Biol"},{"issue":"12","key":"10.1016\/j.healun.2025.11.005_bib24","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1016\/j.ajt.2023.06.003","article-title":"Defining a natural killer cell-enriched molecular rejection-like state in lung transplant transbronchial biopsies","volume":"23","author":"Gauthier","year":"2023","journal-title":"Am J Transpl"},{"issue":"12","key":"10.1016\/j.healun.2025.11.005_bib25","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1164\/rccm.201210-1831OC","article-title":"Acute fibrinoid organizing pneumonia after lung transplantation","volume":"187","author":"Paraskeva","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"4 Supplement","key":"10.1016\/j.healun.2025.11.005_bib26","first-page":"S757","article-title":"Primary graft dysfunction decreases peak lung function after transplantation:\u00a0a lung transplant outcomes group (LTOG) study","volume":"44","author":"Hsu","year":"2025","journal-title":"J Heart Lung Transplant"},{"issue":"7","key":"10.1016\/j.healun.2025.11.005_bib27","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.14315","article-title":"Atelectasis in primary graft dysfunction survivors after lung transplantation","volume":"35","author":"Li","year":"2021","journal-title":"Clin Transpl"},{"issue":"9","key":"10.1016\/j.healun.2025.11.005_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax6352","article-title":"SLC36A1-mTORC1 signaling drives acquired resistance to CDK4\/6 inhibitors","volume":"5","author":"Yoshida","year":"2019","journal-title":"Sci Adv"},{"issue":"1","key":"10.1016\/j.healun.2025.11.005_bib29","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13578-021-00586-5","article-title":"RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS\/STING signaling pathway in lung adenocarcinoma","volume":"11","author":"Jiang","year":"2021","journal-title":"Cell Biosci"},{"issue":"1","key":"10.1016\/j.healun.2025.11.005_bib30","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13578-020-00493-1","article-title":"Thymidine kinase 1 through the ages: a comprehensive review","volume":"10","author":"Bitter","year":"2020","journal-title":"Cell Biosci"},{"issue":"5","key":"10.1016\/j.healun.2025.11.005_bib31","doi-asserted-by":"crossref","first-page":"H1087","DOI":"10.1152\/ajpheart.00314.2020","article-title":"TIGAR reduces smooth muscle cell autophagy to prevent pulmonary hypertension","volume":"319","author":"Yamanaka","year":"2020","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"10.1016\/j.healun.2025.11.005_bib32","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.bbrc.2009.02.080","article-title":"A novel polymorphism in CDC6 is associated with the decline in lung function of ex-smokers in COPD","volume":"381","author":"Takabatake","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"issue":"68","key":"10.1016\/j.healun.2025.11.005_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abf2846","article-title":"SLAMF7 engagement superactivates macrophages in acute and chronic inflammation","volume":"7","author":"Simmons","year":"2022","journal-title":"Sci Immunol"},{"issue":"1","key":"10.1016\/j.healun.2025.11.005_bib34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1165\/rcmb.2017-0171TR","article-title":"Semaphorins and their roles in airway biology: potential as therapeutic targets","volume":"58","author":"Movassagh","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"16","key":"10.1016\/j.healun.2025.11.005_bib35","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1007\/s00018-009-0038-y","article-title":"Kank proteins: structure, functions and diseases","volume":"66","author":"Kakinuma","year":"2009","journal-title":"Cell Mol Life Sci"},{"issue":"9","key":"10.1016\/j.healun.2025.11.005_bib36","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.healun.2009.04.022","article-title":"Acute cellular rejection is a risk factor for bronchiolitis obliterans syndrome independent of post-transplant baseline FEV1","volume":"28","author":"Burton","year":"2009","journal-title":"J Heart Lung Transpl"}],"container-title":["The Journal of Heart and Lung Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249825023940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053249825023940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:38:18Z","timestamp":1773916698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053249825023940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1053249825023940"],"URL":"https:\/\/doi.org\/10.1016\/j.healun.2025.11.005","relation":{},"ISSN":["1053-2498"],"issn-type":[{"value":"1053-2498","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular biopsy features associated with baseline lung allograft dysfunction in a multicenter international cohort","name":"articletitle","label":"Article Title"},{"value":"The Journal of Heart and Lung Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.healun.2025.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 International Society for Heart and Lung Transplantation. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}