{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:43:07Z","timestamp":1782481387262,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.heares.2004.10.012","type":"journal-article","created":{"date-parts":[[2004,12,29]],"date-time":"2004-12-29T00:14:09Z","timestamp":1104279249000},"page":"80-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Acceleration of cisplatin ototoxicity by perilymphatic application of 4-methylthiobenzoic acid"],"prefix":"10.1016","volume":"203","author":[{"given":"Natalie L.M.","family":"Cappaert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjaak F.L.","family":"Klis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Wijbenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido F.","family":"Smoorenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2004.10.012_bib1","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/0006-2952(91)90141-Q","article-title":"4-Methylthiobenzoic acid reduces cisplatin nephrotoxicity in rats without compromising anti-tumour activity","volume":"41","author":"Boogaard","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.heares.2004.10.012_bib2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0378-5955(96)00152-9","article-title":"d-Methionine provides excellent protections from cisplatin ototoxicity in the rat","volume":"102","author":"Campbell","year":"1996","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-5955(99)00142-2","article-title":"d-Methionine protects against cisplatin damage to the stria vascularis","volume":"138","author":"Campbell","year":"1999","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0378-5955(00)00059-9","article-title":"Dose-dependent effect of 8-day cisplatin administration upon the morphology of the albino guinea pig cochlea","volume":"144","author":"Cardinaal","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib5","first-page":"367","article-title":"Phase I study of high-dose cis-dichlorodiammineplatinim (II) with forced diuresis","volume":"61","author":"Chary","year":"1977","journal-title":"Cancer Treat. Rep."},{"key":"10.1016\/j.heares.2004.10.012_bib6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0378-5955(95)00066-D","article-title":"The comparative effects of sodium thiosulfate, diethyldithiocarbamate, fosfomycin and WR-2721 on ameliorating cisplatin ototoxicity","volume":"86","author":"Church","year":"1995","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib7","series-title":"Audiovestibular toxicity of drugs","author":"De Oliviera","year":"1989"},{"key":"10.1016\/j.heares.2004.10.012_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0378-5955(02)00277-0","article-title":"d-Methionine and cisplatin ototoxicity in the guinea pig: d-methionine influences cisplatin pharmacokinetics","volume":"165","author":"Ekborn","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0378-5955(97)00103-2","article-title":"Up-regulation of adenosine receptors in the cochlea by cisplatine","volume":"111","author":"Ford","year":"1997","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000073515","article-title":"Cisplatin ototoxicity involves organ of corti, stria vascularis and spiral ganglion: modulation by \u03b1MSH and ORG 2766","volume":"8","author":"Hamers","year":"2003","journal-title":"Audiol. Neurootol."},{"key":"10.1016\/j.heares.2004.10.012_bib11","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1002\/1097-0142(197704)39:4<1372::AID-CNCR2820390404>3.0.CO;2-J","article-title":"High dose cis-platinum diammine dichloride: amelioration of renal toxicity by mannitol diuresis","volume":"39","author":"Hayes","year":"1977","journal-title":"Cancer"},{"key":"10.1016\/j.heares.2004.10.012_bib12","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0194-59989770020-2","article-title":"Comparison of five agents in protecting the cochlea against the ototoxic effects of cisplatin in the hamster","volume":"117","author":"Kaltenbach","year":"1997","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2004.10.012_bib13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0378-5955(99)00017-9","article-title":"Effect of 4-methylthiobenzoic acid on cisplatin-induced ototoxicity in the rat","volume":"131","author":"Kamimura","year":"1999","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0378-5955(85)90054-1","article-title":"Modulation at the guinea pig round window of summating potentials and compound action potentials by low-frequency sound","volume":"20","author":"Klis","year":"1985","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib15","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0378-5955(94)90062-0","article-title":"Osmotically induced pressure difference in the cochlea and its effect on cochlear potentials","volume":"75","author":"Klis","year":"1994","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib16","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/00001756-200002280-00037","article-title":"Reversible cisplatin ototoxicity in the albino guinea pig","volume":"28","author":"Klis","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.heares.2004.10.012_bib17","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0378-5955(01)00425-7","article-title":"Partial recovery of cisplatin-induced hearing loss in the albino guinea pig in relation to cisplatin dose","volume":"164","author":"Klis","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib18","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1288\/00005537-198808000-00015","article-title":"Cisplatin ototoxicity in guinea pigs with special reference to toxic effects in the stria vascularis","volume":"98","author":"Kohn","year":"1988","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2004.10.012_bib19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3109\/01913129709021925","article-title":"Endothelial injury of capillaries in the stria vascularis of guinea pigs treated with cisplatin and gentamicin","volume":"21","author":"Kohn","year":"1997","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.heares.2004.10.012_bib20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/019459988108900226","article-title":"Pathophysiology of the ototoxicity of cis-diamminedichloroplatinum","volume":"89","author":"Komune","year":"1981","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2004.10.012_bib21","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1067\/mhn.2002.125299","article-title":"Round window application of d-methionine provides complete cisplatin otoprotection","volume":"126","author":"Korver","year":"2002","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2004.10.012_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0378-5955(89)90125-1","article-title":"The ototoxic effect of cisplatin in relation to the dosage","volume":"38","author":"Laurell","year":"1989","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0161-813X(00)00010-3","article-title":"Round window membrane delivery of l-methionine provides protection from cisplatin ototoxicity without compromising chemotherapeutic efficacy","volume":"22","author":"Li","year":"2001","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.heares.2004.10.012_bib24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0378-5955(90)90151-E","article-title":"The ototoxic mechanism of cisplatin","volume":"47","author":"McAlpine","year":"1990","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0378-5955(98)00116-6","article-title":"A semiquantitative analysis of the effects of cisplatin on the rat stria vascularis","volume":"124","author":"Meech","year":"1998","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib26","first-page":"309","article-title":"Delayed administration of sodium thiosulfate in animal models reduced platinum ototoxicity without reduction of antitumor activity","volume":"6","author":"Muldoon","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.heares.2004.10.012_bib27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3109\/00016488209130876","article-title":"Ototoxicity of the anticancer drug cisplatin. An experimental study","volume":"93","author":"Nakai","year":"1982","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2004.10.012_bib28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0378-5955(01)00232-5","article-title":"Perilymphatic application of cisplatin over several days in albino guinea pigs: dose-dependency of electrophysiological and morphological effects","volume":"154","author":"O\u2019Leary","year":"2001","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib29","first-page":"1525","article-title":"Recovery of hearing following cisplatin ototoxicity in the guinea pig","volume":"22","author":"O\u2019Leary","year":"2002","journal-title":"Anticancer Res."},{"key":"10.1016\/j.heares.2004.10.012_bib30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-5955(88)90042-1","article-title":"Effects of cisplatin and thiosulfate upon auditory brainstem responses of guinea pigs","volume":"35","author":"Otto","year":"1988","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib31","first-page":"731","article-title":"l- and d-Methionine provide equivalent long term protection against CDDP-induced ototoxicity in vivo, with partial in vitro and in vivo retention of antineoplastiv activity","volume":"20","author":"Reser","year":"1999","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.heares.2004.10.012_bib32","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1600-0773.1997.tb02065.x","article-title":"Protection by 4-methylthiobenzoic acid against cisplatin-induced ototoxicity: antioxidant system","volume":"81","author":"Rybak","year":"1997","journal-title":"Pharm. Toxicol."},{"key":"10.1016\/j.heares.2004.10.012_bib33","first-page":"143","article-title":"Ototoxicity: amelioration by protective agents","volume":"884","author":"Rybak","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.heares.2004.10.012_bib34","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1097\/00005537-199911000-00003","article-title":"Application of antioxidants and other agents to prevent cisplatin ototoxicity","volume":"109","author":"Rybak","year":"1999","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2004.10.012_bib35","first-page":"513","article-title":"Effect of protective agents against cisplatin ototoxicity","volume":"21","author":"Rybak","year":"2000","journal-title":"Am. J. Otol."},{"key":"10.1016\/j.heares.2004.10.012_bib36","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF02905989","article-title":"The effect of sodium thiosulfate on ototoxicity and pharmacokinetics after cisplatin treatment in guinea pigs","volume":"254","author":"Saito","year":"1997","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2004.10.012_bib37","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0030-6665(20)30766-0","article-title":"Ototoxicity of chemotherapeutic agents","volume":"26","author":"Schweitzer","year":"1993","journal-title":"Otolaryngol. Clin. North Am."},{"key":"10.1016\/j.heares.2004.10.012_bib38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0378-5955(03)00260-0","article-title":"Alterations in the stria vascularis in relation to cisplatin ototoxicity and recovery","volume":"185","author":"Sluyter","year":"2003","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib39","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0378-5955(00)00182-9","article-title":"Acute changes in cochlear potentials due to cisplatin","volume":"149","author":"Tsukasaki","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib40","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0378-5955(97)00156-1","article-title":"Identification of the nonlinearity governing even-order distortion products in cochlear potentials","volume":"114","author":"Van Emst","year":"1997","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2004.10.012_bib41","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0028-3908(03)00194-1","article-title":"Local application of sodium thiosulfate prevents cisplatin-induced hearing loss in the guinea pig","volume":"45","author":"Wang","year":"2003","journal-title":"Neuropharmacology"}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595504003867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595504003867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:45:55Z","timestamp":1759920355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595504003867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":41,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S0378595504003867"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2004.10.012","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acceleration of cisplatin ototoxicity by perilymphatic application of 4-methylthiobenzoic acid","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2004.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}