{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:44:03Z","timestamp":1791895443891,"version":"4.3.4"},"reference-count":52,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["13470357"],"award-info":[{"award-number":["13470357"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.heares.2006.06.004","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T09:19:47Z","timestamp":1153905587000},"page":"185-193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":121,"title":["Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss"],"prefix":"10.1016","volume":"226","author":[{"given":"Tatsuya","family":"Yamasoba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Someya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Weindruch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas A.","family":"Prolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Tanokura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2006.06.004_bib1","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.1098014","article-title":"Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration","volume":"305","author":"Araki","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.heares.2006.06.004_bib2","first-page":"449","article-title":"Mitochondrial DNA deletions associated with aging and possibly presbycusis: a human archival temporal bone study","volume":"18","author":"Bai","year":"1997","journal-title":"Am. J. Otol."},{"key":"10.1016\/j.heares.2006.06.004_bib3","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1126\/science.1099196","article-title":"Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase","volume":"305","author":"Cohen","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.heares.2006.06.004_bib4","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/ng1292-324","article-title":"Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age","volume":"2","author":"Corral-Debrinski","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1016\/j.heares.2006.06.004_bib5","doi-asserted-by":"crossref","first-page":"6927","DOI":"10.1093\/nar\/18.23.6927","article-title":"Detection of a specific mitochondrial DNA deletion in tissues of older humans","volume":"18","author":"Cortopassi","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.heares.2006.06.004_bib6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/01.AUD.0000079802.82344.B5","article-title":"Mitochondrial deafness","volume":"24","author":"Fischel-Ghodsian","year":"2003","journal-title":"Ear Hear."},{"key":"10.1016\/j.heares.2006.06.004_bib7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0378-5955(97)00077-4","article-title":"Temporal bone analysis of patients with presbycusis reveals high frequency of mitochondrial mutations","volume":"110","author":"Fischel-Ghodsian","year":"1997","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2006.06.004_bib8","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.mito.2004.07.040","article-title":"Mitochondrial dysfunction in hearing loss","volume":"4","author":"Fischel-Ghodsian","year":"2004","journal-title":"Mitochondrion"},{"key":"10.1016\/j.heares.2006.06.004_bib9","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cell.2005.01.029","article-title":"Calorie restriction. The SIR2 connection","volume":"120","author":"Guarente","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.heares.2006.06.004_bib10","series-title":"Mitochondria and Cell Death","author":"Guy","year":"1999"},{"key":"10.1016\/j.heares.2006.06.004_bib11","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.cell.2005.01.030","article-title":"The future of aging therapies","volume":"120","author":"Hadley","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.heares.2006.06.004_bib12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1096\/fasebj.13.2.411","article-title":"(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate","volume":"13","author":"Hagen","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.heares.2006.06.004_bib13","doi-asserted-by":"crossref","first-page":"9562","DOI":"10.1073\/pnas.95.16.9562","article-title":"Acetyl-l-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity","volume":"95","author":"Hagen","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.heares.2006.06.004_bib14","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/0002-8703(91)90020-I","article-title":"Age-dependent increase in deleted mitochondrial DNA in the human heart: possible contributory factor to presbycardia","volume":"121","author":"Hattori","year":"1991","journal-title":"Am. Heart J."},{"key":"10.1016\/j.heares.2006.06.004_bib15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/00206098609078397","article-title":"Effects of dietary restriction on presbyacusis in the mouse","volume":"25","author":"Henry","year":"1986","journal-title":"Audiology"},{"key":"10.1016\/j.heares.2006.06.004_bib16","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/BF00294665","article-title":"Germanium myopathy: clinical and experimental pathological studies","volume":"79","author":"Higuchi","year":"1989","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"10.1016\/j.heares.2006.06.004_bib17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature01960","article-title":"Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan","volume":"425","author":"Howitz","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.heares.2006.06.004_bib18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/84831","article-title":"A nuclear\u2013mitochondrial DNA interaction affecting hearing impairment in mice","volume":"27","author":"Johnson","year":"2001","journal-title":"Nat Genet."},{"key":"10.1016\/j.heares.2006.06.004_bib19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0378-5955(01)00281-7","article-title":"Mitochondrial cytochrome oxidase immunolabeling in aged human temporal bones","volume":"157","author":"Keithley","year":"2001","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2006.06.004_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0027-5107(03)00010-1","article-title":"Accumulation of point mutations in mitochondrial DNA of aging mice","volume":"526","author":"Khaidakov","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.heares.2006.06.004_bib21","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1112125","article-title":"Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging","volume":"309","author":"Kujoth","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.heares.2006.06.004_bib22","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1126\/science.285.5432.1390","article-title":"Gene expression profile of aging and its retardation by caloric restriction","volume":"285","author":"Lee","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.heares.2006.06.004_bib23","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/77046","article-title":"Gene-expression profile of the ageing brain in mice","volume":"25","author":"Lee","year":"2000","journal-title":"Nat Genet."},{"key":"10.1016\/j.heares.2006.06.004_bib24","first-page":"157","article-title":"The pathogenesis of experimental model of mitochondrial myopathy induced by germanium dioxide","volume":"16","author":"Li","year":"2001","journal-title":"Chin. Med. Sci. J."},{"key":"10.1016\/j.heares.2006.06.004_bib25","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1001\/archotol.1976.00780170065011","article-title":"Histopathologic features of the inner ear associated with Kearns\u2013Sayre syndrome","volume":"102","author":"Lindsay","year":"1976","journal-title":"Arch Otolaryngol."},{"key":"10.1016\/j.heares.2006.06.004_bib26","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1073\/pnas.261709299","article-title":"Memory loss in old rats is associated with brain mitochondrial decay and RNA\/DNA oxidation: partial reversal by feeding acetyl-l-carnitine and\/or R-alpha-lipoic acid","volume":"99","author":"Liu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.heares.2006.06.004_bib27","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1046\/j.1471-4159.2003.01586.x","article-title":"Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms","volume":"84","author":"Mattson","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.heares.2006.06.004_bib28","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1093\/nar\/25.5.974","article-title":"Multi-organ characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age","volume":"25","author":"Melov","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.heares.2006.06.004_bib29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbrc.2004.08.073","article-title":"Accumulation of pathogenic Delta mtDNA induced deafness but not diabetic phenotypes in mito-mice","volume":"323","author":"Nakada","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.heares.2006.06.004_bib30","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0378-5955(90)90067-Y","article-title":"Dietary restriction slows the abnormally rapid loss of spiral ganglion neurons in C57BL\/6 mice","volume":"48","author":"Park","year":"1990","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2006.06.004_bib31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000074184","article-title":"Mutation in mitochondrial DNA as a cause of presbyacusis","volume":"9","author":"Pickles","year":"2004","journal-title":"Audiol. Neurootol."},{"key":"10.1016\/j.heares.2006.06.004_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/00034894931020S101","article-title":"Cochlear pathology in presbycusis","volume":"102","author":"Schuknecht","year":"1993","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2006.06.004_bib33","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/00005537-200005000-00003","article-title":"Effects of dietary restriction and antioxidants on presbyacusis","volume":"110","author":"Seidman","year":"2000","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2006.06.004_bib34","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1568-1637(02)00004-1","article-title":"Molecular mechanisms of age-related hearing loss","volume":"1","author":"Seidman","year":"2002","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.heares.2006.06.004_bib35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0196-0709(00)80003-4","article-title":"Biologic activity of mitochondrial metabolites on aging and age-related hearing loss","volume":"21","author":"Seidman","year":"2000","journal-title":"Am. J. Otol."},{"key":"10.1016\/j.heares.2006.06.004_bib36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0047-6374(94)90104-X","article-title":"Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse","volume":"74","author":"Sohal","year":"1994","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.heares.2006.06.004_bib37","doi-asserted-by":"crossref","unstructured":"Someya, S., Yamasoba, T., Weindruch, R., Prolla, T.A., Tanokura, M., 2006. Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis. Neurobiol Aging, in press.","DOI":"10.1016\/j.neurobiolaging.2006.06.024"},{"key":"10.1016\/j.heares.2006.06.004_bib38","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3109\/00206098809081601","article-title":"Dietary restriction and presbyacusis: periods of restriction and auditory threshold losses in the CBA\/J mouse","volume":"27","author":"Sweet","year":"1988","journal-title":"Audiology"},{"key":"10.1016\/j.heares.2006.06.004_bib39","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1097\/00005537-200308000-00018","article-title":"Temporal bone histopathological and quantitative analysis of mitochondrial DNA in MELAS","volume":"113","author":"Takahashi","year":"2003","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2006.06.004_bib40","doi-asserted-by":"crossref","first-page":"17993","DOI":"10.1073\/pnas.0508886102","article-title":"Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production","volume":"102","author":"Trifunovic","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.heares.2006.06.004_bib41","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature02517","article-title":"Premature ageing in mice expressing defective mitochondrial DNA polymerase","volume":"429","author":"Trifunovic","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.heares.2006.06.004_bib42","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0092-8674(01)00527-X","article-title":"hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase","volume":"107","author":"Vaziri","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.heares.2006.06.004_bib43","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/ajmg.1393","article-title":"Mouse models for mitochondrial disease","volume":"106","author":"Wallace","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.heares.2006.06.004_bib44","series-title":"The Retardation of Aging and Disease by Dietary Restriction","author":"Weindruch","year":"1988"},{"key":"10.1016\/j.heares.2006.06.004_bib45","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/gerona\/56.suppl_1.20","article-title":"Caloric restriction mimetics: metabolic interventions","volume":"56","author":"Weindruch","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.heares.2006.06.004_bib46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0378-5955(95)00107-F","article-title":"Genetics of age-related hearing loss in mice. II. Strain differences and effects of caloric restriction on cochlear pathology and evoked response thresholds","volume":"88","author":"Willott","year":"1995","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2006.06.004_bib47","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/mus.880151107","article-title":"An experimental model of mitochondrial myopathy: germanium-induced myopathy and coenzyme Q10 administration","volume":"15","author":"Wu","year":"1992","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.heares.2006.06.004_bib48","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neulet.2005.10.045","article-title":"Cochlear damage due to germanium-induced mitochondrial dysfunction in guinea pigs","volume":"395","author":"Yamasoba","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.heares.2006.06.004_bib49","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0960-8966(01)00329-7","article-title":"Atypical muscle pathology and a survey of cis-mutations in deaf patients harboring a 1555 A-to-G point mutation in the mitochondrial ribosomal RNA gene","volume":"12","author":"Yamasoba","year":"2002","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.heares.2006.06.004_bib50","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00005537-199601000-00010","article-title":"Auditory findings in patients with maternally inherited diabetes and deafness harboring a point mutation in the mitochondrial transfer RNA(Leu) (UUR) gene","volume":"106","author":"Yamasoba","year":"1996","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2006.06.004_bib51","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1212\/WNL.52.8.1705","article-title":"Cochlear histopathology associated with mitochondrial tRNALeu(UUR) gene mutation","volume":"52","author":"Yamasoba","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.heares.2006.06.004_bib52","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1001\/jama.289.15.1976","article-title":"Screening and management of adult hearing loss in primary care: scientific review","volume":"289","author":"Yueh","year":"2003","journal-title":"JAMA."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595506001547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595506001547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:45:17Z","timestamp":1759920317000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595506001547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":52,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0378595506001547"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2006.06.004","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2006.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}