{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:44:20Z","timestamp":1790401460284,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.heares.2006.08.006","type":"journal-article","created":{"date-parts":[[2006,10,7]],"date-time":"2006-10-07T11:24:25Z","timestamp":1160220265000},"page":"44-51","source":"Crossref","is-referenced-by-count":116,"title":["Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidase"],"prefix":"10.1016","volume":"226","author":[{"given":"Jonathan","family":"Kil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rende","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2006.08.006_bib1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0891-5849(02)00954-1","article-title":"Role of oxygen and nitrogen species in experimental uveitis: anti-inflammatory activity of the synthetic antioxidant ebselen","volume":"33","author":"Bosch-Morell","year":"2002","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.heares.2006.08.006_bib2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/jnr.20764","article-title":"Proinflammatory cytokines expression in noise-induced damaged cochlea","volume":"83","author":"Fujioka","year":"2006","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.heares.2006.08.006_bib3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1006\/abbi.2000.1943","article-title":"Ebselen lowers plasma interleukin-6 levels and glial heme oxygenase-1 expression after focal photothrombotic brain ischemia","volume":"380","author":"Gladilin","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.heares.2006.08.006_bib4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1254\/jjp.72.191","article-title":"Effect of ebselen on bovine and rat nitric oxide synthase activity is modified by thiols","volume":"72","author":"Hattori","year":"1996","journal-title":"Jpn. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.heares.2006.08.006_bib5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s10162-002-3036-4","article-title":"Lateral wall histopathology and endocochlear potential in the noise-damaged mouse cochlea","volume":"4","author":"Hirose","year":"2003","journal-title":"J. Assoc. Res. Otolaryngol."},{"issue":"3","key":"10.1016\/j.heares.2006.08.006_bib6","first-page":"1471","article-title":"Effects of preconditioning with ebselen on glutathione metabolism and stress protein expression","volume":"281","author":"Hoshida","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.heares.2006.08.006_bib7","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1006\/bbrc.2002.6477","article-title":"Ebselen has dehydroascorbate reductase and thioltransferase-like activities","volume":"291","author":"Jung","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"21","key":"10.1016\/j.heares.2006.08.006_bib8","doi-asserted-by":"crossref","first-page":"12766","DOI":"10.1074\/jbc.273.21.12766","article-title":"The thiol-specific antioxidant enzyme prevents mitochondrial permeability transition. Evidence for the participation of reactive oxygen species in this mechanism","volume":"273","author":"Kowaltowski","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.heares.2006.08.006_bib9","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S1359-6446(05)03561-0","article-title":"Compounds for the prevention and treatment of noise-induced hearing loss","volume":"10","author":"Lynch","year":"2005","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.heares.2006.08.006_bib10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/00005537-200402000-00029","article-title":"Ebselen-mediated protection from single and repeated noise exposure in rat","volume":"114","author":"Lynch","year":"2004","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2006.08.006_bib11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0014-5793(96)01237-9","article-title":"Kinetic study of the reaction of ebselen with peroxynitrite","volume":"398","author":"Masumoto","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.heares.2006.08.006_bib12","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/0006-2952(88)90517-5","article-title":"A novel biologically active selenooorganic compound\u2014VII. Biotransformation of ebselen in perfused rat liver","volume":"37","author":"M\u00fcller","year":"1988","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.heares.2006.08.006_bib13","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1161\/01.STR.32.8.1906","article-title":"Ebselen reduces cytochrome c release from mitochondria and subsequent DNA fragmentation after transient focal cerebral ischemia in mice","volume":"32","author":"Namura","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.heares.2006.08.006_bib14","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s10162-002-3038-2","article-title":"The caspase pathway in noise-induced apoptosis of the chinchilla cochlea","volume":"4","author":"Nicotera","year":"2003","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2006.08.006_bib15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0006-2952(92)90035-H","article-title":"Action of ebselen as an antioxidant against lipid peroxidation","volume":"44","author":"Noguchi","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.heares.2006.08.006_bib16","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/0005-2760(94)90024-8","article-title":"Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals","volume":"1213","author":"Noguchi","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"issue":"1\u20132","key":"10.1016\/j.heares.2006.08.006_bib17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0006-8993(00)02733-5","article-title":"Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea","volume":"878","author":"Ohinata","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2006.08.006_bib18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000013846","article-title":"Early elevation of cochlear reactive oxygen species following noise exposure","volume":"4","author":"Ohlemiller","year":"1999","journal-title":"Audiol. Neurootol."},{"key":"10.1016\/j.heares.2006.08.006_bib19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s101620010043","article-title":"Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice","volume":"1","author":"Ohlemiller","year":"2000","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2006.08.006_bib20","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0378-5955(03)00178-3","article-title":"Ebselen attenuates cochlear damage caused by acoustic trauma","volume":"181","author":"Pourbakht","year":"2003","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2006.08.006_bib21","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/0006-2952(96)00084-6","article-title":"Ebselen inhibition of apoptosis by reduction of peroxides","volume":"51","author":"Ramakrishnan","year":"1996","journal-title":"Biochem. Pharmacol."},{"issue":"1 Pt 2","key":"10.1016\/j.heares.2006.08.006_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/00034894931020S101","article-title":"Cochlear pathology in presbycusis","volume":"102","author":"Schuknecht","year":"1993","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"issue":"1\u20132","key":"10.1016\/j.heares.2006.08.006_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(02)04090-8","article-title":"Upregulated iNOS and oxidative damage to the cochlear stria vascularis due to noise stress","volume":"967","author":"Shi","year":"2003","journal-title":"Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.heares.2006.08.006_bib24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0378-5955(01)00409-9","article-title":"The electrochemical and fluorescence detection of nitric oxide in the cochlea and its increase following loud sound","volume":"164","author":"Shi","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2006.08.006_bib25","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1016\/0006-2952(84)90084-4","article-title":"A novel biologically active seleno-organic compound\u2014II. Activity of PZ 51 in relation to glutathione peroxidase","volume":"33","author":"Wendel","year":"1984","journal-title":"Biochem. Pharmacol."},{"issue":"8","key":"10.1016\/j.heares.2006.08.006_bib26","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/BF02114761","article-title":"Appearance of free radicals in the guinea pig inner ear after noise-induced acoustic trauma","volume":"252","author":"Yamane","year":"1995","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2006.08.006_bib27","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0006-8993(98)00660-X","article-title":"Influence of intense sound exposure on glutathione synthesis in the cochlea","volume":"804","author":"Yamasoba","year":"1998","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.heares.2006.08.006_bib28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neulet.2005.10.045","article-title":"Ebselen prevents noise-induced excitotoxicity and temporary threshold shift","volume":"395","author":"Yamasoba","year":"2005","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.heares.2006.08.006_bib29","first-page":"1112","article-title":"Inhibition of endothelial nitric oxide synthase by ebselen. Prevention by thiols suggests the inactivation by ebselen of a critical thiol essential for the catalytic activity of nitric oxide synthase","volume":"267","author":"Zembowicz","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.heares.2006.08.006_bib30","doi-asserted-by":"crossref","first-page":"8579","DOI":"10.1073\/pnas.122061399","article-title":"Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant","volume":"99","author":"Zhao","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595506002176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595506002176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T14:48:10Z","timestamp":1555858090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595506002176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":30,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0378595506002176"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2006.08.006","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}