{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:44:33Z","timestamp":1790329473937,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.heares.2006.08.008","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T11:48:42Z","timestamp":1160048922000},"page":"104-113","source":"Crossref","is-referenced-by-count":70,"title":["Pharmacological rescue of noise induced hearing loss using N-acetylcysteine and acetyl-l-carnitine"],"prefix":"10.1016","volume":"226","author":[{"given":"J.K.M.","family":"Coleman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.D.","family":"Kopke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.A.","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.E.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.L.","family":"Cater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.L.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.heares.2006.08.008_bib1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/0196-0709(94)90036-1","article-title":"Oral magnesium intake reduces permanent hearing loss induced by noise exposure","volume":"15","author":"Attias","year":"1994","journal-title":"Am. J. Otolaryngol."},{"key":"10.1016\/j.heares.2006.08.008_bib2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0378-5955(00)00076-9","article-title":"Succinate dehydrogenase (SDH) activity in HCs: a correlate for permanent threshold elevations","volume":"145","author":"Chen","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2006.08.008_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0378-5955(95)00010-2","article-title":"Direct effects of reactive oxygen species on cochlear outer HC shape in vitro","volume":"84","author":"Clerici","year":"1995","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2006.08.008_bib4","unstructured":"Coleman, J.K.M., Littlesunday, C., Jackson, R., Meyer, T., in press. AM-111 protects against permanent hearing loss from impulse noise trauma. Hear. Res."},{"key":"10.1016\/j.heares.2006.08.008_bib5","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0891-5849(02)01439-9","article-title":"Effect of SOD1 over expression on age- and noise-related hearing loss","volume":"34","author":"Coling","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.heares.2006.08.008_bib6","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1749-6632.1999.tb08652.x","article-title":"Treatment of acoustic trauma","volume":"884","author":"d\u2019Aldin","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.heares.2006.08.008_bib7","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1046\/j.1365-2362.2000.00736.x","article-title":"N-acetylcysteine replenishes glutathione in HIV infection","volume":"30","author":"De Rosa","year":"2000","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.heares.2006.08.008_bib8","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1042\/bst0270790","article-title":"C-Jun and Bax: regulators of programmed cell death in developing neurons","volume":"27","author":"Eilers","year":"1999","journal-title":"Biochem. Soc."},{"key":"10.1016\/j.heares.2006.08.008_bib9","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.mito.2004.07.040","article-title":"Mitochondrial dysfunction in hearing loss","volume":"4","author":"Fischel-Ghodsian","year":"2004","journal-title":"Mitochondrion"},{"key":"10.1016\/j.heares.2006.08.008_bib10","first-page":"123","article-title":"Treatment of noise induced hearing loss","volume":"34","author":"Flottorp","year":"1991","journal-title":"Scand. Audiol. Suppl."},{"key":"10.1016\/j.heares.2006.08.008_bib11","first-page":"106","article-title":"Evaluation of the effects of L-acetylcarnitine on senile patients suffering from depression","volume":"101","author":"Garyza","year":"1990","journal-title":"Drugs Exp. Clin. Res."},{"key":"10.1016\/j.heares.2006.08.008_bib12","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1097\/01.aids.0000131354.14408.fb","article-title":"Acetyl-l-carnitine: a pathogenesis based treatment for HIV-associated antiretroviral toxic neuropathy","volume":"23","author":"Hart","year":"2004","journal-title":"AIDS"},{"key":"10.1016\/j.heares.2006.08.008_bib13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0378-5955(02)00286-1","article-title":"Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise","volume":"166","author":"Hu","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2006.08.008_bib14","series-title":"Seminars in Hearing, New Frontiers in the Amelioration of Hearing Loss: Part 2 HC Development, Regeneration, Protection, and Rescue, vol. 24","first-page":"111","article-title":"Progression of outer HC death in the chinchilla cochlea following traumatic noise exposure","author":"Hu","year":"2003"},{"key":"10.1016\/j.heares.2006.08.008_bib15","first-page":"530","article-title":"Mitochondrial role in HC survival after injury","volume":"113","author":"Hyde","year":"1995","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2006.08.008_bib16","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/01.jom.0000155710.28289.0e","article-title":"Effects of concurrent noise and jet fuel exposure on hearing loss","volume":"47","author":"Kaufman","year":"2005","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.heares.2006.08.008_bib17","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2486\/indhealth.43.567","article-title":"Combined effects of noise and mixed solvents exposure on the hearing function among workers in the aviation industry","volume":"43","author":"Kim","year":"2005","journal-title":"Ind. Health"},{"key":"10.1016\/j.heares.2006.08.008_bib18","unstructured":"Komjathy, D.A., Bai, U., Shirwany, N.A., Malamud, R., Seidman, M.D., Quirk, W.S., 1998. Noise-induced changes in auditory sensitivity and mtDNA and a protective effect of antioxidants. In: Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL."},{"key":"10.1016\/j.heares.2006.08.008_bib19","first-page":"559","article-title":"Use of organotypic cultures of Corti\u2019s organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory HCs","volume":"18","author":"Kopke","year":"1997","journal-title":"Am. J. Otol."},{"key":"10.1016\/j.heares.2006.08.008_bib20","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1749-6632.1999.tb08641.x","article-title":"A radical demise. Toxins and trauma share common pathways in HC death","volume":"884","author":"Kopke","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.heares.2006.08.008_bib21","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0378-5955(00)00176-3","article-title":"Reduction of noise-induced hearing loss using L-NAC and salicylate in the chinchilla","volume":"149","author":"Kopke","year":"2000","journal-title":"Hear. Res."},{"issue":"9","key":"10.1016\/j.heares.2006.08.008_bib22","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1097\/00005537-200209000-00001","article-title":"Enhancing Intrinsic Cochlear Stress Defenses to Reduce Noise-Induced Hearing Loss","volume":"112","author":"Kopke","year":"2002","journal-title":"The Laryngoscope"},{"issue":"3","key":"10.1016\/j.heares.2006.08.008_bib23","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/00016480410023038","article-title":"Prevention of impulse noise-induced hearing loss with antioxidants","volume":"125","author":"Kopke","year":"2005","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2006.08.008_bib24","series-title":"Otolaryngology, Basic Science and Clinical Review","first-page":"395","article-title":"Mechanism of noise-induced hearing loss and otoprotective strategies","author":"Kopke","year":"2006"},{"key":"10.1016\/j.heares.2006.08.008_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bss0660001","article-title":"Mitochondrial control of apoptosis: an overview","volume":"66","author":"Kroemer","year":"1999","journal-title":"Biochem Soc Symp"},{"key":"10.1016\/j.heares.2006.08.008_bib26","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/74994","article-title":"Mitochondrial control of cell death","volume":"6","author":"Kroemer","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.heares.2006.08.008_bib27","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1523\/JNEUROSCI.17-13-05089.1997","article-title":"Evidence that 4-hydroxynenenal mediates oxidative stress-induced neuronal apoptosis","volume":"17","author":"Kruman","year":"1997","journal-title":"J. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.heares.2006.08.008_bib28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0378-5955(97)00186-X","article-title":"The effect of prednisolone and non-steroidal anti-inflammatory agents on the normal and noise-damaged guinea pig inner ear","volume":"115","author":"Lamm","year":"1998","journal-title":"Hear Res"},{"key":"10.1016\/j.heares.2006.08.008_bib29","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0378-5955(99)00174-4","article-title":"Combined effects of noise and styrene exposure on hearing function in the rat","volume":"139","author":"Lataye","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2006.08.008_bib30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4103\/1463-1741.31633","article-title":"Combined effects of noise and styrene on hearing: comparison between active and sedentary rats","volume":"7","author":"Lataye","year":"2005","journal-title":"Noise Health"},{"key":"10.1016\/j.heares.2006.08.008_bib31","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/biof.5520080305","article-title":"Oxidative stress, antioxidant defenses and aging","volume":"8","author":"Lenaz","year":"1998","journal-title":"Biofactors"},{"key":"10.1016\/j.heares.2006.08.008_bib32","unstructured":"Marine Corps Lessons Learned: Command and Control, and Hearing Loss: A summary of collected lessons, observations, after action reports from the Korean and Vietnam Wars, OEF, OFI, and OFII; June 16, 2005."},{"issue":"4","key":"10.1016\/j.heares.2006.08.008_bib33","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s10162-002-3038-2","article-title":"The caspase pathway in noise-induced apoptosis of the chinchilla cochlea","volume":"4","author":"Nicotera","year":"2003","journal-title":"J. Assoc. Res. Otolaryngol."},{"issue":"5","key":"10.1016\/j.heares.2006.08.008_bib34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000013845","article-title":"Elevation of reactive oxygen species following ischemia-reperfusion in mouse cochlea observed in vivo","volume":"4","author":"Ohlemiller","year":"1999","journal-title":"Audiol. Neurootol."},{"issue":"5","key":"10.1016\/j.heares.2006.08.008_bib35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000013846","article-title":"Early elevation of cochlear reactive oxygen species following noise exposure","volume":"4","author":"Ohlemiller","year":"1999","journal-title":"Audiol. Neurotol."},{"key":"10.1016\/j.heares.2006.08.008_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-4580(95)80001-8","article-title":"Clinical and neurochemical effects of acetyl-l-carnitine in Alzheimer\u2019s disease","volume":"16","author":"Pettegrew","year":"1995","journal-title":"Neurobiol. Aging."},{"key":"10.1016\/j.heares.2006.08.008_bib37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/biof.5520110112","article-title":"Mitochondrial oxidative stress: a self-propagating process with implications for signaling cascades","volume":"11","author":"Poderoso","year":"2000","journal-title":"Biofactors"},{"issue":"June","key":"10.1016\/j.heares.2006.08.008_bib38","doi-asserted-by":"crossref","first-page":"429","DOI":"10.7205\/MILMED.169.6.429","article-title":"Hearing health risk in a population of aircraft carrier flight deck personnel","volume":"169","author":"Rovig","year":"2004","journal-title":"Mil. Med."},{"key":"10.1016\/j.heares.2006.08.008_bib39","first-page":"169","article-title":"L-acetylcarnitine treatment of mental decline in the elderly","volume":"20","author":"Salvioli","year":"1994","journal-title":"Drugs Exp. Clin. Res."},{"key":"10.1016\/j.heares.2006.08.008_bib40","first-page":"3","article-title":"Troops return with alarming rates of hearing loss","volume":"20","author":"Schulz","year":"2004","journal-title":"Hear. Health"},{"issue":"2","key":"10.1016\/j.heares.2006.08.008_bib41","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0196-0709(00)80003-4","article-title":"Biologic activity of mitochondrial metabolites on aging and age-related hearing loss","volume":"21","author":"Seidman","year":"2000","journal-title":"Am. J. Otol."},{"key":"10.1016\/j.heares.2006.08.008_bib42","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1212\/WNL.55.6.805","article-title":"A 1-year controlled trial of acetyl-l-carnitine in early-onset AD","volume":"55","author":"Thal","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.heares.2006.08.008_bib43","volume":"vol. 1","author":"Weibel","year":"1979"},{"issue":"5","key":"10.1016\/j.heares.2006.08.008_bib44","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/milmed\/160.5.219","article-title":"The effectiveness of the Navy\u2019s hearing conservation program","volume":"160","author":"Wolgemuth","year":"1995","journal-title":"Mil. Med."},{"key":"10.1016\/j.heares.2006.08.008_bib45","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/00016489509121877","article-title":"The emergence of free radicals after acoustic trauma and strial blood flow","volume":"519","author":"Yamane","year":"1995","journal-title":"Acta Otolaryngol. Suppl."},{"issue":"1\u20132","key":"10.1016\/j.heares.2006.08.008_bib46","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainres.2004.05.104","article-title":"Delayed production of free radicals following noise exposure","volume":"1019","author":"Yamashita","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2006.08.008_bib47","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuroscience.2005.04.015","article-title":"Post-exposure treatment attenuates noise-induced hearing loss","volume":"134","author":"Yamashita","year":"2005","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"10.1016\/j.heares.2006.08.008_bib48","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0006-8993(97)01156-6","article-title":"Role of glutathione in protection against noise-induced hearing loss","volume":"784","author":"Yamasoba","year":"1998","journal-title":"Brain Res."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595506002267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595506002267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T13:39:35Z","timestamp":1555853975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595506002267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":48,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0378595506002267"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2006.08.008","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}