{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:27:54Z","timestamp":1790980074783,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.heares.2008.01.013","type":"journal-article","created":{"date-parts":[[2008,2,9]],"date-time":"2008-02-09T12:42:17Z","timestamp":1202560937000},"page":"79-91","source":"Crossref","is-referenced-by-count":33,"title":["Cisplatin induces cytoplasmic to nuclear translocation of nucleotide excision repair factors among spiral ganglion neurons"],"prefix":"10.1016","volume":"239","author":[{"given":"O\u2019neil W.","family":"Guthrie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha-Sheng","family":"Li-Korotky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Durrant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carey","family":"Balaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2008.01.013_bib1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.0022-202x.2001.01390.x","article-title":"Differential ultraviolet-B-induced immunomodulation in XPA, XPC, and CSD DNA repair-deficient mice","volume":"117","author":"Boonstra","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.heares.2008.01.013_bib2","doi-asserted-by":"crossref","first-page":"22355","DOI":"10.1074\/jbc.M002259200","article-title":"The oxidative DNA lesion 8,5\u2032-(S)-cyclo-2\u2032-deoxyadenosine is repaired by the nucleotide excision repair pathway and blocks gene expression in mammalian cells","volume":"275","author":"Brooks","year":"2000","journal-title":"J. Biol Chem."},{"key":"10.1016\/j.heares.2008.01.013_bib3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1067\/mhn.2001.117408","article-title":"Temporal bone histopathology after treatment by a large amount of cisplatin: a case study","volume":"125","author":"Cheng","year":"2001","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2008.01.013_bib4","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/carcin\/bgg051","article-title":"Defining the function of XPC protein in psoralen and cisplatin-mediated DNA repair and mutagenesis","volume":"24","author":"Chen","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.heares.2008.01.013_bib5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0378-5955(96)00075-5","article-title":"Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants","volume":"8","author":"Clerici","year":"1996","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2008.01.013_bib6","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.biochi.2003.10.017","article-title":"The eukaryotic nucleotide excision repair pathway","volume":"85","author":"Costa","year":"2003","journal-title":"Biochimie"},{"key":"10.1016\/j.heares.2008.01.013_bib7","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1172\/JCI117388","article-title":"Messenger RNA levels of XPAC and ERCC1 in ovarian cancer tissue correlate with response to platinum-based chemotherapy","volume":"94","author":"Dabholkar","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.heares.2008.01.013_bib8","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1101\/gad.13.7.768","article-title":"Molecular mechanism of nucleotide excision repair","volume":"13","author":"de Laat","year":"1999","journal-title":"Gene. Dev."},{"key":"10.1016\/j.heares.2008.01.013_bib9","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1038\/sj.emboj.7601277","article-title":"New functions of XPC in the protection of skin cells from oxidative damage","volume":"25","author":"D\u2019Errico","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.heares.2008.01.013_bib10","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1021\/bi00361a026","article-title":"Reevaluation of interaction of cis-dichloro(ethylenediamine)platinum(II) with DNA","volume":"25","author":"Eastman","year":"1986","journal-title":"Biochemistry"},{"key":"10.1016\/j.heares.2008.01.013_bib11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0378-5955(99)00190-2","article-title":"Cisplatin-induced hearing loss: Influence of mode of drug administration in the guinea pig","volume":"140","author":"Ekborn","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2008.01.013_bib12","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0006-2952(00)00441-X","article-title":"Increased nucleotide excision repair in cisplatin resistant ovarian cancer cells","volume":"60","author":"Ferry","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.heares.2008.01.013_bib13","first-page":"3000","article-title":"cis-Diamminedichloroplatinum(II)-induced DNA adducts in peripheral leukocytes from seven cancer patients: Quantitative immunochemical detection of the adduct induction and removal after a single dose of cis-diamminedichloroplatinum(II)","volume":"47","author":"Fichtinger-Schepman","year":"1987","journal-title":"Cancer Res."},{"key":"10.1016\/j.heares.2008.01.013_bib14","first-page":"1793","article-title":"Excision repair of cis-diamminedichloroplatinum(II)-induced damage to DNA of Chinese hamster cells","volume":"39","author":"Fraval","year":"1979","journal-title":"Cancer Res."},{"issue":"Suppl. 4","key":"10.1016\/j.heares.2008.01.013_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2165\/00003495-200059004-00002","article-title":"Clinical perspectives on platinum resistance","volume":"59","author":"Giaccone","year":"2000","journal-title":"Drugs"},{"key":"10.1016\/j.heares.2008.01.013_bib16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1021\/cr040483f","article-title":"Molecular mechanisms of mammalian global excision repair","volume":"106","author":"Gillet","year":"2006","journal-title":"Chem. Rev."},{"key":"10.1016\/j.heares.2008.01.013_bib17","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1080\/10715769900301121","article-title":"Overexpression of glutathione S-transferase pi enhances the adduct formation of cisplatin with glutathione in human cancer cells","volume":"31","author":"Goto","year":"1999","journal-title":"Free Radical Res."},{"key":"10.1016\/j.heares.2008.01.013_bib18","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0194-5998(98)70276-1","article-title":"Histopathology of human temporal bone after cis-platinum, radiation, or both","volume":"118","author":"Hoistad","year":"1998","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2008.01.013_bib19","doi-asserted-by":"crossref","first-page":"20116","DOI":"10.1016\/S0021-9258(20)80702-9","article-title":"Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells: molecular characterization of glutathione\u2013platinum complex and its biological significance","volume":"268","author":"Ishikawa","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.heares.2008.01.013_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0027-5107(01)00142-7","article-title":"Recognition of cisplatin adducts by cellular proteins","volume":"478","author":"Kartalou","year":"2001","journal-title":"Mutat. Res."},{"issue":"Suppl. 4","key":"10.1016\/j.heares.2008.01.013_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00003495-200059004-00001","article-title":"Preclinical perspectives on platinum resistance","volume":"59","author":"Kelland","year":"2000","journal-title":"Drugs"},{"key":"10.1016\/j.heares.2008.01.013_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0960-9822(99)80118-3","article-title":"Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours","volume":"9","author":"Koberle","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.heares.2008.01.013_bib23","doi-asserted-by":"crossref","first-page":"3832","DOI":"10.1073\/pnas.070471597","article-title":"Removal of oxygen free-radical-induced 5\u2032,8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells","volume":"97","author":"Kuraoka","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.heares.2008.01.013_bib24","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.tig.2006.06.006","article-title":"When transcription and repair meet: a complex system","volume":"22","author":"Lain\u00e9","year":"2006","journal-title":"Trends Genet."},{"key":"10.1016\/j.heares.2008.01.013_bib25","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0378-5955(97)00154-8","article-title":"Glutathione-dependent antioxidant systems in mammalian inner ear: effects of aging, ototoxicity drugs and noise","volume":"114","author":"Lautermann","year":"1997","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2008.01.013_bib26","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1126\/science.6890712","article-title":"New chemistry of an old molecule: cis-(Pt(NH3)2Cl2","volume":"218","author":"Lippard","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.heares.2008.01.013_bib27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods."},{"key":"10.1016\/j.heares.2008.01.013_bib28","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1177\/22.12.1077","article-title":"Periodate\u2013lysine\u2013paraformaldehyde fixative for immunoelectron microscopy","volume":"22","author":"McLean","year":"1974","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.heares.2008.01.013_bib29","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.heares.2004.07.016","article-title":"Antioxidant protection in a new animal model of cisplatin-induced ototoxicity","volume":"198","author":"Minami","year":"2004","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2008.01.013_bib30","doi-asserted-by":"crossref","first-page":"15933","DOI":"10.1073\/pnas.0403664101","article-title":"In vivo dynamics of chromatin-associated complex formation in mammalian nucleotide excision repair","volume":"101","author":"Mon\u00e9","year":"2004","journal-title":"PNAS"},{"key":"10.1016\/j.heares.2008.01.013_bib31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0009-2797(81)90181-2","article-title":"The role of DNA repair in the recovery of human cells from cisplatin toxicity","volume":"37","author":"Pera","year":"1981","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.heares.2008.01.013_bib32","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.molcel.2005.06.036","article-title":"Mathematical modeling of nucleotide excision repair reveals efficiency of sequential assembly strategies","volume":"19","author":"Politi","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.heares.2008.01.013_bib33","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1128\/MCB.23.16.5755-5767.2003","article-title":"Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions","volume":"23","author":"Rademakers","year":"2003","journal-title":"Mol. Cellular Biol."},{"key":"10.1016\/j.heares.2008.01.013_bib34","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1600-0773.1995.tb00167.x","article-title":"Mechanism of cisplatin ototoxicity: antioxidant system","volume":"76","author":"Ravi","year":"1995","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.heares.2008.01.013_bib35","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.1073\/pnas.84.14.5024","article-title":"Platinum-DNA adducts in leukocyte DNA correlate with disease response in ovarian cancer patients receiving platinum-based chemotherapy","volume":"84","author":"Reed","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.heares.2008.01.013_bib36","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1093\/nar\/gkg259","article-title":"Platinum cross-linking of adenines and guanines on the quadruplex structures of the AG3(T2AG3)3 and (T2AG3)4 human telomere sequences in Na+ and K+ solutions","volume":"31","author":"Redon","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.heares.2008.01.013_bib37","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1093\/emboj\/cdg489","article-title":"The coming and goings of nucleotide excision repair factors on damaged DNA","volume":"22","author":"Riedl","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.heares.2008.01.013_bib38","first-page":"764","article-title":"A truncated human xeroderma pigmentosum complementation group A protein expressed from an adenovirus sensitizes human tumor cells to ultraviolet light and cisplatin","volume":"61","author":"Rosenberg","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.heares.2008.01.013_bib39","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1006\/abio.2000.4753","article-title":"Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods","volume":"285","author":"Schmittgen","year":"2000","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.heares.2008.01.013_bib40","first-page":"1311","article-title":"Enhanced cisplatin cytotoxicity by disturbing the nucleotide excision repair pathway in ovarian cancer cell lines","volume":"63","author":"Selvakumaran","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.heares.2008.01.013_bib41","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1038\/sj.onc.1206933","article-title":"Cisplatin: mode of cytotoxic action and molecular basis of resistance","volume":"22","author":"Siddik","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.heares.2008.01.013_bib42","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.mrfmmm.2003.06.002","article-title":"The interacting pathways for prevention and repair of oxidative DNA damage","volume":"531","author":"Slupphaug","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.heares.2008.01.013_bib43","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1288\/00005537-198312000-00007","article-title":"Cis-platin ototoxicity: clinical experience and temporal bone histopathology","volume":"93","author":"Strauss","year":"1983","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2008.01.013_bib44","doi-asserted-by":"crossref","first-page":"10772","DOI":"10.1073\/pnas.89.22.10772","article-title":"An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts","volume":"89","author":"Szymkowski","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.heares.2008.01.013_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mc.10143","article-title":"Critical DNA damage recognition functions of XPC-hHR23B and XPA-RPA in nucleotide excision repair","volume":"38","author":"Thoma","year":"2003","journal-title":"Mol. Carcinogen."},{"key":"10.1016\/j.heares.2008.01.013_bib46","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1124\/mol.106.022244","article-title":"High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisplatin but not carboplatin ototoxicity","volume":"70","author":"Thomas","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.heares.2008.01.013_bib47","doi-asserted-by":"crossref","first-page":"35791","DOI":"10.1074\/jbc.M305394200","article-title":"Behavior of T7 RNA polymerase and mammalian RNA polymerase II at site-specific cisplatin adducts in the template DNA","volume":"278","author":"Tornaletti","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.heares.2008.01.013_bib48","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/PL00007509","article-title":"Effect of cisplatin on the expression of glutathione-S-transferase in the cochlea of the rat","volume":"257","author":"Touliatos","year":"2000","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2008.01.013_bib49","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.heares.2004.12.007","article-title":"Immunohistochemical detection of platinated DNA in the cochlea of cisplatin-treated guinea pigs","volume":"203","author":"van Ruijven","year":"2005","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2008.01.013_bib50","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/ijc.20134","article-title":"Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines","volume":"110","author":"Welsh","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.heares.2008.01.013_bib51","first-page":"5874","article-title":"Sensitization to the cytotoxicity of cisplatin by transfection with nucleotide excision repair gene xeroderma pigmentosum group A antisense RNA in human lung adenocarcinoma cells","volume":"9","author":"Wu","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.heares.2008.01.013_bib52","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/sj.onc.1209828","article-title":"ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation","volume":"26","author":"Wu","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.heares.2008.01.013_bib53","doi-asserted-by":"crossref","first-page":"555","DOI":"10.18388\/abp.1993_4798","article-title":"Cis-DDP induced alteration of DNA structure studied by scanning tunneling microscopy","volume":"40","author":"Zastawny","year":"1993","journal-title":"Acta Biochim. Pol."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595508000245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595508000245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T02:43:08Z","timestamp":1630723388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595508000245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":53,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0378595508000245"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2008.01.013","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}