{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T18:39:31Z","timestamp":1792348771658,"version":"4.4.0"},"reference-count":98,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.heares.2009.10.009","type":"journal-article","created":{"date-parts":[[2009,10,24]],"date-time":"2009-10-24T04:34:32Z","timestamp":1256358872000},"page":"93-97","source":"Crossref","is-referenced-by-count":111,"title":["Age-related loss of spiral ganglion neurons"],"prefix":"10.1016","volume":"264","author":[{"given":"Jianxin","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin K.","family":"Ohlemiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2009.10.009_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0378-5955(96)00184-0","article-title":"Histopathologic observations of the aging gerbil cochlea","volume":"104","author":"Adams","year":"1997","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib2","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/00005537-200103000-00026","article-title":"The expression of apoptosis-related proteins in the aged cochlea of Mongolian gerbils","volume":"111","author":"Alam","year":"2001","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2009.10.009_bib4","first-page":"449","article-title":"Mitochondrial DNA deletions associated with aging and possibly presbycusis: a human archival temporal bone study","volume":"18","author":"Bai","year":"1997","journal-title":"Am. J. Otol."},{"key":"10.1016\/j.heares.2009.10.009_bib5","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1523\/JNEUROSCI.5277-04.2005","article-title":"Requirement of nicotinic acetylcholine receptor subunit beta2 in the maintenance of spiral ganglion neurons during aging","volume":"25","author":"Bao","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2009.10.009_bib6","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.exger.2006.09.001","article-title":"New findings in transgenic, gene knockout and mutant mice","volume":"41","author":"Bartke","year":"2006","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.heares.2009.10.009_bib7","series-title":"Cell Death","first-page":"29","article-title":"Identification of dying cells\u2014in situ staining","author":"Ben-Sasson","year":"1995"},{"key":"10.1016\/j.heares.2009.10.009_bib8","first-page":"911","article-title":"Nutrition, onset of disease, and longevity in the rat","volume":"93","author":"Berg","year":"1965","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.heares.2009.10.009_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-5955(90)90200-9","article-title":"Morphological correlates of aging in the chinchilla cochlea","volume":"48","author":"Bohne","year":"1990","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.heares.2006.10.004","article-title":"Death pathways in noise-damaged outer hair cells","volume":"223","author":"Bohne","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1474-9726.2006.00268.x","article-title":"A steroid hormone that extends the lifespan of Caenorhabditis elegans","volume":"6","author":"Brou\u00e9","year":"2007","journal-title":"Aging Cell"},{"key":"10.1016\/j.heares.2009.10.009_bib12","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0959-4388(96)80101-2","article-title":"Ischemia-induced neuronal apoptosis","volume":"6","author":"Choi","year":"1996","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.heares.2009.10.009_bib13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/neu.20022","article-title":"Age-associated synapse elimination in mouse parasympathetic ganglia","volume":"60","author":"Coggan","year":"2004","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.heares.2009.10.009_bib14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1042\/bj2860331","article-title":"Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation","volume":"286","author":"Cohen","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/j.heares.2009.10.009_bib15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S1566-0702(01)00376-9","article-title":"Selective vulnerability in adult and ageing mammalian neurons","volume":"96","author":"Cowen","year":"2002","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.heares.2009.10.009_bib16","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/neu.20006","article-title":"Overexpression of bcl-2 prevents neomycin-induced hair cell death and caspase-9 activation in the adult mouse utricle in vitro","volume":"60","author":"Cunningham","year":"2004","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.heares.2009.10.009_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0378-5955(96)00100-1","article-title":"Cochlear spiral ganglion cell degeneration in wild-caught mice as a function of age","volume":"100","author":"Dazert","year":"1996","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib18","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0896-6273(00)80173-7","article-title":"BAX is required for neuronal death after trophic factor deprivation and during development","volume":"17","author":"Deckwerth","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.heares.2009.10.009_bib19","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/0896-6273(95)90263-5","article-title":"Complementary roles of BDNF and NT-3 in vestibular and auditory development","volume":"14","author":"Ernfors","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.heares.2009.10.009_bib20","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1749-6632.1998.tb09902.x","article-title":"The effects of dietary restriction on mitochondrial dysfunction in aging","volume":"854","author":"Feuers","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.heares.2009.10.009_bib21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/scdb.1997.0144","article-title":"Effects of neurotrophin and neurotrophin receptor disruption on the afferent inner ear innervation","volume":"8","author":"Fritzsch","year":"1997","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.heares.2009.10.009_bib22","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0140-6736(05)67423-5","article-title":"Presbycusis","volume":"366","author":"Gates","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.heares.2009.10.009_bib23","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.tibs.2007.02.007","article-title":"Role of insulin-like signalling in Drosophila lifespan","volume":"32","author":"Giannakou","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.heares.2009.10.009_bib24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/35041700","article-title":"Genetic pathways that regulate ageing in model organisms","volume":"408","author":"Guarente","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.heares.2009.10.009_bib25","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0092-8674(94)90506-1","article-title":"C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2","volume":"76","author":"Hengartner","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.heares.2009.10.009_bib26","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/00206098609078397","article-title":"Effects of dietary restriction on presbycusis in the mouse","volume":"25","author":"Henry","year":"1986","journal-title":"Audiology"},{"key":"10.1016\/j.heares.2009.10.009_bib27","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s101620010075","article-title":"Spiral ligament pathology: a major aspect of age-related cochlear degeneration in C57BL\/6 mice","volume":"2","author":"Hequembourg","year":"2001","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2009.10.009_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.brainres.2009.02.017","article-title":"The role of glucocorticoids for spiral ganglion neuron survival","volume":"1277","author":"Jin","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2009.10.009_bib30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0378-5955(97)00215-3","article-title":"Apoptosis in the human inner ear. Detection by in situ end-labeling of fragmented DNA and correlation with other markers","volume":"117","author":"Jokay","year":"1998","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib31","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/cne.901880306","article-title":"Spiral ganglion cell counts in an age-graded series of rat cochleas","volume":"188","author":"Keithley","year":"1979","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.heares.2009.10.009_bib32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0378-5955(89)90134-2","article-title":"Spiral ganglion cell density in young and old gerbils","volume":"38","author":"Keithley","year":"1989","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib33","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.heares.2005.06.009","article-title":"Cu\/Zn superoxide dismutase and age-related hearing loss","volume":"209","author":"Keithley","year":"2005","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/bjc.1972.33","article-title":"Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics","volume":"26","author":"Kerr","year":"1972","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.heares.2009.10.009_bib35","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/BF00331373","article-title":"Distinction of apoptotic and necrotic cell death by in situ labeling of fragmented DNA","volume":"278","author":"Kressel","year":"1994","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.heares.2009.10.009_bib36","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1523\/JNEUROSCI.4985-05.2006","article-title":"Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth","volume":"26","author":"Kujawa","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2009.10.009_bib37","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2174\/156720507780362083","article-title":"A new glucocorticoid hypothesis of brain aging: implications for Alzheimer\u2019s disease","volume":"4","author":"Landfield","year":"2007","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.heares.2009.10.009_bib38","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1523\/JNEUROSCI.2488-05.2006","article-title":"Nuclear factor kappaB deficiency is associated with auditory nerve degeneration and increased noise-induced hearing loss","volume":"26","author":"Lang","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2009.10.009_bib39","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/MAO.0b013e31819a8827","article-title":"Spiral ganglion cell loss is unrelated to segmental cochlear sensory system degeneration in humans","volume":"30","author":"Linthicum","year":"2009","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.heares.2009.10.009_bib40","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1146\/annurev.biochem.77.061206.171059","article-title":"Aging and survival: the genetics of life span extension by dietary restriction","volume":"77","author":"Mair","year":"2008","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.heares.2009.10.009_bib42","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1152\/physrev.00004.2002","article-title":"Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior","volume":"82","author":"Mattson","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.heares.2009.10.009_bib43","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/jn\/10.1.63","article-title":"The effects of retarded growth upon the length of life span and upon the ultimate body size","volume":"10","author":"McCay","year":"1935","journal-title":"J. Nutr."},{"key":"10.1016\/j.heares.2009.10.009_bib45","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.metabol.2005.01.008","article-title":"Glucocorticoids, depression, and mood disorders: structural remodeling in the brain","volume":"54","author":"McEwen","year":"2005","journal-title":"Metabolism"},{"key":"10.1016\/j.heares.2009.10.009_bib46","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ejphar.2007.11.071","article-title":"Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators","volume":"583","author":"McEwen","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.heares.2009.10.009_bib47","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1192\/S0007125000296645","article-title":"The vulnerability of the hippocampus to protective and destructive effects of glucocorticoids in relation to stress","author":"McEwen","year":"1992","journal-title":"Br. J. Psychiatry Suppl."},{"key":"10.1016\/j.heares.2009.10.009_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0197-4580(99)00018-4","article-title":"Age-related cochlear hair cell loss is enhanced in mice lacking copper\/zinc superoxide dismutase","volume":"20","author":"McFadden","year":"1999","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heares.2009.10.009_bib49","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0168-9525(98)01573-X","article-title":"Genetics of programmed cell death in C. elegans: past, present and future","volume":"14","author":"Metzstein","year":"1998","journal-title":"Trends Genet."},{"key":"10.1016\/j.heares.2009.10.009_bib50","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.arr.2005.03.002","article-title":"Aging, stress and the hippocampus","volume":"4","author":"Miller","year":"2005","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.heares.2009.10.009_bib51","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0074-7742(06)81004-4","article-title":"Life and death of neurons in the aging cerebral cortex","volume":"81","author":"Morrison","year":"2007","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.heares.2009.10.009_bib52","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1523\/JNEUROSCI.22-11-04670.2002","article-title":"Bcl-2 Overexpression eliminates deprivation-induced cell death of brainstem auditory neurons","volume":"22","author":"Mostafapour","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2009.10.009_bib53","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1523\/JNEUROSCI.0206-07.2007","article-title":"Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit","volume":"27","author":"Nelson","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2009.10.009_bib54","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1080\/00016480600672592","article-title":"Ageing evokes an intrinsic pro-apoptotic signalling pathway in rat cochlea","volume":"126","author":"Nevado","year":"2006","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2009.10.009_bib55","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0378-5955(99)00002-7","article-title":"TUNEL staining of inner ear structure may reflect autolysis, not apoptosis","volume":"130","author":"Nishizaki","year":"1999","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib56","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1016\/j.yexcr.2007.05.029","article-title":"Somatic mtDNA mutations cause progressive hearing loss in the mouse","volume":"313","author":"Niu","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.heares.2009.10.009_bib57","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/01.moo.0000134450.99615.22","article-title":"Age-related hearing loss: the status of Schuknecht\u2019s typology","volume":"12","author":"Ohlemiller","year":"2004","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2009.10.009_bib58","series-title":"Auditory Trauma, Protection, and Repair","first-page":"145","article-title":"Age-related hearing loss and its cellular and molecular bases","author":"Ohlemiller","year":"2008"},{"key":"10.1016\/j.heares.2009.10.009_bib59","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/cne.20326","article-title":"Apical-to-basal gradients in age-related cochlear degeneration and their relationship to \u201cprimary\u201d loss of cochlear neurons","volume":"479","author":"Ohlemiller","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.heares.2009.10.009_bib60","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0378-5955(90)90067-Y","article-title":"Dietary restriction slows the abnormally rapid loss of spiral ganglion neurons in C57BL\/6 mice","volume":"48","author":"Park","year":"1990","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib61","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/BF00470622","article-title":"Correlative studies of cochlear neuronal loss with speech discrimination and pure-tone thresholds","volume":"243","author":"Pauler","year":"1986","journal-title":"Arch. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2009.10.009_bib62","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000074184","article-title":"Mutation in mitochondrial DNA as a cause of presbyacusis","volume":"9","author":"Pickles","year":"2004","journal-title":"Audiol. Neurootol."},{"key":"10.1016\/j.heares.2009.10.009_bib63","doi-asserted-by":"crossref","first-page":"B475","DOI":"10.1093\/gerona\/56.11.B475","article-title":"Apoptosis and aging: role of the mitochondria","volume":"56","author":"Pollack","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.heares.2009.10.009_bib64","doi-asserted-by":"crossref","first-page":"9926","DOI":"10.1073\/pnas.93.18.9926","article-title":"Preserved neuron number in the hippocampus of aged rats with spatial learning deficits","volume":"93","author":"Rapp","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.heares.2009.10.009_bib65","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nrn2007","article-title":"Macular degeneration: recent advances and therapeutic opportunities","volume":"7","author":"Rattner","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.heares.2009.10.009_bib66","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/01.moo.0000180919.68812.b9","article-title":"Strategies to preserve or regenerate spiral ganglion neurons","volume":"13","author":"Roehm","year":"2005","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2009.10.009_bib67","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nrm2234","article-title":"Endocrine regulation of ageing","volume":"8","author":"Russell","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.heares.2009.10.009_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5955(88)90133-5","article-title":"Ganglion cell and hair cell loss in Coturnix quail associated with aging","volume":"36","author":"Ryals","year":"1988","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib69","doi-asserted-by":"crossref","first-page":"78970","DOI":"10.1155\/2007\/78970","article-title":"Stress and memory: behavioral effects and neurobiological mechanisms","volume":"2007","author":"Sandi","year":"2007","journal-title":"Neural Plast."},{"key":"10.1016\/j.heares.2009.10.009_bib70","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1210\/edrv-7-3-284","article-title":"The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis","volume":"7","author":"Sapolsky","year":"1986","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.heares.2009.10.009_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1471-4159.2000.0740001.x","article-title":"Apoptosis and the nervous system","volume":"74","author":"Sastry","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.heares.2009.10.009_bib72","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000086524","article-title":"Sketches of otohistory. Part 9: presby[a]cusis","volume":"10","author":"Schacht","year":"2005","journal-title":"Audiol. Neurootol."},{"key":"10.1016\/j.heares.2009.10.009_bib73","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.neurobiolaging.2003.08.002","article-title":"Synaptic pathology in Alzheimer\u2019s disease: a review of ultrastructural studies","volume":"24","author":"Scheff","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heares.2009.10.009_bib74","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archotol.1964.00750040381003","article-title":"Further observations on the pathology of presbycusis","volume":"80","author":"Schuknecht","year":"1964","journal-title":"Arch. Otolaryngol."},{"key":"10.1016\/j.heares.2009.10.009_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/00034894931020S101","article-title":"Cochlear pathology in presbycusis","volume":"102","author":"Schuknecht","year":"1993","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2009.10.009_bib76","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/00005537-200005000-00003","article-title":"Effects of dietary restriction and antioxidants on presbyacusis","volume":"110","author":"Seidman","year":"2000","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2009.10.009_bib77","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.heares.2008.06.001","article-title":"Age-related auditory pathology in the CBA\/J mouse","volume":"243","author":"Sha","year":"2008","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib78","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0006-8993(02)02249-7","article-title":"Caloric restricted male rats demonstrate fewer synapses in layer 2 of sensorimotor cortex","volume":"931","author":"Shi","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2009.10.009_bib79","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1292\/jvms.60.41","article-title":"Age-related changes in the cochlea and cochlear nuclei of dogs","volume":"60","author":"Shimada","year":"1998","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.heares.2009.10.009_bib80","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.neurobiolaging.2006.06.024","article-title":"Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis","volume":"28","author":"Someya","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heares.2009.10.009_bib81","doi-asserted-by":"crossref","first-page":"B521","DOI":"10.1093\/gerona\/54.12.B521","article-title":"Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals","volume":"54","author":"Sonntag","year":"1999","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.heares.2009.10.009_bib82","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.heares.2006.07.014","article-title":"Synaptic alterations at inner hair cells precede spiral ganglion cell loss in aging C57BL\/6J mice","volume":"221","author":"Stamataki","year":"2006","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib83","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S1044-7431(03)00219-7","article-title":"Response of motoneurons to neonatal sciatic nerve axotomy in Bax-knockout mice","volume":"24","author":"Sun","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.heares.2009.10.009_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/00016488809098973","article-title":"Retrograde cochlear neuronal degeneration in human subjects","volume":"450","author":"Suzuka","year":"1988","journal-title":"Acta Otolaryngol. Suppl."},{"key":"10.1016\/j.heares.2009.10.009_bib85","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3109\/00206098809081601","article-title":"Dietary restriction and presbyacusis: periods of restriction and auditory threshold losses in the CBA\/J mouse","volume":"27","author":"Sweet","year":"1988","journal-title":"Audiology"},{"key":"10.1016\/j.heares.2009.10.009_bib86","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.heares.2005.05.009","article-title":"Higher serum aldosterone correlates with lower hearing thresholds: a possible protective hormone against presbycusis","volume":"209","author":"Tadros","year":"2005","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib87","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/jnr.20795","article-title":"NF-kappaB mediated glucocorticoid response in the inner ear after acoustic trauma","volume":"83","author":"Tahera","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib88","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0006-8993(01)02123-0","article-title":"Caspase-3-deficiency induces hyperplasia of supporting cells and degeneration of sensory cells resulting in the hearing loss","volume":"894","author":"Takahashi","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2009.10.009_bib89","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000013800","article-title":"Degeneration of spiral ganglion cells in the chinchilla after inner hair cell loss induced by carboplatin","volume":"3","author":"Takeno","year":"1998","journal-title":"Audiol. Neurootol."},{"key":"10.1016\/j.heares.2009.10.009_bib90","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1474-9726.2006.00214.x","article-title":"Reactive oxygen species, dietary restriction and neurotrophic factors in age-related loss of myenteric neurons","volume":"5","author":"Thrasivoulou","year":"2006","journal-title":"Aging Cell"},{"key":"10.1016\/j.heares.2009.10.009_bib91","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.neurobiolaging.2003.09.006","article-title":"Assessment of auditory function in rhesus monkeys (Macaca mulatta): effects of age and calorie restriction","volume":"25","author":"Torre","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heares.2009.10.009_bib92","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0006-8993(96)01243-7","article-title":"Cell death in the inner ear associated with aging is apoptosis?","volume":"747","author":"Usami","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2009.10.009_bib93","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.7063854","article-title":"Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence","volume":"215","author":"Weindruch","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.heares.2009.10.009_bib94","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1523\/JNEUROSCI.18-04-01428.1998","article-title":"Widespread elimination of naturally occurring neuronal death in Bax-deficient mice","volume":"18","author":"White","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2009.10.009_bib95","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0378-5955(99)00204-X","article-title":"Pattern of degeneration of the spiral ganglion cell and its processes in the C57BL\/6J mouse","volume":"141","author":"White","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib96","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0378-5955(95)00107-F","article-title":"Genetics of age-related hearing loss in mice. II. Strain differences and effects of caloric restriction on cochlear pathology and evoked response thresholds","volume":"88","author":"Willott","year":"1995","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib97","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0896-6273(93)90074-2","article-title":"In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum","volume":"11","author":"Wood","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.heares.2009.10.009_bib98","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.heares.2006.06.004","article-title":"Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss","volume":"226","author":"Yamasoba","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2009.10.009_bib99","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/S0092-8674(04)00028-5","article-title":"A first insight into the molecular mechanisms of apoptosis","volume":"116","author":"Yuan","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.heares.2009.10.009_bib100","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0092-8674(93)90485-9","article-title":"The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme","volume":"75","author":"Yuan","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.heares.2009.10.009_bib101","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0896-6273(03)00601-9","article-title":"Diversity in the mechanisms of neuronal cell death","volume":"40","author":"Yuan","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.heares.2009.10.009_bib102","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1093\/emboj\/18.5.1235","article-title":"Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors","volume":"18","author":"Zoli","year":"1999","journal-title":"EMBO J."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595509002548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595509002548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T06:24:07Z","timestamp":1558592647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595509002548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":98,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0378595509002548"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2009.10.009","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}