{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:23:44Z","timestamp":1770413024671,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.heares.2010.03.082","type":"journal-article","created":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T13:04:05Z","timestamp":1272459845000},"page":"71-77","source":"Crossref","is-referenced-by-count":38,"title":["N-acetylcysteine attenuates noise-induced permanent hearing loss in diabetic rats"],"prefix":"10.1016","volume":"267","author":[{"given":"Hung-Pin","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan-Jen","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsun-Jen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueliang Leon","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2010.03.082_bib1","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1080\/00016480601110188","article-title":"Noise protection with N-acetyl-l-cysteine (NAC) using a variety of noise exposures, NAC doses, and routes of administration","volume":"127","author":"Bielefeld","year":"2007","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2010.03.082_bib2","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1121\/1.398609","article-title":"Noise level, inner hair cell damage, audiometric features, and equal-energy hypothesis","volume":"86","author":"Borg","year":"1989","journal-title":"J. Acoust. Soc. Am."},{"key":"10.1016\/j.heares.2010.03.082_bib3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and molecular cell biology of diabetic complications","volume":"414","author":"Brownlee","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.heares.2010.03.082_bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-5955(02)00802-X","article-title":"The relationship between noise-induced hearing loss and hair cell loss in rats","volume":"177","author":"Chen","year":"2003","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2010.03.082_bib5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0378-5955(00)00076-9","article-title":"Succinate dehydrogenase (SDH) activity in hair cells: a correlate for permanent threshold elevations","volume":"145","author":"Chen","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2010.03.082_bib6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.heares.2004.12.006","article-title":"Involvement of nitric oxide generation in noise-induced temporary threshold shift in guinea pigs","volume":"203","author":"Chen","year":"2005","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2010.03.082_bib7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0378-5955(96)00126-8","article-title":"Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function","volume":"101","author":"Clerici","year":"1996","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2010.03.082_bib8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.heares.2006.08.008","article-title":"Pharmacological rescue of noise induced hearing loss using N-acetylcysteine and acetyl-l-carnitine","volume":"226","author":"Coleman","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2010.03.082_bib9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1746-1561.2007.00197.x","article-title":"Noise and hearing loss: a review","volume":"77","author":"Daniel","year":"2007","journal-title":"J. Sch. Health"},{"key":"10.1016\/j.heares.2010.03.082_bib10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3109\/00016488309122873","article-title":"Cochlear morphology in relation to loss of behavioural, electrophysiological, and middle ear reflex thresholds after exposure to noise","volume":"402","author":"Engstrom","year":"1983","journal-title":"Acta Otolaryngol. Suppl."},{"key":"10.1016\/j.heares.2010.03.082_bib11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0378-5955(88)90049-4","article-title":"Potentiation of noise induced threshold shifts and hair cell loss by carbon monoxide","volume":"34","author":"Fechter","year":"1988","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2010.03.082_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/taap.1996.8027","article-title":"Cochlear protection from carbon monoxide exposure by free radical blockers in the guinea pig","volume":"142","author":"Fechter","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.heares.2010.03.082_bib13","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.otohns.2005.02.004","article-title":"Cochlear changes in patients with type 1 diabetes mellitus","volume":"133","author":"Fukushima","year":"2005","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2010.03.082_bib14","first-page":"576","article-title":"Diabetes, noise exposure, and hearing loss","volume":"29","author":"Hodgson","year":"1987","journal-title":"J. Occup. Med."},{"key":"10.1016\/j.heares.2010.03.082_bib15","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000027616","article-title":"Effect of acoustic trauma on cytochrome oxidase activity in stria vascularis","volume":"60","author":"Hsu","year":"1998","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"key":"10.1016\/j.heares.2010.03.082_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0048-9697(92)90474-7","article-title":"Is NIDDM a risk factor for noise-induced hearing loss in an occupationally noise exposed cohort?","volume":"127","author":"Ishii","year":"1992","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.heares.2010.03.082_bib17","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/diacare.21.9.1414","article-title":"Global burden of diabetes, 1995\u20132025: prevalence, numerical estimates, and projections","volume":"21","author":"King","year":"1998","journal-title":"Diabetes Care"},{"key":"10.1016\/j.heares.2010.03.082_bib18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1749-6632.1999.tb08641.x","article-title":"A radical demise. Toxins and trauma share common pathways in hair cell death","volume":"884","author":"Kopke","year":"1999","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.heares.2010.03.082_bib19","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1097\/00005537-200209000-00001","article-title":"Candidate\u2019s thesis: enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss","volume":"112","author":"Kopke","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2010.03.082_bib20","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.heares.2006.10.008","article-title":"NAC for noise: from the bench top to the clinic","volume":"226","author":"Kopke","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2010.03.082_bib21","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0892-0362(97)00049-4","article-title":"Combined effects of a simultaneous exposure to noise and toluene on hearing function","volume":"19","author":"Lataye","year":"1997","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.heares.2010.03.082_bib22","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1080\/00016480801935541","article-title":"Ototoxic interaction of kanamycin and 3-nitropropionic acid","volume":"128","author":"Lin","year":"2008","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2010.03.082_bib23","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S1359-6446(05)03561-0","article-title":"Compounds for the prevention and treatment of noise-induced hearing loss","volume":"10","author":"Lynch","year":"2005","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.heares.2010.03.082_bib24","first-page":"271","article-title":"Diabetes and hearing loss","volume":"30","author":"Mandel","year":"1988","journal-title":"J. Occup. Med."},{"key":"10.1016\/j.heares.2010.03.082_bib25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1191\/0960327104ht416oa","article-title":"Glucose-stimulated acrolein production from unsaturated fatty acids","volume":"23","author":"Medina-Navarro","year":"2004","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.heares.2010.03.082_bib26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1001\/jama.289.1.76","article-title":"Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001","volume":"289","author":"Mokdad","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.heares.2010.03.082_bib44","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0378-5955(91)90041-7","article-title":"Frequency representation in the rat cochlea","volume":"51","author":"Muller","year":"1991","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2010.03.082_bib27","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1001\/jama.279.14.1071","article-title":"Prevalence of hearing loss among children 6 to 19 years of age: the Third National Health and Nutrition Examination Survey","volume":"279","author":"Niskar","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.heares.2010.03.082_bib28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1542\/peds.108.1.40","article-title":"Estimated prevalence of noise-induced hearing threshold shifts among children 6 to 19 years of age: the Third National Health and Nutrition Examination Survey, 1988-1994, United States","volume":"108","author":"Niskar","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.heares.2010.03.082_bib29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000013846","article-title":"Early elevation of cochlear reactive oxygen species following noise exposure","volume":"4","author":"Ohlemiller","year":"1999","journal-title":"Audiol. Neurootol."},{"key":"10.1016\/j.heares.2010.03.082_bib30","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/10408449991349276","article-title":"Glutathione redox system in oxidative lung injury","volume":"29","author":"Rahman","year":"1999","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.heares.2010.03.082_bib31","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/dmrr.200","article-title":"Brain and liver mitochondria isolated from diabetic Goto-Kakizaki rats show different susceptibility to induced oxidative stress","volume":"17","author":"Santos","year":"2001","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.heares.2010.03.082_bib32","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/BF02969268","article-title":"Glycation-induced inactivation of antioxidant enzymes and modulation of cellular redox status in lens cells","volume":"29","author":"Shin","year":"2006","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.heares.2010.03.082_bib33","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1288\/00005537-199503000-00002","article-title":"Insulin-dependent diabetic microangiopathy in the inner ear","volume":"105","author":"Smith","year":"1995","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2010.03.082_bib34","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.semnephrol.2007.01.006","article-title":"AGE, RAGE, and ROS in diabetic nephropathy","volume":"27","author":"Tan","year":"2007","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.heares.2010.03.082_bib35","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1210\/er.2003-0019","article-title":"Oxidative stress in the pathogenesis of diabetic neuropathy","volume":"25","author":"Vincent","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.heares.2010.03.082_bib37","doi-asserted-by":"crossref","first-page":"726","DOI":"10.2337\/diabetes.53.3.726","article-title":"Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death","volume":"53","author":"Vincent","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.heares.2010.03.082_bib36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2174\/138945008783431754","article-title":"The antioxidant response as a drug target in diabetic neuropathy","volume":"9","author":"Vincent","year":"2008","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.heares.2010.03.082_bib38","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1210\/en.2006-0073","article-title":"Receptor for advanced glycation end products activation injures primary sensory neurons via oxidative stress","volume":"148","author":"Vincent","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.heares.2010.03.082_bib39","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.2337\/diacare.28.6.1326","article-title":"Work disability among individuals with diabetes","volume":"28","author":"Von Korff","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.heares.2010.03.082_bib40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3109\/00016488509119143","article-title":"Methyl mercury ototoxicity in mice determined by auditory brainstem responses","volume":"99","author":"Wassick","year":"1985","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2010.03.082_bib41","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.heares.2010.03.082_bib42","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/lary.20221","article-title":"Diabetes impairs recovery from noise-induced temporary hearing loss","volume":"119","author":"Wu","year":"2009","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2010.03.082_bib43","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/BF02114761","article-title":"Appearance of free radicals in the guinea pig inner ear after noise-induced acoustic trauma","volume":"252","author":"Yamane","year":"1995","journal-title":"Eur. Arch. Otorhinolaryngol."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595510001942?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595510001942?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T14:53:18Z","timestamp":1544539998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595510001942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":44,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0378595510001942"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2010.03.082","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}