{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:11:22Z","timestamp":1791443482537,"version":"4.3.3"},"reference-count":101,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.heares.2011.07.002","type":"journal-article","created":{"date-parts":[[2011,7,23]],"date-time":"2011-07-23T08:53:13Z","timestamp":1311411193000},"page":"18-27","source":"Crossref","is-referenced-by-count":138,"title":["Apoptosis in acquired and genetic hearing impairment: The programmed death of the hair cell"],"prefix":"10.1016","volume":"281","author":[{"given":"Ken","family":"Op de Beeck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Schacht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Van Camp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2011.07.002_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ajhg.2010.11.010","article-title":"Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74","volume":"88","author":"Ahmed","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.heares.2011.07.002_bib2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.bbrc.2005.07.114","article-title":"Anti-apoptotic role of retinoic acid in the inner ear of noise-exposed mice","volume":"335","author":"Ahn","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.heares.2011.07.002_bib3","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1349-7006.2006.00351.x","article-title":"Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer","volume":"98","author":"Akino","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1016\/j.heares.2011.07.002_bib4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0378-5955(99)00211-7","article-title":"Cisplatin-induced apoptotic cell death in Mongolian gerbil cochlea","volume":"141","author":"Alam","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1999.tb00277.x","article-title":"Global problem of drug-induced hearing loss","volume":"884","author":"Arslan","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.heares.2011.07.002_bib6","doi-asserted-by":"crossref","first-page":"46065","DOI":"10.1074\/jbc.M403046200","article-title":"NOX3, a superoxide-generating NADPH oxidase of the inner ear","volume":"279","author":"Banfi","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.heares.2011.07.002_bib7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000074185","article-title":"A\u00a0second mutation identified in the DFNA5 gene in a Dutch family. A clinical and genetic evaluation","volume":"9","author":"Bischoff","year":"2004","journal-title":"Audiol. Neuro-otol."},{"key":"10.1016\/j.heares.2011.07.002_bib8","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0378-5955(96)00152-9","article-title":"D-methionine provides excellent protection from cisplatin ototoxicity in the rat","volume":"102","author":"Campbell","year":"1996","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.heares.2006.11.012","article-title":"Prevention of noise- and drug-induced hearing loss with D-methionine","volume":"226","author":"Campbell","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib10","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.heares.2006.05.008","article-title":"Aspirin attenuates gentamicin ototoxicity: from the laboratory to the clinic","volume":"226","author":"Chen","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib11","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1399-0004.2007.00889.x","article-title":"A\u00a0novel DFNA5 mutation, IVS8+4 A>G, in the splice donor site of intron 8 causes late-onset non-syndromic hearing loss in a Chinese family","volume":"72","author":"Cheng","year":"2007","journal-title":"Clin. Genet."},{"key":"10.1016\/j.heares.2011.07.002_bib12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0378-5955(95)00066-D","article-title":"The comparative effects of sodium thiosulfate, diethyldithiocarbamate, fosfomycin and WR-2721 on ameliorating cisplatin-induced ototoxicity","volume":"86","author":"Church","year":"1995","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0378-5955(96)00075-5","article-title":"Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants","volume":"98","author":"Clerici","year":"1996","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/taap.2001.9171","article-title":"Cisplatin ototoxicity: involvement of iron and enhanced formation of superoxide anion radicals","volume":"174","author":"Dehne","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.heares.2011.07.002_bib15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0378-5955(02)00338-6","article-title":"Involvement of the mitochondrial permeability transition in gentamicin ototoxicity","volume":"169","author":"Dehne","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neulet.2004.04.089","article-title":"Induction of memory-associated immediate early genes by nerve growth factor in rat primary cortical neurons and differentiated mouse Neuro2A cells","volume":"366","author":"Dickey","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.heares.2011.07.002_bib17","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1177\/019459988108900424","article-title":"Cis-diamminedichloroplatinum (II) ototoxicity in the guinea pig","volume":"89","author":"Estrem","year":"1981","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2011.07.002_bib18","first-page":"729","article-title":"Riluzole improves functional recovery after ischemia in the rat retina","volume":"40","author":"Ettaiche","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.heares.2011.07.002_bib19","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2008.12.027","article-title":"Water-soluble Coenzyme Q10 formulation (Q-ter) promotes outer hair cell survival in a guinea pig model of noise induced hearing loss (NIHL)","volume":"1257","author":"Fetoni","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2011.07.002_bib20","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.neuroscience.2010.06.022","article-title":"in\u00a0vivo protective effect of ferulic acid against noise-induced hearing loss in the guinea-pig","volume":"169","author":"Fetoni","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2011.07.002_bib21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0378-5955(85)90121-2","article-title":"Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment","volume":"19","author":"Forge","year":"1985","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0378-5955(99)00177-X","article-title":"Apoptotic death of hair cells in mammalian vestibular sensory epithelia","volume":"139","author":"Forge","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib23","article-title":"Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer","author":"Fujikane","year":"2009","journal-title":"Breast Cancer Res. Treat"},{"key":"10.1016\/j.heares.2011.07.002_bib24","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0140-6736(05)67423-5","article-title":"Presbycusis","volume":"366","author":"Gates","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.heares.2011.07.002_bib25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0378-5955(84)90077-7","article-title":"Anatomical correlates of impulse noise-induced mechanical damage in the cochlea","volume":"13","author":"Hamernik","year":"1984","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.heares.2005.10.004","article-title":"AIF and endoG translocation in noise exposure induced hair cell death","volume":"211","author":"Han","year":"2006","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.aud.0000191942.36672.f3","article-title":"The role of oxidative stress in noise-induced hearing loss","volume":"27","author":"Henderson","year":"2006","journal-title":"Ear Hear"},{"key":"10.1016\/j.heares.2011.07.002_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0378-5955(03)00067-4","article-title":"Noise-induced hearing loss in chinchillas pre-treated with glutathione monoethylester and R-PIA","volume":"179","author":"Hight","year":"2003","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib29","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1097\/MAO.0b013e31818599d5","article-title":"Cisplatin-induced ototoxicity: effect of intratympanic dexamethasone injections","volume":"29","author":"Hill","year":"2008","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.heares.2011.07.002_bib30","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.heares.2005.08.009","article-title":"Gentamicin induced nitric oxide-related oxidative damages on vestibular afferents in the guinea pig","volume":"211","author":"Hong","year":"2006","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/000164800760370774","article-title":"Intense noise-induced apoptosis in hair cells of guinea pig cochleae","volume":"120","author":"Hu","year":"2000","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2011.07.002_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(01)00361-6","article-title":"F-actin cleavage in apoptotic outer hair cells in chinchilla cochleas exposed to intense noise","volume":"172","author":"Hu","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0378-5955(02)00286-1","article-title":"Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise","volume":"166","author":"Hu","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib34","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.neuroscience.2009.03.072","article-title":"Differential expression of apoptosis-related genes in the cochlea of noise-exposed rats","volume":"161","author":"Hu","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2011.07.002_bib35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1749-6632.1999.tb00278.x","article-title":"Insights into ototoxicity. Analogies to nephrotoxicity","volume":"884","author":"Humes","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.heares.2011.07.002_bib36","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/jnr.20392","article-title":"NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity","volume":"79","author":"Jiang","year":"2005","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib37","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/sj.cdd.4401706","article-title":"Caspase-independent pathways of hair cell death induced by kanamycin in\u00a0vivo","volume":"13","author":"Jiang","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.heares.2011.07.002_bib38","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.neurobiolaging.2006.06.025","article-title":"Oxidative imbalance in the aging inner ear","volume":"28","author":"Jiang","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heares.2011.07.002_bib39","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/geno.2000.6377","article-title":"A\u00a0major gene affecting age-related hearing loss is common to at least ten inbred strains of mice","volume":"70","author":"Johnson","year":"2000","journal-title":"Genomics"},{"key":"10.1016\/j.heares.2011.07.002_bib40","doi-asserted-by":"crossref","first-page":"16019","DOI":"10.1073\/pnas.0508053102","article-title":"Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss","volume":"102","author":"Kalinec","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heares.2011.07.002_bib41","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ymthe.2003.11.020","article-title":"Antioxidant gene therapy can protect hearing and hair cells from ototoxicity","volume":"9","author":"Kawamoto","year":"2004","journal-title":"Mol. Ther."},{"key":"10.1016\/j.heares.2011.07.002_bib42","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/bjc.1972.33","article-title":"Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics","volume":"26","author":"Kerr","year":"1972","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.heares.2011.07.002_bib43","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1038\/sj.onc.1211021","article-title":"Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma","volume":"27","author":"Kim","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.heares.2011.07.002_bib44","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbrc.2008.03.026","article-title":"Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer","volume":"370","author":"Kim","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.heares.2011.07.002_bib45","first-page":"559","article-title":"Use of organotypic cultures of Corti\u2019s organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells","volume":"18","author":"Kopke","year":"1997","journal-title":"Am. J. Otol."},{"key":"10.1016\/j.heares.2011.07.002_bib46","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0014-5793(01)02304-3","article-title":"DFNA5 (ICERE-1) contributes to acquired etoposide resistance in melanoma cells","volume":"494","author":"Lage","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.heares.2011.07.002_bib47","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1010-7940(00)00430-9","article-title":"Ischemic spinal cord injury induced by aortic cross-clamping: prevention by riluzole","volume":"18","author":"Lang-Lazdunski","year":"2000","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.heares.2011.07.002_bib48","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0378-5955(89)90125-1","article-title":"The ototoxic effect of cisplatin on guinea pigs in relation to dosage","volume":"38","author":"Laurell","year":"1989","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib49","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1097\/00005537-200306000-00015","article-title":"A\u00a0novel model for rapid induction of apoptosis in spiral ganglions of mice","volume":"113","author":"Lee","year":"2003","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2011.07.002_bib50","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/tx0496946","article-title":"Ternary complexes of gentamicin with iron and lipid catalyze formation of reactive oxygen species","volume":"18","author":"Lesniak","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.heares.2011.07.002_bib51","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/cne.903550307","article-title":"Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig inner ear","volume":"355","author":"Li","year":"1995","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2011.07.002_bib52","doi-asserted-by":"crossref","first-page":"15703","DOI":"10.1074\/jbc.271.26.15703","article-title":"Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases","volume":"271","author":"Lo","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.heares.2011.07.002_bib53","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/ajmg.1320460504","article-title":"Genetic epidemiological studies of early-onset deafness in the U.S. school-age population","volume":"46","author":"Marazita","year":"1993","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.heares.2011.07.002_bib54","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/s10038-006-0004-6","article-title":"The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage","volume":"51","author":"Masuda","year":"2006","journal-title":"J.\u00a0Hum. Genet."},{"key":"10.1016\/j.heares.2011.07.002_bib55","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0301-0082(99)00042-8","article-title":"JNK and p38 stresskinases\u2013degenerative effectors of signal-transduction-cascades in the nervous system","volume":"61","author":"Mielke","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.heares.2011.07.002_bib56","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.neuroscience.2005.12.044","article-title":"Expression of the kidney injury molecule 1 in the rat cochlea and induction by cisplatin","volume":"139","author":"Mukherjea","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2011.07.002_bib57","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00381-010-1300-1","article-title":"Carboplatin and ototoxicity: hearing loss rates among survivors of childhood medulloblastoma","volume":"27","author":"Musial-Bright","year":"2011","journal-title":"Childs Nerv. Syst."},{"key":"10.1016\/j.heares.2011.07.002_bib58","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s004050050027","article-title":"Apoptosis of guinea pig cochlear hair cells following chronic aminoglycoside treatment","volume":"255","author":"Nakagawa","year":"1998","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2011.07.002_bib59","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.heares.2010.01.004","article-title":"Estradiol protects the cochlea against gentamicin ototoxicity through inhibition of the JNK pathway","volume":"261","author":"Nakamagoe","year":"2010","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib60","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/ajim.20223","article-title":"The global burden of occupational noise-induced hearing loss","volume":"48","author":"Nelson","year":"2005","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.heares.2011.07.002_bib61","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s10162-002-3038-2","article-title":"The caspase pathway in noise-induced apoptosis of the chinchilla cochlea","volume":"4","author":"Nicotera","year":"2003","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2011.07.002_bib62","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/00001756-200305230-00024","article-title":"Suppression of apoptosis occurs in the cochlea by sound conditioning","volume":"14","author":"Niu","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.heares.2011.07.002_bib63","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0006-8993(02)04205-1","article-title":"Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea","volume":"966","author":"Ohinata","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2011.07.002_bib64","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000013846","article-title":"Early elevation of cochlear reactive oxygen species following noise exposure","volume":"4","author":"Ohlemiller","year":"1999","journal-title":"Audiol. Neurootol."},{"key":"10.1016\/j.heares.2011.07.002_bib65","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainres.2006.03.017","article-title":"Contributions of mouse models to understanding of age- and noise-related hearing loss","volume":"1091","author":"Ohlemiller","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2011.07.002_bib66","article-title":"The DFNA5 gene, responsible for hearing loss and involved in cancer, encodes a novel apoptosis-inducing protein","author":"Op de Beeck","year":"2011","journal-title":"Eur. J. Hum. Genet"},{"key":"10.1016\/j.heares.2011.07.002_bib67","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1523\/JNEUROSCI.20-01-00043.2000","article-title":"Rescue of hearing, auditory hair cells, and neurons by CEP-1347\/KT7515, an inhibitor of c-Jun N-terminal kinase activation","volume":"20","author":"Pirvola","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2011.07.002_bib68","first-page":"1","article-title":"Prevalence and characteristics of persons with hearing trouble: United States, 1990\u201391","volume":"10","author":"Ries","year":"1994","journal-title":"Vital Health Stat."},{"key":"10.1016\/j.heares.2011.07.002_bib69","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/sj.ki.5002434","article-title":"Ototoxicity","volume":"72","author":"Rybak","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.heares.2011.07.002_bib70","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.heares.2006.09.015","article-title":"Mechanisms of cisplatin-induced ototoxicity and prevention","volume":"226","author":"Rybak","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib71","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1121\/1.392915","article-title":"The anatomical consequences of acoustic injury: a review and tutorial","volume":"78","author":"Saunders","year":"1985","journal-title":"J.\u00a0Acoust. Soc. Am."},{"key":"10.1016\/j.heares.2011.07.002_bib72","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/01.wnr.0000221834.18470.8c","article-title":"Protective properties of idebenone in noise-induced hearing loss in the guinea pig","volume":"17","author":"Sergi","year":"2006","journal-title":"Neuroreport"},{"key":"10.1016\/j.heares.2011.07.002_bib73","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0891-5849(98)00207-X","article-title":"Formation of reactive oxygen species following bioactivation of gentamicin","volume":"26","author":"Sha","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.heares.2011.07.002_bib74","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0378-5955(00)00003-4","article-title":"Antioxidants attenuate gentamicin-induced free radical formation in\u00a0vitro and ototoxicity in\u00a0vivo: D-methionine is a potential protectant","volume":"142","author":"Sha","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib75","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.heares.2008.06.001","article-title":"Age-related auditory pathology in the CBA\/J mouse","volume":"243","author":"Sha","year":"2008","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib76","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.heares.2009.04.019","article-title":"Activation of cell death pathways in the inner ear of the aging CBA\/J mouse","volume":"254","author":"Sha","year":"2009","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib77","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/00016480802226155","article-title":"Retinoic acid applied after noise exposure can recover the noise-induced hearing loss in mice","volume":"129","author":"Shim","year":"2009","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2011.07.002_bib78","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0378-5955(86)90107-3","article-title":"Overview of mechanical damage to the inner ear: noise as a tool to probe cochlear function","volume":"22","author":"Slepecky","year":"1986","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib79","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.neurobiolaging.2006.06.024","article-title":"Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis","volume":"28","author":"Someya","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heares.2011.07.002_bib80","doi-asserted-by":"crossref","first-page":"19432","DOI":"10.1073\/pnas.0908786106","article-title":"Age-related hearing loss in C57BL\/6J mice is mediated by Bak-dependent mitochondrial apoptosis","volume":"106","author":"Someya","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heares.2011.07.002_bib81","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.mad.2010.04.006","article-title":"Mitochondrial oxidative damage and apoptosis in age-related hearing loss","volume":"131","author":"Someya","year":"2010","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.heares.2011.07.002_bib82","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0891-5849(98)00037-9","article-title":"Iron chelators protect from aminoglycoside-induced cochleo- and vestibulo-toxicity","volume":"25","author":"Song","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.heares.2011.07.002_bib83","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1080\/00016480701714244","article-title":"Time course of apoptotic cell death in guinea pig cochlea following intratympanic gentamicin application","volume":"128","author":"Suzuki","year":"2008","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2011.07.002_bib84","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neuroscience.2007.06.061","article-title":"Role of inhibitor of apoptosis protein in gentamicin-induced cochlear hair cell damage","volume":"149","author":"Tabuchi","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2011.07.002_bib85","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s10495-008-0266-x","article-title":"Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea","volume":"13","author":"Tadros","year":"2008","journal-title":"Apoptosis"},{"key":"10.1016\/j.heares.2011.07.002_bib86","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejphar.2005.08.026","article-title":"Post-exposure administration of edaravone attenuates noise-induced hearing loss","volume":"522","author":"Tanaka","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.heares.2011.07.002_bib87","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1006\/bbrc.1997.7962","article-title":"Involvement of H2O2 production in cisplatin-induced nephrotoxicity","volume":"242","author":"Tsutsumishita","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.heares.2011.07.002_bib88","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0006-8993(96)01243-7","article-title":"Cell death in the inner ear associated with aging is apoptosis?","volume":"747","author":"Usami","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2011.07.002_bib89","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/2503","article-title":"Nonsyndromic hearing impairment is associated with a mutation in DFNA5","volume":"20","author":"Van Laer","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.heares.2011.07.002_bib90","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/jmg.2003.015073","article-title":"DFNA5: hearing impairment exon instead of hearing impairment gene?","volume":"41","author":"Van Laer","year":"2004","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.heares.2011.07.002_bib91","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1002\/jnr.20832","article-title":"A\u00a0BAD link to mitochondrial cell death in the cochlea of mice with noise-induced hearing loss","volume":"83","author":"Vicente-Torres","year":"2006","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib92","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ajhg.2010.05.011","article-title":"Genomic duplication and overexpression of TJP2\/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51","volume":"87","author":"Walsh","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.heares.2011.07.002_bib93","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0306-4522(02)00004-0","article-title":"Riluzole rescues cochlear sensory cells from acoustic trauma in the guinea-pig","volume":"111","author":"Wang","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2011.07.002_bib94","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1124\/mol.106.028936","article-title":"Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals","volume":"71","author":"Wang","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.heares.2011.07.002_bib95","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1124\/jpet.104.075119","article-title":"The chemoprotective agent N-acetylcysteine blocks cisplatin-induced apoptosis through caspase signaling pathway","volume":"312","author":"Wu","year":"2005","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.heares.2011.07.002_bib96","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainres.2004.05.104","article-title":"Delayed production of free radicals following noise exposure","volume":"1019","author":"Yamashita","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2011.07.002_bib97","first-page":"2719","article-title":"AIF and EndoG in noise-induced hearing loss","volume":"15","author":"Yamashita","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.heares.2011.07.002_bib98","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuroscience.2005.04.015","article-title":"Post-exposure treatment attenuates noise-induced hearing loss","volume":"134","author":"Yamashita","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2011.07.002_bib99","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.heares.2004.04.015","article-title":"Quantitative analysis of apoptotic and necrotic outer hair cells after exposure to different levels of continuous noise","volume":"196","author":"Yang","year":"2004","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib100","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0378-5955(01)00380-X","article-title":"Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death","volume":"163","author":"Ylikoski","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2011.07.002_bib101","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0888-7543(03)00175-7","article-title":"A\u00a03-nucleotide deletion in the polypyrimidine tract of intron 7 of the DFNA5 gene causes nonsyndromic hearing impairment in a Chinese family","volume":"82","author":"Yu","year":"2003","journal-title":"Genomics"}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595511001857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595511001857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T03:21:32Z","timestamp":1560396092000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595511001857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":101,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0378595511001857"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2011.07.002","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}