{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:23:27Z","timestamp":1792113807921,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.heares.2011.07.007","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T02:12:57Z","timestamp":1311646377000},"page":"236-242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Fucoidan promotes mechanosensory hair cell regeneration following amino glycoside-induced cell death"],"prefix":"10.1016","volume":"282","author":[{"given":"In Seok","family":"Moon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Hoon","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Mi","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Sang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Hwa","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol-Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.heares.2011.07.007_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0304-3940(96)12367-3","article-title":"New hair cells arise from supporting cell conversion in the acoustically damaged chick inner ear","volume":"205","author":"Adler","year":"1996","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.heares.2011.07.007_bib2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0378-5955(93)90211-I","article-title":"Hair cell regeneration in the bullfrog vestibular otolith organs following amino glycoside toxicity","volume":"65","author":"Baird","year":"1993","journal-title":"Hear Res"},{"issue":"4","key":"10.1016\/j.heares.2011.07.007_bib3","doi-asserted-by":"crossref","first-page":"e1000455","DOI":"10.1371\/journal.pgen.1000455","article-title":"Phoenix is required for mechanosensory hair cell regeneration in the zebrafish lateral line","volume":"5","author":"Behra","year":"2009","journal-title":"PLoS Genet"},{"issue":"3","key":"10.1016\/j.heares.2011.07.007_bib4","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/jbm.a.31819","article-title":"Potential effects of a low-molecular-weight fucoidan extracted from brown algae on bone biomaterial osteoconductive properties","volume":"87","author":"Changotade","year":"2008","journal-title":"J\u00a0Biomed Mater Res A"},{"issue":"2","key":"10.1016\/j.heares.2011.07.007_bib5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s10162-008-0118-y","article-title":"Using the zebrafish lateral line to screen for ototoxicity","volume":"9","author":"Chiu","year":"2008","journal-title":"J\u00a0Assoc Res Otolaryngol"},{"key":"10.1016\/j.heares.2011.07.007_bib6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1211\/jpp.60.4.0013","article-title":"Induction of hepatocyte growth factor by fucoidan and fucoidan-derived oligosaccharides","volume":"60","author":"Fukuta","year":"2008","journal-title":"J\u00a0Pharm Pharmacol"},{"issue":"2","key":"10.1016\/j.heares.2011.07.007_bib7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s10162-002-3022-x","article-title":"Neomycin-induced hair cell death and rapid regeneration in the lateral line of zebrafish (Danio rerio)","volume":"4","author":"Harris","year":"2003","journal-title":"J\u00a0Assoc Res Otolaryngol"},{"issue":"18","key":"10.1016\/j.heares.2011.07.007_bib8","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1097\/WNR.0b013e3282f213e0","article-title":"Pharmacological inhibition of Notch signaling in the mature guinea pig cochlea","volume":"18","author":"Hori","year":"2007","journal-title":"NeuroReport"},{"issue":"1\u20132","key":"10.1016\/j.heares.2011.07.007_bib9","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0925-4773(01)00308-2","article-title":"Expression of proneural and neurogenic genes in the zebrafish lateral line primordium correlates with selection of hair cell fate in neuromasts","volume":"102","author":"Itoh","year":"2001","journal-title":"Mech Dev"},{"issue":"1","key":"10.1016\/j.heares.2011.07.007_bib10","first-page":"79","article-title":"Single dose toxicity study of low molecular fucoidan in mice","volume":"24","author":"Jung","year":"2008","journal-title":"Off J Korean Society Toxicology"},{"key":"10.1016\/j.heares.2011.07.007_bib11","unstructured":"Jung, Y.M., Kim, T.K., Park, D.C., Lee, Y.H., 2007. Bioavailable fucoidan and methods for preparing the same. Korean Patent. (http:\/\/www.wipo.int\/pctdb\/en\/wo.jsp?WO=2008041799)."},{"issue":"9","key":"10.1016\/j.heares.2011.07.007_bib12","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1021\/jm8014734","article-title":"Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity","volume":"52","author":"Kang","year":"2009","journal-title":"J\u00a0Med Chem"},{"issue":"9","key":"10.1016\/j.heares.2011.07.007_bib13","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1007\/s10495-008-0242-5","article-title":"Epicatechin protects auditory cells against cisplatin-induced death","volume":"13","author":"Kim","year":"2008","journal-title":"Apoptosis"},{"issue":"1\u20133","key":"10.1016\/j.heares.2011.07.007_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejphar.2005.10.027","article-title":"EK-6136 (3-methyl-4-(O-methyl-oximino)-1-phenylpyrazolin-5-one): a novel Cdc25B inhibitor with antiproliferative activity","volume":"528","author":"Kim","year":"2005","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"10.1016\/j.heares.2011.07.007_bib15","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3390\/molecules13081671","article-title":"Fucoidan: structure and bioactivity","volume":"13","author":"Li","year":"2008","journal-title":"Molecules"},{"key":"10.1016\/j.heares.2011.07.007_bib16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0378-5955(91)90171-5","article-title":"Hair cell regeneration in the chicken cochlea following amino glycoside toxicity","volume":"56","author":"Lippe","year":"1991","journal-title":"Hear Res"},{"key":"10.1016\/j.heares.2011.07.007_bib17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1124\/jpet.102.046144","article-title":"Low-molecular-weight fucoidan promotes therapeutic revascularization in a rat model of critical hindlimb ischemia","volume":"305","author":"Luyt","year":"2003","journal-title":"J\u00a0Pharmacol Exp Therapeut"},{"key":"10.1016\/j.heares.2011.07.007_bib18","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1523\/JNEUROSCI.4372-07.2008","article-title":"Notch signaling regulates the extent of hair cell regeneration in the zebrafish lateral line","volume":"28","author":"Ma","year":"2008","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.heares.2011.07.007_bib19","doi-asserted-by":"crossref","first-page":"R381","DOI":"10.1016\/j.cub.2009.03.057","article-title":"Signaling pathway regulating zebrafish lateral line development","volume":"19","author":"Ma","year":"2009","journal-title":"Curr Biol"},{"key":"10.1016\/j.heares.2011.07.007_bib20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1242\/dev.02734","article-title":"Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by FGF and Notch","volume":"134","author":"Millimaki","year":"2007","journal-title":"Development"},{"issue":"5884","key":"10.1016\/j.heares.2011.07.007_bib21","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1126\/science.1156547","article-title":"FGF-dependent mechanosensory organ patterning in zebrafish","volume":"320","author":"Nechiporuk","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.heares.2011.07.007_bib22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1146\/annurev.genet.39.073003.105049","article-title":"The genetics of hearing and balance in zebrafish","volume":"39","author":"Nicolson","year":"2005","journal-title":"Annu Rev Genet"},{"issue":"2","key":"10.1016\/j.heares.2011.07.007_bib23","doi-asserted-by":"crossref","first-page":"e1000020","DOI":"10.1371\/journal.pgen.1000020","article-title":"Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death","volume":"4","author":"Owens","year":"2008","journal-title":"PLoS Genet"},{"key":"10.1016\/j.heares.2011.07.007_bib24","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/dvdy.20157","article-title":"Tol2 transposon-mediated enhancer Trap to identify developmentally regulated zebrafish genes in\u00a0vivo","volume":"231","author":"Parinov","year":"2004","journal-title":"Dev Dyn"},{"key":"10.1016\/j.heares.2011.07.007_bib25","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1126\/science.7839150","article-title":"Mammalian vestibular hair cell regeneration","volume":"267","author":"Rubel","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.heares.2011.07.007_bib26","first-page":"1","article-title":"Development of the inner ear of the mouse: a radioautographic study of terminal mitoses","volume":"s220","author":"Ruben","year":"1967","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.heares.2011.07.007_bib27","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/sj.ki.5002434","article-title":"Ototoxicity","volume":"72","author":"Rybak","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.heares.2011.07.007_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/00034894931020S101","article-title":"Cochlear pathology in presbycusis","volume":"102","author":"Schuknecht","year":"1993","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.heares.2011.07.007_bib29","doi-asserted-by":"crossref","first-page":"11714","DOI":"10.1073\/pnas.97.22.11714","article-title":"Cellular studies of auditory hair cell regeneration in birds","volume":"97","author":"Stone","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.heares.2011.07.007_bib30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1182\/blood.V99.1.44","article-title":"Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem\/progenitor cells","volume":"99","author":"Sweeney","year":"2002","journal-title":"Blood"},{"issue":"1\u20132","key":"10.1016\/j.heares.2011.07.007_bib31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.heares.2005.05.005","article-title":"The use of zebrafish for assessing ototoxic and otoprotective agents","volume":"208","author":"Ton","year":"2005","journal-title":"Hear Res"},{"key":"10.1016\/j.heares.2011.07.007_bib32","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijbiomac.2008.11.010","article-title":"Synthesized phosphorylated and aminated derivatives of fucoidan and their potential antioxidant activity in\u00a0vitro","volume":"44","author":"Wang","year":"2009","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.heares.2011.07.007_bib33","series-title":"The zebrafish book;a guide ofr the laboratory use of zebrafish(Danio rerio)","author":"Westerfield","year":"2000"},{"key":"10.1016\/j.heares.2011.07.007_bib34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/neu.10123","article-title":"Zebrafish as a model for hearing and deafness","volume":"53","author":"Whitfield","year":"2002","journal-title":"J\u00a0Neurobiol"},{"key":"10.1016\/j.heares.2011.07.007_bib35","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1242\/dev.01861","article-title":"A\u00a0GFP-based genetic screen reveals mutations that disrupt the architecture of the zebrafish retinotectal projection","volume":"132","author":"Xiao","year":"2005","journal-title":"Dev"}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595511001985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595511001985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:47:09Z","timestamp":1759920429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595511001985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":35,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0378595511001985"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2011.07.007","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fucoidan promotes mechanosensory hair cell regeneration following amino glycoside-induced cell death","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2011.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}