{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:27:43Z","timestamp":1793276863720,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.heares.2012.06.001","type":"journal-article","created":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T23:01:20Z","timestamp":1340319680000},"page":"150-160","source":"Crossref","is-referenced-by-count":93,"special_numbering":"C","title":["The gap-startle paradigm for tinnitus screening in animal models: Limitations and optimization"],"prefix":"10.1016","volume":"295","author":[{"given":"Edward","family":"Lobarinas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah H.","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"Allman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2012.06.001_bib1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s101620010030","article-title":"Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model","volume":"2","author":"Bauer","year":"2001","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2012.06.001_bib2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0194-5998(99)70237-8","article-title":"Behavioral model of chronic tinnitus in rats","volume":"121","author":"Bauer","year":"1999","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2012.06.001_bib3","doi-asserted-by":"crossref","first-page":"726","DOI":"10.7205\/MILMED.172.7.726","article-title":"Blast injury of the ear: clinical update from the global war on terror","volume":"172","author":"Cave","year":"2007","journal-title":"Mil. Med."},{"key":"10.1016\/j.heares.2012.06.001_bib4","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1523\/JNEUROSCI.4608-11.2012","article-title":"Noise overexposure alters long-term somatosensory-auditory processing in the dorsal cochlear nucleus\u2014possible basis for tinnitus-related hyperactivity?","volume":"32","author":"Dehmel","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2012.06.001_bib5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature09656","article-title":"Reversing pathological neural activity using targeted plasticity","volume":"470","author":"Engineer","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.heares.2012.06.001_bib6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.heares.2009.03.002","article-title":"Acute high-intensity sound exposure alters responses of place cells in hippocampus","volume":"253","author":"Goble","year":"2009","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2012.06.001_bib7","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1523\/JNEUROSCI.23-09-03944.2003","article-title":"Salicylate induces tinnitus through activation of cochlear NMDA receptors","volume":"23","author":"Guitton","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2012.06.001_bib8","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3758\/s13428-011-0061-4","article-title":"A\u00a0two-choice sound localization procedure for detecting lateralized tinnitus in animals","volume":"43","author":"Heffner","year":"2011","journal-title":"Behav. Res. Methods"},{"key":"10.1016\/j.heares.2012.06.001_bib9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-5955(02)00343-X","article-title":"Tinnitus in hamsters following exposure to intense sound","volume":"170","author":"Heffner","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2012.06.001_bib10","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1037\/0735-7044.119.3.734","article-title":"Tinnitus and hearing loss in hamsters (Mesocricetus auratus) exposed to loud sound","volume":"119","author":"Heffner","year":"2005","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.heares.2012.06.001_bib11","doi-asserted-by":"crossref","first-page":"e14260","DOI":"10.1371\/journal.pone.0014260","article-title":"Evidence of key tinnitus-related brain regions documented by a unique combination of manganese-enhanced MRI and acoustic startle reflex testing","volume":"5","author":"Holt","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2012.06.001_bib12","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1037\/0735-7036.96.6.945","article-title":"Temporal acuity in auditory function in the rat: reflex inhibition by brief gaps in noise","volume":"96","author":"Ison","year":"1982","journal-title":"J.\u00a0Comp. Physiol. Psychol."},{"key":"10.1016\/j.heares.2012.06.001_bib13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1037\/0735-7044.105.1.33","article-title":"Temporal resolution of gaps in noise by the rat is lost with functional decortication","volume":"105","author":"Ison","year":"1991","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.heares.2012.06.001_bib14","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1288\/00005537-198803000-00008","article-title":"An animal model for tinnitus","volume":"98","author":"Jastreboff","year":"1988","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2012.06.001_bib15","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.neuroscience.2010.02.071","article-title":"Noise trauma impairs neurogenesis in the rat hippocampus","volume":"167","author":"Kraus","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2012.06.001_bib16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0306-4522(98)00436-9","article-title":"Summation between acoustic and trigeminal stimuli evoking startle","volume":"90","author":"Li","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2012.06.001_bib17a","unstructured":"Lobarinas, E., Allman, B.L., Salvi, R., 2012. Modeling blast induced tinnitus. Association for Research in Otolaryngology-Abstract."},{"key":"10.1016\/j.heares.2012.06.001_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-5955(04)00019-X","article-title":"A\u00a0novel behavioral paradigm for assessing tinnitus using schedule-induced polydipsia avoidance conditioning (SIP-AC)","volume":"190","author":"Lobarinas","year":"2004","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2012.06.001_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/03655230600895408","article-title":"Salicylate- and quinine-induced tinnitus and effects of memantine","author":"Lobarinas","year":"2006","journal-title":"Acta Otolaryngol. Suppl."},{"key":"10.1016\/j.heares.2012.06.001_bib19","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10162-011-0276-1","article-title":"Development of tinnitus in CBA\/CaJ mice following sound exposure","volume":"12","author":"Longenecker","year":"2011","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2012.06.001_bib20","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1046\/j.1365-2273.2001.00490.x","article-title":"Guidelines for the grading of tinnitus severity: the results of a working group commissioned by the British Association of Otolaryngologists, Head and Neck Surgeons, 1999","volume":"26","author":"McCombe","year":"2001","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"10.1016\/j.heares.2012.06.001_bib21","doi-asserted-by":"crossref","first-page":"7601","DOI":"10.1073\/pnas.1100223108","article-title":"Mice with behavioral evidence of tinnitus exhibit dorsal cochlear nucleus hyperactivity because of decreased GABAergic inhibition","volume":"108","author":"Middleton","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.heares.2012.06.001_bib22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0378-5955(03)00075-3","article-title":"A\u00a0behavioral paradigm to judge acute sodium salicylate-induced sound experience in rats: a new approach for an animal model on tinnitus","volume":"180","author":"Ruttiger","year":"2003","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2012.06.001_bib23","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.amjmed.2010.02.015","article-title":"Prevalence and characteristics of tinnitus among US adults","volume":"123","author":"Shargorodsky","year":"2010","journal-title":"Am. J. Med."},{"key":"10.1016\/j.heares.2012.06.001_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00008877-200006000-00002","article-title":"Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon","volume":"11","author":"Swerdlow","year":"2000","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.heares.2012.06.001_bib25","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1152\/physrev.00002.2002","article-title":"Plastic changes in the central auditory system after hearing loss, restoration of function, and during learning","volume":"82","author":"Syka","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.heares.2012.06.001_bib26","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1044\/1059-0889(2008\/08-0006)","article-title":"Gap detection methods for assessing salicylate-induced tinnitus and hyperacusis in rats","volume":"17","author":"Turner","year":"2008","journal-title":"Am. J. Audiol."},{"key":"10.1016\/j.heares.2012.06.001_bib27","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1037\/0735-7044.120.1.188","article-title":"Gap detection deficits in rats with tinnitus: a potential novel screening tool","volume":"120","author":"Turner","year":"2006","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.heares.2012.06.001_bib28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0197-4580(98)00053-0","article-title":"Aging effects on the startle response and startle plasticity in Fischer F344 rats","volume":"19","author":"Varty","year":"1998","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heares.2012.06.001_bib29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0166-4328(98)00129-6","article-title":"Is there a critical developmental \u2019window\u2019 for isolation rearing-induced changes in prepulse inhibition of the acoustic startle response?","volume":"100","author":"Varty","year":"1999","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.heares.2012.06.001_bib30","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00221-003-1614-2","article-title":"Expression of c-fos in auditory and non-auditory brain regions of the gerbil after manipulations that induce tinnitus","volume":"153","author":"Wallhausser-Franke","year":"2003","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.heares.2012.06.001_bib31","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neuroscience.2009.08.026","article-title":"Plasticity at glycinergic synapses in dorsal cochlear nucleus of rats with behavioral evidence of tinnitus","volume":"164","author":"Wang","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2012.06.001_bib32","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.heares.2006.06.013","article-title":"Salicylate induced tinnitus: behavioral measures and neural activity in auditory cortex of awake rats","volume":"226","author":"Yang","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2012.06.001_bib33","doi-asserted-by":"crossref","first-page":"14974","DOI":"10.1073\/pnas.1107998108","article-title":"Homeostatic plasticity drives tinnitus perception in an animal model","volume":"108","author":"Yang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.heares.2012.06.001_bib34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10162-010-0246-z","article-title":"Auditory cortex electrical stimulation suppresses tinnitus in rats","volume":"12","author":"Zhang","year":"2011","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595512001633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595512001633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T05:41:43Z","timestamp":1561873303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595512001633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":35,"alternative-id":["S0378595512001633"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2012.06.001","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}