{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:58:19Z","timestamp":1791053899281,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.heares.2012.08.016","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T05:16:16Z","timestamp":1351142176000},"page":"125-132","source":"Crossref","is-referenced-by-count":74,"title":["GRM7 variants associated with age-related hearing loss based on auditory perception"],"prefix":"10.1016","volume":"294","author":[{"given":"Dina L.","family":"Newman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel M.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Ohmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Parody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-To","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan T.","family":"Frisina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Mapes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Eddins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Robert Frisina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Frisina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick A.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2012.08.016_bib1","volume":"vol. ANSI S3.5-1997","author":"Acoustical Society of America","year":"1998"},{"key":"10.1016\/j.heares.2012.08.016_bib2","series-title":"Aging and Slowing of Behavior: Consequences for Cognition and Survival, Nebraska Symposium on Motivation","author":"Birren","year":"1991"},{"key":"10.1016\/j.heares.2012.08.016_bib3","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1046\/j.1532-5415.2001.4911245.x","article-title":"Genetic and environmental influences on self-reported reduced hearing in the old and oldest old","volume":"49","author":"Christensen","year":"2001","journal-title":"Journal of Geriatrics Society"},{"key":"10.1016\/j.heares.2012.08.016_bib4","series-title":"The Aging Auditory System","first-page":"259","article-title":"Epidemiology of age-related hearing loss","author":"Cruickshanks","year":"2010"},{"key":"10.1016\/j.heares.2012.08.016_bib5","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/ije\/dyh386","article-title":"Socioeconomic differences in the prevalence of common chronic diseases: an overview of eight European countries","volume":"34","author":"Dalstra","year":"2005","journal-title":"International Journal of Epidemiology"},{"key":"10.1016\/j.heares.2012.08.016_bib6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1001\/archotol.129.3.285","article-title":"Genomewide linkage analysis to presbycusis in the Framingham Heart Study","volume":"129","author":"DeStefano","year":"2003","journal-title":"Archives of Otolaryngology\u2014Head & Neck Surgery"},{"key":"10.1016\/j.heares.2012.08.016_bib7","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1044\/jslhr.4002.444","article-title":"Age-related and gender-related changes in monaural speech recognition","volume":"40","author":"Dubno","year":"1997","journal-title":"Journal of Speech, Language, and Hearing Research"},{"key":"10.1016\/j.heares.2012.08.016_bib8","first-page":"183","article-title":"Auditory temporal processing in elderly listeners","volume":"7","author":"Fitzgibbons","year":"1996","journal-title":"Journal of the American Academy of Audiology"},{"key":"10.1016\/j.heares.2012.08.016_bib9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/01.AUD.0000120362.69077.0B","article-title":"A\u00a0novel Z-score-based method to analyze\u00a0candidate genes for age-related hearing impairment","volume":"25","author":"Fransen","year":"2004","journal-title":"Ear and Hearing"},{"key":"10.1016\/j.heares.2012.08.016_bib10","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/hmg\/ddn402","article-title":"GRM7 variants confer susceptibility to age-related hearing impairment","volume":"18","author":"Friedman","year":"2009","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.heares.2012.08.016_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0378-5955(97)00006-3","article-title":"Speech recognition in noise and presbycusis: relations to possible neural mechanisms","volume":"106","author":"Frisina","year":"1997","journal-title":"Hearing Research"},{"key":"10.1016\/j.heares.2012.08.016_bib12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.heares.2005.09.002","article-title":"Characterization of hearing loss in aged type II diabetics","volume":"211","author":"Frisina","year":"2006","journal-title":"Hearing Research"},{"key":"10.1016\/j.heares.2012.08.016_bib13","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1001\/archotol.132.5.506","article-title":"Hearing impairment susceptibility in elderly men and the DFNA18 locus","volume":"132","author":"Garringer","year":"2006","journal-title":"Archives of Otolaryngology\u2014Head & Neck Surgery"},{"key":"10.1016\/j.heares.2012.08.016_bib14","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1001\/archotol.125.6.654","article-title":"Genetic associations in age-related hearing thresholds","volume":"125","author":"Gates","year":"1999","journal-title":"Archives of Otolaryngology\u2014Head & Neck Surgery"},{"key":"10.1016\/j.heares.2012.08.016_bib15","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1044\/1092-4388(2001\/056)","article-title":"Sources of age-related recognition difficulty for time-compressed speech","volume":"44","author":"Gordon-Salant","year":"2001","journal-title":"Journal of Speech, Language, and Hearing Research"},{"key":"10.1016\/j.heares.2012.08.016_bib16","doi-asserted-by":"crossref","first-page":"14246","DOI":"10.1073\/pnas.0606891103","article-title":"Progestin negatively affects hearing in aged women","volume":"103","author":"Guimaraes","year":"2006","journal-title":"Proceedings of National Academy of Sciences USA"},{"key":"10.1016\/j.heares.2012.08.016_bib17","series-title":"Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis","author":"Harrell","year":"2010"},{"key":"10.1016\/j.heares.2012.08.016_bib18","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3766\/jaaa.20.4.6","article-title":"Speech recognition and temporal processing in middle-aged women","volume":"20","author":"Helfer","year":"2009","journal-title":"Journal of the American Academy of Audiology"},{"key":"10.1016\/j.heares.2012.08.016_bib19","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1177\/0898264309347821","article-title":"The health impact of a hearing disability on older people in Australia","volume":"21","author":"Hogan","year":"2009","journal-title":"Journal of Aging and Health"},{"key":"10.1016\/j.heares.2012.08.016_bib20","series-title":"Multilevel Analysis: Techniques and Applications","author":"Hox","year":"2010"},{"key":"10.1016\/j.heares.2012.08.016_bib21","series-title":"The Aging Auditory System","first-page":"211","article-title":"Factors affecting speech understanding in older adults","author":"Humes","year":"2010"},{"key":"10.1016\/j.heares.2012.08.016_bib22","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ajhg.2008.08.002","article-title":"Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait","volume":"83","author":"Huyghe","year":"2008","journal-title":"American Journal of Human Genetics"},{"key":"10.1016\/j.heares.2012.08.016_bib23","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00003446-199704000-00003","article-title":"Description and primary results from an audiometric study of male twins","volume":"18","author":"Karlsson","year":"1997","journal-title":"Ear and Hearing"},{"key":"10.1016\/j.heares.2012.08.016_bib24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ajog.2003.06.001","article-title":"Effects of estrogen therapy on hearing in postmenopausal women","volume":"190","author":"Kilicdag","year":"2004","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1016\/j.heares.2012.08.016_bib25","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0029-7844(02)01963-4","article-title":"The association between serum estradiol level and hearing sensitivity in postmenopausal women","volume":"99","author":"Kim","year":"2002","journal-title":"Obstetrics & Gynecology"},{"key":"10.1016\/j.heares.2012.08.016_bib26","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/gerona\/glr115","article-title":"Hearing loss and cognition among older adults in the United States","volume":"66A","author":"Lin","year":"2011","journal-title":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.heares.2012.08.016_bib27","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1037\/a0024238","article-title":"Hearing loss and cognition in the Baltimore longitudinal study of aging","volume":"25","author":"Lin","year":"2011","journal-title":"Neuropsychology"},{"key":"10.1016\/j.heares.2012.08.016_bib28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0531-5565(02)00155-9","article-title":"Auditory function in presbycusis: peripheral vs. central changes","volume":"38","author":"Mazelov\u00e1","year":"2003","journal-title":"Experimental Gerontology"},{"key":"10.1016\/j.heares.2012.08.016_bib29","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1121\/1.408469","article-title":"Development of the Hearing in Noise Test for the measurement of speech reception thresholds in quiet and in noise","volume":"95","author":"Nilsson","year":"1994","journal-title":"Journal of the Acoustical Society of America"},{"key":"10.1016\/j.heares.2012.08.016_bib30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev.psych.59.103006.093656","article-title":"The adaptive brain: aging and neurocognitive scaffolding","volume":"60","author":"Park","year":"2009","journal-title":"The Annual Review of Psychology"},{"key":"10.1016\/j.heares.2012.08.016_bib31","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1001\/jama.298.1.130","article-title":"JAMA patient page. Adult hearing loss","volume":"298","author":"Parmet","year":"2007","journal-title":"JAMA"},{"issue":"Suppl. 2","key":"10.1016\/j.heares.2012.08.016_bib32","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.3109\/14992020309074638","article-title":"Effects of aging on auditory processing of speech","volume":"42","author":"Pichora-Fuller","year":"2003","journal-title":"International Journal of Audiology"},{"key":"10.1016\/j.heares.2012.08.016_bib33","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.heares.2006.10.009","article-title":"Temporal jitter disrupts speech intelligibility: a simulation of auditory aging","volume":"223","author":"Pichora-Fuller","year":"2007","journal-title":"Hearing Research"},{"key":"10.1016\/j.heares.2012.08.016_bib34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.heares.2009.02.010","article-title":"Hormone replacement therapy diminishes hearing in peri-menopausal mice","volume":"252","author":"Price","year":"2009","journal-title":"Hearing Research"},{"key":"10.1016\/j.heares.2012.08.016_bib35","first-page":"32","article-title":"Glutamate neurotoxicity in the cochlea: a possible consequence of ischaemic or anoxic conditions occurring in ageing","volume":"476","author":"Pujol","year":"1990","journal-title":"Acta Oto-Laryngologica. Supplementum"},{"key":"10.1016\/j.heares.2012.08.016_bib36","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/aje\/kwn359","article-title":"Hardy\u2013Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies","volume":"169","author":"Rodriguez","year":"2009","journal-title":"American Journal of Epidemiology"},{"key":"10.1016\/j.heares.2012.08.016_bib37","series-title":"The Aging Auditory System","first-page":"31","article-title":"The physiology of cochlear presbycusis","author":"Schmiedt","year":"2010"},{"key":"10.1016\/j.heares.2012.08.016_bib38","series-title":"The Aging Auditory System","first-page":"167","article-title":"Effects of senescent changes in audition and cognition on spoken language comprehension","author":"Schneider","year":"2010"},{"key":"10.1016\/j.heares.2012.08.016_bib39","first-page":"366","article-title":"Lesions of the organ of Corti","volume":"57","author":"Schuknecht","year":"1953","journal-title":"Transactions of the American Academy of Ophthalmology & Otolaryngology"},{"key":"10.1016\/j.heares.2012.08.016_bib40","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archotol.1964.00750040381003","article-title":"Further observations on the pathology of presbycusis","volume":"80","author":"Schuknecht","year":"1964","journal-title":"Archives of Otolaryngology\u2014Head & Neck Surgery"},{"key":"10.1016\/j.heares.2012.08.016_bib41","series-title":"Pathology of The Ear","author":"Schuknecht","year":"1993"},{"key":"10.1016\/j.heares.2012.08.016_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/00034894931020S101","article-title":"Cochlear pathology in presbycusis","volume":"102","author":"Schuknecht","year":"1993","journal-title":"Annals of Otology, Rhinology and Laryngology"},{"key":"10.1016\/j.heares.2012.08.016_bib43","series-title":"Applied Longitudinal Data Analysis","author":"Singer","year":"2003"},{"key":"10.1016\/j.heares.2012.08.016_bib44","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1121\/1.418205","article-title":"Age-related changes in temporal gap detection","volume":"101","author":"Snell","year":"1997","journal-title":"Journal of the Acoustical Society of America"},{"key":"10.1016\/j.heares.2012.08.016_bib45","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1080\/14992020801895136","article-title":"Assessment of speech intelligibility in noise with the Hearing in Noise Test","volume":"47","author":"Soli","year":"2008","journal-title":"International Journal of Audiology"},{"key":"10.1016\/j.heares.2012.08.016_bib46","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1086\/319501","article-title":"A\u00a0new statistical method for haplotype reconstruction from population data","volume":"68","author":"Stephens","year":"2001","journal-title":"American Journal of Human Genetics"},{"key":"10.1016\/j.heares.2012.08.016_bib47","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.heares.2005.05.009","article-title":"Higher serum aldosterone correlates with lower hearing thresholds: a possible protective hormone against presbycusis","volume":"209","author":"Tadros","year":"2005","journal-title":"Hearing Research"},{"key":"10.1016\/j.heares.2012.08.016_bib48","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1097\/01.mlg.0000183694.10583.12","article-title":"N-acetyltransferase 2 gene polymorphism and presbycusis","volume":"115","author":"Unal","year":"2005","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2012.08.016_bib49","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/humu.20375","article-title":"KCNQ4: a gene for age-related hearing impairment?","volume":"27","author":"Van Eyken","year":"2006","journal-title":"Human Mutation"},{"key":"10.1016\/j.heares.2012.08.016_bib50","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/jmg.2007.049205","article-title":"Contribution of the N-acetyltransferase 2 polymorphism NAT2*6A to age-related hearing impairment","volume":"44","author":"Van Eyken","year":"2007","journal-title":"Journal of Medical Genetics"},{"key":"10.1016\/j.heares.2012.08.016_bib51","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/ejhg.2009.234","article-title":"A\u00a0genome-wide association study for age-related hearing impairment in the Saami","volume":"18","author":"Van Laer","year":"2010","journal-title":"European Journal of Human Genetics"},{"key":"10.1016\/j.heares.2012.08.016_bib52","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddm292","article-title":"The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment","volume":"17","author":"Van Laer","year":"2008","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.heares.2012.08.016_bib53","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/14992020801908251","article-title":"The American English hearing in noise test","volume":"47","author":"Vermiglio","year":"2008","journal-title":"International Journal of Audiology"},{"key":"10.1016\/j.heares.2012.08.016_bib54","series-title":"Linear Mixed Models: A Practical Guide Using Statistical Software","author":"West","year":"2007"},{"key":"10.1016\/j.heares.2012.08.016_bib55","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3766\/jaaa.19.4.2","article-title":"Changes in hearing thresholds over 10 years in older adults","volume":"19","author":"Wiley","year":"2008","journal-title":"Journal of the American Academy of Audiology"},{"key":"10.1016\/j.heares.2012.08.016_bib56","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1093\/gerona\/62.11.1294","article-title":"A\u00a0twin-study of genetic contributions to hearing acuity in late middle age","volume":"62","author":"Wingfield","year":"2007","journal-title":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences"}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595512002092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595512002092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T17:54:20Z","timestamp":1542650060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595512002092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":56,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0378595512002092"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2012.08.016","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}