{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:43:03Z","timestamp":1777549383040,"version":"3.51.4"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["24592545"],"award-info":[{"award-number":["24592545"]}]},{"name":"JSPS KAKENHI","award":["26462557"],"award-info":[{"award-number":["26462557"]}]},{"name":"JSPS KAKENHI","award":["23229009"],"award-info":[{"award-number":["23229009"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.heares.2015.04.009","type":"journal-article","created":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T22:36:30Z","timestamp":1430606190000},"page":"2-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"PA","title":["Insulin-like growth factor 1: A novel treatment for the protection or regeneration of cochlear hair cells"],"prefix":"10.1016","volume":"330","author":[{"given":"Kohei","family":"Yamahara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8924-0710","authenticated-orcid":false,"given":"Norio","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juichi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2015.04.009_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0304-3940(96)12367-3","article-title":"New hair cells arise from supporting cell conversion in the acoustically damaged chick inner ear","volume":"205","author":"Adler","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.heares.2015.04.009_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0896-6273(89)90110-4","article-title":"The neural crest cell lineage problem: neuropoiesis?","volume":"3","author":"Anderson","year":"1989","journal-title":"Neuron"},{"key":"10.1016\/j.heares.2015.04.009_bib3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1159\/000276013","article-title":"The microsphere method for studies of inner ear blood flow","volume":"50","author":"Angelborg","year":"1988","journal-title":"ORL J. Oto-rhino-laryng. Relat. Spec."},{"key":"10.1016\/j.heares.2015.04.009_bib4","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.heares.2015.04.009_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1091\/mbc.12.1.27","article-title":"Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism","volume":"12","author":"Bhowmick","year":"2001","journal-title":"Mol. Biol. cell"},{"key":"10.1016\/j.heares.2015.04.009_bib6","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1136\/jmg.40.12.913","article-title":"A\u00a0novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency","volume":"40","author":"Bonapace","year":"2003","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.heares.2015.04.009_bib7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.stemcr.2014.01.008","article-title":"Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea","volume":"2","author":"Bramhall","year":"2014","journal-title":"Stem Cell. Rep."},{"key":"10.1016\/j.heares.2015.04.009_bib8","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1288\/00005537-198405000-00014","article-title":"Sudden hearing loss: eight years' experience and suggested prognostic table","volume":"94","author":"Byl","year":"1984","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2015.04.009_bib9","doi-asserted-by":"crossref","first-page":"7630","DOI":"10.1523\/JNEUROSCI.21-19-07630.2001","article-title":"Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice","volume":"21","author":"Camarero","year":"2001","journal-title":"J.\u00a0Neurosci. : Official J. Soc. Neurosci."},{"key":"10.1016\/j.heares.2015.04.009_bib10","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/347762a0","article-title":"Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor","volume":"347","author":"Cattaneo","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.heares.2015.04.009_bib11","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1460-9568.2005.04584.x","article-title":"Sensorineural hearing loss in insulin-like growth factor I-null mice: a new model of human deafness","volume":"23","author":"Cediel","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.heares.2015.04.009_bib12","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/01.mlg.0000205183.29986.f6","article-title":"Intratympanic dexamethasone injection for refractory sudden sensorineural hearing loss","volume":"116","author":"Choung","year":"2006","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2015.04.009_bib13","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.3381100","article-title":"Regeneration of sensory hair cells after acoustic trauma","volume":"240","author":"Corwin","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.heares.2015.04.009_bib14","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0896-6273(00)80386-4","article-title":"Fish n' chicks: model recipes for hair-cell regeneration?","volume":"19","author":"Corwin","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.heares.2015.04.009_bib15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0378-5955(91)90027-7","article-title":"Stereociliary bundles reorient during hair cell development and regeneration in the chick cochlea","volume":"52","author":"Cotanche","year":"1991","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.009_bib16","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1001\/archotol.1987.01860100036017","article-title":"Light microscopic evidence of hair cell regeneration after gentamicin toxicity in chick cochlea","volume":"113","author":"Cruz","year":"1987","journal-title":"Arch. Otolaryngol. Head. Neck Surg."},{"key":"10.1016\/j.heares.2015.04.009_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(03)00369-1","article-title":"Induction of heat shock protein 32 (Hsp32) in the rat cochlea following hyperthermia","volume":"188","author":"Fairfield","year":"2004","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.009_bib18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0378-5955(85)90121-2","article-title":"Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment","volume":"19","author":"Forge","year":"1985","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.009_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0378-5955(99)00177-X","article-title":"Apoptotic death of hair cells in mammalian vestibular sensory epithelia","volume":"139","author":"Forge","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.009_bib20","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1126\/science.8456284","article-title":"Ultrastructural evidence for hair cell regeneration in the mammalian inner ear","volume":"259","author":"Forge","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.heares.2015.04.009_bib21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/path.1712","article-title":"Insulin-like growth factor ligands, receptors, and binding proteins in cancer","volume":"205","author":"Foulstone","year":"2005","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.heares.2015.04.009_bib22","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1242\/jcs.00223","article-title":"Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I","volume":"116","author":"Frago","year":"2003","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.heares.2015.04.009_bib23","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1097\/WNR.0b013e328311ca4b","article-title":"Insulin-like growth factor 1 treatment via hydrogels rescues cochlear hair cells from ischemic injury","volume":"19","author":"Fujiwara","year":"2008","journal-title":"Neuroreport"},{"key":"10.1016\/j.heares.2015.04.009_bib24","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1523\/JNEUROSCI.15-04-02656.1995","article-title":"Neurotrophin-4\/5 (NT-4\/5) and brain-derived neurotrophic factor (BDNF) act at later stages of cerebellar granule cell differentiation","volume":"15","author":"Gao","year":"1995","journal-title":"J.\u00a0Neurosci. : Off. J. Soc. Neurosci."},{"key":"10.1016\/j.heares.2015.04.009_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0896-6273(95)90067-5","article-title":"Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis","volume":"15","author":"Ghosh","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.heares.2015.04.009_bib26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0304-3940(97)00462-X","article-title":"Efflux of glutamate into the perilymph of the cochlea following transient ischemia in the gerbil","volume":"230","author":"Hakuba","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.heares.2015.04.009_bib27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mcn.2013.03.003","article-title":"Insulin-like growth factor 1 inhibits hair cell apoptosis and promotes the cell cycle of supporting cells by activating different downstream cascades after pharmacological hair cell injury in neonatal mice","volume":"56","author":"Hayashi","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.heares.2015.04.009_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neulet.2013.11.062","article-title":"Insulin-like growth factor 1 induces the transcription of Gap43 and Ntn1 during hair cell protection in the neonatal murine cochlea","volume":"560","author":"Hayashi","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.heares.2015.04.009_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/01.mlg.0000245058.11866.15","article-title":"Intratympanic dexamethasone for sudden sensorineural hearing loss after failure of systemic therapy","volume":"117","author":"Haynes","year":"2007","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2015.04.009_bib30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tcb.2004.02.005","article-title":"Brain meets pancreas: netrin, an axon guidance molecule, controls epithelial cell migration","volume":"14","author":"Hebrok","year":"2004","journal-title":"Trends cell Biol."},{"key":"10.1016\/j.heares.2015.04.009_bib31","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1097\/00005537-200407000-00010","article-title":"Effectiveness of intratympanic dexamethasone injection in sudden-deafness patients as salvage treatment","volume":"114","author":"Ho","year":"2004","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2015.04.009_bib32","doi-asserted-by":"crossref","first-page":"5991","DOI":"10.1128\/MCB.19.9.5991","article-title":"Inhibition of mitogen-activated kinase signaling sensitizes HeLa cells to Fas receptor-mediated apoptosis","volume":"19","author":"Holmstrom","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.heares.2015.04.009_bib33","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/01.mlg.0000200791.77819.eb","article-title":"Cochlear protection by local insulin-like growth factor-1 application using biodegradable hydrogel","volume":"116","author":"Iwai","year":"2006","journal-title":"Laryngoscope"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.heares.2015.04.009_bib34","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1530\/eje.0.151S017","article-title":"Evidence for a link between IGF-I and cancer","volume":"151","author":"Jenkins","year":"2004","journal-title":"Eur. J. Endocrinol.\/Eur. Fed. Endocr. Soc."},{"key":"10.1016\/j.heares.2015.04.009_bib35","first-page":"319","article-title":"The avian inner ear. Continuous production of hair cells in vestibular sensory organs, but not in the auditory papilla","volume":"75","author":"Jorgensen","year":"1988","journal-title":"Naturwissenschaften"},{"key":"10.1016\/j.heares.2015.04.009_bib36","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3109\/00016488109138538","article-title":"Labyrinthine barriers and cochlear homeostasis","volume":"91","author":"Juhn","year":"1981","journal-title":"Acta Oto-Laryngologica"},{"key":"10.1016\/j.heares.2015.04.009_bib37","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000320269","article-title":"Daily short-term intratympanic dexamethasone treatment alone as an initial or salvage treatment for idiopathic sudden sensorineural hearing loss","volume":"16","author":"Kakehata","year":"2011","journal-title":"Audiol. Neuro-Otol."},{"key":"10.1016\/j.heares.2015.04.009_bib38","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1242\/dev.02002","article-title":"The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear","volume":"132","author":"Kiernan","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.heares.2015.04.009_bib39","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ydbio.2009.10.027","article-title":"Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors","volume":"337","author":"Laine","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.heares.2015.04.009_bib40","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/6804","article-title":"Notch signalling pathway mediates hair cell development in mammalian cochlea","volume":"21","author":"Lanford","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.heares.2015.04.009_bib41","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2174\/138161207780249146","article-title":"The IGF-I signaling pathway","volume":"13","author":"Laviola","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.heares.2015.04.009_bib42","doi-asserted-by":"crossref","first-page":"E991","DOI":"10.1152\/ajpendo.90452.2008","article-title":"Abnormalities of IGF-I signaling in the pathogenesis of diseases of the bone, brain, and fetoplacental unit in humans","volume":"295","author":"Laviola","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.heares.2015.04.009_bib43","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3342\/ceo.2010.3.3.122","article-title":"Intratympanic steroids in severe to profound sudden sensorineural hearing loss as salvage treatment","volume":"3","author":"Lee","year":"2010","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2015.04.009_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5955(95)00220-0","article-title":"Potential role of bFGF and retinoic acid in the regeneration of chicken cochlear hair cells","volume":"94","author":"Lee","year":"1996","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.009_bib45","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1097\/MAO.0b013e31811f40db","article-title":"Novel therapy for hearing loss: delivery of insulin-like growth factor 1 to the cochlea using gelatin hydrogel","volume":"28","author":"Lee","year":"2007","journal-title":"Otol. Neurotol. : Offic. Publ. Am. Otolog. Soc"},{"key":"10.1016\/j.heares.2015.04.009_bib46","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1126\/science.8480180","article-title":"Retinoic acid stimulates regeneration of mammalian auditory hair cells","volume":"260","author":"Lefebvre","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.heares.2015.04.009_bib47","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/000164800750000784","article-title":"Epidermal growth factor upregulates production of supernumerary hair cells in neonatal rat organ of corti explants","volume":"120","author":"Lefebvre","year":"2000","journal-title":"Acta Oto-Laryngol."},{"key":"10.1016\/j.heares.2015.04.009_bib48","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/(SICI)1096-9861(19980831)398:3<323::AID-CNE2>3.0.CO;2-1","article-title":"Induction of cell growth by insulin and insulin-like growth factor-I is associated with Jun expression in the otic vesicle","volume":"398","author":"Leon","year":"1998","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2015.04.009_bib49","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1210\/endo.136.8.7628386","article-title":"Insulin-like growth factor-I regulates cell proliferation in the developing inner ear, activating glycosyl-phosphatidylinositol hydrolysis and Fos expression","volume":"136","author":"Leon","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.heares.2015.04.009_bib50","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/gerona\/glr002","article-title":"Hearing loss prevalence and risk factors among older adults in the United States","volume":"66","author":"Lin","year":"2011","journal-title":"J.\u00a0Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.heares.2015.04.009_bib51","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.cub.2004.05.020","article-title":"Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis","volume":"14","author":"Liu","year":"2004","journal-title":"Curr. Biol. : CB"},{"key":"10.1016\/j.heares.2015.04.009_bib52","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1093\/emboj\/20.11.2715","article-title":"Netrin-1 acts as a survival factor via its receptors UNC5H and DCC","volume":"20","author":"Llambi","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.heares.2015.04.009_bib53","doi-asserted-by":"crossref","first-page":"e14435","DOI":"10.1371\/journal.pone.0014435","article-title":"RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development","volume":"5","author":"Magarinos","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2015.04.009_bib54","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0378-5955(02)00451-3","article-title":"Identification of factors that maintain mammalian outer hair cells in adult organ of Corti explants","volume":"170","author":"Malgrange","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.009_bib55","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1253\/circj.71.1181","article-title":"A\u00a0novel approach to therapeutic angiogenesis for patients with critical limb ischemia by sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel: an initial report of the phase I-IIa study","volume":"71","author":"Marui","year":"2007","journal-title":"Circ. J. : Off. J. Jpn. Circ. Soc."},{"key":"10.1016\/j.heares.2015.04.009_bib56","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1387\/ijdb.072273tm","article-title":"Analysis of Netrin 1 receptors during inner ear development","volume":"51","author":"Matilainen","year":"2007","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.heares.2015.04.009_bib57","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1172\/JCI68480","article-title":"Inner ear supporting cells protect hair cells by secreting HSP70","volume":"123","author":"May","year":"2013","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.heares.2015.04.009_bib58","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuron.2012.10.032","article-title":"Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma","volume":"77","author":"Mizutari","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.heares.2015.04.009_bib59","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-0-387-76715-4_2","article-title":"Netrins and their receptors","volume":"621","author":"Moore","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.heares.2015.04.009_bib60","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fphar.2014.00206","article-title":"Strategies for developing novel therapeutics for sensorineural hearing loss","volume":"5","author":"Nakagawa","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.heares.2015.04.009_bib61","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1097\/MAO.0b013e31825f251a","article-title":"Audiometric outcomes of topical IGF1 treatment for sudden deafness refractory to systemic steroids","volume":"33","author":"Nakagawa","year":"2012","journal-title":"Otol. Neurotol. : Off. Publ. Am. Otol. Soc"},{"key":"10.1016\/j.heares.2015.04.009_bib62","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1741-7015-8-76","article-title":"Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial","volume":"8","author":"Nakagawa","year":"2010","journal-title":"BMC Med."},{"key":"10.1016\/j.heares.2015.04.009_bib63","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12916-014-0219-x","article-title":"A\u00a0randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment","volume":"12","author":"Nakagawa","year":"2014","journal-title":"BMC Med."},{"key":"10.1016\/j.heares.2015.04.009_bib64","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1210\/jc.2009-0452","article-title":"Partial primary deficiency of insulin-like growth factor (IGF)-I activity associated with IGF1 mutation demonstrates its critical role in growth and brain development","volume":"94","author":"Netchine","year":"2009","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.heares.2015.04.009_bib65","doi-asserted-by":"crossref","first-page":"6530","DOI":"10.1073\/pnas.0511011103","article-title":"Netrin-1 induces angiogenesis via a DCC-dependent ERK1\/2-eNOS feed-forward mechanism","volume":"103","author":"Nguyen","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heares.2015.04.009_bib66","doi-asserted-by":"crossref","first-page":"18104","DOI":"10.1523\/JNEUROSCI.3619-11.2011","article-title":"Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea","volume":"31","author":"Okano","year":"2011","journal-title":"J.\u00a0Neurosci. : Off. J. Soc. Neurosci."},{"key":"10.1016\/j.heares.2015.04.009_bib67","doi-asserted-by":"crossref","first-page":"8319","DOI":"10.1073\/pnas.90.18.8319","article-title":"Mitogen-activated protein kinases p42mapk and p44mapk are required\u00a0for fibroblast proliferation","volume":"90","author":"Pages","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heares.2015.04.009_bib68","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1523\/JNEUROSCI.20-01-00043.2000","article-title":"Rescue of hearing, auditory hair cells, and neurons by CEP-1347\/KT7515, an inhibitor of c-Jun N-terminal kinase activation","volume":"20","author":"Pirvola","year":"2000","journal-title":"J.\u00a0Neurosci. : Off. J. Soc. Neurosci."},{"key":"10.1016\/j.heares.2015.04.009_bib69","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1080\/00016480510037898","article-title":"Outcomes research analysis of continuous intratympanic glucocorticoid delivery in patients with acute severe to profound hearing loss: basis for planning randomized controlled trials","volume":"125","author":"Plontke","year":"2005","journal-title":"Acta Oto-Laryngol."},{"key":"10.1016\/j.heares.2015.04.009_bib70","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1111\/j.0953-816X.2004.03320.x","article-title":"In\u00a0vivo effects of insulin-like growth factor-I (IGF-I) on prenatal and early postnatal development of the central nervous system","volume":"19","author":"Popken","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.heares.2015.04.009_bib71","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1038\/labinvest.2011.126","article-title":"Netrin-1 overexpression in kidney proximal tubular epithelium ameliorates cisplatin nephrotoxicity","volume":"91","author":"Rajasundari","year":"2011","journal-title":"Lab. Investig.; A J. Tech. Methods Pathol."},{"key":"10.1016\/j.heares.2015.04.009_bib72","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1073\/pnas.73.7.2365","article-title":"Polypeptides with nonsuppressible insulin-like and cell-growth promoting activities in human serum: isolation, chemical characterization, and some biological properties of forms I and II","volume":"73","author":"Rinderknecht","year":"1976","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heares.2015.04.009_bib73","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0021-9258(17)40889-1","article-title":"The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin","volume":"253","author":"Rinderknecht","year":"1978","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.heares.2015.04.009_bib74","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.otohns.2006.03.035","article-title":"Efficacy of steroid injection on idiopathic sudden sensorineural hearing loss","volume":"135","author":"Roebuck","year":"2006","journal-title":"Otolaryngol.\u2013Head Neck Surg. : Official J. Am. Acad. Otolaryngol.\u2013Head Neck Surg."},{"key":"10.1016\/j.heares.2015.04.009_bib75","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0006-8993(99)01211-1","article-title":"Effects of growth factors on the hair cells after ototoxic treatment of the neonatal mammalian cochlea in\u00a0vitro","volume":"825","author":"Romand","year":"1999","journal-title":"Brain Res."},{"issue":"Suppl.\u00a0220","key":"10.1016\/j.heares.2015.04.009_bib76","first-page":"1","article-title":"Development of the inner ear of the mouse: a radioautographic study of terminal mitoses","author":"Ruben","year":"1967","journal-title":"Acta Oto-Laryngol."},{"key":"10.1016\/j.heares.2015.04.009_bib77","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1126\/science.3381101","article-title":"Hair cell regeneration after acoustic trauma in adult Coturnix quail","volume":"240","author":"Ryals","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.heares.2015.04.009_bib78","first-page":"825","article-title":"A\u00a0hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in\u00a0vitro","volume":"49","author":"Salmon","year":"1957","journal-title":"J.\u00a0Lab. Clin. Med."},{"key":"10.1016\/j.heares.2015.04.009_bib79","doi-asserted-by":"crossref","first-page":"e8699","DOI":"10.1371\/journal.pone.0008699","article-title":"RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors","volume":"5","author":"Sanchez-Calderon","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2015.04.009_bib80","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0092-8674(94)90420-0","article-title":"The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6","volume":"78","author":"Serafini","year":"1994","journal-title":"Cell"},{"issue":"Pt 3","key":"10.1016\/j.heares.2015.04.009_bib81","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1042\/bj3330471","article-title":"Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling","volume":"333","author":"Shepherd","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.heares.2015.04.009_bib82","doi-asserted-by":"crossref","first-page":"9639","DOI":"10.1523\/JNEUROSCI.1064-12.2012","article-title":"Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea","volume":"32","author":"Shi","year":"2012","journal-title":"J.\u00a0Neurosci. : Off. J. Soc. Neurosci."},{"issue":"Suppl","key":"10.1016\/j.heares.2015.04.009_bib83","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1507\/endocrj.46.Suppl_S59","article-title":"IGF-1 regulates migration and angiogenesis of human endothelial cells","volume":"46","author":"Shigematsu","year":"1999","journal-title":"Endocr. J."},{"key":"10.1016\/j.heares.2015.04.009_bib84","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/00016489609137836","article-title":"Post-traumatic survival and recovery of the auditory sensory cells in culture","volume":"116","author":"Sobkowicz","year":"1996","journal-title":"Acta Oto-Laryngol."},{"key":"10.1016\/j.heares.2015.04.009_bib85","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0736-5748(96)00104-9","article-title":"Cellular interactions as a response to injury in the organ of Corti in culture","volume":"15","author":"Sobkowicz","year":"1997","journal-title":"Int. J. Dev. Neurosci. : Off. J. Int. Soc. Dev. Neurosci."},{"key":"10.1016\/j.heares.2015.04.009_bib86","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1080\/00016480601110212","article-title":"Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I\/II study","volume":"127","author":"Suckfuell","year":"2007","journal-title":"Acta Oto-Laryngol."},{"key":"10.1016\/j.heares.2015.04.009_bib87","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ydbio.2007.04.035","article-title":"Multiple roles of Notch signaling in cochlear development","volume":"307","author":"Takebayashi","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.heares.2015.04.009_bib88","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.brainres.2006.04.090","article-title":"Recovery of hair cell function after damage induced by gentamicin in organ culture of rat vestibular maculae","volume":"1098","author":"Taura","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2015.04.009_bib89","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1080\/00016480701242410","article-title":"Thirty-year trends in sudden deafness from four nationwide epidemiological surveys in Japan","volume":"127","author":"Teranishi","year":"2007","journal-title":"Acta Oto-Laryngol."},{"key":"10.1016\/j.heares.2015.04.009_bib90","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-2202-15-66","article-title":"Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss","volume":"15","author":"Tona","year":"2014","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.heares.2015.04.009_bib91","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1385\/MN:28:1:23","article-title":"Cell death in the nervous system: lessons from insulin and insulin-like growth factors","volume":"28","author":"Varela-Nieto","year":"2003","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.heares.2015.04.009_bib92","doi-asserted-by":"crossref","first-page":"687","DOI":"10.2174\/138161207780249164","article-title":"Anti-apoptotic actions of insulin-like growth factors: lessons from development and implications in neoplastic cell transformation","volume":"13","author":"Varela-Nieto","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.heares.2015.04.009_bib93","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1210\/jc.2004-1254","article-title":"Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation","volume":"90","author":"Walenkamp","year":"2005","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.heares.2015.04.009_bib94","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1523\/JNEUROSCI.23-24-08596.2003","article-title":"A\u00a0peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss","volume":"23","author":"Wang","year":"2003","journal-title":"J.\u00a0Neurosci. : Off. J. Soc. Neurosci."},{"key":"10.1016\/j.heares.2015.04.009_bib95","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1126\/science.8456285","article-title":"Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans","volume":"259","author":"Warchol","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.heares.2015.04.009_bib96","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1056\/NEJM199610313351805","article-title":"Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene","volume":"335","author":"Woods","year":"1996","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.heares.2015.04.009_bib97","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ydbio.2011.03.016","article-title":"Rbpj regulates development of prosensory cells in the mammalian inner ear","volume":"353","author":"Yamamoto","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.heares.2015.04.009_bib98","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00109-005-0706-9","article-title":"Inhibition of Notch\/RBP-J signaling induces hair cell formation in neonate mouse cochleas","volume":"84","author":"Yamamoto","year":"2006","journal-title":"J.\u00a0Mol. Med. (Berl., Ger."},{"key":"10.1016\/j.heares.2015.04.009_bib99","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1073\/pnas.92.8.3152","article-title":"Induction of cell proliferation in mammalian inner-ear sensory epithelia by transforming growth factor alpha and epidermal growth factor","volume":"92","author":"Yamashita","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heares.2015.04.009_bib100","doi-asserted-by":"crossref","first-page":"10116","DOI":"10.1523\/JNEUROSCI.19-22-10116.1999","article-title":"Heat stress and protection from permanent acoustic injury in mice","volume":"19","author":"Yoshida","year":"1999","journal-title":"J.\u00a0Neurosci. : Off. J. Soc. Neurosci."},{"key":"10.1016\/j.heares.2015.04.009_bib101","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1523\/JNEUROSCI.17-01-00216.1997","article-title":"Induction of cell proliferation by fibroblast and insulin-like growth factors in pure rat inner ear epithelial cell cultures","volume":"17","author":"Zheng","year":"1997","journal-title":"J.\u00a0Neurosci. : Off. J. Soc. Neurosci."},{"key":"10.1016\/j.heares.2015.04.009_bib102","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1523\/JNEUROSCI.19-06-02161.1999","article-title":"Immunocytochemical and morphological evidence for intracellular self-repair as an important contributor to mammalian hair cell recovery","volume":"19","author":"Zheng","year":"1999","journal-title":"J.\u00a0Neurosci. : Off. J. Soc. Neurosci."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595515000982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595515000982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T01:34:50Z","timestamp":1651887290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595515000982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":102,"alternative-id":["S0378595515000982"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2015.04.009","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insulin-like growth factor 1: A novel treatment for the protection or regeneration of cochlear hair cells","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2015.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}