{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:11:36Z","timestamp":1778310696351,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["1R01DC010154"],"award-info":[{"award-number":["1R01DC010154"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.heares.2015.04.010","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T04:31:49Z","timestamp":1432701109000},"page":"78-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"PA","title":["Variation analysis of transcriptome changes reveals cochlear genes and their associated functions in cochlear susceptibility to acoustic overstimulation"],"prefix":"10.1016","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0663-9211","authenticated-orcid":false,"given":"Shuzhi","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9619-8872","authenticated-orcid":false,"given":"Qunfeng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Bard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Jamison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Hua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2015.04.010_bib1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3109\/03005369109076602","article-title":"The influence of eye colour on susceptibility to TTS in humans","volume":"25","author":"Barrenas","year":"1991","journal-title":"Br. J. Audiol."},{"key":"10.1016\/j.heares.2015.04.010_bib2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1471-2105-11-94","article-title":"Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments","volume":"11","author":"Bullard","year":"2010","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.heares.2015.04.010_bib3","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.nbd.2011.10.018","article-title":"Transcriptional changes in adhesion-related genes are site-specific during noise-induced cochlear pathogenesis","volume":"45","author":"Cai","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.heares.2015.04.010_bib4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jneumeth.2013.08.010","article-title":"RNAlater facilitates microdissection of sensory cell-enriched samples from the mouse cochlea for transcriptional analyses","volume":"219","author":"Cai","year":"2013","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.heares.2015.04.010_bib5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s12974-014-0173-8","article-title":"Molecular profile of cochlear immunity in the resident cells of the organ of Corti","volume":"11","author":"Cai","year":"2014","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.heares.2015.04.010_bib6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.heares.2004.09.005","article-title":"The influence of genetic variation in oxidative stress genes on human noise susceptibility","volume":"202","author":"Carlsson","year":"2005","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.010_bib7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0378-5955(00)00076-9","article-title":"Succinate dehydrogenase (SDH) activity in hair cells: a correlate for permanent threshold elevations","volume":"145","author":"Chen","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.010_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0378-5955(83)90134-X","article-title":"Variability of noise-induced damage in the guinea pig cochlea: electrophysiological and morphological correlates after strictly controlled exposures","volume":"9","author":"Cody","year":"1983","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.010_bib9","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: Database for Annotation, Visualization, and Integrated Discovery","volume":"4","author":"Dennis","year":"2003","journal-title":"Genome Biol."},{"key":"10.1016\/j.heares.2015.04.010_bib10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0378-5955(93)90207-H","article-title":"Genetics of age-related hearing loss in mice: I. Inbred and F1 hybrid strains","volume":"65","author":"Erway","year":"1993","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.010_bib11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0378-5955(95)00226-X","article-title":"Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss","volume":"93","author":"Erway","year":"1996","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.010_bib12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.heares.2010.12.014","article-title":"Noise-induced changes in gene expression in the cochleae of mice differing in their susceptibility to noise damage","volume":"277","author":"Gratton","year":"2010","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.010_bib13","doi-asserted-by":"crossref","first-page":"8750","DOI":"10.1523\/JNEUROSCI.20-23-08750.2000","article-title":"Exacerbation of noise-induced hearing loss in mice lacking the glutamate transporter GLAST","volume":"20","author":"Hakuba","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2015.04.010_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.heares.2005.10.004","article-title":"AIF and endoG translocation in noise exposure induced hair cell death","volume":"211","author":"Han","year":"2006","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.010_bib15","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.gene.2012.02.042","article-title":"Identification of new altered genes in rat cochleae with noise-induced hearing loss","volume":"499","author":"Han","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.heares.2015.04.010_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.aud.0000191942.36672.f3","article-title":"The role of oxidative stress in noise-induced hearing loss","volume":"27","author":"Henderson","year":"2006","journal-title":"Ear Hear."},{"key":"10.1016\/j.heares.2015.04.010_bib17","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s10495-006-0027-7","article-title":"Delayed mitochondrial dysfunction in apoptotic hair cells in chinchilla cochleae following exposure to impulse noise","volume":"12","author":"Hu","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.heares.2015.04.010_bib18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0378-5955(02)00286-1","article-title":"Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise","volume":"166","author":"Hu","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.010_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(01)00361-6","article-title":"F-actin cleavage in apoptotic outer hair cells in chinchilla cochleas exposed to intense noise","volume":"172","author":"Hu","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.010_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/000164800760370774","article-title":"Intense noise-induced apoptosis in hair cells of guinea pig cochleae","volume":"120","author":"Hu","year":"2000","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2015.04.010_bib21","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.neuroscience.2009.03.072","article-title":"Differential expression of apoptosis-related genes in the cochlea of noise-exposed rats","volume":"161","author":"Hu","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2015.04.010_bib22","first-page":"422","article-title":"Inner ear correlates in acoustic trauma","volume":"84","author":"Hunter-Duvar","year":"1977","journal-title":"Trans. Sect. Otolaryngol. Am. Acad. Ophthalmol. Otolaryngol."},{"key":"10.1016\/j.heares.2015.04.010_bib23","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s002210000470","article-title":"Noise-induced aspartate and glutamate efflux in the guinea pig cochlea and hearing loss","volume":"134","author":"Jager","year":"2000","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.heares.2015.04.010_bib24","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jprot.2011.08.007","article-title":"Noise induced changes in the expression of p38\/MAPK signaling proteins in the sensory epithelium of the inner ear","volume":"75","author":"Jamesdaniel","year":"2011","journal-title":"J.\u00a0Proteomics"},{"key":"10.1016\/j.heares.2015.04.010_bib25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-5955(97)00155-X","article-title":"A\u00a0major gene affecting age-related hearing loss in C57BL\/6J mice","volume":"114","author":"Johnson","year":"1997","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2015.04.010_bib26","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"10.1016\/j.heares.2015.04.010_bib27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3109\/00016487709123941","article-title":"The effect of high level sound on hearing sensitivity, cochlear sensorineuroepithelium and vasculature of the chinchilla","volume":"84","author":"Lipscomb","year":"1977","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2015.04.010_bib28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.heares.2015.04.010_bib29","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1101\/gr.079558.108","article-title":"RNA-seq: an assessment of technical reproducibility and comparison with gene expression arrays","volume":"18","author":"Marioni","year":"2008","journal-title":"Genome Res."},{"key":"10.1016\/j.heares.2015.04.010_bib30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/1471-2164-12-293","article-title":"RNA-seq: technical variability and sampling","volume":"12","author":"McIntyre","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.heares.2015.04.010_bib31","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nmeth.1226","article-title":"Mapping and quantifying mammalian transcriptomes by RNA-Seq","volume":"5","author":"Mortazavi","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.heares.2015.04.010_bib32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1089\/neu.2007.0346","article-title":"Activation of JNK in the inner ear following impulse noise exposure","volume":"25","author":"Murai","year":"2008","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.heares.2015.04.010_bib33","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s10162-002-3038-2","article-title":"The caspase pathway in noise-induced apoptosis of the chinchilla cochlea","volume":"4","author":"Nicotera","year":"2003","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2015.04.010_bib34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s101620010043","article-title":"Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice","volume":"1","author":"Ohlemiller","year":"2000","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2015.04.010_bib35","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.mam.2012.05.005","article-title":"The mitochondrial transporter family SLC25: identification, properties and physiopathology","volume":"34","author":"Palmieri","year":"2013","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.heares.2015.04.010_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2013.05.038","article-title":"Transcriptome characterization by RNA-Seq reveals the involvement of the complement components in noise-traumatized rat cochleae","volume":"248C","author":"Patel","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2015.04.010_bib37","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nature08872","article-title":"Understanding mechanisms underlying human gene expression variation with RNA sequencing","volume":"464","author":"Pickrell","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.heares.2015.04.010_bib38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/16513860601175998","article-title":"Individual susceptibility to noise-induced hearing loss","volume":"5","author":"Pyykk\u00f6","year":"2007","journal-title":"Audiol. Med."},{"key":"10.1016\/j.heares.2015.04.010_bib39","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.ygeno.2003.12.013","article-title":"Individual-specific variation of gene expression in peripheral blood leukocytes","volume":"83","author":"Radich","year":"2004","journal-title":"Genomics"},{"key":"10.1016\/j.heares.2015.04.010_bib40","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/1471-2105-12-480","article-title":"GC-content normalization for RNA-Seq data","volume":"12","author":"Risso","year":"2011","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.heares.2015.04.010_bib41","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1121\/1.392915","article-title":"The anatomical consequences of acoustic injury: a review and tutorial","volume":"78","author":"Saunders","year":"1985","journal-title":"J.\u00a0Acoust. Soc. Am."},{"key":"10.1016\/j.heares.2015.04.010_bib42","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/00016488409130966","article-title":"A\u00a0quantitative study of the sequence of topographical changes in the organ of Corti following acoustic trauma","volume":"97","author":"Thorne","year":"1984","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2015.04.010_bib43","first-page":"59","article-title":"Individual risk factors in the development of noise-induced hearing loss","volume":"2","author":"Toppila","year":"2000","journal-title":"Noise Health"},{"key":"10.1016\/j.heares.2015.04.010_bib44","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: discovering splice junctions with RNA-Seq","volume":"25","author":"Trapnell","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.heares.2015.04.010_bib45","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.heares.2015.04.010_bib46","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1002\/jnr.20832","article-title":"A\u00a0BAD link to mitochondrial cell death in the cochlea of mice with noise-induced hearing loss","volume":"83","author":"Vicente-Torres","year":"2006","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.heares.2015.04.010_bib47","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrg2484","article-title":"RNA-Seq: a revolutionary tool for transcriptomics","volume":"10","author":"Wang","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.heares.2015.04.010_bib48","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1073\/pnas.252784499","article-title":"Individuality and variation in gene expression patterns in human blood","volume":"100","author":"Whitney","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heares.2015.04.010_bib49","first-page":"2719","article-title":"AIF and EndoG in noise-induced hearing loss","volume":"15","author":"Yamashita","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.heares.2015.04.010_bib50","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/jnr.21533","article-title":"Bcl-2 genes regulate noise-induced hearing loss","volume":"86","author":"Yamashita","year":"2008","journal-title":"J.\u00a0Neurosci. Res."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595515000994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595515000994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T12:40:57Z","timestamp":1566736857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595515000994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":50,"alternative-id":["S0378595515000994"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2015.04.010","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Variation analysis of transcriptome changes reveals cochlear genes and their associated functions in cochlear susceptibility to acoustic overstimulation","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2015.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}