{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:59:57Z","timestamp":1784224797820,"version":"3.55.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Erlangen University Hospital"},{"name":"Friedrich-Alexander University Erlangen-N\u00fcrnberg"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.heares.2016.05.004","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T13:55:08Z","timestamp":1463579708000},"page":"25-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Loss of glycine receptors containing the \u03b13 subunit compromises auditory nerve activity, but not outer hair cell function"],"prefix":"10.1016","volume":"337","author":[{"given":"Julia","family":"Dlugaiczyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Hecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Neubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Buerbank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Campanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6522-5970","authenticated-orcid":false,"given":"Cord-Michael","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6623-3198","authenticated-orcid":false,"given":"Heinrich","family":"Betz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Knipper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"R\u00fcttiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Schick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"41","key":"10.1016\/j.heares.2016.05.004_bib1","doi-asserted-by":"crossref","first-page":"14156","DOI":"10.1523\/JNEUROSCI.2176-12.2012","article-title":"Aging affects neural precision of speech encoding","volume":"32","author":"Anderson","year":"2012","journal-title":"J.\u00a0Neurosci."},{"issue":"4","key":"10.1016\/j.heares.2016.05.004_bib2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00418-011-0855-6","article-title":"Developmental regulation of glycine receptors at efferent synapses in the murine cochlea","volume":"136","author":"Buerbank","year":"2011","journal-title":"Histochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.heares.2016.05.004_bib3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/jn.1978.41.2.365","article-title":"Properties of auditory nerve responses in absence of outer hair cells","volume":"41","author":"Dallos","year":"1978","journal-title":"J.\u00a0Neurophysiol."},{"issue":"2","key":"10.1016\/j.heares.2016.05.004_bib4","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1152\/jn.00955.2006","article-title":"Selective removal of lateral olivocochlear efferents increases vulnerability to acute acoustic injury","volume":"97","author":"Darrow","year":"2007","journal-title":"J.\u00a0Neurophysiol."},{"issue":"4","key":"10.1016\/j.heares.2016.05.004_bib5","first-page":"513","article-title":"Expression of glycine receptors and gephyrin in the rat cochlea. Histochem","volume":"129","author":"Dlugaiczyk","year":"2008","journal-title":"Cell Biol."},{"issue":"48","key":"10.1016\/j.heares.2016.05.004_bib6","doi-asserted-by":"crossref","first-page":"40216","DOI":"10.1074\/jbc.R112.408229","article-title":"Inhibitory glycine receptors: an update","volume":"287","author":"Dutertre","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"issue":"3","key":"10.1016\/j.heares.2016.05.004_bib7","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.neuroscience.2006.08.060","article-title":"Two classes of outer hair cells along the tonotopic axis of the cochlea","volume":"143","author":"Engel","year":"2006","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.heares.2016.05.004_bib9","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1152\/jn.00164.2013","article-title":"Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates","volume":"110","author":"Furman","year":"2013","journal-title":"J.\u00a0Neurophysiol."},{"issue":"6","key":"10.1016\/j.heares.2016.05.004_bib11","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s10162-012-0344-1","article-title":"Brainstem auditory evoked potentials suggest a role for the ventral cochlear nucleus in tinnitus","volume":"13","author":"Gu","year":"2012","journal-title":"JARO"},{"key":"10.1016\/j.heares.2016.05.004_bib12","series-title":"Auditory and Vestibular Efferents. Springer Handbook of Auditory Research","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4419-7070-1_3","article-title":"Physiology of the medial and lateral olivocochlear systems","author":"Guinan","year":"2011"},{"issue":"5672","key":"10.1016\/j.heares.2016.05.004_bib13","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1126\/science.1094925","article-title":"GlyR\u03b13: an essential target for spinal PGE2-mediated inflammatory pain sensitization","volume":"304","author":"Harvey","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.heares.2016.05.004_bib14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/neuro.02.014.2009","article-title":"A\u00a0selective role for alpha3 subunit glycine receptors in inflammatory pain","volume":"2","author":"Harvey","year":"2009","journal-title":"Front. Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.heares.2016.05.004_bib15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/cne.10852","article-title":"Diversity of glycine receptors in the mouse retina: localization of the alpha3 subunit","volume":"465","author":"Haverkamp","year":"2003","journal-title":"J.\u00a0Comp. Neurol."},{"issue":"4","key":"10.1016\/j.heares.2016.05.004_bib16","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/cne.21201","article-title":"Diversity of glycine receptors in the mouse retina: localization of the \u03b14 subunit","volume":"500","author":"Heinze","year":"2007","journal-title":"J.\u00a0Comp. Neurol."},{"issue":"3","key":"10.1016\/j.heares.2016.05.004_bib17","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1152\/jn.00184.2013","article-title":"Is noise-induced cochlear neuropathy key to the generation of hyperacusis or tinnitus?","volume":"111","author":"Hickox","year":"2014","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.heares.2016.05.004_bib18","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.neuroscience.2013.11.027","article-title":"Effects of congenital blindness on the subcortical representation of speech cues","volume":"258","author":"Jafari","year":"2014","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/j.heares.2016.05.004_bib19","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0006-3495(76)85724-4","article-title":"Analysis of discharges recorded simultaneously from pairs of auditory nerve fibers","volume":"16","author":"Johnson","year":"1976","journal-title":"Biophys. J."},{"issue":"6","key":"10.1016\/j.heares.2016.05.004_bib20","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.1523\/JNEUROSCI.15-06-04148.1995","article-title":"The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton","volume":"15","author":"Kirsch","year":"1995","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.05.004_bib21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pneurobio.2013.08.002","article-title":"Advances in the neurobiology of hearing disorders: recent developments regarding the basis of tinnitus and hyperacusis","volume":"111","author":"Knipper","year":"2013","journal-title":"Prog. Neurobiol."},{"issue":"45","key":"10.1016\/j.heares.2016.05.004_bib22","doi-asserted-by":"crossref","first-page":"14077","DOI":"10.1523\/JNEUROSCI.2845-09.2009","article-title":"Adding insult to injury: cochlear nerve degeneration after \u201ctemporary\u201d noise-induced threshold shift","volume":"29","author":"Kujawa","year":"2009","journal-title":"J.\u00a0Neurosci."},{"issue":"Pt B","key":"10.1016\/j.heares.2016.05.004_bib23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.heares.2015.02.009","article-title":"Synaptopathy in the noise-exposed and aging cochlea: primary neural degeneration in acquired sensorineural hearing loss","volume":"330","author":"Kujawa","year":"2015","journal-title":"Hear. Res."},{"issue":"2","key":"10.1016\/j.heares.2016.05.004_bib24","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s10162-002-3018-6","article-title":"Disruption of lateral efferent pathways: functional changes in auditory evoked responses","volume":"4","author":"Le Prell","year":"2003","journal-title":"JARO"},{"issue":"20","key":"10.1016\/j.heares.2016.05.004_bib25","first-page":"1","article-title":"Pathways for protection from noise induced hearing loss","volume":"5","author":"Le Prell","year":"2003","journal-title":"Noise Health"},{"issue":"1","key":"10.1016\/j.heares.2016.05.004_bib26","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s10162-004-5009-2","article-title":"Disruption of lateral olivocochlear neurons via a dopaminergic neurotoxin depresses sound-evoked auditory nerve activity","volume":"6","author":"Le Prell","year":"2005","journal-title":"JARO"},{"issue":"17","key":"10.1016\/j.heares.2016.05.004_bib27","doi-asserted-by":"crossref","first-page":"7434","DOI":"10.1523\/JNEUROSCI.19-17-07434.1999","article-title":"Synaptic control of glycine and GABA(A) receptors and gephyrin expression in cultured motoneurons","volume":"19","author":"L\u00e9vi","year":"1999","journal-title":"J.\u00a0Neurosci."},{"issue":"5","key":"10.1016\/j.heares.2016.05.004_bib28","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s10162-011-0277-0","article-title":"Primary neural degeneration in the guinea pig after reversible noise-induced threshold shift","volume":"12","author":"Lin","year":"2011","journal-title":"JARO"},{"issue":"11","key":"10.1016\/j.heares.2016.05.004_bib29","doi-asserted-by":"crossref","first-page":"e49550","DOI":"10.1371\/journal.pone.0049550","article-title":"Silent damage of noise on cochlear afferent innervation in guinea pigs and the impact on temporal processing","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2016.05.004_bib30","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.heares.2015.01.013","article-title":"Forward acoustic masking enhances the auditory brainstem response in a diotic, but not dichotic, paradigm in salicylate-induced tinnitus","volume":"323","author":"Liu","year":"2015","journal-title":"Hear. Res."},{"issue":"5","key":"10.1016\/j.heares.2016.05.004_bib31","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1152\/jn.00596.2003","article-title":"Loss of \u03b1CGRP reduces sound-evoked activity in the cochlear nerve","volume":"90","author":"Maison","year":"2003","journal-title":"J.\u00a0Neurophysiol."},{"issue":"1","key":"10.1016\/j.heares.2016.05.004_bib32","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1523\/JNEUROSCI.4720-11.2012","article-title":"Dopaminergic signaling in the cochlea: receptor expression patterns and deletion phenotypes","volume":"32","author":"Maison","year":"2012","journal-title":"J.\u00a0Neurosci."},{"issue":"13","key":"10.1016\/j.heares.2016.05.004_bib33","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1523\/JNEUROSCI.5027-12.2013","article-title":"Efferent feedback minimizes cochlear neuropathy from moderate noise exposure","volume":"33","author":"Maison","year":"2013","journal-title":"J.\u00a0Neurosci."},{"issue":"4","key":"10.1016\/j.heares.2016.05.004_bib34","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1017\/S0952523807070174","article-title":"Glycine receptors of A-type ganglion cells of the mouse retina","volume":"24","author":"Majumdar","year":"2007","journal-title":"Vis. Neurosci."},{"issue":"15","key":"10.1016\/j.heares.2016.05.004_bib35","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1113\/jphysiol.2009.171207","article-title":"Glycinergic input of widefield, displaced amacrine cells in the mouse retina","volume":"587","author":"Majumdar","year":"2009","journal-title":"J.\u00a0Physiol."},{"issue":"1","key":"10.1016\/j.heares.2016.05.004_bib36","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0378-5955(02)00495-1","article-title":"Behavioral investigation in some possible effects of the central olivocochlear pathways in transgenic mice","volume":"171","author":"May","year":"2002","journal-title":"Hear. Res."},{"issue":"1","key":"10.1016\/j.heares.2016.05.004_bib37","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0378-5955(95)00200-6","article-title":"Generators of the brainstem auditory evoked potential in cat. III: identified cell populations","volume":"93","author":"Melcher","year":"1996","journal-title":"Hear. Res."},{"issue":"10","key":"10.1016\/j.heares.2016.05.004_bib38","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1523\/JNEUROSCI.5341-11.2012","article-title":"Selective glycine receptor \u03b1 subunit control of crossover inhibition between the on and off retinal pathways","volume":"32","author":"Nobles","year":"2012","journal-title":"J.\u00a0Neurosci."},{"issue":"1","key":"10.1016\/j.heares.2016.05.004_bib39","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2307\/2685263","article-title":"Thirteen ways to look at the correlation coefficient","volume":"42","author":"Rodgers","year":"1988","journal-title":"Am. Statistican"},{"issue":"6","key":"10.1016\/j.heares.2016.05.004_bib40","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1046\/j.0953-816x.2001.01721.x","article-title":"Dopamine inhibition of auditory nerve activity in the adult mammalian cochlea","volume":"14","author":"Ruel","year":"2001","journal-title":"Eur. J. Neurosci."},{"issue":"3","key":"10.1016\/j.heares.2016.05.004_bib41","doi-asserted-by":"crossref","first-page":"e57247","DOI":"10.1371\/journal.pone.0057247","article-title":"The reduced cochlear output and the failure to adapt to central auditory response causes tinnitus in noise exposed rats","volume":"8","author":"R\u00fcttiger","year":"2013","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.heares.2016.05.004_bib42","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0378-5955(00)00127-1","article-title":"Diversity and plasticity in amino acid receptor subunits in the rat auditory brainstem","volume":"147","author":"Sato","year":"2000","journal-title":"Hear. Res."},{"issue":"38","key":"10.1016\/j.heares.2016.05.004_bib43","doi-asserted-by":"crossref","first-page":"13452","DOI":"10.1523\/JNEUROSCI.2156-11.2011","article-title":"Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model","volume":"31","author":"Schaette","year":"2011","journal-title":"J.\u00a0Neurosci."},{"issue":"1","key":"10.1016\/j.heares.2016.05.004_bib44","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1021\/bi00215a007","article-title":"Mapping of antigenic epitopes on the alpha 1 subunit of the inhibitory glycine receptor","volume":"30","author":"Schr\u00f6der","year":"1991","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.heares.2016.05.004_bib45","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/AUD.0b013e3181cdb272","article-title":"Auditory brain stem response to complex sounds: a tutorial","volume":"31","author":"Skoe","year":"2010","journal-title":"Ear Hear"},{"issue":"2","key":"10.1016\/j.heares.2016.05.004_bib46","doi-asserted-by":"crossref","first-page":"e9058","DOI":"10.1371\/journal.pone.0009058","article-title":"Lack of nAChR activity depresses cochlear maturation and up-regulates GABA system components: temporal profiling of gene expression in \u03b19 null mice","volume":"5","author":"Turcan","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.heares.2016.05.004_bib47","series-title":"Electrical Engineering 103: Applied Numerical Computing","author":"Vandenberghe","year":"2011"},{"issue":"1","key":"10.1016\/j.heares.2016.05.004_bib48","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0896-6273(00)80756-4","article-title":"Role of \u03b19 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation","volume":"23","author":"Vetter","year":"1999","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.heares.2016.05.004_bib49","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.mcn.2007.08.012","article-title":"Glycinergic input of small-field amacrine cells in the retinas of wildtype and glycine receptor deficient mice","volume":"37","author":"Weiss","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"issue":"5","key":"10.1016\/j.heares.2016.05.004_bib50","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/nchembio.552","article-title":"Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia","volume":"7","author":"Xiong","year":"2011","journal-title":"Nat. Chem. Biol."},{"issue":"6","key":"10.1016\/j.heares.2016.05.004_bib51","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1084\/jem.20120242","article-title":"Cannabinoids suppress inflammatory and neuropathic pain by targeting \u03b13 glycine receptors","volume":"209","author":"Xiong","year":"2012","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.heares.2016.05.004_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001048","article-title":"Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells","author":"Zampini","year":"2011","journal-title":"PLoS Biol."},{"issue":"25","key":"10.1016\/j.heares.2016.05.004_bib53","doi-asserted-by":"crossref","first-page":"8545","DOI":"10.1523\/JNEUROSCI.1247-12.2012","article-title":"Lack of brain-derived neurotrophic factor hampers inner hair cell synapse physiology, but protects against noise-induced hearing loss","volume":"32","author":"Zuccotti","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.05.004_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2013.00020","article-title":"L-type CaV1.2 deletion in the cochlea but not in the brainstem reduces noise vulnerability: implication for CaV1.2-mediated control of cochlear BDNF expression","author":"Zuccotti","year":"2013","journal-title":"Front. Mol. Neurosci."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595515302872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595515302872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T13:05:53Z","timestamp":1572699953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595515302872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":52,"alternative-id":["S0378595515302872"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2016.05.004","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of glycine receptors containing the \u03b13 subunit compromises auditory nerve activity, but not outer hair cell function","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2016.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}