{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:30:05Z","timestamp":1782365405975,"version":"3.54.5"},"reference-count":104,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Health and Medical Research Council (NHMRC","award":["1080652"],"award-info":[{"award-number":["1080652"]}]},{"name":"National Health and Medical Research Council (NHMRC","award":["1081478"],"award-info":[{"award-number":["1081478"]}]},{"DOI":"10.13039\/501100007696","name":"Oticon Foundation","doi-asserted-by":"crossref","award":["12-1540"],"award-info":[{"award-number":["12-1540"]}],"id":[{"id":"10.13039\/501100007696","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Walker Family Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.heares.2016.07.004","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T18:26:40Z","timestamp":1469644000000},"page":"14-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["The effect of progressive hearing loss on the morphology of endbulbs of Held and bushy cells"],"prefix":"10.1016","volume":"343","author":[{"given":"Catherine J.","family":"Connelly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Ryugo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8047-5871","authenticated-orcid":false,"given":"Michael A.","family":"Muniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2016.07.004_bib1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/0006-8993(86)90542-1","article-title":"Identification of glycinergic synapses in the cochlear nucleus through immunocytochemical localization of the postsynaptic receptor","volume":"369","author":"Altschuler","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2016.07.004_bib2","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s00221-003-1619-x","article-title":"Discharge properties of identified cochlear nucleus neurons and auditory nerve fibers in response to repetitive electrical stimulation of the auditory nerve","volume":"153","author":"Babalian","year":"2003","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.heares.2016.07.004_bib3","first-page":"19","article-title":"Postnatal development of the endbulb of held in congenitally deaf cats","volume":"4","author":"Baker","year":"2010","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.heares.2016.07.004_bib4","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1523\/JNEUROSCI.04-03-00638.1984","article-title":"Effects of sensory deprivation on the developing mouse olfactory system: a light and electron microscopic, morphometric analysis","volume":"4","author":"Benson","year":"1984","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.07.004_bib5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0378-5955(94)90063-9","article-title":"Central trajectories of type II spiral ganglion cells from various cochlear regions in mice","volume":"75","author":"Berglund","year":"1994","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.07.004_bib6","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1006\/exnr.1997.6636","article-title":"New growth of axons in the cochlear nucleus of adult chinchillas after acoustic trauma","volume":"147","author":"Bilak","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/00016488309132873","article-title":"Inner ear pathology in the deafness mutant mouse","volume":"96","author":"Bock","year":"1983","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2016.07.004_bib8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1471-2202-10-104","article-title":"Automated threshold detection for auditory brainstem responses: comparison with visual estimation in a stem cell transplantation study","volume":"10","author":"Bogaerts","year":"2009","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.heares.2016.07.004_bib9","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/cne.902310403","article-title":"Afferent influences on brain stem auditory nuclei of the chicken: neuron number and size following cochlea removal","volume":"231","author":"Born","year":"1985","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib10","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1523\/JNEUROSCI.4669-13.2014","article-title":"A\u00a0map of functional synaptic connectivity in the mouse anteroventral cochlear nucleus","volume":"34","author":"Campagnola","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.07.004_bib11","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/0306-4522(79)90066-6","article-title":"The bushy cells in the anteroventral cochlear nucleus of the cat. A study with the electron microscope","volume":"4","author":"Cant","year":"1979","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2016.07.004_bib12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/cne.21788","article-title":"Connections and synaptic function in the posteroventral cochlear nucleus of deaf jerker mice","volume":"510","author":"Cao","year":"2008","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib13","doi-asserted-by":"crossref","first-page":"e38011","DOI":"10.1371\/journal.pone.0038011","article-title":"TrakEM2 software for neural circuit reconstruction","volume":"7","author":"Cardona","year":"2012","journal-title":"PloS ONE"},{"key":"10.1016\/j.heares.2016.07.004_bib14","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0014-4886(83)90419-3","article-title":"Effects of acetylcholine on cochlear nucleus neurons","volume":"82","author":"Caspary","year":"1983","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib15","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0006-8993(74)90464-8","article-title":"Pentobarbital-induced configurational changes at the synapse","volume":"76","author":"Cooke","year":"1974","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2016.07.004_bib16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/cne.902230308","article-title":"Effects of neonatal whisker lesions on mouse central trigeminal pathways","volume":"223","author":"Durham","year":"1984","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib17","first-page":"179","article-title":"Development of absolute auditory thresholds in the house mouse (Mus musculus)","volume":"1","author":"Ehret","year":"1976","journal-title":"J.\u00a0Am. Audiol. Soc."},{"key":"10.1016\/j.heares.2016.07.004_bib18","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/cne.902290311","article-title":"The central projections of intracellularly labeled auditory nerve fibers in cats","volume":"229","author":"Fekete","year":"1984","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib19","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/cne.902350410","article-title":"Functional organization of the cochlear nucleus of rufous horseshoe bats (Rhinolophus rouxi): frequencies and internal connections are arranged in slabs","volume":"235","author":"Feng","year":"1985","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib20","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.heares.2006.02.003","article-title":"Age-related structural and functional changes in the cochlear nucleus","volume":"216\u2013217","author":"Frisina","year":"2006","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.07.004_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1044\/jslhr.4001.183","article-title":"Cochlear implant use by prelingually deafened children: the influences of age at implant and length of device use","volume":"40","author":"Fryauf-Bertschy","year":"1997","journal-title":"J.\u00a0Speech Lang. Hear Res."},{"key":"10.1016\/j.heares.2016.07.004_bib22","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10162-006-0046-7","article-title":"Age-related changes in cochlear gene expression in normal and shaker 2 mice","volume":"7","author":"Gong","year":"2006","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2016.07.004_bib23","series-title":"Handbook on Genetically Standardized JAX Mice","author":"Green","year":"1991"},{"key":"10.1016\/j.heares.2016.07.004_bib24","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0006-8993(78)90675-3","article-title":"Changes in the synapses of spiral ganglion cells in the rostral anteroventral cochlear nucleus of the waltzing guinea pig following hair cell loss","volume":"158","author":"Gulley","year":"1978","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2016.07.004_bib25","doi-asserted-by":"crossref","first-page":"14068","DOI":"10.1523\/JNEUROSCI.3213-10.2010","article-title":"Neural coding of interaural time differences with bilateral cochlear implants: effects of congenital deafness","volume":"30","author":"Hancock","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.07.004_bib26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/cne.902830402","article-title":"Effects of unilateral cochlea removal on anteroventral cochlear nucleus neurons in developing gerbils","volume":"283","author":"Hashisaki","year":"1989","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib27","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0378-5955(03)00194-1","article-title":"Age-related synaptic changes in the anteroventral cochlear nucleus of Fischer-344 rats","volume":"183","author":"Helfert","year":"2003","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.07.004_bib28","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1037\/h0076794","article-title":"Auditory similarities associated with genetic and experimental acoustic deprivation","volume":"89","author":"Henry","year":"1975","journal-title":"J.\u00a0Comp. Physiol. Psychol."},{"key":"10.1016\/j.heares.2016.07.004_bib29","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3109\/00016489709113461","article-title":"Pathology of the cochlea following a spontaneous mutation in DBA\/2 mice","volume":"117","author":"Hultcrantz","year":"1997","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2016.07.004_bib30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/geno.2000.6377","article-title":"A\u00a0major gene affecting age-related hearing loss is common to at least ten inbred strains of mice","volume":"70","author":"Johnson","year":"2000","journal-title":"Genomics"},{"key":"10.1016\/j.heares.2016.07.004_bib31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/(SICI)1096-9861(19960909)373:1<11::AID-CNE2>3.0.CO;2-G","article-title":"Three classes of inhibitory amino acid terminals in the cochlear nucleus of the guinea pig","volume":"373","author":"Juiz","year":"1996","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib32","doi-asserted-by":"crossref","first-page":"e05793","DOI":"10.7554\/eLife.05793","article-title":"Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation","volume":"4","author":"Korogod","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.heares.2016.07.004_bib33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tins.2011.09.004","article-title":"Developmental neuroplasticity after cochlear implantation","volume":"35","author":"Kral","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.heares.2016.07.004_bib34","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/cercor\/10.7.714","article-title":"Congenital auditory deprivation reduces synaptic activity within the auditory cortex in a layer-specific manner","volume":"10","author":"Kral","year":"2000","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.heares.2016.07.004_bib35","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1159\/000046845","article-title":"Delayed maturation and sensitive periods in the auditory cortex","volume":"6","author":"Kral","year":"2001","journal-title":"Audiol. Neurotol."},{"key":"10.1016\/j.heares.2016.07.004_bib36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0014-4886(92)90240-Q","article-title":"Anatomical evidence of synaptic plasticity in the cochlear nuclei of white-deaf cats","volume":"115","author":"Larsen","year":"1992","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib37","doi-asserted-by":"crossref","first-page":"e73308","DOI":"10.1371\/journal.pone.0073308","article-title":"Morphological characterization of bushy cells and their inputs in the laboratory mouse (Mus musculus) anteroventral cochlear nucleus","volume":"8","author":"Lauer","year":"2013","journal-title":"PloS ONE"},{"key":"10.1016\/j.heares.2016.07.004_bib38","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/cne.902810410","article-title":"Topographic organization of the central projections of the spiral ganglion in cats","volume":"281","author":"Leake","year":"1989","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/cne.20968","article-title":"Neonatal deafness results in degraded topographic specificity of auditory nerve projections to the cochlear nucleus in cats","volume":"497","author":"Leake","year":"2006","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1023\/B:NEUR.0000010082.99874.14","article-title":"Effects of congenital deafness in the cochlear nuclei of Shaker-2 mice: an ultrastructural analysis of synapse morphology in the endbulbs of Held","volume":"32","author":"Lee","year":"2003","journal-title":"J.\u00a0Neurocytol."},{"key":"10.1016\/j.heares.2016.07.004_bib41","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/aja.1001180205","article-title":"The fine structure of nerve endings in the nucleus of the trapezoid body and the ventral cochlear nucleus","volume":"118","author":"Lenn","year":"1966","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.heares.2016.07.004_bib42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0378-5955(95)00056-A","article-title":"Deafness induced cell size changes in rostral AVCN of the guinea pig","volume":"86","author":"Lesperance","year":"1995","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.07.004_bib43","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/geno.1999.5976","article-title":"Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2","volume":"61","author":"Liang","year":"1999","journal-title":"Genomics"},{"key":"10.1016\/j.heares.2016.07.004_bib44","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1469-7793.2000.t01-1-00447.x","article-title":"GABA mediates presynaptic inhibition at glycinergic synapses in a rat auditory brainstem nucleus","volume":"2","author":"Lim","year":"2000","journal-title":"J.\u00a0Physiol. 525 Pt"},{"key":"10.1016\/j.heares.2016.07.004_bib45","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s101620010032","article-title":"Development of primary axosomatic endings in the anteroventral cochlear nucleus of mice","volume":"1","author":"Limb","year":"2000","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2016.07.004_bib46","series-title":"The Primary Acoustic Nuclei","author":"Lorente de N\u00f3","year":"1981"},{"key":"10.1016\/j.heares.2016.07.004_bib47","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neulet.2009.07.075","article-title":"Enlargement of neuronal size in rat auditory cortex after prolonged sound exposure","volume":"463","author":"Lu","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.heares.2016.07.004_bib48","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.heares.2014.05.005","article-title":"Prolonged sound exposure has different effects on increasing neuronal size in the auditory cortex and brainstem","volume":"314","author":"Lu","year":"2014","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.07.004_bib49","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0006-8993(00)03054-7","article-title":"An immunogold investigation of the relationship between the amino acids GABA and glycine and their transporters in terminals in the guinea-pig anteroventral cochlear nucleus","volume":"887","author":"Mahendrasingam","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2016.07.004_bib50","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/j.1460-9568.2004.03193.x","article-title":"An immunogold investigation of the distribution of GABA and glycine in nerve terminals on the somata of spherical bushy cells in the anteroventral cochlear nucleus of guinea pig","volume":"19","author":"Mahendrasingam","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.heares.2016.07.004_bib51","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1523\/JNEUROSCI.11-09-02865.1991","article-title":"Outward currents in isolated ventral cochlear nucleus neurons","volume":"11","author":"Manis","year":"1991","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.07.004_bib52","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/cne.901970111","article-title":"Morphology of the cochlear nucleus of the normal and reeler mutant mouse","volume":"197","author":"Martin","year":"1981","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib53","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brainres.2015.02.012","article-title":"Auditory nerve synapses persist in ventral cochlear nucleus long after loss of acoustic input in mice with early-onset progressive hearing loss","volume":"1605","author":"McGuire","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2016.07.004_bib54","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00359-007-0222-1","article-title":"Seasonal changes in intrinsic electrophysiological activity of song control neurons in wild song sparrows","volume":"193","author":"Meitzen","year":"2007","journal-title":"J.\u00a0Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol."},{"key":"10.1016\/j.heares.2016.07.004_bib55","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/cne.903020412","article-title":"Auditory brainstem of the ferret: early cessation of developmental sensitivity of neurons in the cochlear nucleus to removal of the cochlea","volume":"302","author":"Moore","year":"1990","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib56","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0378-5955(83)90024-2","article-title":"Noise-induced degeneration in the brain and representation of inner and outer hair cells","volume":"9","author":"Morest","year":"1983","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.07.004_bib57","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/(SICI)1097-0029(19980501)41:3<205::AID-JEMT4>3.0.CO;2-S","article-title":"Long-term degeneration in the cochlear nerve and cochlear nucleus of the adult chinchilla following acoustic overstimulation","volume":"41","author":"Morest","year":"1998","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.heares.2016.07.004_bib58","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1002\/cne.23238","article-title":"3D model of frequency representation in the cochlear nucleus of the CBA\/J mouse","volume":"521","author":"Muniak","year":"2013","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib59","series-title":"The Primary Auditory Neurons of the Mammalian Cochlea","first-page":"157","article-title":"Central projections of spiral ganglion neurons","author":"Muniak","year":"2016"},{"key":"10.1016\/j.heares.2016.07.004_bib60","doi-asserted-by":"crossref","first-page":"11604","DOI":"10.1523\/JNEUROSCI.0719-14.2014","article-title":"Dynamic fidelity control to the central auditory system: synergistic glycine\/GABAergic inhibition in the cochlear nucleus","volume":"34","author":"Nerlich","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.07.004_bib61","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1113\/jphysiol.2001.012972","article-title":"Ultrastructural basis of synaptic transmission between endbulbs of Held and bushy cells in the rat cochlear nucleus","volume":"539","author":"Nicol","year":"2002","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.heares.2016.07.004_bib62","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1001\/jama.2010.451","article-title":"Spoken language development in children following cochlear implantation","volume":"303","author":"Niparko","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.heares.2016.07.004_bib63","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng1226","article-title":"Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss","volume":"35","author":"Noben-Trauth","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.heares.2016.07.004_bib64","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1002\/cne.22339","article-title":"Bilateral effects of unilateral cochlear implantation in congenitally deaf cats","volume":"518","author":"O'Neil","year":"2010","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib65","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000046825","article-title":"Role of biophysical specialization in cholinergic modulation in neurons of the ventral cochlear nuclei","volume":"6","author":"Oertel","year":"2001","journal-title":"Audiol. Neurotol."},{"key":"10.1016\/j.heares.2016.07.004_bib66","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1113\/jphysiol.2001.013821","article-title":"Synaptic transmission in the auditory brainstem of normal and congenitally deaf mice","volume":"540","author":"Oleskevich","year":"2002","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.heares.2016.07.004_bib67","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/cne.902830403","article-title":"Rapid changes in cochlear nucleus cell size following blockade of auditory nerve electrical activity in gerbils","volume":"283","author":"Pasic","year":"1989","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib68","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1126\/science.154.3749.667","article-title":"Anteroventral cochlear nucleus: wave forms of extracellularly recorded spike potentials","volume":"154","author":"Pfeiffer","year":"1966","journal-title":"Science"},{"key":"10.1016\/j.heares.2016.07.004_bib69","first-page":"249","article-title":"Transneuronal cell degeneration in the auditory relay nuclei of the cat","volume":"96","author":"Powell","year":"1962","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.heares.2016.07.004_bib70","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.280.5368.1444","article-title":"Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene","volume":"280","author":"Probst","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.heares.2016.07.004_bib71","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/cne.902100304","article-title":"Morphology of primary axosomatic endings in the anteroventral cochlear nucleus of the cat: a study of the endbulbs of Held","volume":"210","author":"Ryugo","year":"1982","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib72","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/cne.903050105","article-title":"Synaptic connections of the auditory nerve in cats: relationship between endbulbs of Held and spherical bushy cells","volume":"305","author":"Ryugo","year":"1991","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib73","first-page":"759","article-title":"Auditory system: giant synaptic terminals, endbulbs, and calyces","volume":"vol. 1","author":"Ryugo","year":"2009"},{"key":"10.1016\/j.heares.2016.07.004_bib74","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/(SICI)1096-9861(19960129)365:1<141::AID-CNE11>3.0.CO;2-T","article-title":"Activity-related features of synapse morphology: a study of endbulbs of held","volume":"365","author":"Ryugo","year":"1996","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib75","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/(SICI)1096-9861(19970825)385:2<230::AID-CNE4>3.0.CO;2-2","article-title":"Ultrastructural analysis of primary endings in deaf white cats: morphologic alterations in endbulbs of Held","volume":"385","author":"Ryugo","year":"1997","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib76","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/(SICI)1096-9861(19980810)397:4<532::AID-CNE6>3.0.CO;2-2","article-title":"Single unit recordings in the auditory nerve of congenitally deaf white cats: morphological correlates in the cochlea and cochlear nucleus","volume":"397","author":"Ryugo","year":"1998","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib77","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0006-8993(96)00719-6","article-title":"Morphological changes in the cochlear nucleus of congenitally deaf white cats","volume":"736","author":"Saada","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2016.07.004_bib78","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/cne.902800406","article-title":"Endbulbs of held and spherical bushy cells in cats: morphological correlates with physiological properties","volume":"280","author":"Sento","year":"1989","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib79","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000046843","article-title":"Deafness-induced changes in the auditory pathway: implications for cochlear implants","volume":"6","author":"Shepherd","year":"2001","journal-title":"Audiol. Neurotol."},{"key":"10.1016\/j.heares.2016.07.004_bib80","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1523\/JNEUROSCI.1541-10.2010","article-title":"The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA\/2J mice","volume":"30","author":"Shin","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.07.004_bib81","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/cne.21142","article-title":"Heterogeneity of glycinergic and gabaergic interneurons in the granule cell layer of mouse cerebellum","volume":"500","author":"Simat","year":"2007","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib82","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0378-5955(00)00132-5","article-title":"Acute spiral ganglion lesions change the tuning and tonotopic organization of cat inferior colliculus neurons","volume":"147","author":"Snyder","year":"2000","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.07.004_bib83","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.heares.2008.05.007","article-title":"Effects of age at onset of deafness and electrical stimulation on the developing cochlear nucleus in cats","volume":"243","author":"Stakhovskaya","year":"2008","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.07.004_bib84","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1001\/archotol.1983.00800150026005","article-title":"Hereditary inner-ear abnormalities in animals. Relationships with human abnormalities","volume":"109","author":"Steel","year":"1983","journal-title":"Arch. Otolaryngol."},{"key":"10.1016\/j.heares.2016.07.004_bib85","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1002\/cne.23038","article-title":"Synaptic plasticity in the medial superior olive of hearing, deaf, and cochlear-implanted cats","volume":"520","author":"Tirko","year":"2012","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib86","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature06233","article-title":"The origin of spontaneous activity in the developing auditory system","volume":"450","author":"Tritsch","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.heares.2016.07.004_bib87","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/nn.2604","article-title":"Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset","volume":"13","author":"Tritsch","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.heares.2016.07.004_bib88","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/cne.902090410","article-title":"Influence of neonatal cochlear removal on the development of mouse cochlear nucleus: I. Number, size, and density of its neurons","volume":"209","author":"Trune","year":"1982","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib89","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1152\/jn.00374.2005","article-title":"Synaptic transmission at the cochlear nucleus endbulb synapse during age-related hearing loss in mice","volume":"94","author":"Wang","year":"2005","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.heares.2016.07.004_bib90","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s10162-006-0052-9","article-title":"Temporal coding by cochlear nucleus bushy cells in DBA\/2J mice with early onset hearing loss","volume":"7","author":"Wang","year":"2006","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2016.07.004_bib91","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/cne.902760307","article-title":"Glycine receptor immunoreactivity in the ventral cochlear nucleus of the guinea pig","volume":"276","author":"Wenthold","year":"1988","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib92","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/cne.901510406","article-title":"Transneuronal cell atrophy in the congenitally deaf white cat","volume":"151","author":"West","year":"1973","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib93","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1152\/jn.1963.26.6.978","article-title":"Effects of visual deprivation on morphology and physiology of cells in the cats lateral geniculate body","volume":"26","author":"Wiesel","year":"1963","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.heares.2016.07.004_bib94","series-title":"The Auditory Psychobiology of the Mouse","article-title":"Anatomy of the central auditory system","author":"Willard","year":"1983"},{"key":"10.1016\/j.heares.2016.07.004_bib95","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1152\/jn.1986.56.2.391","article-title":"Effects of aging, hearing loss, and anatomical location on thresholds of inferior colliculus neurons in C57BL\/6 and CBA mice","volume":"56","author":"Willott","year":"1986","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.heares.2016.07.004_bib96","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0165-3806(95)00188-3","article-title":"Morphological changes in the anteroventral cochlear nucleus that accompany sensorineural hearing loss in DBA\/2J and C57BL\/6J mice","volume":"91","author":"Willott","year":"1996","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.heares.2016.07.004_bib97","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0378-5955(98)00029-X","article-title":"Genetics of age-related hearing loss in mice. IV. Cochlear pathology and hearing loss in 25 BXD recombinant inbred mouse strains","volume":"119","author":"Willott","year":"1998","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.07.004_bib98","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0378-5955(99)00094-5","article-title":"Prolonged exposure to an augmented acoustic environment ameliorates age-related auditory changes in C57BL\/6J and DBA\/2J mice","volume":"135","author":"Willott","year":"1999","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.07.004_bib99","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0378-5955(84)90005-4","article-title":"The acoustic startle response in DBA\/2 and C57BL\/6 mice: relationship to auditory neuronal response properties and hearing impairment","volume":"16","author":"Willott","year":"1984","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.07.004_bib100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0304-3940(82)90085-4","article-title":"Abnormal tonotopic organization in the ventral cochlear nucleus of the hearing-impaired DBA\/2 mouse","volume":"34","author":"Willott","year":"1982","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.heares.2016.07.004_bib101","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1152\/jn.00522.2014","article-title":"Synaptic transmission between end bulbs of Held and bushy cells in the cochlear nucleus of mice with a mutation in Otoferlin","volume":"112","author":"Wright","year":"2014","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.heares.2016.07.004_bib102","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/cne.21566","article-title":"Maturation of auditory brainstem projections and calyces in the congenitally deaf (dn\/dn) mouse","volume":"506","author":"Youssoufian","year":"2008","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib103","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/cne.20349","article-title":"Glycinergic neurons expressing enhanced green fluorescent protein in bacterial artificial chromosome transgenic mice","volume":"482","author":"Zeilhofer","year":"2005","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2016.07.004_bib104","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0378-5955(99)00003-9","article-title":"Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses","volume":"130","author":"Zheng","year":"1999","journal-title":"Hear Res."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595516301472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595516301472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T13:06:41Z","timestamp":1572700001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595516301472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":104,"alternative-id":["S0378595516301472"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2016.07.004","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of progressive hearing loss on the morphology of endbulbs of Held and bushy cells","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2016.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}