{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:19:10Z","timestamp":1792516750718,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:00:00Z","timestamp":1504828800000},"content-version":"vor","delay-in-days":99,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Decibel Therapeutics, and by NIH","award":["R01-DC009838"],"award-info":[{"award-number":["R01-DC009838"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.heares.2016.12.010","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T11:31:41Z","timestamp":1483788701000},"page":"164-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":146,"special_numbering":"C","title":["Translational issues in cochlear synaptopathy"],"prefix":"10.1016","volume":"349","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1033-9887","authenticated-orcid":false,"given":"Ann E.","family":"Hickox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Heinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Shinobu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon P.","family":"Whitton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2016.12.010_bib1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuroscience.2015.01.068","article-title":"Age-related changes in auditory nerve-inner hair cell connections, hair cell numbers, auditory brain stem response and gap detection in UM-HET4 mice","volume":"292","author":"Altschuler","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2016.12.010_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep30821","article-title":"Treatment with piribedil and memantine reduces noise-induced loss of inner hair cell synaptic ribbons","volume":"6","author":"Altschuler","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.heares.2016.12.010_bib3","doi-asserted-by":"crossref","first-page":"13110","DOI":"10.1523\/JNEUROSCI.1014-14.2014","article-title":"Postnatal expression of neurotrophic factors accessible to spiral ganglion neurons in the auditory system of adult hearing and deafened rats","volume":"34","author":"Bailey","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.12.010_bib4","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1523\/JNEUROSCI.3915-14.2015","article-title":"Individual differences reveal correlates of hidden hearing deficits","volume":"35","author":"Bharadwaj","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.12.010_bib5","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1159\/000374000","article-title":"Cochlear NMDA receptors as a therapeutic target of noise-induced tinnitus","volume":"35","author":"Bing","year":"2015","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.heares.2016.12.010_bib6","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/jn.00738.2013","article-title":"Contribution of auditory nerve fibres to compound action potential of the auditory nerve","volume":"112","author":"Bourien","year":"2014","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.heares.2016.12.010_bib7","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.neuron.2015.12.041","article-title":"Central gain restores auditory processing following near-complete cochlear denervation","volume":"89","author":"Chambers","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.heares.2016.12.010_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067618","article-title":"Mechanisms of hearing loss after blast injury to the ear","volume":"8","author":"Cho","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2016.12.010_bib9","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10162-013-0396-x","article-title":"Classifying human audiometric phenotypes of age-related hearing loss from animal models","volume":"14","author":"Dubno","year":"2013","journal-title":"JARO J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2016.12.010_bib10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00236671","article-title":"Relationship between the dynamic range of cochlear nerve fibres and their spontaneous activity","volume":"40","author":"Evans","year":"1980","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.heares.2016.12.010_bib11","doi-asserted-by":"crossref","first-page":"7509","DOI":"10.1523\/JNEUROSCI.5138-14.2015","article-title":"Aging after noise exposure: acceleration of cochlear synaptopathy in \u201crecovered\u201d ears","volume":"35","author":"Fernandez","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.12.010_bib12","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1152\/jn.00164.2013","article-title":"Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates","volume":"110","author":"Furman","year":"2013","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.heares.2016.12.010_bib13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.exger.2016.08.011","article-title":"Behavioral auditory thresholds and loss of ribbon synapses at inner hair cells in aged gerbils","volume":"84","author":"Gleich","year":"2016","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.heares.2016.12.010_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fneur.2016.00133","article-title":"Non-monotonic relation between noise exposure severity and neuronal hyperactivity in the auditory midbrain","volume":"7","author":"Hesse","year":"2016","journal-title":"Front. Neurol."},{"key":"10.1016\/j.heares.2016.12.010_bib15","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1152\/jn.00184.2013","article-title":"Is noise-induced cochlear neuropathy key to the generation of hyperacusis or tinnitus?","volume":"111","author":"Hickox","year":"2014","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.heares.2016.12.010_bib16","doi-asserted-by":"crossref","first-page":"7497","DOI":"10.1523\/JNEUROSCI.0782-16.2016","article-title":"Noise-induced loss of hair cells and cochlear synaptopathy are mediated by the activation of AMPK","volume":"36","author":"Hill","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.12.010_bib17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.heares.2016.05.006","article-title":"Sound coding in the auditory nerve of gerbils","volume":"338","author":"Huet","year":"2016","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.12.010_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0125160","article-title":"Immediate and delayed cochlear neuropathy after noise exposure in pubescent mice","volume":"10","author":"Jensen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2016.12.010_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/000348947208100203","article-title":"Sensory and neural degeneration with aging, as seen in microdissections of the human inner ear","volume":"81","author":"Johnsson","year":"1972","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2016.12.010_bib20","doi-asserted-by":"crossref","first-page":"17516","DOI":"10.1073\/pnas.1105867108","article-title":"Frequency selectivity in Old-World monkeys corroborates sharp cochlear tuning in humans","volume":"108","author":"Joris","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.heares.2016.12.010_bib21","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1152\/jn.1992.68.3.807","article-title":"Acoustic reflex frequency selectivity in single stapedius motoneurons of the cat","volume":"68","author":"Kobler","year":"1992","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.heares.2016.12.010_bib22","doi-asserted-by":"crossref","first-page":"14077","DOI":"10.1523\/JNEUROSCI.2845-09.2009","article-title":"Adding insult to injury: cochlear nerve degeneration after \u201ctemporary\u201d noise- induced hearing loss","volume":"29","author":"Kujawa","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.12.010_bib23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10162-004-5021-6","article-title":"Ouabain induces apoptotic cell death in type I spiral ganglion neurons, but not type II neurons","volume":"6","author":"Lang","year":"2005","journal-title":"JARO - J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2016.12.010_bib24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.heares.2015.11.011","article-title":"FGF22 protects hearing function from gentamycin ototoxicity by maintaining ribbon synapse number","volume":"332","author":"Li","year":"2016","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.12.010_bib25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10162-015-0510-3","article-title":"Dynamics of cochlear synaptopathy after acoustic overexposure","volume":"16","author":"Liberman","year":"2015","journal-title":"JARO - J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2016.12.010_bib26","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1121\/1.381736","article-title":"Auditory-nerve response from cats raised in a low-noise chamber","volume":"63","author":"Liberman","year":"1978","journal-title":"J.\u00a0Acoust. Soc. Am."},{"key":"10.1016\/j.heares.2016.12.010_bib27","doi-asserted-by":"crossref","first-page":"e0162726","DOI":"10.1371\/journal.pone.0162726","article-title":"Toward a differential diagnosis of hidden hearing loss in humans","volume":"11","author":"Liberman","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2016.12.010_bib28","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1523\/JNEUROSCI.4923-13.2014","article-title":"Efferent feedback slows cochlear aging","volume":"34","author":"Liberman","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.12.010_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0142341","article-title":"Chronic conductive hearing loss leads to cochlear degeneration","volume":"10","author":"Liberman","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2016.12.010_bib30","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s10162-011-0277-0","article-title":"Primary neural degeneration in the Guinea pig cochlea after reversible noise-induced threshold shift","volume":"12","author":"Lin","year":"2011","journal-title":"JARO J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2016.12.010_bib31","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1007\/s12035-014-8951-y","article-title":"Spontaneous and partial repair of ribbon synapse in cochlear inner hair cells after ototoxic withdrawal","volume":"52","author":"Liu","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.heares.2016.12.010_bib32","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s12035-013-8454-2","article-title":"Cochlear inner hair cell ribbon synapse is the primary target of ototoxic aminoglycoside stimuli","volume":"48","author":"Liu","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.heares.2016.12.010_bib33","first-page":"1","article-title":"Silent damage of noise on cochlear afferent innervation in Guinea pigs and the impact on temporal processing","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2016.12.010_bib34","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1523\/JNEUROSCI.5027-12.2013","article-title":"Efferent feedback minimizes cochlear neuropathy from moderate noise exposure","volume":"33","author":"Maison","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.12.010_bib35","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.heares.2016.02.006","article-title":"Perinatal thiamine deficiency causes cochlear innervation abnormalities in mice","volume":"335","author":"Maison","year":"2016","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.12.010_bib36","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10162-011-0283-2","article-title":"Age-related primary cochlear neuronal degeneration in human temporal bones","volume":"12","author":"Makary","year":"2011","journal-title":"JARO - J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2016.12.010_bib37","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1523\/JNEUROSCI.4460-15.2016","article-title":"Auditory brainstem response latency in noise as a marker of cochlear synaptopathy","volume":"36","author":"Mehraei","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2016.12.010_bib38","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.cub.2014.01.047","article-title":"TrkB-mediated protection against circadian sensitivity to noise trauma in the murine cochlea","volume":"24","author":"Meltser","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.heares.2016.12.010_bib39","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neurobiolaging.2016.05.001","article-title":"Loss of auditory sensitivity from inner hair cell synaptopathy can be centrally compensated in the young but not old brain","volume":"44","author":"M\u00f6hrle","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heares.2016.12.010_bib40","series-title":"Cochlear Hearing Loss: Physiological, Psychological and Technical Issues","author":"Moore","year":"2007"},{"key":"10.1016\/j.heares.2016.12.010_bib41","doi-asserted-by":"crossref","first-page":"31754","DOI":"10.1038\/srep31754","article-title":"Pathophysiology of the inner ear after blast injury caused by laser-induced shock wave","volume":"6","author":"Niwa","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.heares.2016.12.010_bib42","first-page":"201605737","article-title":"Hair cells use active zones with different voltage dependence of Ca 2+ influx to decompose sounds into complementary neural codes","author":"Ohn","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heares.2016.12.010_bib43","first-page":"1","article-title":"Noise exposure modulates cochlear inner hair cell ribbon volumes, correlating with changes in auditory measures in the FVB\/nJ mouse","author":"Paquette","year":"2016","journal-title":"Nat. Publ. Gr"},{"key":"10.1016\/j.heares.2016.12.010_bib44","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1121\/1.380834","article-title":"Effect of activating signal bandwidth on acoustic-reflex thresholds","volume":"59","author":"Popelka","year":"1976","journal-title":"J.\u00a0Acoust. Soc. Am1"},{"key":"10.1016\/j.heares.2016.12.010_bib45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0378-5955(91)90106-J","article-title":"Recovery from prior stimulation. I: relationship to spontaneous firing rates of primary auditory neurons","volume":"55","author":"Relkin","year":"1991","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.12.010_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0057247","article-title":"The reduced cochlear output and the failure to adapt the central auditory response causes tinnitus in noise exposed rats","volume":"8","author":"Ruttiger","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2016.12.010_bib47","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbr.2015.02.046","article-title":"Development of the acoustic startle response in rats and its change after early acoustic trauma","volume":"286","author":"Rybalko","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.heares.2016.12.010_bib48","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1152\/jn.1996.76.4.2799","article-title":"Age-related loss of activity of auditory-nerve fibers","volume":"76","author":"Schmiedt","year":"1996","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.heares.2016.12.010_bib49","first-page":"13686","article-title":"Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline","volume":"33","author":"Sergeyenko","year":"2013"},{"key":"10.1016\/j.heares.2016.12.010_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(01)00224-6","article-title":"Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals","volume":"155","author":"Sha","year":"2001","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.12.010_bib51","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s10162-015-0539-3","article-title":"Towards a diagnosis of cochlear neuropathy with envelope following responses","volume":"16","author":"Shaheen","year":"2015","journal-title":"JARO J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2016.12.010_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081566","article-title":"Ribbon synapse plasticity in the cochleae of Guinea pigs after noise-induced silent damage","volume":"8","author":"Shi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2016.12.010_bib53","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12035-012-8372-8","article-title":"Noise-induced inner hair cell ribbon loss disturbs central arc mobilization: a novel molecular paradigm for understanding tinnitus","volume":"47","author":"Singer","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.heares.2016.12.010_bib54","doi-asserted-by":"crossref","first-page":"25200","DOI":"10.1038\/srep25200","article-title":"Coding deficits in hidden hearing loss induced by noise: the nature and impacts","volume":"6","author":"Song","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.heares.2016.12.010_bib55","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1111\/j.1460-9568.2012.08151.x","article-title":"Auditory nerve fibre responses in the ferret","volume":"36","author":"Sumner","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.heares.2016.12.010_bib56","doi-asserted-by":"crossref","first-page":"24907","DOI":"10.1038\/srep24907","article-title":"Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure","volume":"6","author":"Suzuki","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.heares.2016.12.010_bib57","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1152\/jn.00574.2004","article-title":"Response properties of single auditory nerve fibers in the mouse","volume":"93","author":"Taberner","year":"2004","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.heares.2016.12.010_bib58","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0378-5955(88)90088-3","article-title":"The relative importance of head size, gender and age on the auditory brainstem response","volume":"32","author":"Trune","year":"1988","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.12.010_bib59","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/(SICI)1096-9861(19970505)381:2<188::AID-CNE6>3.0.CO;2-#","article-title":"Intracellular labeling of auditory nerve fibers in Guinea pig","volume":"202","author":"Tsuji","year":"1997","journal-title":"Cent. J. Comp. Neurol."},{"key":"10.1016\/j.heares.2016.12.010_bib60","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ijdevneu.2014.06.002","article-title":"Long-term recovery from hippocampal-related behavioral and biochemical abnormalities induced by noise exposure during brain development. Evaluation of auditory pathway integrity","volume":"37","author":"Uran","year":"2014","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.heares.2016.12.010_bib61","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.heares.2015.11.005","article-title":"The middle ear muscle reflex in the diagnosis of cochlear neuropathy","volume":"332","author":"Valero","year":"2016","journal-title":"Hear Res."},{"key":"10.1016\/j.heares.2016.12.010_bib62","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/978-3-319-25474-6_49","article-title":"On the interplay between cochlear gain loss and temporal envelope coding deficits","author":"Verhulst","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.heares.2016.12.010_bib63","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10162-012-0329-0","article-title":"Effects of repeated \u201cbenign\u201d noise exposures in young cba mice: shedding light on age-related hearing loss","volume":"13","author":"Wang","year":"2012","journal-title":"JARO J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2016.12.010_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu8080456","article-title":"Low iron diet increases susceptibility to noise-induced hearing loss in young rats","volume":"8","author":"Yu","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.heares.2016.12.010_bib65","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neulet.2015.04.049","article-title":"Insulin resistance due to dietary iron overload disrupts inner hair cell ribbon synapse plasticity in male mice","volume":"597","author":"Yu","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.heares.2016.12.010_bib66","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10162-013-0419-7","article-title":"Ouabain-induced cochlear nerve degeneration: synaptic loss and plasticity in a mouse model of auditory neuropathy","volume":"15","author":"Yuan","year":"2014","journal-title":"JARO J. Assoc. Res. Otolaryngol."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595516304440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595516304440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T13:31:42Z","timestamp":1756819902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595516304440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":66,"alternative-id":["S0378595516304440"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2016.12.010","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727192264.793532887","asserted-by":"object"}]},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Translational issues in cochlear synaptopathy","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2016.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}