{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T03:27:51Z","timestamp":1772249271075,"version":"3.50.1"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100010611","name":"University of Toledo Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010611","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.heares.2017.05.002","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T14:17:32Z","timestamp":1493907452000},"page":"173-188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Amino acid and acetylcholine chemistry in the central auditory system of young, middle-aged and old rats"],"prefix":"10.1016","volume":"350","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8349-4146","authenticated-orcid":false,"given":"Donald A.","family":"Godfrey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"O'Toole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdurrahman I.A.A.","family":"Mustapha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.heares.2017.05.002_bib1","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/0306-4522(79)90067-8","article-title":"Distribution of putative amino acid transmitters, choline acetyltransferase and glutamate decarboxylase in the inferior colliculus","volume":"4","author":"Adams","year":"1979","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.heares.2017.05.002_bib2","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1007\/s11064-005-8986-6","article-title":"Taurine interaction with neurotransmitter receptors in the CNS: an update","volume":"30","author":"Albrecht","year":"2005","journal-title":"Neurochem. Res."},{"issue":"6","key":"10.1016\/j.heares.2017.05.002_bib3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1017\/S002221510009277X","article-title":"Presbyacusis-loss of neurons in the human cochlear nuclei","volume":"96","author":"Arnesen","year":"1982","journal-title":"J.\u00a0Laryngol. Otol."},{"issue":"6","key":"10.1016\/j.heares.2017.05.002_bib4","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1001\/archneur.60.6.835","article-title":"A\u00a0longitudinal study of gait and balance dysfunction in normal older people","volume":"60","author":"Baloh","year":"2003","journal-title":"Arch. Neurol."},{"issue":"6","key":"10.1016\/j.heares.2017.05.002_bib5","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/BF00964918","article-title":"Changes with aging in the levels of amino acids in rat CNS structural elements. I. Glutamate and related amino acids","volume":"14","author":"Banay-Schwartz","year":"1989","journal-title":"Neurochem. Res."},{"issue":"6","key":"10.1016\/j.heares.2017.05.002_bib6","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/BF00964919","article-title":"Changes with aging in the levels of amino acids in rat CNS structural elements. II. Taurine and small neutral amino acids","volume":"14","author":"Banay-Schwartz","year":"1989","journal-title":"Neurochem. Res."},{"issue":"2","key":"10.1016\/j.heares.2017.05.002_bib7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/jnr.490260210","article-title":"Changes with aging in the levels of amino acids in rat CNS structural elements: III. Large neutral amino acids","volume":"26","author":"Banay-Schwartz","year":"1990","journal-title":"J.\u00a0Neurosci. Res."},{"issue":"2","key":"10.1016\/j.heares.2017.05.002_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jnr.490260211","article-title":"Changes with aging in the levels of amino acids in rat CNS structural elements: IV. Methionine and basic amino acids","volume":"26","author":"Banay-Schwartz","year":"1990","journal-title":"J.\u00a0Neurosci. Res."},{"issue":"2","key":"10.1016\/j.heares.2017.05.002_bib9","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0006-8993(92)91149-9","article-title":"Regional distribution of glutamate and aspartate in adult and old human brain","volume":"594","author":"Banay-Schwartz","year":"1992","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.heares.2017.05.002_bib10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00805990","article-title":"Levels of amino acids in 52 discrete areas of postmortem brain of adult and aged humans","volume":"5","author":"Banay-Schwartz","year":"1993","journal-title":"Amino acids"},{"issue":"11","key":"10.1016\/j.heares.2017.05.002_bib11","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1002\/jnr.21699","article-title":"Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma","volume":"86","author":"Bauer","year":"2008","journal-title":"J.\u00a0Neurosci. Res."},{"issue":"1\u20132","key":"10.1016\/j.heares.2017.05.002_bib12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-5955(90)90200-9","article-title":"Morphological correlates of aging in the chinchilla cochlea","volume":"48","author":"Bohne","year":"1990","journal-title":"Hear. Res."},{"issue":"3","key":"10.1016\/j.heares.2017.05.002_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/cne.901550302","article-title":"The neuronal architecture of the cochlear nucleus of the cat","volume":"155","author":"Brawer","year":"1974","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2017.05.002_bib14","first-page":"217","article-title":"Volumes of superior olivary nuclei of CBA mice during aging","volume":"27","author":"Brescia","year":"2004","journal-title":"Abstr. Assoc. Res. Otolaryngol."},{"issue":"3","key":"10.1016\/j.heares.2017.05.002_bib15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.exger.2008.09.012","article-title":"Age-related changes in GAD levels in the central auditory system of the rat","volume":"44","author":"Burianova","year":"2009","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.heares.2017.05.002_bib16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fnagi.2015.00027","article-title":"The influence of aging on the number of neurons and levels of non-phosphorylated neurofilament proteins in the central auditory system of rats","volume":"7","author":"Burianov\u00e1","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.heares.2017.05.002_bib17","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1523\/JNEUROSCI.15-03-02312.1995","article-title":"Involvement of subcortical and cortical afferents to the lateral nucleus of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli","volume":"15","author":"Campeau","year":"1995","journal-title":"J.\u00a0Neurosci."},{"issue":"4","key":"10.1016\/j.heares.2017.05.002_bib18","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0197-4580(90)90004-J","article-title":"The effects of aging on neuron number in the rat superior olivary complex","volume":"11","author":"Casey","year":"1990","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.heares.2017.05.002_bib19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0306-4522(88)90322-3","article-title":"Age-related loss of synaptic terminals in the rat medial nucleus of the trapezoid body","volume":"24","author":"Casey","year":"1988","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/j.heares.2017.05.002_bib20","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1523\/JNEUROSCI.10-07-02363.1990","article-title":"Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis","volume":"10","author":"Caspary","year":"1990","journal-title":"J.\u00a0Neurosci."},{"issue":"3\u20134","key":"10.1016\/j.heares.2017.05.002_bib21","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0531-5565(94)00052-5","article-title":"Central auditory aging: GABA changes in the inferior colliculus","volume":"30","author":"Caspary","year":"1995","journal-title":"Exp. Gerontol."},{"issue":"Pt 11","key":"10.1016\/j.heares.2017.05.002_bib22","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1242\/jeb.013581","article-title":"Inhibitory neurotransmission, plasticity and aging in the mammalian central auditory system","volume":"211","author":"Caspary","year":"2008","journal-title":"J.\u00a0Exp. Biol."},{"key":"10.1016\/j.heares.2017.05.002_bib23","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.neurobiolaging.2012.11.009","article-title":"Age-related GABAA receptor changes in rat auditory cortex","volume":"34","author":"Caspary","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heares.2017.05.002_bib24","first-page":"187","article-title":"Choline acetyltransferase activity in young and aged CBA mouse brainstem auditory structures","volume":"25","author":"Chen","year":"2002","journal-title":"Abstr. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2017.05.002_bib25","first-page":"188","article-title":"Age related changes in ChAT and VAChT immunoreactivity of CBA mouse lateral superior olive and cochlear nucleus","volume":"25","author":"Chen","year":"2002","journal-title":"Abstr. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2017.05.002_bib26","series-title":"Basic Neurochemistry","first-page":"389","article-title":"GABA and glycine","author":"DeLorey","year":"1994"},{"key":"10.1016\/j.heares.2017.05.002_bib27","series-title":"Basic Neurochemistry","first-page":"367","article-title":"Excitatory amino acid transmitters","author":"Dingledine","year":"1994"},{"issue":"5","key":"10.1016\/j.heares.2017.05.002_bib28","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1111\/j.1471-4159.1976.tb00321.x","article-title":"GABA and its related enzymes in the lower auditory system of the Guinea pig","volume":"27","author":"Fisher","year":"1976","journal-title":"J.\u00a0Neurochem."},{"issue":"3","key":"10.1016\/j.heares.2017.05.002_bib29","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1042\/bj1150465","article-title":"Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities","volume":"115","author":"Fonnum","year":"1969","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.heares.2017.05.002_bib30","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00441-015-2230-8","article-title":"Age-related changes in sound localisation ability","volume":"361","author":"Freigang","year":"2015","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.heares.2017.05.002_bib31","series-title":"Functional Neurobiology of Aging","first-page":"531","article-title":"Anatomical and neurochemical bases of presbycusis","author":"Frisina","year":"2001"},{"issue":"1","key":"10.1016\/j.heares.2017.05.002_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5955(88)90047-0","article-title":"Layer V in rat auditory cortex: projections to the inferior colliculus and contralateral cortex","volume":"34","author":"Games","year":"1988","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.05.002_bib33","first-page":"30","article-title":"Amino acid concentrations in the central auditory system of young and old rats","volume":"32","author":"Godfrey","year":"2009","journal-title":"Abstr. Assoc. Res. Otolaryngol."},{"issue":"6","key":"10.1016\/j.heares.2017.05.002_bib34","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1177\/24.6.781128","article-title":"Approach to three-dimensional mapping of quantitative histochemical measurements applied to studies of the cochlear nucleus","volume":"24","author":"Godfrey","year":"1976","journal-title":"J.\u00a0Histochem. Cytochem."},{"issue":"2","key":"10.1016\/j.heares.2017.05.002_bib35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0378-5955(83)90076-X","article-title":"Effects of large brain stem lesions on the cholinergic system in the rat cochlear nucleus","volume":"11","author":"Godfrey","year":"1983","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.05.002_bib36","series-title":"Auditory Biochemistry","first-page":"163","article-title":"Cholinergic neurotransmission in the cochlear nucleus","author":"Godfrey","year":"1985"},{"issue":"3","key":"10.1016\/j.heares.2017.05.002_bib37","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0378-5955(87)90188-2","article-title":"Quantitative inter-strain comparison of the distribution of choline acetyltransferase activity in the rat cochlear nucleus","volume":"31","author":"Godfrey","year":"1987","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.05.002_bib38","series-title":"Auditory Pathway: Structure and Function","first-page":"107","article-title":"Neurotransmitter microchemistry of the cochlear nucleus and superior olivary complex","author":"Godfrey","year":"1988"},{"key":"10.1016\/j.heares.2017.05.002_bib39","series-title":"Acoustical Signal Processing in the Central Auditory System","first-page":"139","article-title":"Chemistry of granular and closely related regions of the cochlear nucleus","author":"Godfrey","year":"1997"},{"issue":"1\u20132","key":"10.1016\/j.heares.2017.05.002_bib40","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0378-5955(00)00199-4","article-title":"Amino acid concentrations in rat cochlear nucleus and superior olive","volume":"150","author":"Godfrey","year":"2000","journal-title":"Hear. Res."},{"issue":"4","key":"10.1016\/j.heares.2017.05.002_bib41","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/jnr.20179","article-title":"Effects of unilateral vestibular ganglionectomy on glutaminase activity in the vestibular nerve root and vestibular nuclear complex of the rat","volume":"77","author":"Godfrey","year":"2004","journal-title":"J.\u00a0Neurosci. Res."},{"issue":"1\u20132","key":"10.1016\/j.heares.2017.05.002_bib42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.heares.2005.03.004","article-title":"Amino acid concentrations in chinchilla cochlear nucleus at different times after carboplatin treatment","volume":"206","author":"Godfrey","year":"2005","journal-title":"Hear. Res."},{"issue":"1","key":"10.1016\/j.heares.2017.05.002_bib43","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.neuroscience.2007.12.031","article-title":"Effects of cochlear ablation on amino acid concentrations in the chinchilla posteroventral cochlear nucleus, as compared to rat","volume":"154","author":"Godfrey","year":"2008","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.heares.2017.05.002_bib44","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1002\/jnr.23095","article-title":"Amino acid concentrations in the hamster central auditory system and long-term effects of intense tone exposure","volume":"90","author":"Godfrey","year":"2012","journal-title":"J.\u00a0Neurosci. Res."},{"issue":"7","key":"10.1016\/j.heares.2017.05.002_bib45","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/jnr.23227","article-title":"Choline acetyltransferase activity in the hamster central auditory system and long-term effects of intense tone exposure","volume":"91","author":"Godfrey","year":"2013","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.heares.2017.05.002_bib46","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.heares.2013.11.005","article-title":"Effects of cochlear ablation on amino acid levels in the rat cochlear nucleus and superior olive","volume":"309","author":"Godfrey","year":"2014","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.05.002_bib47","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neuroscience.2015.03.055","article-title":"Cochlear ablation effects on amino acid levels in the chinchilla cochlear nucleus","volume":"297","author":"Godfrey","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2017.05.002_bib48","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fnins.2014.00110","article-title":"Insult-induced adaptive plasticity of the auditory system","volume":"8","author":"Gold","year":"2014","journal-title":"Front. Neurosci."},{"issue":"7","key":"10.1016\/j.heares.2017.05.002_bib49","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1002\/cne.23479","article-title":"Age-related neurochemical changes in the rhesus macaque cochlear nucleus","volume":"522","author":"Gray","year":"2014","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2017.05.002_bib50","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.1523\/JNEUROSCI.14-12-07469.1994","article-title":"Age-related decrease of GABAA receptor subunits and glutamic acid decarboxylase in the rat inferior colliculus","volume":"14","author":"Guti\u00e9rrez","year":"1994","journal-title":"J.\u00a0Neurosci."},{"issue":"1","key":"10.1016\/j.heares.2017.05.002_bib51","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/cne.901240103","article-title":"The anterior ventral cochlear nucleus","volume":"124","author":"Harrison","year":"1965","journal-title":"J.\u00a0Comp. Neurol."},{"issue":"3","key":"10.1016\/j.heares.2017.05.002_bib52","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/cne.901260303","article-title":"The organization of the posterior ventral cochlear nucleus in the rat","volume":"126","author":"Harrison","year":"1966","journal-title":"J.\u00a0Comp. Neurol."},{"issue":"4","key":"10.1016\/j.heares.2017.05.002_bib53","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/BF00973096","article-title":"Metabolic differences between primary cultures of astrocytes and neurons from cerebellum and cerebral cortex. Effects of fluorocitrate","volume":"20","author":"Hassel","year":"1995","journal-title":"Neurochem. Res."},{"issue":"3","key":"10.1016\/j.heares.2017.05.002_bib54","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/(SICI)1096-9861(19990412)406:3<285::AID-CNE1>3.0.CO;2-P","article-title":"Age-related synaptic changes in the central nucleus of the inferior colliculus of Fischer-344 rats","volume":"406","author":"Helfert","year":"1999","journal-title":"J.\u00a0Comp. Neurol."},{"issue":"5","key":"10.1016\/j.heares.2017.05.002_bib55","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1044\/1092-4388(2005\/084)","article-title":"General review of tinnitus: prevalence, mechanisms, effects, and management","volume":"48","author":"Henry","year":"2005","journal-title":"J.\u00a0Speech, Lang. Hear. Res. JSLHR"},{"issue":"8","key":"10.1016\/j.heares.2017.05.002_bib56","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1021\/ac50044a055","article-title":"High performance liquid chromatographic determination of amino acids in the picomole range","volume":"51","author":"Hill","year":"1979","journal-title":"Anal. Chem."},{"issue":"1\u20132","key":"10.1016\/j.heares.2017.05.002_bib57","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.heares.2009.09.005","article-title":"Processing of broadband stimuli across A1 layers in young and aged rats","volume":"264","author":"Hughes","year":"2010","journal-title":"Hear. Res."},{"issue":"8","key":"10.1016\/j.heares.2017.05.002_bib58","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.neurobiolaging.2003.11.004","article-title":"Age-related increases in calcium-binding protein immunoreactivity in the cochlear nucleus of hearing impaired C57BL\/6J mice","volume":"25","author":"Idrizbegovic","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heares.2017.05.002_bib59","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.heares.2006.01.009","article-title":"Presbyacusis and calcium-binding protein immunoreactivity in the cochlear nucleus of BALB\/c mice","volume":"216\u2013217","author":"Idrizbegovic","year":"2006","journal-title":"Hear. Res."},{"issue":"1\u20132","key":"10.1016\/j.heares.2017.05.002_bib60","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0378-5955(97)00026-9","article-title":"Age-related changes in GFAP-immunoreactive astrocytes in the rat ventral cochlear nucleus","volume":"107","author":"Jalenques","year":"1997","journal-title":"Hear. Res."},{"issue":"1","key":"10.1016\/j.heares.2017.05.002_bib61","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/jnr.20536","article-title":"Effects of cochlear ablation on choline acetyltransferase activity in the rat cochlear nucleus and superior olive","volume":"81","author":"Jin","year":"2005","journal-title":"J.\u00a0Neurosci. Res."},{"issue":"1\u20133","key":"10.1016\/j.heares.2017.05.002_bib62","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0378-5955(90)90103-V","article-title":"Spiral ganglion cell endings in the cochlear nucleus of young and old rats","volume":"49","author":"Keithley","year":"1990","journal-title":"Hear. Res."},{"issue":"3","key":"10.1016\/j.heares.2017.05.002_bib63","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0378-5955(82)90017-X","article-title":"Hair cell counts in an age-graded series of rat cochleas","volume":"8","author":"Keithley","year":"1982","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.05.002_bib64","series-title":"Glutamine, Glutamate, and GABA in the Central Nervous System","first-page":"51","article-title":"Glutaminase (PAG)","author":"Kvamme","year":"1983"},{"issue":"4","key":"10.1016\/j.heares.2017.05.002_bib65","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1523\/JNEUROSCI.10-04-01062.1990","article-title":"The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning","volume":"10","author":"LeDoux","year":"1990","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2017.05.002_bib66","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3389\/fneur.2014.00227","article-title":"Cochlear damage affects neurotransmitter chemistry in the central auditory system","volume":"5","author":"Lee","year":"2014","journal-title":"Front. Neurol."},{"key":"10.1016\/j.heares.2017.05.002_bib67","series-title":"Biochemistry","author":"Lehninger","year":"1975"},{"issue":"4","key":"10.1016\/j.heares.2017.05.002_bib68","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.neuroscience.2004.12.043","article-title":"Age-related loss of the GABA synthetic enzyme glutamic acid decarboxylase in rat primary auditory cortex","volume":"132","author":"Ling","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2017.05.002_bib69","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.heares.2010.06.019","article-title":"A\u00a0multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus","volume":"269","author":"Liu","year":"2010","journal-title":"Hear. Res."},{"issue":"1","key":"10.1016\/j.heares.2017.05.002_bib70","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.neuroscience.2008.01.019","article-title":"The cytoarchitecture of the inferior colliculus revisited: a common organization of the lateral cortex in rat and cat","volume":"154","author":"Loftus","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2017.05.002_bib71","series-title":"A\u00a0Flexible System of Enzymatic Analysis","author":"Lowry","year":"1972"},{"key":"10.1016\/j.heares.2017.05.002_bib72","series-title":"Acoustical Signal Processing in the Central Auditory System","first-page":"1","article-title":"Role of the mammalian forebrain in hearing","author":"Masterton","year":"1997"},{"key":"10.1016\/j.heares.2017.05.002_bib73","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0197-4580(94)90051-5","article-title":"Age-related decrease in GABAB receptor binding in the Fischer 344 rat inferior colliculus","volume":"15","author":"Milbrandt","year":"1994","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heares.2017.05.002_bib74","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0306-4522(95)00082-T","article-title":"Age-related reduction of [3H]strychnine binding sites in the cochlear nucleus of the Fischer 344 rat","volume":"67","author":"Milbrandt","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2017.05.002_bib75","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0378-5955(98)00177-4","article-title":"Age-related changes in [3H]strychnine binding in the vestibular nuclei of rats","volume":"127","author":"Nakayama","year":"1999","journal-title":"Hear. Res."},{"issue":"2","key":"10.1016\/j.heares.2017.05.002_bib76","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0306-4522(99)00143-8","article-title":"Direct innervation of identified tectothalamic neurons in the inferior colliculus by axons from the cochlear nucleus","volume":"93","author":"Oliver","year":"1999","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.heares.2017.05.002_bib77","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/cne.901360407","article-title":"Cytoarchitecture of the cochlear nuclei in the cat","volume":"136","author":"Osen","year":"1969","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2017.05.002_bib78","series-title":"Auditory Pathway: Structure and Function","first-page":"65","article-title":"Anatomy of the mammalian cochlear nuclei; a review","author":"Osen","year":"1988"},{"key":"10.1016\/j.heares.2017.05.002_bib79","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.brainres.2012.03.018","article-title":"Downregulation of N-methyl-D-aspartate receptor \u03b61 subunit (GluN1) gene in inferior colliculus with aging","volume":"1454","author":"Osumi","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2017.05.002_bib80","first-page":"30","article-title":"Age related volume changes in superior olivary complex nuclei of F344BN rats","volume":"32","author":"O'Toole","year":"2009","journal-title":"Abstr. Assoc. Res. Otolaryngol."},{"issue":"3","key":"10.1016\/j.heares.2017.05.002_bib81","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0306-4522(92)90141-N","article-title":"Metabolic compartmentation of glutamate and glutamine: morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum","volume":"46","author":"Ottersen","year":"1992","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/j.heares.2017.05.002_bib82","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.exger.2012.04.003","article-title":"Age-related changes in calbindin and calretinin immunoreactivity in the central auditory system of the rat","volume":"47","author":"Ouda","year":"2012","journal-title":"Exp. Gerontol."},{"issue":"1","key":"10.1016\/j.heares.2017.05.002_bib83","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00441-014-2107-2","article-title":"Age-related changes in the central auditory system","volume":"361","author":"Ouda","year":"2015","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.heares.2017.05.002_bib84","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fnana.2014.00040","article-title":"Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortex","volume":"8","author":"Ouellet","year":"2014","journal-title":"Front. Neuroanat."},{"issue":"6","key":"10.1016\/j.heares.2017.05.002_bib85","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/j.1471-4159.1985.tb07173.x","article-title":"Concentration of free amino acids in primary cultures of neurones and astrocytes","volume":"44","author":"Patel","year":"1985","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.heares.2017.05.002_bib86","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"issue":"8","key":"10.1016\/j.heares.2017.05.002_bib87","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.exger.2013.04.012","article-title":"Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy","volume":"48","author":"Profant","year":"2013","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.heares.2017.05.002_bib88","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fnagi.2015.00004","article-title":"Restricted loss of olivocochlear but not vestibular efferent neurons in the senescent gerbil (Meriones unguiculatus)","volume":"7","author":"Radtke-Schuller","year":"2015","journal-title":"Front. Aging Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.heares.2017.05.002_bib89","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0378-5955(94)90270-4","article-title":"Age-related changes in brainstem auditory neurotransmitters: measures of GABA and acetylcholine function","volume":"77","author":"Raza","year":"1994","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.05.002_bib90","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1523\/JNEUROSCI.3277-12.2013","article-title":"Reduced GABAAR-mediated tonic inhibition in aged rat auditory thalamus","volume":"33","author":"Richardson","year":"2013","journal-title":"J.\u00a0Neurosci."},{"issue":"12","key":"10.1016\/j.heares.2017.05.002_bib91","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1007\/BF00970598","article-title":"Amino acid concentrations and selected enzyme activities in rat auditory, olfactory, and visual systems","volume":"20","author":"Ross","year":"1995","journal-title":"Neurochem. Res."},{"issue":"12","key":"10.1016\/j.heares.2017.05.002_bib92","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/jemt.20512","article-title":"Age-related changes of NADPH-diaphorase-positive neurons in the rat inferior colliculus and auditory cortex","volume":"70","author":"S\u00e1nchez-Zuriaga","year":"2007","journal-title":"Microsc. Res. Tech."},{"issue":"34","key":"10.1016\/j.heares.2017.05.002_bib93","doi-asserted-by":"crossref","first-page":"13686","DOI":"10.1523\/JNEUROSCI.1783-13.2013","article-title":"Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline","volume":"33","author":"Sergeyenko","year":"2013","journal-title":"J.\u00a0Neurosci."},{"issue":"8","key":"10.1016\/j.heares.2017.05.002_bib94","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0024-3205(81)90044-8","article-title":"Present status and significance of the glutamine cycle in neural tissues","volume":"28","author":"Shank","year":"1981","journal-title":"Life Sci."},{"key":"10.1016\/j.heares.2017.05.002_bib95","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fneur.2016.00020","article-title":"Age-related neurochemical changes in the vestibular nuclei","volume":"7","author":"Smith","year":"2016","journal-title":"Front. Neurol."},{"key":"10.1016\/j.heares.2017.05.002_bib96","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1113\/JP271221","article-title":"Ageing-related changes in GABAergic inhibition in mouse auditory cortex, measured using in\u00a0vitro flavoprotein autofluorescence imaging","volume":"594","author":"Stebbings","year":"2016","journal-title":"J.\u00a0Physiol."},{"issue":"3","key":"10.1016\/j.heares.2017.05.002_bib97","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/jnr.21136","article-title":"Changes of amino acid concentrations in the rat vestibular nuclei after inferior cerebellar peduncle transection","volume":"85","author":"Sun","year":"2007","journal-title":"J.\u00a0Neurosci. Res."},{"issue":"3","key":"10.1016\/j.heares.2017.05.002_bib98","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1152\/physrev.00002.2002","article-title":"Plastic changes in the central auditory system after hearing loss, restoration of function, and during learning","volume":"82","author":"Syka","year":"2002","journal-title":"Physiol. Rev."},{"issue":"1\u20132","key":"10.1016\/j.heares.2017.05.002_bib99","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.heares.2009.11.003","article-title":"The Fischer 344 rat as a model of presbycusis","volume":"264","author":"Syka","year":"2010","journal-title":"Hear. Res."},{"issue":"2","key":"10.1016\/j.heares.2017.05.002_bib100","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0006-8993(74)90017-1","article-title":"Gamma-aminobutyric acid in the lower auditory pathway of the Guinea pig","volume":"69","author":"Tachibana","year":"1974","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.heares.2017.05.002_bib101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2006.09.081","article-title":"Glutamate-related gene expression changes with age in the mouse auditory midbrain","volume":"1127","author":"Tadros","year":"2007","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.heares.2017.05.002_bib102","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/glia.22287","article-title":"Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices","volume":"60","author":"Tremblay","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.heares.2017.05.002_bib103","series-title":"Handbook of Auditory Research","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/978-1-4612-4416-5_7","article-title":"Organization of olivocochlear efferent systems in mammals","author":"Warr","year":"1992"},{"issue":"3","key":"10.1016\/j.heares.2017.05.002_bib104","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/0006-8993(78)90365-7","article-title":"Glutamic acid and aspartic acid in subdivisions of the cochlear nucleus after auditory nerve lesion","volume":"143","author":"Wenthold","year":"1978","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.heares.2017.05.002_bib105","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/cne.902190206","article-title":"The dual origins of the olivocochlear bundle in the albino rat","volume":"219","author":"White","year":"1983","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2017.05.002_bib106","series-title":"Pathobiology of the Aging Mouse","first-page":"179","article-title":"Aging and the auditory system","author":"Willott","year":"1996"},{"issue":"2","key":"10.1016\/j.heares.2017.05.002_bib107","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0165-3806(95)00188-3","article-title":"Morphological changes in the anteroventral cochlear nucleus that accompany sensorineural hearing loss in DBA\/2J and C57BL\/6J mice","volume":"91","author":"Willott","year":"1996","journal-title":"Dev. Brain Res."},{"issue":"3","key":"10.1016\/j.heares.2017.05.002_bib108","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/cne.902600312","article-title":"Morphometric study of the anteroventral cochlear nucleus of two mouse models of presbycusis","volume":"260","author":"Willott","year":"1987","journal-title":"J.\u00a0Comp. Neurol."},{"issue":"4","key":"10.1016\/j.heares.2017.05.002_bib109","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/cne.903210412","article-title":"Morphology of the dorsal cochlear nucleus in C57BL\/6J and CBA\/J mice across the life span","volume":"321","author":"Willott","year":"1992","journal-title":"J.\u00a0Comp. Neurol."},{"issue":"2","key":"10.1016\/j.heares.2017.05.002_bib110","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0197-4580(94)90109-0","article-title":"Morphology of the inferior colliculus in C57BL\/6J and CBA\/J mice across the life span","volume":"15","author":"Willott","year":"1994","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.heares.2017.05.002_bib111","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/(SICI)1096-9861(19970901)385:3<405::AID-CNE5>3.0.CO;2-7","article-title":"Glycine immunoreactivity and receptor binding in the cochlear nucleus of C57BL\/6J and CBA\/CaJ mice: effects of cochlear impairment and aging","volume":"385","author":"Willott","year":"1997","journal-title":"J.\u00a0Comp. Neurol."},{"issue":"1\u20132","key":"10.1016\/j.heares.2017.05.002_bib112","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0378-5955(98)00216-0","article-title":"Neural architecture of the rat medial geniculate body","volume":"130","author":"Winer","year":"1999","journal-title":"Hear. Res."},{"issue":"1\u20132","key":"10.1016\/j.heares.2017.05.002_bib113","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.heares.2007.01.017","article-title":"The distributed auditory cortex","volume":"229","author":"Winer","year":"2007","journal-title":"Hear. Res."},{"issue":"3","key":"10.1016\/j.heares.2017.05.002_bib114","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/(SICI)1097-0029(19980501)41:3<270::AID-JEMT10>3.0.CO;2-L","article-title":"Immunohistochemical evaluation of cholinergic neurons in the rat superior olivary complex","volume":"41","author":"Yao","year":"1998","journal-title":"Microsc. Res. Tech."},{"issue":"2","key":"10.1016\/j.heares.2017.05.002_bib115","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s10162-007-0075-x","article-title":"Age-related decline in Kv3.1b expression in the mouse auditory brainstem correlates with functional deficits in the medial olivocochlear efferent system","volume":"8","author":"Zettel","year":"2007","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2017.05.002_bib116","series-title":"The Cortex of the Rat","author":"Zilles","year":"1985"}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595517301181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595517301181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T12:37:08Z","timestamp":1565354228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595517301181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":116,"alternative-id":["S0378595517301181"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2017.05.002","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amino acid and acetylcholine chemistry in the central auditory system of young, middle-aged and old rats","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2017.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}