{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:39:01Z","timestamp":1784680741266,"version":"3.55.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.heares.2017.12.004","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T03:17:35Z","timestamp":1513221455000},"page":"10-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea"],"prefix":"10.1016","volume":"358","author":[{"given":"Fernando","family":"Garc\u00eda-Alc\u00e1ntara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Murillo-Cuesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Pulido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6034-9285","authenticated-orcid":false,"given":"Jose M.","family":"Berm\u00fadez-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Mart\u00ednez-Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6996-6431","authenticated-orcid":false,"given":"Marta","family":"Milo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3077-0500","authenticated-orcid":false,"given":"Isabel","family":"Varela-Nieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1708-3485","authenticated-orcid":false,"given":"Teresa","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2017.12.004_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.132","article-title":"Early otic development depends on autophagy for apoptotic cell clearance and neural differentiation","volume":"3","author":"Aburto","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.heares.2017.12.004_bib2","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1158\/0008-5472.CAN-04-0496","article-title":"Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets","volume":"64","author":"Andersen","year":"2004","journal-title":"Canc. Res."},{"key":"10.1016\/j.heares.2017.12.004_bib3","doi-asserted-by":"crossref","first-page":"290","DOI":"10.5152\/iao.2016.2617","article-title":"A\u00a0prospective experimental study on the protective effect of resveratrol against amikacin-induced ototoxicity in rats","volume":"12","author":"Avci","year":"2016","journal-title":"J.\u00a0Int. Adv. Otol."},{"key":"10.1016\/j.heares.2017.12.004_bib4","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1177\/014556130808701010","article-title":"Resveratrol protects auditory hair cells from gentamicin toxicity","volume":"87","author":"Bonabi","year":"2008","journal-title":"Ear Nose Throat J."},{"key":"10.1016\/j.heares.2017.12.004_bib5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/00016489.2016.1214981","article-title":"N-acetylcysteine as a single therapy for sudden deafness","volume":"137","author":"Chen","year":"2017","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2017.12.004_bib6","unstructured":"https:\/\/clinicaltrials.gov\/ct2\/home. ClinicalTrials.gov. National Library of Medicine (US), Bethesda (MD)."},{"key":"10.1016\/j.heares.2017.12.004_bib7","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.8332913","article-title":"Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4","volume":"261","author":"Colotta","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.heares.2017.12.004_bib8","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/00005537-199802000-00023","article-title":"Attenuation of neomycin ototoxicity by iron chelation","volume":"108","author":"Conlon","year":"1998","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2017.12.004_bib9","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1007\/s00018-015-1919-x","article-title":"C-Raf deficiency leads to hearing loss and increased noise susceptibility","volume":"72","author":"de Iriarte Rodriguez","year":"2015","journal-title":"Cell. Mol. Life Sci. : CMLS"},{"key":"10.1016\/j.heares.2017.12.004_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.heares.2015.07.020","article-title":"Age-regulated function of autophagy in the mouse inner ear","volume":"330","author":"de Iriarte Rodriguez","year":"2015","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.12.004_bib11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.heares.2009.08.008","article-title":"Mechanisms of rapid sensory hair-cell death following co-administration of gentamicin and ethacrynic acid","volume":"259","author":"Ding","year":"2010","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.12.004_bib12","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1093\/bioinformatics\/btp578","article-title":"HTqPCR: high-throughput analysis and visualization of quantitative real-time PCR data in R","volume":"25","author":"Dvinge","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.heares.2017.12.004_bib13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.lfs.2016.03.003","article-title":"A\u00a0minireview on N-acetylcysteine: an old drug with new approaches","volume":"151","author":"Elbini Dhouib","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.heares.2017.12.004_bib14","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1007\/s00405-011-1883-5","article-title":"The effect of resveratrol on the prevention of cisplatin ototoxicity","volume":"269","author":"Erdem","year":"2012","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"10.1016\/j.heares.2017.12.004_bib15","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1172\/JCI84939","article-title":"Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death","volume":"126","author":"Esterberg","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.heares.2017.12.004_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1525-139X.2012.01090.x","article-title":"N-acetylcysteine use for amelioration of aminoglycoside-induced ototoxicity in dialysis patients","volume":"25","author":"Feldman","year":"2012","journal-title":"Semin. Dial."},{"key":"10.1016\/j.heares.2017.12.004_bib70","first-page":"70","article-title":"Protective effects of N-acetylcysteine on noise-induced hearing loss in guinea pigs","volume":"29","author":"Fetoni","year":"2009","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"10.1016\/j.heares.2017.12.004_bib17","first-page":"103","article-title":"Antioxidant treatment with coenzyme Q-ter in prevention of gentamycin ototoxicity in an animal model","volume":"32","author":"Fetoni","year":"2012","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"10.1016\/j.heares.2017.12.004_bib18","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1745-6215-15-110","article-title":"Using prophylactic antioxidants to prevent noise-induced hearing damage in young adults: a protocol for a double-blind, randomized controlled trial","volume":"15","author":"Gilles","year":"2014","journal-title":"Trials"},{"key":"10.1016\/j.heares.2017.12.004_bib19","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1002\/mnfr.201400933","article-title":"Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner","volume":"59","author":"Gonzalez-Rodriguez","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.heares.2017.12.004_bib20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.otohns.2010.04.266","article-title":"A\u00a0combination antioxidant therapy prevents age-related hearing loss in C57BL\/6 mice","volume":"143","author":"Heman-Ackah","year":"2010","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2017.12.004_bib21","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.heares.2010.10.011","article-title":"Comparative analysis of combination kanamycin-furosemide versus kanamycin alone in the mouse cochlea","volume":"272","author":"Hirose","year":"2011","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.12.004_bib22","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.3892\/ijmm.2014.1967","article-title":"Prednisone inhibits the IL-1beta-induced expression of COX-2 in HEI-OC1 murine auditory cells through the inhibition of ERK-1\/2, JNK-1 and AP-1 activity","volume":"34","author":"Hong","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.heares.2017.12.004_bib23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ajhg.2011.11.030","article-title":"Mutations in SLC33A1 cause a lethal autosomal-recessive disorder with congenital cataracts, hearing loss, and low serum copper and ceruloplasmin","volume":"90","author":"Huppke","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.heares.2017.12.004_bib24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.heares.2010.05.002","article-title":"Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL\/6J mice","volume":"268","author":"Johnson","year":"2010","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.12.004_bib25","first-page":"17","article-title":"The toxicity of N-acetylcysteine in laboratory animals","volume":"10","author":"Johnston","year":"1983","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.heares.2017.12.004_bib26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/jn\/132.2.257","article-title":"The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful","volume":"132","author":"Juan","year":"2002","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.heares.2017.12.004_bib27","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1523\/JNEUROSCI.6054-09.2010","article-title":"Roles of NADPH oxidases in cisplatin-induced reactive oxygen species generation and ototoxicity","volume":"30","author":"Kim","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2017.12.004_bib28","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1136\/thoraxjnl-2015-207245","article-title":"A\u00a0systematic review and meta-analysis of the efficacy and safety of N-acetylcysteine in preventing aminoglycoside-induced ototoxicity: implications for the treatment of multidrug-resistant TB","volume":"70","author":"Kranzer","year":"2015","journal-title":"Thorax"},{"key":"10.1016\/j.heares.2017.12.004_bib29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ijporl.2014.11.008","article-title":"Protective effect of resveratrol against cisplatin-induced ototoxicity in HEI-OC1 auditory cells","volume":"79","author":"Lee","year":"2015","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2017.12.004_bib30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.heares.2010.07.005","article-title":"N-Acetyl-cysteine against noise-induced temporary threshold shift in male workers","volume":"269","author":"Lin","year":"2010","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.12.004_bib31","doi-asserted-by":"crossref","first-page":"392","DOI":"10.4103\/1463-1741.90293","article-title":"The efficacy of N-acetylcysteine to protect the human cochlea from subclinical hearing loss caused by impulse noise: a controlled trial","volume":"13","author":"Lindblad","year":"2011","journal-title":"Noise Health"},{"key":"10.1016\/j.heares.2017.12.004_bib32","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1097\/00001756-199808030-00034","article-title":"Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells","volume":"9","author":"Liu","year":"1998","journal-title":"Neuroreport"},{"key":"10.1016\/j.heares.2017.12.004_bib33","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.heares.2017.12.004_bib34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3389\/fncel.2015.00143","article-title":"Cellular glutathione content in the organ of Corti and its role during ototoxicity","volume":"9","author":"Majumder","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.heares.2017.12.004_bib35","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1096\/fj.14-259283","article-title":"Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism","volume":"29","author":"Martinez-Vega","year":"2015","journal-title":"FASEB J"},{"key":"10.1016\/j.heares.2017.12.004_bib36","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0378-5955(03)00134-5","article-title":"Susceptibility of the hair cells of the newborn rat cochlea to hypoxia and ischemia","volume":"182","author":"Mazurek","year":"2003","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.12.004_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0197-4580(99)00018-4","article-title":"Age-related cochlear hair cell loss is enhanced in mice lacking copper\/zinc superoxide dismutase","volume":"20","author":"McFadden","year":"1999","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heares.2017.12.004_bib38","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.otohns.2009.07.014","article-title":"Direct drug application to the round window: a comparative study of ototoxicity in rats","volume":"141","author":"Murillo-Cuesta","year":"2009","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2017.12.004_bib39","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1755-148X.2009.00646.x","article-title":"Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice","volume":"23","author":"Murillo-Cuesta","year":"2010","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.heares.2017.12.004_bib40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fnmol.2011.00011","article-title":"The role of insulin-like growth factor-I in the physiopathology of hearing","volume":"4","author":"Murillo-Cuesta","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.heares.2017.12.004_bib41","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2119\/molmed.2011.00328","article-title":"Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function","volume":"18","author":"Murillo-Cuesta","year":"2012","journal-title":"Mol. Med."},{"key":"10.1016\/j.heares.2017.12.004_bib42","first-page":"32","article-title":"Transforming growth factor beta1 inhibition protects from noise-induced hearing loss","volume":"7","author":"Murillo-Cuesta","year":"2015","journal-title":"Front. Aging Neurosci."},{"issue":"121","key":"10.1016\/j.heares.2017.12.004_bib43","article-title":"A\u00a0comparative study of drug delivery methods targeted to the mouse inner ear: bullostomy versus transtympanic injection","author":"Murillo-Cuesta","year":"2017","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.heares.2017.12.004_bib44","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000013847","article-title":"Targeted deletion of the cytosolic Cu\/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss","volume":"4","author":"Ohlemiller","year":"1999","journal-title":"Audiol. Neuro. Otol."},{"key":"10.1016\/j.heares.2017.12.004_bib45","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s101620010043","article-title":"Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice","volume":"1","author":"Ohlemiller","year":"2000","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2017.12.004_bib46","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1097\/MLG.0b013e31813e6041","article-title":"Effect of N-acetylcysteine on carboplatin-induced ototoxicity and nitric oxide levels in a rat model","volume":"117","author":"Okur","year":"2007","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2017.12.004_bib47","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.bbadis.2015.01.014","article-title":"The pharmacology of resveratrol in animals and humans","volume":"1852","author":"Park","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.heares.2017.12.004_bib48","doi-asserted-by":"crossref","first-page":"960","DOI":"10.3892\/ijmm.2017.2916","article-title":"Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes","volume":"39","author":"Park","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.heares.2017.12.004_bib49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1523\/JNEUROSCI.20-01-00043.2000","article-title":"Rescue of hearing, auditory hair cells, and neurons by CEP-1347\/KT7515, an inhibitor of c-Jun N-terminal kinase activation","volume":"20","author":"Pirvola","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2017.12.004_bib50","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.2174\/092986710792927895","article-title":"Oxidative stress in the cochlea: an update","volume":"17","author":"Poirrier","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.heares.2017.12.004_bib51","first-page":"27","article-title":"A\u00a0comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice","volume":"4","author":"Riquelme","year":"2010","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.heares.2017.12.004_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008699","article-title":"RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors","volume":"5","author":"Sanchez-Calderon","year":"2010","journal-title":"PLos One"},{"issue":"Pt 22","key":"10.1016\/j.heares.2017.12.004_bib53","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1242\/jcs.112.22.3967","article-title":"Pattern of expression of the jun family of transcription factors during the early development of the inner ear: implications in apoptosis","volume":"112","author":"Sanz","year":"1999","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.heares.2017.12.004_bib54","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1002\/ar.22578","article-title":"Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention","volume":"295","author":"Schacht","year":"2012","journal-title":"Anat. Rec."},{"key":"10.1016\/j.heares.2017.12.004_bib55","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1177\/0194599813475777","article-title":"Resveratrol decreases noise-induced cyclooxygenase-2 expression in the rat cochlea","volume":"148","author":"Seidman","year":"2013","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2017.12.004_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(01)00224-6","article-title":"Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals","volume":"155","author":"Sha","year":"2001","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.12.004_bib57","doi-asserted-by":"crossref","first-page":"12","DOI":"10.5152\/iao.2015.650","article-title":"N-acetylcysteine prevents gentamicin ototoxicity in a rat model","volume":"11","author":"Somdas","year":"2015","journal-title":"J.\u00a0Int. Adv. Otol."},{"key":"10.1016\/j.heares.2017.12.004_bib58","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ijporl.2016.08.012","article-title":"Intraperitoneal curcumin and vitamin E combination for the treatment of cisplatin-induced ototoxicity in rats","volume":"89","author":"Soyalic","year":"2016","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2017.12.004_bib59","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.2174\/092986711797535254","article-title":"Ototoxicity: mechanisms of cochlear impairment and its prevention","volume":"18","author":"Tabuchi","year":"2011","journal-title":"Curr. Med. Chem."},{"issue":"1842","key":"10.1016\/j.heares.2017.12.004_bib60","first-page":"e1","article-title":"Expression pattern of oxidative stress and antioxidant defense-related genes in the aging Fischer 344\/NHsd rat cochlea","volume":"33","author":"Tanaka","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heares.2017.12.004_bib71","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1093\/ndt\/gfr211","article-title":"Protective effect of N-acetylcysteine from drug-induced ototoxicity in uraemic patients with CAPD peritonitis","volume":"26","author":"Tokgoz","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.heares.2017.12.004_bib72","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.heares.2013.07.012","article-title":"Noise-induced changes in expression levels of NADPH oxidases in the cochlea","volume":"304","author":"Vlajkovic","year":"2013","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.12.004_bib61","doi-asserted-by":"crossref","first-page":"7195","DOI":"10.1073\/pnas.86.18.7195","article-title":"Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase","volume":"86","author":"Volpp","year":"1989","journal-title":"Proceed. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.heares.2017.12.004_bib62","article-title":"Resveratrol attenuates CoCl2-induced cochlear hair cell damage through upregulation of Sirtuin1 and NF-kappaB deacetylation","volume":"8","author":"Wang","year":"2013","journal-title":"PLos One"},{"key":"10.1016\/j.heares.2017.12.004_bib63","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s004050100335","article-title":"Expression of myeloperoxidase and cochlear dysfunction in the lipopolysaccharide-treated guinea pig","volume":"258","author":"Watanabe","year":"2001","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"10.1016\/j.heares.2017.12.004_bib64","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/0041-008X(70)90077-3","article-title":"Increased ethanol toxicity in old rats: changes in LD50, in\u00a0vivo and in\u00a0vitro metabolism, and liver alcohol dehydrogenase activity","volume":"16","author":"Wiberg","year":"1970","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.heares.2017.12.004_bib65","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nature03173","article-title":"Regulation of cellular response to oncogenic and oxidative stress by Seladin-1","volume":"432","author":"Wu","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.heares.2017.12.004_bib66","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.heares.2011.05.008","article-title":"New developments in aminoglycoside therapy and ototoxicity","volume":"281","author":"Xie","year":"2011","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.12.004_bib67","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102133","article-title":"Disruption of ion-trafficking system in the cochlear spiral ligament prior to permanent hearing loss induced by exposure to intense noise: possible involvement of 4-hydroxy-2-nonenal as a mediator of oxidative stress","volume":"9","author":"Yamaguchi","year":"2014","journal-title":"PLos One"},{"key":"10.1016\/j.heares.2017.12.004_bib68","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0378-5955(01)00380-X","article-title":"Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death","volume":"163","author":"Ylikoski","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2017.12.004_bib69","doi-asserted-by":"crossref","first-page":"E87","DOI":"10.1002\/lary.24360","article-title":"Cisplatin otoprotection using transtympanic L-N-acetylcysteine: a pilot randomized study in head and neck cancer patients","volume":"124","author":"Yoo","year":"2014","journal-title":"Laryngoscope"}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595516305615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595516305615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:49:28Z","timestamp":1759920568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595516305615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":72,"alternative-id":["S0378595516305615"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2017.12.004","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2017.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}