{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:23:38Z","timestamp":1772601818527,"version":"3.50.1"},"reference-count":144,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003354","name":"Garnett Passe and Rodney Williams Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003354","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.heares.2019.107870","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T20:12:16Z","timestamp":1576181536000},"page":"107870","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Intravenously delivered aminoglycoside antibiotics, tobramycin and amikacin, are not ototoxic in mice"],"prefix":"10.1016","volume":"386","author":[{"given":"Jacqueline M.","family":"Ogier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Lockhart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel A.","family":"Burt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2019.107870_bib1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/infdis\/140.3.342","article-title":"Furosemide enhancement of experimental gentamicin nephrotoxicity: comparison of functional and morphological changes with activities of urinary enzymes","volume":"140","author":"Adelman","year":"1979","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.heares.2019.107870_bib2","article-title":"Audiological monitoring in ototoxicity - are we doing enough?","volume":"25","author":"Al-Malky","year":"2016","journal-title":"ENT and Audiology News"},{"key":"10.1016\/j.heares.2019.107870_bib3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3109\/14992027.2010.524253","article-title":"Aminoglycoside antibiotics cochleotoxicity in paediatric cystic fibrosis (CF) patients: a study using extended high-frequency audiometry and distortion product otoacoustic emissions","volume":"50","author":"Al-Malky","year":"2011","journal-title":"Int. J. Audiol."},{"key":"10.1016\/j.heares.2019.107870_bib4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jcf.2014.07.009","article-title":"High-frequency audiometry reveals high prevalence of aminoglycoside ototoxicity in children with cystic fibrosis","volume":"14","author":"Al-Malky","year":"2015","journal-title":"J.\u00a0Cyst. Fibros."},{"key":"10.1016\/j.heares.2019.107870_bib5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.nefro.2016.06.004","article-title":"Reno-protective effects of propolis on gentamicin-induced acute renal toxicity in swiss albino mice","volume":"36","author":"Aldahmash","year":"2016","journal-title":"Nefrologia"},{"key":"10.1016\/j.heares.2019.107870_bib6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/000348940010900105","article-title":"Extraneous round window membranes and plugs: possible effect on intratympanic therapy","volume":"109","author":"Alzamil","year":"2000","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2019.107870_bib9","first-page":"138","article-title":"Our experience with the medical treatment of endolymphatic hydrops","volume":"13","author":"Ataman","year":"2007","journal-title":"Int. Tinnitus J."},{"key":"10.1016\/j.heares.2019.107870_bib10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1046\/j.1469-0691.2000.00105.x","article-title":"Does once-daily dosing prevent nephrotoxicity in all aminoglycosides equally?","volume":"6","author":"Beaucaire","year":"2000","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.heares.2019.107870_bib11","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.1088\/0031-9155\/58\/16\/5351","article-title":"A\u00a0semi-automated vascular access system (VAS) for preclinical models","volume":"58","author":"Berry-Pusey","year":"2013","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.heares.2019.107870_bib12","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1128\/AAC.9.6.956","article-title":"Ototoxicity of amikacin","volume":"9","author":"Black","year":"1976","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.heares.2019.107870_bib13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jconrel.2013.11.021","article-title":"Round window membrane intracochlear drug delivery enhanced by induced advection","volume":"174","author":"Borkholder","year":"2014","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.heares.2019.107870_bib14","first-page":"135","article-title":"Mouse models of membranous nephropathy: the road less travelled by","volume":"2","author":"Borza","year":"2013","journal-title":"Am. J. Clin. Exp. Immunol."},{"key":"10.1016\/j.heares.2019.107870_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1749-6632.2011.06325.x","article-title":"The blessings and curses of C57BL\/6 substrains in mouse genetic studies","volume":"1245","author":"Bryant","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.heares.2019.107870_bib16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/clpt.1983.138","article-title":"Tobramycin kinetics during continuous ambulatory peritoneal dialysis","volume":"34","author":"Bunke","year":"1983","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.heares.2019.107870_bib17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jneumeth.2005.05.017","article-title":"A\u00a0method for intracochlear drug delivery in the mouse","volume":"150","author":"Chen","year":"2006","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.heares.2019.107870_bib18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.heares.2006.05.006","article-title":"AM-111 protects against permanent hearing loss from impulse noise trauma","volume":"226","author":"Coleman","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2019.107870_bib19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0378-5955(89)90177-9","article-title":"Differential susceptibility to gentamicin ototoxicity between albino and pigmented Guinea pigs","volume":"41","author":"Conlee","year":"1989","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2019.107870_bib20","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1002\/gps.4968","article-title":"The relationship between hearing loss in older adults and depression over 12 years: findings from the Three-City prospective cohort study","author":"Cosh","year":"2018","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.heares.2019.107870_bib21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/jac\/27.suppl_C.29","article-title":"Pharmacodynamics of amikacin in\u00a0vitro and in mouse thigh and lung infections","volume":"27","author":"Craig","year":"1991","journal-title":"JAC (J. Antimicrob. Chemother.)"},{"key":"10.1016\/j.heares.2019.107870_bib22","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/jac\/48.6.869","article-title":"The activity of low-clearance liposomal amikacin in experimental murine tuberculosis","volume":"48","author":"Dhillon","year":"2001","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.heares.2019.107870_bib23","first-page":"67","article-title":"Antimicrobial efficacy of doripenem and its combinations with sulbactam, amikacin, colistin, tigecycline in experimental sepsis of carbapenem-resistant Acinetobacter baumannii","volume":"38","author":"Dinc","year":"2015","journal-title":"New Microbiol."},{"key":"10.1016\/j.heares.2019.107870_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8648297","article-title":"Effect of endolymphatic hydrops on sound transmission in live Guinea pigs measured with a laser Doppler vibrometer","author":"Ding","year":"2016","journal-title":"Neural Plast."},{"key":"10.1016\/j.heares.2019.107870_bib25","first-page":"145","article-title":"Ototoxic effects and mechanisms of loop diuretics","volume":"11","author":"Ding","year":"2016","journal-title":"J.\u00a0Otolaryngol."},{"key":"10.1016\/j.heares.2019.107870_bib26","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0025-6196(12)65048-4","article-title":"The aminoglycosides: streptomycin, kanamycin, gentamicin, tobramycin, amikacin, netilmicin, and sisomicin","volume":"62","author":"Edson","year":"1987","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.heares.2019.107870_bib27","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/S0025-6196(11)62603-7","article-title":"Vestibular toxicity due to inhaled tobramycin in a patient with renal insufficiency","volume":"79","author":"Edson","year":"2004","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.heares.2019.107870_bib28","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0934-8840(96)80097-1","article-title":"Liposomal amikacin for treatment of M. avium infections in clinically relevant experimental settings","volume":"284","author":"Ehlers","year":"1996","journal-title":"Zentralblatt Bakteriol."},{"key":"10.1016\/j.heares.2019.107870_bib29","doi-asserted-by":"crossref","first-page":"S304","DOI":"10.1093\/clinids\/5.Supplement_2.S304","article-title":"Gentamicin and tobramycin: comparison of ototoxicity","volume":"5","author":"Fee","year":"1983","journal-title":"CID"},{"key":"10.1016\/j.heares.2019.107870_bib30","doi-asserted-by":"crossref","first-page":"e195","DOI":"10.1038\/cddis.2011.76","article-title":"Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32","volume":"2","author":"Francis","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.heares.2019.107870_bib31","doi-asserted-by":"crossref","first-page":"744","DOI":"10.7326\/0003-4819-91-5-744","article-title":"Furosemide-induced ototoxicity","volume":"91","author":"Gallagher","year":"1979","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.heares.2019.107870_bib32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jcf.2017.01.006","article-title":"The cumulative effects of intravenous antibiotic treatments on hearing in patients with cystic fibrosis","volume":"16","author":"Garinis","year":"2017","journal-title":"J.\u00a0Cyst. Fibros."},{"key":"10.1016\/j.heares.2019.107870_bib33","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1080\/14992027.2018.1514537","article-title":"Negative hearing effects of a single course of IV aminoglycoside therapy in cystic fibrosis patients","volume":"57","author":"Gleser","year":"2018","journal-title":"Int. J. Audiol."},{"key":"10.1016\/j.heares.2019.107870_bib34","first-page":"1811","article-title":"Aminoglycosides: a practical review","volume":"58","author":"Gonzalez","year":"1998","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.heares.2019.107870_bib35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.5152\/iao.2016.2181","article-title":"Cochlear and vestibular effects of combined intratympanic gentamicin and dexamethasone","volume":"13","author":"Guneri","year":"2017","journal-title":"J.\u00a0Int. Adv. Otol."},{"key":"10.1016\/j.heares.2019.107870_bib36","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s12070-015-0859-y","article-title":"Electronystagmography a very useful diagnostic tool in cases of vertigo","volume":"67","author":"Gupta","year":"2015","journal-title":"Indian J. Otolaryngol. Head Neck Surg.: Off. Publ. Assoc. Otolaryngol. India"},{"key":"10.1016\/j.heares.2019.107870_bib37","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/ppul.23763","article-title":"Prevalence of hearing and vestibular loss in cystic fibrosis patients exposed to aminoglycosides","volume":"52","author":"Handelsman","year":"2017","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.heares.2019.107870_bib38","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10162-009-0162-2","article-title":"Hes5 expression in the postnatal and adult mouse inner ear and the drug-damaged cochlea","volume":"10","author":"Hartman","year":"2009","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2019.107870_bib39","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1044\/2018_JSLHR-H-17-0485","article-title":"Positive social interaction and hearing loss in older adults living in rural and urban communities","volume":"61","author":"Hay-McCutcheon","year":"2018","journal-title":"J.\u00a0Speech Lang. Hear. Res."},{"key":"10.1016\/j.heares.2019.107870_bib40","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1007\/s00018-007-7034-x","article-title":"Aminoglycoside antibiotics: old drugs and new therapeutic approaches","volume":"64","author":"Hermann","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.heares.2019.107870_bib41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.heares.2004.01.006","article-title":"Round window gentamicin application: an inner ear hair cell damage protocol for the mouse","volume":"192","author":"Heydt","year":"2004","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2019.107870_bib42","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3109\/00016487709123939","article-title":"Pigmentation of the stria vascularis. The contribution of neural crest melanocytes","volume":"84","author":"Hilding","year":"1977","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2019.107870_bib43","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.heares.2010.10.011","article-title":"Comparative analysis of combination kanamycin-furosemide versus kanamycin alone in the mouse cochlea","volume":"272","author":"Hirose","year":"2011","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2019.107870_bib44","first-page":"1123","article-title":"Functional and morphological analysis of different aminoglycoside treatment regimens inducing hearing loss in mice","volume":"18","author":"Horvath","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.heares.2019.107870_bib45","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1128\/AAC.18.1.176","article-title":"Comparative low-dose nephrotoxicities of gentamicin, tobramycin, and amikacin","volume":"18","author":"Hottendorf","year":"1980","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.heares.2019.107870_bib46","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/019262338601400108","article-title":"Aminoglycoside nephrotoxicity","volume":"14","author":"Hottendorf","year":"1986","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.heares.2019.107870_bib47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000346180","article-title":"Development of a chronic kidney disease model in C57BL\/6 mice with relevance to human pathology","volume":"3","author":"Huang","year":"2013","journal-title":"Nephron extra"},{"key":"10.1016\/j.heares.2019.107870_bib48","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/937861","article-title":"Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection","volume":"2011","author":"Huth","year":"2011","journal-title":"Int. J. Otolaryngol."},{"key":"10.1016\/j.heares.2019.107870_bib49","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s10162-002-2036-8","article-title":"Distribution of gentamicin in the Guinea pig inner ear after local or systemic application","volume":"4","author":"Imamura","year":"2003","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2019.107870_bib50","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.ymthe.2017.01.007","article-title":"Gene therapy restores balance and auditory functions in a mouse model of usher syndrome","volume":"25","author":"Isgrig","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.heares.2019.107870_bib51","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/01.mlg.0000200791.77819.eb","article-title":"Cochlear protection by local insulin-like growth factor-1 application using biodegradable hydrogel","volume":"116","author":"Iwai","year":"2006","journal-title":"The Laryngoscope"},{"key":"10.1016\/j.heares.2019.107870_bib52","unstructured":"Javadi, M. R. et\u00a0al.. The incidence of amikacin ototoxicity in multidrug-ResistantTuberculosis patients. Iran. J. Pharm. Res. (IJPR) 10, 905\u2013911."},{"key":"10.1016\/j.heares.2019.107870_bib53","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1089\/104303401300042465","article-title":"Cochlear gene delivery through an intact round window membrane in mouse","volume":"12","author":"Jero","year":"2001","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.heares.2019.107870_bib54","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/jnr.20392","article-title":"NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity","volume":"79","author":"Jiang","year":"2005","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.heares.2019.107870_bib55","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3389\/fncel.2017.00308","article-title":"Aminoglycoside-induced cochleotoxicity: a review","volume":"11","author":"Jiang","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.heares.2019.107870_bib56","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw1836","article-title":"Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss","volume":"5","author":"Jiang","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.heares.2019.107870_bib57","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4630241","article-title":"A\u00a0simple model for inducing optimal increase of SDF-1 with aminoglycoside ototoxicity","volume":"2017","author":"Ju","year":"2017","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.heares.2019.107870_bib58","first-page":"235","article-title":"Tobramycin-furosemide interaction","volume":"18","author":"Kaka","year":"1984","journal-title":"Drug Intell. Clin. Pharm."},{"key":"10.1016\/j.heares.2019.107870_bib59","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/08860220601039072","article-title":"Amikacin-induced nephropathy: is there any protective way?","volume":"29","author":"Kaynar","year":"2007","journal-title":"Ren. Fail."},{"key":"10.1016\/j.heares.2019.107870_bib60","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1121\/1.382104","article-title":"Stimulated acoustic emissions from within the human auditory system","volume":"64","author":"Kemp","year":"1978","journal-title":"J.\u00a0Acoust. Soc. Am."},{"key":"10.1016\/j.heares.2019.107870_bib61","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1177\/000348947408300518","article-title":"Melanocytes of the vestibular labyrinth and their relationship to the microvasculature","volume":"83","author":"LaFerriere","year":"1974","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2019.107870_bib62","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/000348949110000502","article-title":"Effect of ototoxic drug administration to the endolymphatic sac","volume":"100","author":"Lee","year":"1991","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2019.107870_bib63","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/jac\/48.4.535","article-title":"Departmental consumption of antibiotic drugs and subsequent resistance: a quantitative link","volume":"48","author":"Leibovici","year":"2001","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.heares.2019.107870_bib64","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s12640-011-9244-0","article-title":"Co-administration of cisplatin and furosemide causes rapid and massive loss of cochlear hair cells in mice","volume":"20","author":"Li","year":"2011","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.heares.2019.107870_bib65","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.heares.2015.11.011","article-title":"FGF22 protects hearing function from gentamycin ototoxicity by maintaining ribbon synapse number","volume":"332","author":"Li","year":"2016","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2019.107870_bib66","author":"Liberman"},{"key":"10.1016\/j.heares.2019.107870_bib67","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1128\/AAC.02624-12","article-title":"Impact of meropenem in combination with tobramycin in a murine model of Pseudomonas aeruginosa pneumonia","volume":"57","author":"Louie","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.heares.2019.107870_bib68","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/00016487909137141","article-title":"Melanin capacity to accumulate drugs in the internal ear: a study on lidocaine, bupivacaine and chlorpromazine","volume":"88","author":"Lyttkens","year":"2009","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2019.107870_bib69","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1046\/j.1523-1755.2003.00058.x","article-title":"Model of robust induction of glomerulosclerosis in mice: importance of genetic background","volume":"64","author":"Ma","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.heares.2019.107870_bib70","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1097\/01.mlg.0000224527.41288.c4","article-title":"C3H\/HeJ mouse model for spontaneous chronic otitis media","volume":"116","author":"MacArthur","year":"2006","journal-title":"The Laryngoscope"},{"key":"10.1016\/j.heares.2019.107870_bib71","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0821cs34","article-title":"Assessment of cochlear function in mice: distortion-product otoacoustic emissions","author":"Martin","year":"2006","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.heares.2019.107870_bib72","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.diagmicrobio.2006.11.013","article-title":"The effect of amikacin and imipenem alone and in combination against an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae strain","volume":"58","author":"Mathe","year":"2007","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.heares.2019.107870_bib73","doi-asserted-by":"crossref","first-page":"ddv403","DOI":"10.1093\/hmg\/ddv403","article-title":"A\u00a0study of whirlin isoforms in the mouse vestibular system suggests potential vestibular dysfunction in DFNB31-deficient patients","volume":"17","author":"Mathur","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.heares.2019.107870_bib74","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0196-0709(86)80040-0","article-title":"Aminoglycoside ototoxicity","volume":"7","author":"Matz","year":"1986","journal-title":"Am. J. Otolaryngol."},{"key":"10.1016\/j.heares.2019.107870_bib75","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/AUD.0b013e3181c351f2","article-title":"Drug delivery for treatment of inner ear disease: current state of knowledge","volume":"31","author":"McCall","year":"2010","journal-title":"Ear Hear."},{"key":"10.1016\/j.heares.2019.107870_bib76","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ki.2015.115","article-title":"Phenotype standardization for drug-induced kidney disease","volume":"88","author":"Mehta","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.heares.2019.107870_bib77","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1600-0749.1988.tb00422.x","article-title":"Physiology and pathophysiology of inner ear melanin","volume":"1","author":"Meyer zum Gottesberge","year":"1988","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.heares.2019.107870_bib78","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/infdis\/149.1.23","article-title":"Risk factors for the development of auditory toxicity in patients receiving aminoglycosides","volume":"149","author":"Moore","year":"1984","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.heares.2019.107870_bib79","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/jac\/37.4.645","article-title":"A\u00a0meta-analysis of studies on the safety and efficacy of aminoglycosides given either once daily or as divided doses","volume":"37","author":"Munckhof","year":"1996","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.heares.2019.107870_bib80","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1258\/la.2009.009046","article-title":"Comparison of different aminoglycoside antibiotic treatments to refine ototoxicity studies in adult mice","volume":"44","author":"Murillo-Cuesta","year":"2010","journal-title":"Lab. Anim."},{"key":"10.1016\/j.heares.2019.107870_bib81","article-title":"A\u00a0comparative study of drug delivery methods targeted to the mouse inner ear: bullostomy versus transtympanic injection","volume":"54951","author":"Murillo-Cuesta","year":"2017","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.heares.2019.107870_bib82","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A\u00a0simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J.\u00a0Basic Clin. Pharm."},{"key":"10.1016\/j.heares.2019.107870_bib83","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1080\/00016480050218627","article-title":"Vestibular and cochlear toxicity of aminoglycosides--a review","volume":"120","author":"Nakashima","year":"2000","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2019.107870_bib84","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10162-007-0106-7","article-title":"Sox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner ear","volume":"9","author":"Oesterle","year":"2008","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2019.107870_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097559","article-title":"CHD7 deficiency in \u2018Looper\u2019, a new mouse model of CHARGE syndrome, results in ossicle malformation, otosclerosis and hearing impairment","volume":"9","author":"Ogier","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2019.107870_bib86","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1038\/s41598-018-23856-8","article-title":"An intronic mutation in Chd7 creates a cryptic splice site, causing aberrant splicing in a mouse model of CHARGE syndrome","volume":"8","author":"Ogier","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.heares.2019.107870_bib87","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3389\/fncel.2019.00170","article-title":"Organotypic culture of neonatal murine inner ear explants","volume":"13","author":"Ogier","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.heares.2019.107870_bib88","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000275386","article-title":"Potentiation and its mechanism of cochlear damage resulting from furosemide and aminoglycoside antibiotics","volume":"40","author":"Ohtani","year":"1978","journal-title":"ORL"},{"key":"10.1016\/j.heares.2019.107870_bib89","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.heares.2012.10.011","article-title":"Intra-tympanic delivery of short interfering RNA into the adult mouse cochlea","volume":"296","author":"Oishi","year":"2013","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2019.107870_bib90","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.108","article-title":"XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death","volume":"6","author":"Oishi","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.heares.2019.107870_bib91","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1128\/AAC.31.4.594","article-title":"Cumulative and acute toxicity of repeated high-dose tobramycin treatment in cystic fibrosis","volume":"31","author":"Pedersen","year":"1987","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.heares.2019.107870_bib92","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.toxlet.2009.12.003","article-title":"Ototoxic drugs: difference in sensitivity between mice and Guinea pigs","volume":"193","author":"Poirrier","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.heares.2019.107870_bib93","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1136\/thx.2009.131532","article-title":"Side effects of aminoglycosides on the kidney, ear and balance in cystic fibrosis","volume":"65","author":"Prayle","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.heares.2019.107870_bib94","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.4187\/respcare.02980","article-title":"A\u00a0survey of extended-interval aminoglycoside dosing practices in United States adult cystic fibrosis programs","volume":"59","author":"Prescott","year":"2014","journal-title":"Respir. Care"},{"key":"10.1016\/j.heares.2019.107870_bib95","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.2337\/diabetes.54.9.2628","article-title":"Characterization of susceptibility of inbred mouse strains to diabetic nephropathy","volume":"54","author":"Qi","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.heares.2019.107870_bib96","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1177\/000348947508400114","article-title":"Permanent deafness associated with furosemide administration","volume":"84","author":"Quick","year":"1975","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2019.107870_bib97","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000445171","article-title":"Non-transgenic mouse models of kidney disease","volume":"133","author":"Rabe","year":"2016","journal-title":"Nephron"},{"key":"10.1016\/j.heares.2019.107870_bib98","doi-asserted-by":"crossref","DOI":"10.1186\/1824-7288-36-75","article-title":"Comparison of health related quality of life of primary school deaf children with and without motor impairment","volume":"36","author":"Rajendran","year":"2010","journal-title":"Ital. J. Pediatr."},{"key":"10.1016\/j.heares.2019.107870_bib99","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.3390\/molecules22122267","article-title":"Amikacin: uses, resistance, and prospects for inhibition","volume":"22","author":"Ramirez","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.heares.2019.107870_bib100","series-title":"Melbourne Handbook for the Management of Children with Cystic Fibrosis","author":"Ranganathan","year":"2006"},{"key":"10.1016\/j.heares.2019.107870_bib101","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jcf.2009.08.004","article-title":"Aminoglycoside therapy against Pseudomonas aeruginosa in cystic fibrosis: a review","volume":"8","author":"Ratjen","year":"2009","journal-title":"J.\u00a0Cyst. Fibros."},{"key":"10.1016\/j.heares.2019.107870_bib102","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.heares.2019.107870_bib103","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00007611-197801000-00029","article-title":"Deafness associated with oral furosemide","volume":"71","author":"Rifkin","year":"1978","journal-title":"South. Med. J."},{"key":"10.1016\/j.heares.2019.107870_bib104","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/0194599816640485","article-title":"Quality of life in children with hearing impairment: systematic review and meta-analysis","volume":"155","author":"Roland","year":"2016","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2019.107870_bib105","first-page":"518","article-title":"Free radical scavenging properties of melanin interaction of eu- and pheo-melanin models with reducing and oxidising radicals","volume":"26","author":"Rozanowska","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.heares.2019.107870_bib106","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neuro.2013.11.002","article-title":"Topographic and quantitative evaluation of gentamicin-induced damage to peripheral innervation of mouse cochleae","volume":"40","author":"Ruan","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.heares.2019.107870_bib107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1288\/00005537-198509010-00001","article-title":"Furosemide ototoxicity: clinical and experimental aspects","volume":"95","author":"Rybak","year":"1985","journal-title":"The Laryngoscope"},{"key":"10.1016\/j.heares.2019.107870_bib108","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0030-6665(20)30770-2","article-title":"Ototoxicity of loop diuretics","volume":"26","author":"Rybak","year":"1993","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"10.1016\/j.heares.2019.107870_bib109","article-title":"Extended-Interval aminoglycoside use in cystic fibrosis exacerbation in children and young adults: a prospective quality improvement project","volume":"3","author":"Safi","year":"2016","journal-title":"Glob. Pediatr. Health"},{"key":"10.1016\/j.heares.2019.107870_bib110","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1211\/0022357023051","article-title":"Acute nephrotoxicity of aristolochic acids in mice","volume":"56","author":"Sato","year":"2004","journal-title":"J.\u00a0Pharm. Pharmacol."},{"key":"10.1016\/j.heares.2019.107870_bib111","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/00016480801968534","article-title":"Vestibulotoxicity as a consequence of systemically administered tobramycin in cystic fibrosis patients","volume":"129","author":"Scheenstra","year":"2009","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2019.107870_bib112","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s1016200220017","article-title":"Ouabain application to the round window of the gerbil cochlea: a model of auditory neuropathy and apoptosis","volume":"3","author":"Schmiedt","year":"2002","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2019.107870_bib113","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1074\/jbc.M109959200","article-title":"Megalin deficiency offers protection from renal aminoglycoside accumulation","volume":"277","author":"Schmitz","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.heares.2019.107870_bib114","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1056\/NEJM197006182822506","article-title":"Ototoxicity induced by furosemide","volume":"282","author":"Schwartz","year":"1970","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.heares.2019.107870_bib115","article-title":"Vestibular function is also vulnerable","volume":"335","author":"Seemungal","year":"2007","journal-title":"BMJ Br. Med. J. (Clin. Res. Ed.)"},{"key":"10.1016\/j.heares.2019.107870_bib116","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.heares.2005.10.016","article-title":"2,3-Dihydroxybenzoic acid attenuates kanamycin-induced volume reduction in mouse utricular type I hair cells","volume":"212","author":"Severinsen","year":"2006","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2019.107870_bib117","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1476-5381.2009.00267.x","article-title":"To scale or not to scale: the principles of dose extrapolation","volume":"157","author":"Sharma","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.heares.2019.107870_bib118","article-title":"Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis","volume":"3","author":"Smyth","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.heares.2019.107870_bib119","doi-asserted-by":"crossref","first-page":"7528","DOI":"10.1038\/s41598-018-25766-1","article-title":"Generation and characterisation of a parkin-Pacrg knockout mouse line and a Pacrg knockout mouse line","volume":"8","author":"Stephenson","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.heares.2019.107870_bib120","article-title":"The mouse round-window approach for ototoxic agent delivery: a rapid and reliable technique for inducing cochlear cell degeneration","volume":"53131","author":"Stevens","year":"2015","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.heares.2019.107870_bib121","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.biopha.2017.10.107","article-title":"The effect of the dipeptidyl peptidase-4 inhibitor sitagliptin on gentamicin nephrotoxicity in mice","volume":"97","author":"Al Suleimani","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.heares.2019.107870_bib122","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0742-8413(94)00037-B","article-title":"Toxicity of neomycin on enzyme activities of kidney and duodenal mucosa in\u00a0vivo: organ specificity and species difference between rats and mice","volume":"109","author":"Suzuki","year":"1994","journal-title":"Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol."},{"key":"10.1016\/j.heares.2019.107870_bib123","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0742-8413(95)00075-5","article-title":"Comparison of gentamicin nephrotoxicity between rats and mice","volume":"112","author":"Suzuki","year":"1995","journal-title":"Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol."},{"key":"10.1016\/j.heares.2019.107870_bib124","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1472-8206.2009.00702.x","article-title":"A\u00a0prospective comparative study of gentamicin- and amikacin-induced nephrotoxicity in patients with normal baseline renal function","volume":"23","author":"Sweileh","year":"2009","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.heares.2019.107870_bib125","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1600-0749.1999.tb00518.x","article-title":"Sound needs sound melanocytes to Be heard","volume":"12","author":"Tachibana","year":"1999","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.heares.2019.107870_bib126","first-page":"1","article-title":"A\u00a014 day toxicity study of trehalose in the albino mouse, unpublished report No. 434","author":"Thomas","year":"1994","journal-title":"Frederick Res. Centre"},{"key":"10.1016\/j.heares.2019.107870_bib127","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168159","article-title":"Ectopic mineralization and conductive hearing loss in Enpp1asj mutant mice, a new model for otitis media and tympanosclerosis","volume":"11","author":"Tian","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2019.107870_bib128","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1172\/JCI112463","article-title":"Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs","volume":"77","author":"Tran Ba Huy","year":"1986","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.heares.2019.107870_bib129","article-title":"Behavioral assessment of the aging mouse vestibular system","volume":"51605","author":"Tung","year":"2014","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.heares.2019.107870_bib130","first-page":"600","article-title":"Administration of substances to laboratory animals: routes of administration and factors to consider","volume":"50","author":"Turner","year":"2011","journal-title":"J.\u00a0Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.heares.2019.107870_bib131","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/jac\/dkp352","article-title":"Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa","volume":"64","author":"van Gennip","year":"2009","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.heares.2019.107870_bib132","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/jac\/42.4.483","article-title":"Treatment of disseminated Mycobacterium genavense infection in a murine model with ciprofloxacin, amikacin, ethambutol, clarithromycin and rifabutin","volume":"42","author":"Vrioni","year":"1998","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.heares.2019.107870_bib133","first-page":"170","article-title":"Dose-related vestibular and cochlear effects of transtympanic gentamicin","volume":"19","author":"Wanamaker","year":"1998","journal-title":"Am. J. Otol."},{"key":"10.1016\/j.heares.2019.107870_bib134","first-page":"457","article-title":"Comparison of vestibular and cochlear ototoxicity from transtympanic streptomycin administration","volume":"20","author":"Wanamaker","year":"1999","journal-title":"Am. J. Otol."},{"key":"10.1016\/j.heares.2019.107870_bib135","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10162-009-0160-4","article-title":"Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells","volume":"10","author":"Wang","year":"2009","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2019.107870_bib136","first-page":"200","article-title":"Gentamicin-induced nephrotoxicity in mice: protection by loop diuretics","volume":"62","author":"Whiting","year":"1981","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.heares.2019.107870_bib137","first-page":"1035","article-title":"Amikacin, kanamycin and tobramycin binding to melanin in the presence of Ca(2+) and Mg(2+) ions","volume":"69","author":"Wrzesniok","year":"2012","journal-title":"Acta Pol. Pharm."},{"key":"10.1016\/j.heares.2019.107870_bib138","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0378-5955(01)00303-3","article-title":"Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat","volume":"158","author":"Wu","year":"2001","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2019.107870_bib139","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.heares.2011.05.008","article-title":"New developments in aminoglycoside therapy and ototoxicity","volume":"281","author":"Xie","year":"2011","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2019.107870_bib140","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.pharep.2019.01.002","article-title":"Vitamin C alleviates ototoxic effect caused by coadministration of amikacin and furosemide","volume":"71","author":"Zadrozniak","year":"2019","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.heares.2019.107870_bib141","first-page":"534","article-title":"Vestibular system in infants after systemic therapy with amikacin","volume":"37","author":"Zagolski","year":"2008","journal-title":"J.\u00a0Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2019.107870_bib142","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1177\/0194599818782444","article-title":"Progressive hearing loss among patients with cystic fibrosis and parenteral aminoglycoside treatment","volume":"159","author":"Zettner","year":"2018","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2019.107870_bib143","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1097\/MAO.0b013e3181dbb30e","article-title":"Evidence-based modification of intratympanic gentamicin injections in patients with intractable vertigo","volume":"31","author":"Zhai","year":"2010","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.heares.2019.107870_bib144","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.4103\/0366-6999.191767","article-title":"Characteristics of the cochlear symptoms and functions in meniere\u2019s disease","volume":"129","author":"Zhang","year":"2016","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.heares.2019.107870_bib145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1179\/1973947812Y.0000000064","article-title":"A\u00a0comparative study on the activities of six combination regimens against multidrug-resistant Mycobacterium tuberculosis infection in BALB\/c mice","volume":"25","author":"Zheng","year":"2013","journal-title":"J.\u00a0Chemother."},{"key":"10.1016\/j.heares.2019.107870_bib146","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1186\/s13104-015-1507-z","article-title":"Pharmacodynamics of nine generic products of amikacin compared with the innovator in the neutropenic mouse thigh infection model","volume":"8","author":"Zuluaga","year":"2015","journal-title":"BMC Res. Notes"}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595519303673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595519303673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:52:38Z","timestamp":1759920758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595519303673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":144,"alternative-id":["S0378595519303673"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2019.107870","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intravenously delivered aminoglycoside antibiotics, tobramycin and amikacin, are not ototoxic in mice","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2019.107870","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107870"}}