{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:25:25Z","timestamp":1780601125163,"version":"3.54.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["INBRE - P20GM103427-14"],"award-info":[{"award-number":["INBRE - P20GM103427-14"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DC015385"],"award-info":[{"award-number":["R01 DC015385"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.heares.2020.107935","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T12:37:56Z","timestamp":1584535076000},"page":"107935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Pericyte abnormalities precede strial capillary basement membrane thickening in Alport mice"],"prefix":"10.1016","volume":"390","author":[{"given":"Brianna","family":"Dufek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Meehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duane","family":"Delimont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Samuelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Madison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiourui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flint","family":"Boettcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Trosky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Anne","family":"Gratton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Cosgrove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2020.107935_bib1","doi-asserted-by":"crossref","first-page":"e545","DOI":"10.1097\/MAO.0000000000001523","article-title":"Cochlear pericytes are capable of decreasing capillary diameter in\u00a0vivo after tumor necrosis factor exposure","volume":"38","author":"Bertlich","year":"2017","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.heares.2020.107935_bib2","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1101\/gad.10.23.2981","article-title":"Collagen 4A3 knockout: a mouse model for autosomal Alport Syndrome","volume":"10","author":"Cosgrove","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.heares.2020.107935_bib3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0378-5955(98)00069-0","article-title":"Ultrastructural, physiological, and molecular defects in the inner ear of a gene-knockout mouse model for autosomal Alport syndrome","volume":"121","author":"Cosgrove","year":"1998","journal-title":"Hear. Res."},{"issue":"6","key":"10.1016\/j.heares.2020.107935_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099083","article-title":"Laminin 211-mediated FAK activation triggers Alport glomerular pathogenesis","volume":"9","author":"Delimont","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.heares.2020.107935_bib5","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.cell.2005.09.021","article-title":"\u03b1-catenin is a molecular switch that binds E-cadherin-\u03b2-catenin and regulates actin filament assembly","volume":"123","author":"Drees","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.heares.2020.107935_bib7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.kint.2016.02.018","article-title":"Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease","volume":"90","author":"Dufek","year":"2016","journal-title":"Kidney Int."},{"key":"10.1016\/j.heares.2020.107935_bib8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0378-5955(98)00206-8","article-title":"Immunoreactivity of endothelins and endothelin receptor in the stria vascularis of the mouse cochlea","volume":"128","author":"Fujimura","year":"1999","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.107935_bib9","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1242\/jcs.089367","article-title":"Differential regulation of actin microfilaments by human MICAL proteins","volume":"125","author":"Giridharan","year":"2012","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.heares.2020.107935_bib10","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1002\/jcp.27545","article-title":"Isolation, cultivation, and characterization of primary bovine cochlear pericytes: a new in vito model of the stria vascularis","volume":"234","author":"Giurdanella","year":"2019","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.heares.2020.107935_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0378-5955(01)00358-6","article-title":"Strial marginal cells play a role in basement membrane homeostasis: in\u00a0vitro and in\u00a0vivo evidence","volume":"163","author":"Gratton","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.107935_bib12","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/S0002-9440(10)62363-2","article-title":"Matrix metalloproteinase dysregulation in the stria vascularis of Alport mice: implications for capillary basement membrane pathology","volume":"166","author":"Gratton","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.heares.2020.107935_bib14","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10162-018-0670-z","article-title":"Platelet-derived growth factor subunit B signaling promotes pericyte migration in response to loud sound in the cochlear stria vascularis","volume":"9","author":"Hou","year":"2018","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2020.107935_bib15","doi-asserted-by":"crossref","first-page":"109656","DOI":"10.1016\/j.ijporl.2019.109656","article-title":"Lipopolysaccharide disrupts the cochlear blood-labyrinth barrier by activating perivascular resident macrophages up-regulating MMP-9","volume":"127","author":"Jiang","year":"2019","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2020.107935_bib16","doi-asserted-by":"crossref","first-page":"6427","DOI":"10.1523\/JNEUROSCI.1335-04.2004","article-title":"The retinitis pigmentosa 1 protein is a photoreceptor microtubule-associated protein","volume":"24","author":"Liu","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2020.107935_bib18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.heares.2016.08.003","article-title":"Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial capillary basement membrane thickening in Alport mice","volume":"34","author":"Meehan","year":"2016","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.107935_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0378-5955(96)00010-X","article-title":"Localization of actin in basal cells of the stria vascularis","volume":"96","author":"Nakazawa","year":"1996","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.107935_bib20","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nprot.2013.033","article-title":"Isolation and culture of endothelial cells, pericytes, and perivascular resident macrophage-like melanocytes from the young mouse ear","volume":"8","author":"Neng","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.heares.2020.107935_bib21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.heares.2016.01.010","article-title":"Pathophysiology of the cochlear intrastrial fluid-blood barrier (review)","volume":"338","author":"Shi","year":"2016","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.107935_bib22","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.heares.2020.107935_bib23","first-page":"483","volume":"vol. 15","author":"Wu","year":"2005"},{"key":"10.1016\/j.heares.2020.107935_bib24","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.ajpath.2013.06.015","article-title":"\u03b11\u03b21 integrin\/Rac1-dependent mesangial invasion of glomerular capillaries in Alport syndrome","volume":"183","author":"Zallocchi","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.heares.2020.107935_bib25","article-title":"Lipopolysaccharide-induced middle ear inflammation disrupts cochlear intra-strial fluid-blood barrier through down regulation of tight junction poteins","volume":"10","author":"Zhang","year":"2015","journal-title":"PloS One"}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595519304812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595519304812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:00:03Z","timestamp":1778691603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595519304812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":22,"alternative-id":["S0378595519304812"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2020.107935","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pericyte abnormalities precede strial capillary basement membrane thickening in Alport mice","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2020.107935","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107935"}}