{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:33:06Z","timestamp":1784813586771,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T00:00:00Z","timestamp":1586217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014653","name":"Manchester Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.heares.2020.107960","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T21:32:10Z","timestamp":1587072730000},"page":"107960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["The ongoing search for cochlear synaptopathy in humans: Masked thresholds for brief tones in Threshold Equalizing Noise"],"prefix":"10.1016","volume":"392","author":[{"given":"Frederic","family":"Marmel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Cortese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Kluk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2020.107960_bib1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.heares.2019.02.016","article-title":"The search for noise-induced cochlear synaptopathy in humans: mission impossible?","volume":"377","author":"Bramhall","year":"2019","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.107960_bib2","series-title":"Pure-tone Air-Conduction and Bone-Conduction Threshold Audiometry with and without Masking","author":"British Society of Audiology","year":"2017"},{"issue":"1","key":"10.1016\/j.heares.2020.107960_bib3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3109\/14992027.2013.840931","article-title":"Psychoacoustic analyses of cochlear mechanisms in tinnitus patients with normal auditory thresholds","volume":"53","author":"Buzo","year":"2014","journal-title":"Int. J. Audiol."},{"key":"10.1016\/j.heares.2020.107960_bib4","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/biomet\/58.2.341","article-title":"An omnibus test of normality for moderate and large sample size","volume":"58","author":"D\u2019Agostino","year":"1971","journal-title":"Biometrika"},{"key":"10.1016\/j.heares.2020.107960_bib5","first-page":"613","article-title":"Testing for departures from normality. Empirical Results for the Distributions of b2 and \u221a b 1","volume":"60","author":"D\u2019Agostino","year":"1973","journal-title":"Biometrika"},{"issue":"1","key":"10.1016\/j.heares.2020.107960_bib6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1121\/1.396964","article-title":"Temporal integration in normal hearing, cochlear impairment, and impairment simulated by masking","volume":"84","author":"Florentine","year":"1988","journal-title":"J.\u00a0Acoust. Soc. Am."},{"key":"10.1016\/j.heares.2020.107960_bib7","first-page":"298","volume":"vol. 38","author":"Fulbright","year":"2017"},{"issue":"3","key":"10.1016\/j.heares.2020.107960_bib8","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1152\/jn.00164.2013","article-title":"Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates","volume":"110","author":"Furman","year":"2013","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.heares.2020.107960_bib9","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1121\/1.399726","article-title":"Auditory temporal integration and the power function model","volume":"88","author":"Gerken","year":"1990","journal-title":"J.\u00a0Acoust. Soc. Am."},{"issue":"1\u20132","key":"10.1016\/j.heares.2020.107960_bib10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0378-5955(90)90170-T","article-title":"Derivation of auditory filter shapes from notched-noise data","volume":"47","author":"Glasberg","year":"1990","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.107960_bib11","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3389\/fnins.2017.00465","article-title":"Hidden hearing loss? No effect of common recreational noise exposure on cochlear nerve response amplitude in humans","volume":"11","author":"Grinn","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.heares.2020.107960_bib12","first-page":"1","article-title":"Loud music exposure and cochlear synaptopathy in young adults: isolated auditory brainstem response effects but no perceptual consequences","volume":"21","author":"Grose","year":"2017","journal-title":"Trends Hear."},{"key":"10.1016\/j.heares.2020.107960_bib13","first-page":"1","article-title":"The noise exposure structured Interview (NESI): an instrument for the comprehensive estimation of lifetime noise exposure","volume":"22","author":"Guest","year":"2018","journal-title":"Trends Hear."},{"issue":"45","key":"10.1016\/j.heares.2020.107960_bib14","doi-asserted-by":"crossref","first-page":"14077","DOI":"10.1523\/JNEUROSCI.2845-09.2009","article-title":"Adding insult to injury: cochlear nerve degeneration after \"temporary\" noise-induced hearing loss","volume":"29","author":"Kujawa","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2020.107960_bib15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.heares.2015.02.009","article-title":"Synaptopathy in the noise-exposed and aging cochlea: primary neural degeneration in acquired sensorineural hearing loss","volume":"330","author":"Kujawa","year":"2015","journal-title":"Hear. Res."},{"issue":"2B","key":"10.1016\/j.heares.2020.107960_bib16","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1121\/1.1912375","article-title":"Transformed up-down methods in psychoacoustics","volume":"49","author":"Levitt","year":"1971","journal-title":"J.\u00a0Acoust. Soc. Am."},{"issue":"5","key":"10.1016\/j.heares.2020.107960_bib17","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s10162-011-0277-0","article-title":"Primary neural degeneration in the Guinea pig cochlea after reversible noise-induced threshold shift","volume":"12","author":"Lin","year":"2011","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2020.107960_bib18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.heares.2016.12.009","article-title":"Evidence of \u201chidden hearing loss\u201d following noise exposures that produce robust TTS and ABR wave-I amplitude reductions","volume":"349","author":"Lobarinas","year":"2017","journal-title":"Hear. Res."},{"issue":"348","key":"10.1016\/j.heares.2020.107960_bib19","first-page":"1","article-title":"Why do I hear but not understand? Stochastic undersampling as a model of degraded neural encoding of speech","volume":"8","author":"Lopez-Poveda","year":"2014","journal-title":"Front. Neurosci."},{"issue":"124","key":"10.1016\/j.heares.2020.107960_bib20","first-page":"1","article-title":"Perception of stochastically undersampled sound waveforms: a model of auditory deafferentation","volume":"7","author":"Lopez-Poveda","year":"2013","journal-title":"Front. Neurosci."},{"issue":"6","key":"10.1016\/j.heares.2020.107960_bib21","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10162-011-0283-2","article-title":"Age-related primary cochlear neuronal degeneration in human temporal bones","volume":"12","author":"Makary","year":"2011","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"issue":"63","key":"10.1016\/j.heares.2020.107960_bib22","article-title":"Stochastic undersampling steepens auditory threshold\/duration functions: implications for understanding auditory deafferentation and aging","volume":"7","author":"Marmel","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.heares.2020.107960_bib23","article-title":"A\u00a0computer model of the auditory periphery and its application to the study of hearing","volume":"vol. 787","author":"Meddis","year":"2013"},{"issue":"4","key":"10.1016\/j.heares.2020.107960_bib24","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/AUD.0b013e31824b9e43","article-title":"A\u00a0version of the TEN test for use with ER-3A insert earphones","volume":"33","author":"Moore","year":"2012","journal-title":"Ear Hear."},{"key":"10.1016\/j.heares.2020.107960_bib25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3109\/03005364000000131","article-title":"A\u00a0test for the diagnosis of dead regions in the cochlea","volume":"34","author":"Moore","year":"2000","journal-title":"Br. J. Audiol."},{"key":"10.1016\/j.heares.2020.107960_bib26","series-title":"Cochlear Hearing Loss: Physiological, Psychological and Technical Issues","first-page":"137","author":"Moore","year":"2007"},{"key":"10.1016\/j.heares.2020.107960_bib27","first-page":"1","article-title":"Perceptual consequences of \u201chidden\u201d hearing loss","volume":"18","author":"Plack","year":"2014","journal-title":"Trends Hear."},{"key":"10.1016\/j.heares.2020.107960_bib28","first-page":"1","article-title":"Toward a diagnostic test for hidden hearing loss","volume":"20","author":"Plack","year":"2016","journal-title":"Trends Hear."},{"key":"10.1016\/j.heares.2020.107960_bib29","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1121\/1.2769829","article-title":"Temporal integration and compression near absolute threshold in normal and impaired ears","volume":"122","author":"Plack","year":"2007","journal-title":"J.\u00a0Acoust. Soc. Am."},{"key":"10.1016\/j.heares.2020.107960_bib30","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.heares.2016.10.028","article-title":"Effects of noise exposure on young adults with normal audiograms I: Electrophysiology","volume":"344","author":"Prendergast","year":"2017","journal-title":"Hear. Res."},{"issue":"38","key":"10.1016\/j.heares.2020.107960_bib31","doi-asserted-by":"crossref","first-page":"13452","DOI":"10.1523\/JNEUROSCI.2156-11.2011","article-title":"Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model","volume":"31","author":"Schaette","year":"2011","journal-title":"J.\u00a0Neurosci."},{"issue":"34","key":"10.1016\/j.heares.2020.107960_bib32","doi-asserted-by":"crossref","first-page":"13686","DOI":"10.1523\/JNEUROSCI.1783-13.2013","article-title":"Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline","volume":"33","author":"Sergeyenko","year":"2013","journal-title":"J.\u00a0Neurosci."},{"issue":"6","key":"10.1016\/j.heares.2020.107960_bib33","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s10162-015-0539-3","article-title":"Towards a diagnosis of cochlear neuropathy with envelope following responses","volume":"16","author":"Shaheen","year":"2015","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2020.107960_bib34","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.heares.2018.06.003","article-title":"Effects of lifetime noise exposure on the middle-age human auditory brainstem response, tinnitus and speech-in-noise intelligibility","volume":"365","author":"Valderrama","year":"2018","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.107960_bib35","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.heares.2015.11.005","article-title":"The middle ear muscle reflex in the diagnosis of cochlear neuropathy","volume":"332","author":"Valero","year":"2016","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.107960_bib36","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.heares.2017.07.003","article-title":"Noise-induced cochlear synaptopathy in rhesus monkeys (Macaca mulatta)","volume":"353","author":"Valero","year":"2017","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.107960_bib37","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.heares.2018.03.012","article-title":"Effects of cochlear synaptopathy on middle-ear muscle reflexes in unanesthetized mice","volume":"363","author":"Valero","year":"2018","journal-title":"Hear. Res."},{"issue":"1","key":"10.1016\/j.heares.2020.107960_bib38","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/14992020601077992","article-title":"TEN(HL)-test results and psychophysical tuning curves for subjects with auditory neuropathy","volume":"46","author":"Vinay","year":"2007","journal-title":"Int. J. Audiol."},{"issue":"1\u20132","key":"10.1016\/j.heares.2020.107960_bib39","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.heares.2006.09.003","article-title":"High-frequency tinnitus without hearing loss does not mean absence of deafferentation","volume":"222","author":"Weisz","year":"2006","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.107960_bib40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.heares.2019.01.019","article-title":"Effects of selective auditory-nerve damage on the behavioral audiogram and temporal integration in the budgerigar","volume":"374","author":"Wong","year":"2019","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.107960_bib41","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.neuroscience.2018.07.053","article-title":"Primary neural degeneration in the human cochlea: evidence for hidden hearing loss in the aging ear","volume":"407","author":"Wu","year":"2019","journal-title":"Neuroscience"}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595519305295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595519305295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:53:13Z","timestamp":1759920793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595519305295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":41,"alternative-id":["S0378595519305295"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2020.107960","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The ongoing search for cochlear synaptopathy in humans: Masked thresholds for brief tones in Threshold Equalizing Noise","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2020.107960","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107960"}}