{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T01:01:24Z","timestamp":1768266084251,"version":"3.49.0"},"reference-count":104,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.heares.2020.108000","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T11:33:22Z","timestamp":1593430402000},"page":"108000","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Zika virus infection causes widespread damage to the inner ear"],"prefix":"10.1016","volume":"395","author":[{"given":"Kathleen T.","family":"Yee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biswas","family":"Neupane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengwei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas E.","family":"Vetter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2020.108000_bib1","article-title":"Characterization of lethal Zika virus infection in AG129 mice","volume":"10","author":"Aliota","year":"2016","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.heares.2020.108000_bib2","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.18632\/oncotarget.26861","article-title":"Expression profile and functional role of S100A14 in human cancer","volume":"10","author":"Basnet","year":"2019","journal-title":"Oncotarget"},{"key":"10.1016\/j.heares.2020.108000_bib3","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1021\/bi00355a011","article-title":"p-(Chloromercuri)benzenesulfonate binding by membrane proteins and the inhibition of water transport in human erythrocytes","volume":"25","author":"Benga","year":"1986","journal-title":"Biochemistry"},{"key":"10.1016\/j.heares.2020.108000_bib4","first-page":"252","article-title":"Water permeability in human erythrocytes: identification of membrane proteins involved in water transport","volume":"41","author":"Benga","year":"1986","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.heares.2020.108000_bib5","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES2014.19.13.20751","article-title":"Evidence of perinatal transmission of Zika virus, French polynesia, december 2013 and february 2014","volume":"19","author":"Besnard","year":"2014","journal-title":"Euro Surveill."},{"key":"10.1016\/j.heares.2020.108000_bib6","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1056\/NEJMoa1602412","article-title":"Zika virus infection in pregnant women in rio de Janeiro","volume":"375","author":"Brasil","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.heares.2020.108000_bib7","doi-asserted-by":"crossref","first-page":"981","DOI":"10.15585\/mmwr.mm6536e4","article-title":"Preliminary findings from an investigation of Zika virus infection in a patient with No known risk factors - Utah, 2016","volume":"65","author":"Brent","year":"2016","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.heares.2020.108000_bib8","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3201\/eid2006.140138","article-title":"Zika virus, French polynesia, South pacific, 2013","volume":"20","author":"Cao-Lormeau","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.heares.2020.108000_bib9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.heares.2015.11.010","article-title":"Partial corrosion casting to assess cochlear vasculature in mouse models of presbycusis and CMV infection","volume":"332","author":"Carraro","year":"2016","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108000_bib10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s10162-016-0606-4","article-title":"Cytomegalovirus (CMV) infection causes degeneration of cochlear vasculature and hearing loss in a mouse model","volume":"18","author":"Carraro","year":"2017","journal-title":"J\u00a0Assoc Res Otolaryngol"},{"key":"10.1016\/j.heares.2020.108000_bib11","doi-asserted-by":"crossref","first-page":"8325","DOI":"10.1038\/s41598-019-44582-9","article-title":"Zika virus associated pathology and antigen presence in the testicle in the absence of sexual transmission during subacute to chronic infection in a mouse model","volume":"9","author":"Clancy","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.heares.2020.108000_bib12","doi-asserted-by":"crossref","first-page":"6229","DOI":"10.1073\/pnas.0605108104","article-title":"Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis","volume":"104","author":"Cohen-Salmon","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heares.2020.108000_bib13","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1089\/mab.2017.0029","article-title":"Production of monoclonal antibody that recognizes Zika virus and other flaviviruses in serum-free conditions","volume":"36","author":"Conte","year":"2017","journal-title":"Monoclon. Antibodies Immunodiagn. Immunother."},{"key":"10.1016\/j.heares.2020.108000_bib14","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1177\/002215549704500601","article-title":"Immunohistochemical localization of the Na-K-Cl co-transporter (NKCC1) in the gerbil inner ear","volume":"45","author":"Crouch","year":"1997","journal-title":"J.\u00a0Histochem. Cytochem."},{"key":"10.1016\/j.heares.2020.108000_bib15","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.15585\/mmwr.mm6549e1","article-title":"Preliminary report of microcephaly potentially associated with Zika virus infection during pregnancy - Colombia, january-november 2016","volume":"65","author":"Cuevas","year":"2016","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.heares.2020.108000_bib16","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMc1604449","article-title":"Evidence of sexual transmission of Zika virus","volume":"374","author":"D\u2019Ortenzio","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.heares.2020.108000_bib17","first-page":"H234","article-title":"Aquaporin-1 and endothelial nitric oxide synthase expression in capillary endothelia of human peritoneum","volume":"275","author":"Devuyst","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.heares.2020.108000_bib18","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika virus. I. Isolations and serological specificity","volume":"46","author":"Dick","year":"1952","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.heares.2020.108000_bib19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/00129492-200407000-00010","article-title":"Spiral ligament and stria vascularis changes in cochlear otosclerosis: effect on hearing level","volume":"25","author":"Doherty","year":"2004","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.heares.2020.108000_bib20","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1357-2725(01)00046-2","article-title":"S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles","volume":"33","author":"Donato","year":"2001","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.heares.2020.108000_bib21","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1056\/NEJMoa0805715","article-title":"Zika virus outbreak on yap island, Federated States OF Micronesia","volume":"360","author":"Duffy","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.heares.2020.108000_bib22","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.mam.2012.06.004","article-title":"Water channel proteins in the inner ear and their link to hearing impairment and deafness","volume":"33","author":"Eckhard","year":"2012","journal-title":"Mol. Aspect. Med."},{"issue":"1985","key":"10.1016\/j.heares.2020.108000_bib23","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1152\/jappl.1997.83.3.1002","article-title":"Water transport and the distribution of aquaporin-1 in pulmonary air spaces","volume":"83","author":"Effros","year":"1997","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.heares.2020.108000_bib24","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1126\/science.aaf5036","article-title":"Zika virus in the Americas: early epidemiological and genetic findings","volume":"352","author":"Faria","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.heares.2020.108000_bib25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-5955(84)90108-4","article-title":"Gap junctions in the stria vascularis and effects of ethacrynic acid","volume":"13","author":"Forge","year":"1984","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108000_bib26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0378-5955(94)90176-7","article-title":"Immunohistochemical localization of S-100 protein in auditory and vestibular end organs of the mouse and hamster","volume":"74","author":"Foster","year":"1994","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108000_bib27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0196-0709(88)80019-X","article-title":"Experimental cytomegalovirus infection: viremic spread to the inner ear","volume":"9","author":"Fukuda","year":"1988","journal-title":"Am. J. Otolaryngol."},{"key":"10.1016\/j.heares.2020.108000_bib28","doi-asserted-by":"crossref","first-page":"7051","DOI":"10.1523\/JNEUROSCI.1640-04.2004","article-title":"Deafness in Claudin 11-null mice reveals the critical contribution of basal cell tight junctions to stria vascularis function","volume":"24","author":"Gow","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.heares.2020.108000_bib29","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.chom.2016.05.009","article-title":"Zika virus targets human STAT2 to inhibit type I interferon signaling","volume":"19","author":"Grant","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.heares.2020.108000_bib30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.brainres.2005.04.023","article-title":"Endothelial nitric oxide synthase upregulation in the Guinea pig organ of Corti after acute noise trauma","volume":"1047","author":"Heinrich","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2020.108000_bib31","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s101620010075","article-title":"Spiral ligament pathology: a major aspect of age-related cochlear degeneration in C57BL\/6 mice","volume":"2","author":"Hequembourg","year":"2001","journal-title":"J\u00a0Assoc Res Otolaryngol"},{"key":"10.1016\/j.heares.2020.108000_bib32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.15585\/mmwr.mm6508e2","article-title":"Transmission of Zika virus through sexual contact with travelers to areas of ongoing transmission - continental United States, 2016","volume":"65","author":"Hills","year":"2016","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.heares.2020.108000_bib33","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/cne.20619","article-title":"Mononuclear phagocytes migrate into the murine cochlea after acoustic trauma","volume":"489","author":"Hirose","year":"2005","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2020.108000_bib34","doi-asserted-by":"crossref","first-page":"40096","DOI":"10.1074\/jbc.M006993200","article-title":"Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation","volume":"275","author":"Huttunen","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.heares.2020.108000_bib35","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3109\/00016489109131371","article-title":"Immunohistochemical examination of S-100 protein and substance P in the inner ear of the rat","volume":"481","author":"Igarashi","year":"1991","journal-title":"Acta Otolaryngol Suppl"},{"key":"10.1016\/j.heares.2020.108000_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125160","article-title":"Immediate and delayed cochlear neuropathy after noise exposure in pubescent mice","volume":"10","author":"Jensen","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.heares.2020.108000_bib37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/00016488809125107","article-title":"Barrier systems in the inner ear","volume":"458","author":"Juhn","year":"1988","journal-title":"Acta Otolaryngol Suppl"},{"key":"10.1016\/j.heares.2020.108000_bib38","doi-asserted-by":"crossref","first-page":"9384","DOI":"10.1038\/s41598-018-27611-x","article-title":"Consequences of in utero exposure to Zika virus in offspring of AG129 mice","volume":"8","author":"Julander","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.heares.2020.108000_bib39","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0006-8993(01)02164-3","article-title":"Reactive nitrogen species contribute to blood-labyrinth barrier disruption in suppurative labyrinthitis complicating experimental pneumococcal meningitis in the rat","volume":"904","author":"Kastenbauer","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2020.108000_bib40","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3109\/00016488809107370","article-title":"Temporal sequence of viral antigen expression in the cochlea induced by cytomegalovirus","volume":"106","author":"Keithley","year":"1988","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2020.108000_bib41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00186783","article-title":"Gap junctions in the rat cochlea: immunohistochemical and ultrastructural analysis","volume":"191","author":"Kikuchi","year":"1995","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.heares.2020.108000_bib42","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1177\/000348946907800311","article-title":"Distribution, structure, and function of dark cells in the vestibular labyrinth","volume":"78","author":"Kimura","year":"1969","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2020.108000_bib43","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1242\/jcs.01393","article-title":"Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential","volume":"117","author":"Kitajiri","year":"2004","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.heares.2020.108000_bib44","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/cne.20929","article-title":"Contribution of bone marrow hematopoietic stem cells to adult mouse inner ear: mesenchymal cells and fibrocytes","volume":"496","author":"Lang","year":"2006","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2020.108000_bib45","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.chom.2016.03.010","article-title":"A\u00a0mouse model of Zika virus pathogenesis","volume":"19","author":"Lazear","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.heares.2020.108000_bib46","article-title":"Sensorineural hearing loss in a case of congenital Zika virus","author":"Leal","year":"2016","journal-title":"Braz J Otorhinolaryngol"},{"key":"10.1016\/j.heares.2020.108000_bib47","doi-asserted-by":"crossref","first-page":"917","DOI":"10.15585\/mmwr.mm6534e3","article-title":"Hearing loss in infants with microcephaly and evidence of congenital Zika virus infection - Brazil, november 2015-may 2016","volume":"65","author":"Leal","year":"2016","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.heares.2020.108000_bib48","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.ijporl.2014.03.013","article-title":"Observation of permeability of blood-labyrinth barrier during cytomegalovirus-induced hearing loss","volume":"78","author":"Li","year":"2014","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2020.108000_bib49","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.15585\/mmwr.mm6538e1","article-title":"Local mosquito-borne transmission of Zika virus - miami-dade and broward counties, Florida, june-august 2016","volume":"65","author":"Likos","year":"2016","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.heares.2020.108000_bib50","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1177\/000348945406300310","article-title":"Inner ear pathology due to measles","volume":"63","author":"Lindsay","year":"1954","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2020.108000_bib51","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1177\/000348946006900318","article-title":"Inner ear pathology in deafness due to mumps","volume":"69","author":"Lindsay","year":"1960","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2020.108000_bib52","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1080\/00016480801901774","article-title":"Expression of VEGF, iNOS, and eNOS is increased in cochlea of diabetic rat","volume":"128","author":"Liu","year":"2008","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2020.108000_bib53","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00441-007-0380-z","article-title":"Immunohistochemical localization of aquaporins in the human inner ear","volume":"328","author":"Lopez","year":"2007","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.heares.2020.108000_bib54","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/003591575204500308","article-title":"Recording of responses from individual end-organs of the vestibular apparatus","volume":"45","author":"Lowenstein","year":"1952","journal-title":"Proc. Roy. Soc. Med."},{"key":"10.1016\/j.heares.2020.108000_bib55","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1473-3099(16)00138-9","article-title":"Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen?","volume":"16","author":"Mansuy","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.heares.2020.108000_bib56","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/S0006-3495(94)80987-7","article-title":"Potassium secretion by vestibular dark cell epithelium demonstrated by vibrating probe","volume":"66","author":"Marcus","year":"1994","journal-title":"Biophys. J."},{"key":"10.1016\/j.heares.2020.108000_bib57","doi-asserted-by":"crossref","first-page":"C857","DOI":"10.1152\/ajpcell.1994.267.3.C857","article-title":"Slowly activating voltage-dependent K+ conductance is apical pathway for K+ secretion in vestibular dark cells","volume":"267","author":"Marcus","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.heares.2020.108000_bib58","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.bbrc.2004.07.096","article-title":"S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)","volume":"322","author":"Marenholz","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.heares.2020.108000_bib59","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/jnc.14574","article-title":"The S100B story: from biomarker to active factor in neural injury","volume":"148","author":"Michetti","year":"2019","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.heares.2020.108000_bib60","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1620\/tjem.196.247","article-title":"Comparative immunohistochemical localizations of aquaporin-1 and aquaporin-4 in the cochleae of three different species of rodents","volume":"196","author":"Miyabe","year":"2002","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.heares.2020.108000_bib61","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.chom.2016.06.011","article-title":"Interferon-induced spermidine-spermine acetyltransferase and polyamine depletion restrict Zika and chikungunya viruses","volume":"20","author":"Mounce","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.heares.2020.108000_bib62","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jcv.2015.04.021","article-title":"Detection of Zika virus in saliva","volume":"68","author":"Musso","year":"2015","journal-title":"J.\u00a0Clin. Virol. : the official publication of the Pan American Society for Clinical Virology"},{"key":"10.1016\/j.heares.2020.108000_bib63","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3201\/eid2102.141363","article-title":"Potential sexual transmission of Zika virus","volume":"21","author":"Musso","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.heares.2020.108000_bib64","doi-asserted-by":"crossref","first-page":"7275","DOI":"10.1073\/pnas.90.15.7275","article-title":"Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia","volume":"90","author":"Nielsen","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heares.2020.108000_bib65","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000158536","article-title":"Effects of fixative and embedding medium on morphology and immunostaining of the cochlea","volume":"14","author":"O\u2019Malley","year":"2009","journal-title":"Audiol. Neuro. Otol."},{"key":"10.1016\/j.heares.2020.108000_bib66","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/jnr.21625","article-title":"Bone marrow-derived cells expressing Iba1 are constitutively present as resident tissue macrophages in the mouse cochlea","volume":"86","author":"Okano","year":"2008","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.heares.2020.108000_bib67","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.bbalip.2012.08.011","article-title":"Advanced glycated albumin impairs HDL anti-inflammatory activity and primes macrophages for inflammatory response that reduces reverse cholesterol transport","volume":"1821","author":"Okuda","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.heares.2020.108000_bib68","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.heares.2020.108000_bib69","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1099\/vir.0.066084-0","article-title":"Delivery of antiviral small interfering RNA with gold nanoparticles inhibits dengue virus infection in\u00a0vitro","volume":"95","author":"Paul","year":"2014","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.heares.2020.108000_bib70","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1080\/000164801300366570","article-title":"Localization of nitric oxide synthase isoforms in the human cochlea","volume":"121","author":"Popa","year":"2001","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2020.108000_bib71","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1056\/NEJMsr1604338","article-title":"Zika virus and birth defects--reviewing the evidence for causality","volume":"374","author":"Rasmussen","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.heares.2020.108000_bib72","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.4269\/ajtmh.16-0111","article-title":"Characterization of a novel murine model to study Zika virus","volume":"94","author":"Rossi","year":"2016","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.heares.2020.108000_bib73","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/jemt.10303","article-title":"S100B in brain damage and neurodegeneration","volume":"60","author":"Rothermundt","year":"2003","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.heares.2020.108000_bib74","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0378-5955(98)00022-7","article-title":"Na-K-Cl cotransporter expression in the developing and senescent gerbil cochlea","volume":"118","author":"Sakaguchi","year":"1998","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108000_bib75","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/cne.21583","article-title":"Repopulation of cochlear macrophages in murine hematopoietic progenitor cell chimeras: the role of CX3CR1","volume":"506","author":"Sato","year":"2008","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.heares.2020.108000_bib76","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s13365-011-0024-7","article-title":"Cytomegalovirus-induced sensorineural hearing loss with persistent cochlear inflammation in neonatal mice","volume":"17","author":"Schachtele","year":"2011","journal-title":"J.\u00a0Neurovirol."},{"key":"10.1016\/j.heares.2020.108000_bib77","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.otohns.2007.03.044","article-title":"Macrophage inflammatory proteins in cytomegalovirus-related inner ear injury","volume":"137","author":"Schraff","year":"2007","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2020.108000_bib78","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0378-5955(94)90045-0","article-title":"Expression of alpha and beta subunit isoforms of Na,K-ATPase in the mouse inner ear and changes with mutations at the Wv or Sld loci","volume":"78","author":"Schulte","year":"1994","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108000_bib79","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/37.2.2536055","article-title":"Distribution of immunoreactive Na+,K+-ATPase in gerbil cochlea","volume":"37","author":"Schulte","year":"1989","journal-title":"J.\u00a0Histochem. Cytochem."},{"key":"10.1016\/j.heares.2020.108000_bib80","doi-asserted-by":"crossref","first-page":"615","DOI":"10.15585\/mmwr.mm6623e1","article-title":"Pregnancy outcomes after maternal Zika virus infection during pregnancy - U.S. Territories, january 1, 2016-april 25, 2017","volume":"66","author":"Shapiro-Mendoza","year":"2017","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.heares.2020.108000_bib81","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1288\/00005537-199207000-00002","article-title":"S-100 protein in human inner ear: use of a novel immunohistochemical technique on routinely processed, celloidin-embedded human temporal bone sections","volume":"102","author":"Shi","year":"1992","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2020.108000_bib82","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0378-5955(91)90153-Z","article-title":"Differentiation of inner ear fibrocytes according to their ion transport related activity","volume":"56","author":"Spicer","year":"1991","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108000_bib83","doi-asserted-by":"crossref","first-page":"C1450","DOI":"10.1152\/ajpcell.1995.269.6.C1450","article-title":"Immunolocalization of aquaporin CHIP in the Guinea pig inner ear","volume":"269","author":"Stankovic","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.heares.2020.108000_bib84","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.neuroscience.2008.03.060","article-title":"S100B is expressed in, and released from, OLN-93 oligodendrocytes: influence of serum and glucose deprivation","volume":"154","author":"Steiner","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2020.108000_bib85","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1080\/000164801300102716","article-title":"Direct evidence of nitric oxide production in the Guinea pig organ of Corti","volume":"121","author":"Takumida","year":"2001","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2020.108000_bib86","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1080\/000164801300366589","article-title":"Detection of nitric oxide in the Guinea pig inner ear, using a combination of aldehyde fixative and 4,5-diaminofluorescein diacetate","volume":"121","author":"Takumida","year":"2001","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2020.108000_bib87","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00019052-200202000-00003","article-title":"Nitric oxide in the inner ear","volume":"15","author":"Takumida","year":"2002","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.heares.2020.108000_bib88","first-page":"345","article-title":"Functional significance of nitric oxide in the inner ear","volume":"18","author":"Takumida","year":"2004","journal-title":"Vivo"},{"key":"10.1016\/j.heares.2020.108000_bib89","first-page":"807","article-title":"Localization of aquaporins 1, 2, and 3 and vasopressin type 2 receptor in the mouse inner ear","volume":"132","author":"Takumida","year":"2012","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2020.108000_bib90","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12974-018-1311-5","article-title":"ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells","volume":"15","author":"Tan","year":"2018","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.heares.2020.108000_bib91","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.heares.2006.09.004","article-title":"Immune cell recruitment following acoustic trauma","volume":"222","author":"Tornabene","year":"2006","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108000_bib92","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1602899","article-title":"Zika virus causes testicular atrophy","volume":"3","author":"Uraki","year":"2017","journal-title":"Sci Adv"},{"key":"10.1016\/j.heares.2020.108000_bib93","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/cid\/ciy616","article-title":"Congenital Zika syndrome and extra-central nervous system detection of Zika virus in a pre-term newborn in Mexico","volume":"68","author":"Valdespino-Vazquez","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.heares.2020.108000_bib94","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0896-6273(00)80255-X","article-title":"Inner ear defects induced by null mutation of the isk gene","volume":"17","author":"Vetter","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.heares.2020.108000_bib95","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/cid\/ciw770","article-title":"Transient hearing loss in adults associated with Zika virus infection","volume":"64","author":"Vinhaes","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.heares.2020.108000_bib96","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/169241a0","article-title":"Resting potentials inside the cochlear partition of the Guinea pig","volume":"169","author":"Von Bekesy","year":"1952","journal-title":"Nature"},{"key":"10.1016\/j.heares.2020.108000_bib97","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1158\/1078-0432.CCR-12-3725","article-title":"S100B promotes glioma growth through chemoattraction of myeloid-derived macrophages","volume":"19","author":"Wang","year":"2013","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.heares.2020.108000_bib98","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10162-012-0329-0","article-title":"Effects of repeated \"benign\" noise exposures in young CBA mice: shedding light on age-related hearing loss","volume":"13","author":"Wang","year":"2012","journal-title":"J\u00a0Assoc Res Otolaryngol"},{"key":"10.1016\/j.heares.2020.108000_bib99","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0006-8993(99)01996-4","article-title":"Expression of connexin 26 and Na,K-ATPase in the developing mouse cochlear lateral wall: functional implications","volume":"846","author":"Xia","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2020.108000_bib100","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0006-8993(01)02216-8","article-title":"Expression of connexin 30 in the developing mouse cochlea","volume":"898","author":"Xia","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2020.108000_bib101","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1097\/00001756-200008030-00022","article-title":"Expression of connexin 31 in the developing mouse cochlea","volume":"11","author":"Xia","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.heares.2020.108000_bib102","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/3845","article-title":"Mutations in the gene encoding gap junction protein beta-3 associated with autosomal dominant hearing impairment","volume":"20","author":"Xia","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.heares.2020.108000_bib103","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0378-5955(97)00041-5","article-title":"Nitric oxide synthase and contractile protein in the rat cochlear lateral wall: possible role of nitric oxide in regulation of strial blood flow","volume":"108","author":"Yamane","year":"1997","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108000_bib104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2015.05.081","article-title":"Activation of the antigen presentation function of mononuclear phagocyte populations associated with the basilar membrane of the cochlea after acoustic overstimulation","volume":"303","author":"Yang","year":"2015","journal-title":"Neuroscience"}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595520302719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595520302719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:53:41Z","timestamp":1759920821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595520302719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":104,"alternative-id":["S0378595520302719"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2020.108000","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zika virus infection causes widespread damage to the inner ear","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2020.108000","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108000"}}