{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:16:59Z","timestamp":1786702619724,"version":"build-2736575974"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.heares.2020.108125","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T20:56:10Z","timestamp":1606424170000},"page":"108125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Cochlear spiral ganglion neuron degeneration following cyclodextrin-induced hearing loss"],"prefix":"10.1016","volume":"400","author":[{"given":"Dalian","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9061-8602","authenticated-orcid":false,"given":"Richard","family":"Salvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2020.108125_bib0001","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0378-5955(03)00192-8","article-title":"Expression of prestin, a membrane motor protein, in the mammalian auditory and vestibular periphery","volume":"184","author":"Adler","year":"2003","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0002","doi-asserted-by":"crossref","first-page":"e50262","DOI":"10.1371\/journal.pone.0050262","article-title":"Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content","volume":"7","author":"Appelqvist","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.heares.2020.108125_bib0003","doi-asserted-by":"crossref","first-page":"9404","DOI":"10.1523\/JNEUROSCI.1317-11.2011","article-title":"Unesterified cholesterol accumulation in late endosomes\/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment","volume":"31","author":"Aqul","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2020.108125_bib0004","doi-asserted-by":"crossref","first-page":"13110","DOI":"10.1523\/JNEUROSCI.1014-14.2014","article-title":"Postnatal expression of neurotrophic factors accessible to spiral ganglion neurons in the auditory system of adult hearing and deafened rats","volume":"34","author":"Bailey","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2020.108125_bib0005","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pediatrneurol.2017.12.014","article-title":"Long-term treatment of Niemann-Pick type C1 disease with intrathecal 2-hydroxypropyl-beta-cyclodextrin","volume":"80","author":"Berry-Kravis","year":"2018","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.heares.2020.108125_bib0006","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF00453725","article-title":"Degeneration of cochlear neurons after amikacin intoxication in the rat","volume":"237","author":"Bichler","year":"1983","journal-title":"Arch. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2020.108125_bib0007","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1002\/jnr.24556","article-title":"Ultrastructural defects in stereocilia and tectorial membrane in aging mouse and human cochleae","volume":"98","author":"Bullen","year":"2019","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0008","first-page":"21","article-title":"Cyclodextrins as emerging therapeutic tools in the treatment of cholesterol-associated vascular and neurodegenerative diseases","author":"Coisne","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.heares.2020.108125_bib0009","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s10162-015-0528-6","article-title":"Hearing loss and otopathology following systemic and intracerebroventricular delivery of 2-hydroxypropyl-beta-cyclodextrin","volume":"16","author":"Cronin","year":"2015","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2020.108125_bib0010","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3389\/fncel.2017.00355","article-title":"Cyclodextrins and Iatrogenic hearing loss: new drugs with significant risk","volume":"11","author":"Crumling","year":"2017","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.heares.2020.108125_bib0011","doi-asserted-by":"crossref","first-page":"e53280","DOI":"10.1371\/journal.pone.0053280","article-title":"Hearing loss and hair cell death in mice given the cholesterol-chelating agent hydroxypropyl-beta-cyclodextrin","volume":"7","author":"Crumling","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.heares.2020.108125_bib0012","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/jn.1978.41.2.365","article-title":"Properties of auditory nerve responses in absence of outer hair cells","volume":"41","author":"Dallos","year":"1978","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.heares.2020.108125_bib0013","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1121\/1.381980","article-title":"Behavioral, compound action potential, and single unit thresholds: relationship in normal and abnormal ears","volume":"64","author":"Dallos","year":"1978","journal-title":"J. Acoust. Soc. Am."},{"key":"10.1016\/j.heares.2020.108125_bib0014","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nrd1576","article-title":"Cyclodextrin-based pharmaceutics: past, present and future","volume":"3","author":"Davis","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.heares.2020.108125_bib0015","first-page":"407","article-title":"Review of cellular changes in the cochlea due to aminoglycoside antibiotics","volume":"105","author":"Ding","year":"2005","journal-title":"Volta Rev."},{"key":"10.1016\/j.heares.2020.108125_bib0016","first-page":"657","article-title":"Surface preparation technique of the spiral ligament of the cochlea in guinea pig","volume":"7","author":"Ding","year":"1984","journal-title":"Shanghai Med. J."},{"key":"10.1016\/j.heares.2020.108125_bib0017","series-title":"The Auditory Psychobiology of the Mouse","first-page":"189","article-title":"Cochlear hair cell densities and inner ear staining techniques","author":"Ding","year":"2001"},{"key":"10.1016\/j.heares.2020.108125_bib0018","first-page":"326","article-title":"The silver nitrate staining technique for the inner ear end-organs of guinea pigs","volume":"9","author":"Ding","year":"1989","journal-title":"Acta Univ. Med. Sec. Shanghai"},{"key":"10.1016\/j.heares.2020.108125_bib0019","first-page":"65","article-title":"Early damage of spiral ganglion caused by carboplatin in chinchilla","volume":"6","author":"Ding","year":"1998","journal-title":"J. Audiol. Speech Pathol."},{"key":"10.1016\/j.heares.2020.108125_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2020.108073","article-title":"Hydroxypropyl-beta-cyclodextrin causes massive damage to the developing auditory and vestibular system","volume":"396","author":"Ding","year":"2020","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0021","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.joto.2018.08.002","article-title":"Cisplatin-induced vestibular hair cell lesion-less damage at high doses","volume":"13","author":"Ding","year":"2018","journal-title":"J. Otol."},{"key":"10.1016\/j.heares.2020.108125_bib0022","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.joto.2016.10.001","article-title":"Ototoxic effects and mechanisms of loop diuretics","volume":"11","author":"Ding","year":"2016","journal-title":"J. Otol."},{"key":"10.1016\/j.heares.2020.108125_bib0023","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1749-6632.1999.tb08640.x","article-title":"Selective loss of inner hair cells and type-I ganglion neurons in carboplatin-treated chinchillas. Mechanisms of damage and protection","volume":"884","author":"Ding","year":"1999","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.heares.2020.108125_bib0024","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1242\/jcs.79.1.181","article-title":"Cholesterol distribution in cells of the stria vascularis of the mammalian cochlea and some effects of ototoxic diuretics","volume":"79","author":"Forge","year":"1985","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.heares.2020.108125_bib0025","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0079-6123(03)46017-2","article-title":"Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance","volume":"146","author":"Fritzsch","year":"2004","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.heares.2020.108125_bib0026","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s12640-012-9320-0","article-title":"Ouabain-induced cochlear degeneration in rat","volume":"22","author":"Fu","year":"2012","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0027","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1749-6632.1999.tb08651.x","article-title":"Role of neurotrophins and lectins in prevention of ototoxicity","volume":"884","author":"Gao","year":"1999","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.heares.2020.108125_bib0028","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0378-5955(84)90004-2","article-title":"Surface morphology of the inner sulcus and related epithelial cells of the cochlea following acoustic trauma","volume":"16","author":"Hamernik","year":"1984","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0029","first-page":"53","article-title":"An experimental study on the promoting effect of pilocarpine on the secretory activity of inner ear","volume":"9","author":"Jin","year":"2001","journal-title":"Chin. J. Otolaryngol. Integr. Tradit. West. Med."},{"key":"10.1016\/j.heares.2020.108125_bib0030","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.heares.2010.05.002","article-title":"Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL\/6J mice","volume":"268","author":"Johnson","year":"2010","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0031","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/AUD.0b013e3182a362b8","article-title":"Auditory phenotype of Niemann-Pick disease, type C1","volume":"35","author":"King","year":"2014","journal-title":"Ear Hear."},{"key":"10.1016\/j.heares.2020.108125_bib0032","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3109\/10611861003622552","article-title":"Cyclodextrins for drug delivery","volume":"18","author":"Laza-Knoerr","year":"2010","journal-title":"J. Drug Target."},{"key":"10.1016\/j.heares.2020.108125_bib0033","doi-asserted-by":"crossref","first-page":"69","DOI":"10.7874\/jao.2018.00255","article-title":"ROS scavenger, Ebselen, has no preventive effect in new hearing loss model using a cholesterol-chelating agent","volume":"23","author":"Lee","year":"2019","journal-title":"J. Audiol. Otol."},{"key":"10.1016\/j.heares.2020.108125_bib0034","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175236","article-title":"Direct administration of 2-hydroxypropyl-beta-cyclodextrin into guinea pig cochleae: effects on physiological and histological measurements","volume":"12","author":"Lichtenhan","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.heares.2020.108125_bib0035","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s12640-020-00252-7","article-title":"2-hydroxypropyl-beta-cyclodextrin ototoxicity in adult rats: rapid onset and massive destruction of both inner and outer hair cells above a critical dose","volume":"38","author":"Liu","year":"2020","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0036","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ymgme.2015.07.001","article-title":"Intrathecal 2-hydroxypropyl-beta-cyclodextrin in a single patient with Niemann-Pick C1","volume":"116","author":"Maarup","year":"2015","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.heares.2020.108125_bib0037","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/jsfa.9269","article-title":"Effects of alpha-, beta- and maltosyl-beta-cyclodextrins use on the glucoraphanin-sulforaphane system of broccoli juice","volume":"99","author":"Martinez-Hernandez","year":"2019","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.heares.2020.108125_bib0038","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/10611869808997878","article-title":"Efficacy, safety and mechanism of cyclodextrins as absorption enhancers in nasal delivery of peptide and protein drugs","volume":"6","author":"Marttin","year":"1998","journal-title":"J. Drug Target."},{"key":"10.1016\/j.heares.2020.108125_bib0039","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.brainres.2003.10.031","article-title":"Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla","volume":"997","author":"McFadden","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2020.108125_bib0040","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/(SICI)1096-9861(19991011)413:1<101::AID-CNE7>3.0.CO;2-L","article-title":"Cu\/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129,CD-1 mice","volume":"413","author":"McFadden","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.heares.2020.108125_bib0041","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.2337\/db13-0399","article-title":"Cyclodextrin protects podocytes in diabetic kidney disease","volume":"62","author":"Merscher-Gomez","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.heares.2020.108125_bib0042","doi-asserted-by":"crossref","first-page":"9368","DOI":"10.1523\/JNEUROSCI.22-21-09368.2002","article-title":"Fibroblast growth factor signaling regulates pillar cell development in the organ of corti","volume":"22","author":"Mueller","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2020.108125_bib0043","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0378-5955(91)90041-7","article-title":"Frequency representation in the rat cochlea","volume":"51","author":"M\u00fcller","year":"1991","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0044","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jneumeth.2015.01.009","article-title":"Low-cost blast wave generator for studies of hearing loss and brain injury: blast wave effects in closed spaces","volume":"242","author":"Newman","year":"2015","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.heares.2020.108125_bib0045","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1021\/jo011096y","article-title":"Synthesis and NMR studies of (13)C-labeled vitamin D metabolites","volume":"67","author":"Okamura","year":"2002","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.heares.2020.108125_bib0046","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF00453752","article-title":"Hereditary deafness in the cat: an electron-microscopic study of the tectorial membrane","volume":"229","author":"Pedersen","year":"1980","journal-title":"Arch. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2020.108125_bib0047","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000046861","article-title":"Roles of fibroblast growth factors in the inner ear","volume":"7","author":"Pickles","year":"2002","journal-title":"Audiol. Neurootol."},{"key":"10.1016\/j.heares.2020.108125_bib0048","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10545-012-9583-x","article-title":"Cyclodextrin alleviates neuronal storage of cholesterol in Niemann-Pick C disease without evidence of detectable blood-brain barrier permeability","volume":"36","author":"Pontikis","year":"2013","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.heares.2020.108125_bib0049","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0378-5955(91)90136-W","article-title":"Pilocarpine elicits the interdental cell secretory activity of the inner ear","volume":"54","author":"Prieto","year":"1991","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0050","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1016\/j.msec.2013.04.012","article-title":"A way for improving the stability of the essential oils in an environmental friendly formulation","volume":"33","author":"Raileanu","year":"2013","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.heares.2020.108125_bib0051","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1203\/PDR.0b013e3181ee4dd2","article-title":"Weekly cyclodextrin administration normalizes cholesterol metabolism in nearly every organ of the Niemann-Pick type C1 mouse and markedly prolongs life","volume":"68","author":"Ramirez","year":"2010","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0052","doi-asserted-by":"crossref","first-page":"7262","DOI":"10.1166\/jnn.2010.2822","article-title":"Math1 gene transfer based on the delivery system of quaternized chitosan\/Na-carboxymethyl-beta-cyclodextrin nanoparticles","volume":"10","author":"Ren","year":"2010","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.heares.2020.108125_bib0053","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1177\/42.3.8308257","article-title":"Pilocarpine-induced changes in the saccharide composition of the tectorial membrane and interdental cells of the organ of Corti: a study with gold-labeled lectins","volume":"42","author":"Rubio","year":"1994","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.heares.2020.108125_bib0054","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nn1828","article-title":"Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane","volume":"10","author":"Russell","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.heares.2020.108125_bib0055","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/253044a0","article-title":"Effect of absence of cochlear outer hair cells on behavioural auditory threshold","volume":"253","author":"Ryan","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.heares.2020.108125_bib0056","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3109\/00016486809120951","article-title":"Lipoid materials in the cochlear duct of the guinea pig","volume":"65","author":"Savin-Vazquez","year":"1968","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2020.108125_bib0057","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(98)00006-9","article-title":"Evidence for a medial K+ recycling pathway from inner hair cells","volume":"118","author":"Spicer","year":"1998","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0058","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0378-5955(99)00118-5","article-title":"Ablation of inner hair cells by carboplatin alters cells in the medial K(+) flow route and disrupts tectorial membrane","volume":"136","author":"Spicer","year":"1999","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0059","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s004410000253","article-title":"Ultrastructural changes in the spiral limbus associated with carboplatin-induced ablation of inner hair cells","volume":"302","author":"Spicer","year":"2000","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.heares.2020.108125_bib0060","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/0192623307310945","article-title":"Cyclodextrins","volume":"36","author":"Stella","year":"2008","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.heares.2020.108125_bib0061","doi-asserted-by":"crossref","first-page":"21973","DOI":"10.1038\/srep21973","article-title":"Susceptibility of outer hair cells to cholesterol chelator 2-hydroxypropyl-beta-cyclodextrine is prestin-dependent","volume":"6","author":"Takahashi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.heares.2020.108125_bib0062","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/jgm.874","article-title":"Low molecular weight polyethylenimines linked by beta-cyclodextrin for gene transfer into the nervous system","volume":"8","author":"Tang","year":"2006","journal-title":"J. Gene Med."},{"key":"10.1016\/j.heares.2020.108125_bib0063","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1194\/jlr.M028241","article-title":"Cyclodextrin mediates rapid changes in lipid balance in Npc1-\/- mice without carrying cholesterol through the bloodstream","volume":"53","author":"Taylor","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.heares.2020.108125_bib0064","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0378-5173(99)00342-7","article-title":"Safety assessment of selected cyclodextrins - effect on ciliary activity using a human cell suspension culture model exhibiting in vitro ciliogenesis","volume":"193","author":"Uchenna Agu","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.heares.2020.108125_bib0065","first-page":"9","article-title":"Pharmacokinetic properties of fluorescently labelled hydroxypropyl-beta-cyclodextrin","author":"Varadi","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.heares.2020.108125_bib0066","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0378-5955(03)00176-X","article-title":"Carboplatin-induced early cochlear lesion in chinchillas","volume":"181","author":"Wang","year":"2003","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0067","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1203\/PDR.0b013e3181df4623","article-title":"2-hydroxypropyl-beta-cyclodextrin raises hearing threshold in normal cats and in cats with Niemann-Pick type C disease","volume":"68","author":"Ward","year":"2010","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0068","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/0378-5955(94)90281-X","article-title":"Expression of BDNF and NT-3 mRNA in hair cells of the organ of Corti: quantitative analysis in developing rats","volume":"73","author":"Wheeler","year":"1994","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0069","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1166\/jbn.2013.1684","article-title":"In vivo delivery of Atoh1 gene to rat cochlea using a dendrimer-based nanocarrier","volume":"9","author":"Wu","year":"2013","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.heares.2020.108125_bib0070","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0378-5955(93)90202-C","article-title":"Expression patterns of neurotrophin and their receptor mRNAs in the rat inner ear","volume":"65","author":"Ylikoski","year":"1993","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0071","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12640-010-9221-z","article-title":"Mefloquine damage vestibular hair cells in organotypic cultures","volume":"20","author":"Yu","year":"2011","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0072","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.heares.2018.03.014","article-title":"Paraquat initially damages cochlear support cells leading to anoikis-like hair cell death","volume":"364","author":"Zhang","year":"2018","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2020.108125_bib0073","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1523\/JNEUROSCI.6184-11.2012","article-title":"Large membrane domains in hair bundles specify spatially constricted radixin activation","volume":"32","author":"Zhao","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2020.108125_bib0074","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40478-018-0599-9","article-title":"The susceptibility of cochlear outer hair cells to cyclodextrin is not related to their electromotile activity","volume":"6","author":"Zhou","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.heares.2020.108125_bib0075","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aad6100","article-title":"Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming","volume":"8","author":"Zimmer","year":"2016","journal-title":"Sci. Transl. Med."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595520303968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595520303968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:55:42Z","timestamp":1759920942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595520303968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":75,"alternative-id":["S0378595520303968"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2020.108125","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cochlear spiral ganglion neuron degeneration following cyclodextrin-induced hearing loss","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2020.108125","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108125"}}