{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:16:56Z","timestamp":1793017016847,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004492","name":"National Youth Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771009"],"award-info":[{"award-number":["81771009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570917"],"award-info":[{"award-number":["81570917"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800910"],"award-info":[{"award-number":["81800910"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.heares.2020.108159","type":"journal-article","created":{"date-parts":[[2020,12,27]],"date-time":"2020-12-27T09:31:36Z","timestamp":1609061496000},"page":"108159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Whole-brain monosynaptic inputs and outputs of glutamatergic neurons of the vestibular nuclei complex in mice"],"prefix":"10.1016","volume":"401","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4608-0822","authenticated-orcid":false,"given":"Xunbei","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohua","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeka","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0251-5214","authenticated-orcid":false,"given":"Weimin","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhili","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2020.108159_bib0001","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0006-8993(01)02890-6","article-title":"Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections","volume":"916","author":"Abrahamson","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2020.108159_bib0002","doi-asserted-by":"crossref","first-page":"e8788","DOI":"10.1371\/journal.pone.0008788","article-title":"Brainstem circuitry regulating phasic activation of trigeminal motoneurons during REM sleep","volume":"5","author":"Anaclet","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2020.108159_bib0003","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.neuro.31.060407.125555","article-title":"Vestibular system: the many facets of a multimodal sense","volume":"31","author":"Angelaki","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.heares.2020.108159_bib0004","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0361-9230(03)00055-8","article-title":"Central vestibular system: vestibular nuclei and posterior cerebellum","volume":"60","author":"Barmack","year":"2003","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.heares.2020.108159_bib0005","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1523\/JNEUROSCI.3388-13.2014","article-title":"Acute suppressive and long-term phase modulation actions of orexin on the mammalian circadian clock","volume":"34","author":"Belle","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2020.108159_bib0006","first-page":"438","article-title":"The vestibular nuclei in cat","volume":"91","author":"Brodal","year":"1957","journal-title":"J. Anat."},{"key":"10.1016\/j.heares.2020.108159_bib0007","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.brainres.2008.08.093","article-title":"Excitatory pathways from the vestibular nuclei to the NTS and the PBN and indirect vestibulo-cardiovascular pathway from the vestibular nuclei to the RVLM relayed by the NTS","volume":"1240","author":"Cai","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2020.108159_bib0008","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3389\/fnins.2019.00375","article-title":"Whole-brain neural connectivity to lateral pontine tegmentum GABAergic neurons in mice","volume":"13","author":"Chen","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.heares.2020.108159_bib0009","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fneur.2015.00123","article-title":"REM sleep at its core \u2013 circuits, neurotransmitters, and pathophysiology","volume":"6","author":"Fraigne","year":"2015","journal-title":"Front. Neurol."},{"key":"10.1016\/j.heares.2020.108159_bib0010","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/0748730406288148","article-title":"Genetic evidence for a neurovestibular influence on the mammalian circadian pacemaker","volume":"21","author":"Fuller","year":"2006","journal-title":"J. Biol. Rhythms"},{"key":"10.1016\/j.heares.2020.108159_bib0011","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.neuroscience.2004.05.059","article-title":"Evidence for macular gravity receptor modulation of hypothalamic, limbic and autonomic nuclei","volume":"129","author":"Fuller","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2020.108159_bib0012","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1152\/jn.00082.2019","article-title":"Vestibular neurons with direct projections to the solitary nucleus in the rat","volume":"122","author":"Gagliuso","year":"2019","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.heares.2020.108159_bib0013","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/jnr.22206","article-title":"Identification of vestibuloocular projection neurons in the developing chicken medial vestibular nucleus","volume":"88","author":"Gottesman-Davis","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.heares.2020.108159_bib0014","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s12264-020-00468-9","article-title":"Whole-brain monosynaptic inputs to hypoglossal motor neurons in mice","volume":"36","author":"Guo","year":"2020","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.heares.2020.108159_bib0015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/cne.20521","article-title":"Medial vestibular connections with the hypocretin (orexin) system","volume":"487","author":"Horowitz","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.heares.2020.108159_bib0016","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3233\/NRE-130866","article-title":"Anatomy of the vestibular system: a review","volume":"32","author":"Khan","year":"2013","journal-title":"NeuroRehabilitation"},{"key":"10.1016\/j.heares.2020.108159_bib0017","article-title":"Relationship between sleep quality and dizziness","volume":"13","author":"Kim","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2020.108159_bib0018","doi-asserted-by":"crossref","first-page":"276","DOI":"10.5152\/iao.2017.3042","article-title":"Effects of selective seratonine re-uptake inhibitors on Meniere's disease","volume":"13","author":"Kiroglu","year":"2017","journal-title":"J. Int. Adv. Otol."},{"key":"10.1016\/j.heares.2020.108159_bib0019","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.cub.2018.12.007","article-title":"Rocking promotes sleep in mice through rhythmic stimulation of the vestibular system","volume":"29","author":"Kompotis","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.heares.2020.108159_bib0020","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1126\/science.1191776","article-title":"Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain","volume":"330","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.heares.2020.108159_bib0021","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3109\/00016489.2014.895039","article-title":"Effect of short-duration sleep deprivation on the vestibulo-ocular reflex system evaluated by ocular vestibular-evoked myogenic potential test","volume":"134","author":"Lin","year":"2014","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2020.108159_bib0022","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nature04767","article-title":"A putative flip-flop switch for control of REM sleep","volume":"441","author":"Lu","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.heares.2020.108159_bib0023","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/164_2017_84","article-title":"Neuroanatomical and neurochemical bases of vigilance states","volume":"253","author":"Luppi","year":"2019","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.heares.2020.108159_bib0024","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1152\/japplphysiol.00811.2014","article-title":"Vestibular loss disrupts daily rhythm in rats","volume":"118","author":"Martin","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.heares.2020.108159_bib0025","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.neuron.2015.07.002","article-title":"CRH engagement of the locus coeruleus noradrenergic system mediates stress-induced anxiety","volume":"87","author":"McCall","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.heares.2020.108159_bib0026","doi-asserted-by":"crossref","first-page":"17078","DOI":"10.1073\/pnas.252652299","article-title":"Evidence for vestibular regulation of autonomic functions in a mouse genetic model","volume":"99","author":"Murakami","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.heares.2020.108159_bib0027","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1007\/s00405-014-3294-x","article-title":"Vestibular evoked myogenic potential responses in obstructive sleep apnea syndrome","volume":"272","author":"Mutlu","year":"2015","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2020.108159_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3988\/jcn.2018.14.1.1","article-title":"Roles of the declive, folium, and tuber cerebellar vermian lobules in sportspeople","volume":"14","author":"Park","year":"2018","journal-title":"J. Clin. Neurol."},{"key":"10.1016\/j.heares.2020.108159_bib0029","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.cub.2018.12.028","article-title":"Whole-night continuous rocking entrains spontaneous neural oscillations with benefits for sleep and memory","volume":"29","author":"Perrault","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.heares.2020.108159_bib0030","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.neuron.2014.07.002","article-title":"A whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei","volume":"83","author":"Pollak Dorocic","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.heares.2020.108159_bib0031","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jpsychores.2016.11.013","article-title":"Psychological distress longitudinally mediates the effect of vertigo symptoms on vertigo-related handicap","volume":"93","author":"Probst","year":"2017","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.heares.2020.108159_bib0032","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1365-2869.2006.00550.x","article-title":"Total sleep deprivation can increase vestibulo-ocular responses","volume":"15","author":"Quarck","year":"2006","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.heares.2020.108159_bib0033","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature14600","article-title":"Viral-genetic tracing of the input-output organization of a central noradrenaline circuit","volume":"524","author":"Schwarz","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.heares.2020.108159_bib0034","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fneur.2016.00020","article-title":"Age-related neurochemical changes in the vestibular nuclei","volume":"7","author":"Smith","year":"2016","journal-title":"Front. Neurol."},{"key":"10.1016\/j.heares.2020.108159_bib0035","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/s41593-019-0429-9","article-title":"A whole-brain map of long-range inputs to GABAergic interneurons in the mouse medial prefrontal cortex","volume":"22","author":"Sun","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.heares.2020.108159_bib0036","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1152\/jn.00494.2004","article-title":"Membrane and firing properties of glutamatergic and GABAergic neurons in the rat medial vestibular nucleus","volume":"92","author":"Takazawa","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.heares.2020.108159_bib0037","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.celrep.2015.10.061","article-title":"Activity of raphe serotonergic neurons controls emotional behaviors","volume":"13","author":"Teissier","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.heares.2020.108159_bib0038","doi-asserted-by":"crossref","first-page":"zsz231","DOI":"10.1093\/sleep\/zsz231","article-title":"Selective activation of serotoninergic dorsal raphe neurons facilitates sleep through anxiolysis","volume":"43","author":"Venner","year":"2020","journal-title":"Sleep"},{"key":"10.1016\/j.heares.2020.108159_bib0039","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/j.1460-9568.2008.06074.x","article-title":"Neural correlates of arousal-induced circadian clock resetting: hypocretin\/orexin and the intergeniculate leaflet","volume":"27","author":"Webb","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.heares.2020.108159_bib0040","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nature14979","article-title":"Control of REM sleep by ventral medulla GABAergic neurons","volume":"526","author":"Weber","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.heares.2020.108159_bib0041","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nmeth999","article-title":"Retrograde neuronal tracing with a deletion-mutant rabies virus","volume":"4","author":"Wickersham","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1016\/j.heares.2020.108159_bib0042","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neuron.2007.01.033","article-title":"Monosynaptic restriction of transsynaptic tracing from single, genetically targeted neurons","volume":"53","author":"Wickersham","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.heares.2020.108159_bib0043","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.201800047","article-title":"High-throughput light sheet tomography platform for automated fast imaging of whole mouse brain","volume":"11","author":"Yang","year":"2018","journal-title":"J. Biophoton."},{"key":"10.1016\/j.heares.2020.108159_bib0044","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3389\/fnins.2018.00807","article-title":"Whole-brain monosynaptic afferent projections to the cholecystokinin neurons of the suprachiasmatic nucleus","volume":"12","author":"Yuan","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.heares.2020.108159_bib0045","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/MAO.0000000000001002","article-title":"Quantitative analysis of psychiatric disorders in intractable peripheral vertiginous patients: a prospective study","volume":"37","author":"Zhai","year":"2016","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.heares.2020.108159_bib0046","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuroscience.2010.11.013","article-title":"Expression of vesicular glutamate transporters in peripheral vestibular structures and vestibular nuclear complex of rat","volume":"173","author":"Zhang","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2020.108159_bib0047","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1749-6632.2009.04461.x","article-title":"Parallel ascending vestibular pathways: anatomical localization and functional specialization","volume":"1164","author":"Zwergal","year":"2009","journal-title":"Ann. N.Y. Acad. Sci."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595520304305?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595520304305?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:16:27Z","timestamp":1777569387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595520304305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":47,"alternative-id":["S0378595520304305"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2020.108159","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Whole-brain monosynaptic inputs and outputs of glutamatergic neurons of the vestibular nuclei complex in mice","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2020.108159","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108159"}}