{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:15Z","timestamp":1791229455620,"version":"4.1.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000055","name":"NIDCD","doi-asserted-by":"publisher","award":["R01DC014693"],"award-info":[{"award-number":["R01DC014693"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.heares.2022.108441","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T02:10:25Z","timestamp":1642212625000},"page":"108441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Time- and frequency-dependent changes in acoustic startle reflex amplitude following cyclodextrin-induced outer and inner cell loss"],"prefix":"10.1016","volume":"415","author":[{"given":"Celia","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalian","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Hua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senthilvelan","family":"Manohar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Salvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2022.108441_bib0001","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuroscience.2015.07.004","article-title":"Effects of acoustic trauma on the auditory system of the rat: The role of microglia","volume":"303","author":"Baizer","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2022.108441_bib0002","doi-asserted-by":"crossref","first-page":"e12324","DOI":"10.1111\/cob.12324","article-title":"Effects of alpha-cyclodextrin on cholesterol control and Compound K on glycaemic control in people with pre-diabetes: Protocol for a Phase III randomized controlled trial","volume":"9","author":"Bessell","year":"2019","journal-title":"Clin Obes"},{"key":"10.1016\/j.heares.2022.108441_bib0003","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.heares.2016.11.009","article-title":"Time course of organ of Corti degeneration after noise exposure","volume":"344","author":"Bohne","year":"2017","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0004","doi-asserted-by":"crossref","first-page":"E116","DOI":"10.1002\/lary.24394","article-title":"Round window closure affects cochlear responses to suprathreshold stimuli","volume":"123","author":"Cai","year":"2013","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2022.108441_bib0005","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10162-013-0375-2","article-title":"Behavioral evidence for possible simultaneous induction of hyperacusis and tinnitus following intense sound exposure","volume":"14","author":"Chen","year":"2013","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108441_bib0006","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.heares.2010.02.010","article-title":"Too much of a good thing: long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity","volume":"265","author":"Chen","year":"2010","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0007","doi-asserted-by":"crossref","first-page":"e06576","DOI":"10.7554\/eLife.06576","article-title":"Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network","volume":"4","author":"Chen","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.heares.2022.108441_bib0008","article-title":"Elevated cellular cholesterol in Familial Alzheimer\u2019s presenilin 1 mutation is associated with lipid raft localization of beta-amyloid precursor protein","volume":"14","author":"Cho","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2022.108441_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21121748","article-title":"Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases","volume":"21","author":"Coisne","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.heares.2022.108441_bib0010","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s10162-015-0528-6","article-title":"Hearing Loss and Otopathology Following Systemic and Intracerebroventricular Delivery of 2-Hydroxypropyl-Beta-Cyclodextrin","volume":"16","author":"Cronin","year":"2015","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108441_bib0011","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3389\/fncel.2017.00355","article-title":"Cyclodextrins and Iatrogenic Hearing Loss: New Drugs with Significant Risk","volume":"11","author":"Crumling","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.heares.2022.108441_bib0012","doi-asserted-by":"crossref","first-page":"e53280","DOI":"10.1371\/journal.pone.0053280","article-title":"Hearing loss and hair cell death in mice given the cholesterol-chelating agent hydroxypropyl-beta-cyclodextrin","volume":"7","author":"Crumling","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2022.108441_bib0013","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1523\/JNEUROSCI.02-06-00791.1982","article-title":"A primary acoustic startle circuit: lesion and stimulation studies","volume":"2","author":"Davis","year":"1982","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2022.108441_bib0014","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nrd1576","article-title":"Cyclodextrin-based pharmaceutics: past, present and future","volume":"3","author":"Davis","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.heares.2022.108441_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2020.108125","article-title":"Cochlear spiral ganglion neuron degeneration following cyclodextrin-induced hearing loss","volume":"400","author":"Ding","year":"2021","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.643709","article-title":"Spatiotemporal Developmental Upregulation of Prestin Correlates With the Severity and Location of Cyclodextrin-Induced Outer Hair Cell Loss and Hearing Loss","volume":"9","author":"Ding","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.heares.2022.108441_bib0017","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.heares.2016.05.001","article-title":"Long-term treatment with aldosterone slows the progression of age-related hearing loss","volume":"336","author":"Halonen","year":"2016","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0018","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/00206098009070071","article-title":"Genotypic differences in behavioral, physiological and anatomical expressions of age-related hearing loss in the laboratory mouse","volume":"19","author":"Henry","year":"1980","journal-title":"Audiology"},{"key":"10.1016\/j.heares.2022.108441_bib0019","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10162-002-3046-2","article-title":"Low-frequency tone pips elicit exaggerated startle reflexes in C57BL\/6\u00a0J mice with hearing loss","volume":"4","author":"Ison","year":"2003","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108441_bib0020","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10162-007-0098-3","article-title":"Age-related hearing loss in C57BL\/6\u00a0J mice has both frequency-specific and non-frequency-specific components that produce a hyperacusis-like exaggeration of the acoustic startle reflex","volume":"8","author":"Ison","year":"2007","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108441_bib0021","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s10162-016-0610-8","article-title":"Deleting the HCN1 Subunit of Hyperpolarization-Activated Ion Channels in Mice Impairs Acoustic Startle Reflexes, Gap Detection, and Spatial Localization","volume":"18","author":"Ison","year":"2017","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108441_bib0022","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1037\/0735-7044.105.1.33","article-title":"Temporal resolution of gaps in noise by the rat is lost with functional decortication","volume":"105","author":"Ison","year":"1991","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.heares.2022.108441_bib0023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125160","article-title":"Immediate and delayed cochlear neuropathy after noise exposure in pubescent mice","volume":"10","author":"Jensen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2022.108441_bib0024","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2019.12.021","article-title":"Cyclodextrin polymer improves atherosclerosis therapy and reduces ototoxicity","volume":"319","author":"Kim","year":"2020","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.heares.2022.108441_bib0025","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0378-5955(96)00173-6","article-title":"Degeneration of axons in the brainstem of the chinchilla after auditory overstimulation","volume":"103","author":"Kim","year":"1997","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0026","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/AUD.0b013e3182a362b8","article-title":"Auditory phenotype of Niemann-Pick disease, type C1","volume":"35","author":"King","year":"2014","journal-title":"Ear Hear."},{"key":"10.1016\/j.heares.2022.108441_bib0027","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0166-4328(97)02296-1","article-title":"The acoustic startle response in rats\u2013circuits mediating evocation, inhibition and potentiation","volume":"89","author":"Koch","year":"1997","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.heares.2022.108441_bib0028","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/00062752-200001000-00009","article-title":"Niemann-Pick disease","volume":"7","author":"Kolodny","year":"2000","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.heares.2022.108441_bib0029","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/cercor\/12.8.797","article-title":"Hearing after congenital deafness: central auditory plasticity and sensory deprivation","volume":"12","author":"Kral","year":"2002","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.heares.2022.108441_bib0030","first-page":"222","article-title":"Silybin-beta-cyclodextrin in the treatment of patients with diabetes mellitus and alcoholic liver disease. Efficacy study of a new preparation of an anti-oxidant agent","volume":"15","author":"Lirussi","year":"2002","journal-title":"Nutrition & Metabolism"},{"key":"10.1016\/j.heares.2022.108441_bib0031","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1194\/jlr.M000257","article-title":"Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid","volume":"51","author":"Liu","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.heares.2022.108441_bib0032","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s12640-020-00252-7","article-title":"2-Hydroxypropyl-beta-cyclodextrin Ototoxicity in Adult Rats: Rapid Onset and Massive Destruction of Both Inner and Outer Hair Cells Above a Critical Dose","volume":"38","author":"Liu","year":"2020","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0033","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.heares.2012.06.001","article-title":"The gap-startle paradigm for tinnitus screening in animal models: limitations and optimization","volume":"295","author":"Lobarinas","year":"2013","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0034","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-5955(04)00019-X","article-title":"A novel behavioral paradigm for assessing tinnitus using schedule-induced polydipsia avoidance conditioning (SIP-AC)","volume":"190","author":"Lobarinas","year":"2004","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0035","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s10162-014-0500-x","article-title":"Partial to complete suppression of unilateral noise-induced tinnitus in rats after cyclobenzaprine treatment","volume":"16","author":"Lobarinas","year":"2015","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108441_bib0036","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1111\/j.2042-7158.2010.01030.x","article-title":"Pharmaceutical applications of cyclodextrins: basic science and product development","volume":"62","author":"Loftsson","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.heares.2022.108441_bib0037","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10162-011-0276-1","article-title":"Development of tinnitus in CBA\/CaJ mice following sound exposure","volume":"12","author":"Longenecker","year":"2011","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108441_bib0038","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neuroscience.2011.04.073","article-title":"GABAergic neural activity involved in salicylate-induced auditory cortex gain enhancement","volume":"189","author":"Lu","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2022.108441_bib0039","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ymgme.2015.07.001","article-title":"Intrathecal 2-hydroxypropyl-beta-cyclodextrin in a single patient with Niemann-Pick C1","volume":"116","author":"Maarup","year":"2015","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.heares.2022.108441_bib0040","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neuroscience.2018.12.023","article-title":"Synaptic Reorganization Response in the Cochlear Nucleus Following Intense Noise Exposure","volume":"399","author":"Manohar","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2022.108441_bib0041","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mcn.2016.07.005","article-title":"Noise-induced hearing loss: Neuropathic pain via Ntrk1 signaling","volume":"75","author":"Manohar","year":"2016","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.heares.2022.108441_bib0042","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/10611869808997878","article-title":"Efficacy, safety and mechanism of cyclodextrins as absorption enhancers in nasal delivery of peptide and protein drugs","volume":"6","author":"Marttin","year":"1998","journal-title":"J. Drug Targeting"},{"key":"10.1016\/j.heares.2022.108441_bib0043","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0378-5955(91)90041-7","article-title":"Frequency representation in the rat cochlea","volume":"51","author":"Muller","year":"1991","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0044","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jbior.2018.08.001","article-title":"Niemann-Pick type C disease: The atypical sphingolipidosis","volume":"70","author":"Newton","year":"2018","journal-title":"Adv Biol Regul"},{"key":"10.1016\/j.heares.2022.108441_bib0045","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1126\/science.628846","article-title":"Frequency discrimination following the selective destruction of cochlear inner and outer hair cells","volume":"199","author":"Nienhuys","year":"1978","journal-title":"Science"},{"key":"10.1016\/j.heares.2022.108441_bib0046","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1388-1981(00)00158-X","article-title":"Niemann-Pick type C: a disorder of cellular cholesterol trafficking","volume":"1529","author":"Ory","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.heares.2022.108441_bib0047","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2174\/138955710791572479","article-title":"Cyclodextrins: more than pharmaceutical excipients","volume":"10","author":"Otero-Espinar","year":"2010","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.heares.2022.108441_bib0048","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/cercor\/bhi081","article-title":"Dynamics of auditory plasticity after cochlear implantation: a longitudinal study","volume":"16","author":"Pantev","year":"2006","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.heares.2022.108441_bib0049","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1126\/science.7233219","article-title":"Auditory intensity discrimination following selective loss of cochlear outer hair cells","volume":"212","author":"Prosen","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.heares.2022.108441_bib0050","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.heares.2017.04.004","article-title":"Salicylate-induced hyperacusis in rats: Dose- and frequency-dependent effects","volume":"350","author":"Radziwon","year":"2017","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0051","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1203\/PDR.0b013e3181ee4dd2","article-title":"Weekly cyclodextrin administration normalizes cholesterol metabolism in nearly every organ of the Niemann-Pick type C1 mouse and markedly prolongs life","volume":"68","author":"Ramirez","year":"2010","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0052","doi-asserted-by":"crossref","first-page":"7262","DOI":"10.1166\/jnn.2010.2822","article-title":"Math1 gene transfer based on the delivery system of quaternized chitosan\/Na-carboxymethyl-beta-cyclodextrin nanoparticles","volume":"10","author":"Ren","year":"2010","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.heares.2022.108441_bib0053","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/253044a0","article-title":"Effect of absence of cochlear outer hair cells on behavioural auditory threshold","volume":"253","author":"Ryan","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.heares.2022.108441_bib0054","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111747","article-title":"Induction of enhanced acoustic startle response by noise exposure: dependence on exposure conditions and testing parameters and possible relevance to hyperacusis","volume":"9","author":"Salloum","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2022.108441_bib0055","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0378-5955(00)00136-2","article-title":"Auditory plasticity and hyperactivity following cochlear damage","volume":"147","author":"Salvi","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0056","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/0192623307310945","volume":"36","author":"Stella","year":"2008","journal-title":"Cyclodextrins. Toxicologic Pathology"},{"key":"10.1016\/j.heares.2022.108441_bib0057","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fnbeh.2016.00133","article-title":"Dependence of the Startle Response on Temporal and Spectral Characteristics of Acoustic Modulatory Influences in Rats and Gerbils","volume":"10","author":"Steube","year":"2016","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.heares.2022.108441_bib0058","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2012.02.008","article-title":"Noise exposure enhances auditory cortex responses related to hyperacusis behavior","volume":"1485","author":"Sun","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2022.108441_bib0059","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.neuroscience.2008.12.024","article-title":"Salicylate increases the gain of the central auditory system","volume":"159","author":"Sun","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2022.108441_bib0060","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.heares.2011.08.004","article-title":"Early age conductive hearing loss causes audiogenic seizure and hyperacusis behavior","volume":"282","author":"Sun","year":"2011","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0061","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/jgm.874","article-title":"Low molecular weight polyethylenimines linked by beta-cyclodextrin for gene transfer into the nervous system","volume":"8","author":"Tang","year":"2006","journal-title":"Journal of Gene Medicine"},{"key":"10.1016\/j.heares.2022.108441_bib0062","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1194\/jlr.M028241","article-title":"Cyclodextrin mediates rapid changes in lipid balance in Npc1-\/- mice without carrying cholesterol through the bloodstream","volume":"53","author":"Taylor","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.heares.2022.108441_bib0063","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.heares.2015.11.004","article-title":"Effects of noise exposure on development of tinnitus and hyperacusis: Prevalence rates 12 months after exposure in middle-aged rats","volume":"334","author":"Turner","year":"2016","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0064","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0378-5173(99)00342-7","article-title":"Safety assessment of selected cyclodextrins - effect on ciliary activity using a human cell suspension culture model exhibiting in vitro ciliogenesis","volume":"193","author":"Uchenna Agu","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.heares.2022.108441_bib0065","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1152\/jn.1996.75.1.171","article-title":"Plasticity of response properties of inferior colliculus neurons following acute cochlear damage","volume":"75","author":"Wang","year":"1996","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.heares.2022.108441_bib0066","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1203\/PDR.0b013e3181df4623","article-title":"2-hydroxypropyl-beta-cyclodextrin raises hearing threshold in normal cats and in cats with Niemann-Pick type C disease","volume":"68","author":"Ward","year":"2010","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0067","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0006-8993(84)91022-9","article-title":"Changes in frequency representation in the auditory system of mice with age-related hearing impairment","volume":"309","author":"Willott","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2022.108441_bib0068","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1037\/0735-7044.109.3.396","article-title":"Modification of the acoustic startle response in hearing-impaired C57BL\/6\u00a0J mice: prepulse augmentation and prolongation of prepulse inhibition","volume":"109","author":"Willott","year":"1995","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.heares.2022.108441_bib0069","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0378-5955(00)00137-4","article-title":"Neural plasticity in the mouse inferior colliculus: relationship to hearing loss, augmented acoustic stimulation, and prepulse inhibition","volume":"147","author":"Willott","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0070","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0378-5955(00)00014-9","article-title":"Effects of exposure to an augmented acoustic environment on auditory function in mice: roles of hearing loss and age during treatment","volume":"142","author":"Willott","year":"2000","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0071","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1166\/jbn.2013.1684","article-title":"In vivo delivery of Atoh1 gene to rat cochlea using a dendrimer-based nanocarrier","volume":"9","author":"Wu","year":"2013","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.heares.2022.108441_bib0072","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.heares.2017.03.011","article-title":"Hyperexcitability of inferior colliculus and acoustic startle reflex with age-related hearing loss","volume":"350","author":"Xiong","year":"2017","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108441_bib0073","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8169847","article-title":"Functional Change in the Caudal Pontine Reticular Nucleus Induced by Age-Related Hearing Loss","volume":"2018","author":"Zhao","year":"2018","journal-title":"Neural Plast."},{"key":"10.1016\/j.heares.2022.108441_bib0074","doi-asserted-by":"crossref","first-page":"333ra50","DOI":"10.1126\/scitranslmed.aad6100","article-title":"Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming","volume":"8","author":"Zimmer","year":"2016","journal-title":"Sci. Transl. Med."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595522000120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595522000120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:59:27Z","timestamp":1759921167000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595522000120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":74,"alternative-id":["S0378595522000120"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2022.108441","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Time- and frequency-dependent changes in acoustic startle reflex amplitude following cyclodextrin-induced outer and inner cell loss","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2022.108441","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108441"}}