{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:01:47Z","timestamp":1794016907074,"version":"4.8.0"},"reference-count":146,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.heares.2022.108518","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T13:18:03Z","timestamp":1652275083000},"page":"108518","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Inner ear immunity"],"prefix":"10.1016","volume":"419","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7710-5052","authenticated-orcid":false,"given":"Elizabeth M.","family":"Keithley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2022.108518_bib0001","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.neuroscience.2009.02.073","article-title":"Selective activation of nuclear factor kappa B in the cochlea by sensory and inflammatory stress","volume":"160","author":"Adams","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2022.108518_bib0002","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000276124","article-title":"Human endolymphatic sac: evidence for a role in inner ear immune defence","volume":"52","author":"Altermatt","year":"1990","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"key":"10.1016\/j.heares.2022.108518_bib0003","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/00016489.1992.11665422","article-title":"Immunohistochemical characterization of the human endolymphatic sac and its associated cell populations","volume":"112","author":"Altermatt","year":"1992","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0004","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s10162-014-0480-x","article-title":"How to bury the dead: elimination of apoptotic hair cells from the hearing organ of the mouse","volume":"15","author":"Anttonen","year":"2014","journal-title":"Assoc. Res. Otolaryngol"},{"key":"10.1016\/j.heares.2022.108518_bib0005","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1159\/000275725","article-title":"Secretory immunoglobulin A in the human endolymphatic sac. An immunohistochemical study","volume":"46","author":"Arnold","year":"1984","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"key":"10.1016\/j.heares.2022.108518_bib0006","first-page":"1","article-title":"The vascular anatomy of the cochlea in the guinea pig and in man","volume":"243","author":"Axelsson","year":"1968","journal-title":"Acta-Oto-Laryngologica. Suppl"},{"key":"10.1016\/j.heares.2022.108518_bib0007","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0165-5876(00)00403-1","article-title":"The pathology of the temporal bones of a child with acquired cytomegalovirus infection: studies by light microscopy, immunohistochemistry and polymerase-chain reaction","volume":"55","author":"Bachor","year":"2000","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0008","doi-asserted-by":"crossref","first-page":"179","DOI":"10.21053\/ceo.2020.00395","article-title":"Three-dimensional distribution of cochlear macrophages in the lateral wall of cleared cochlea","volume":"14","author":"Bae","year":"2021","journal-title":"Clin. Exp. Otorhinolaryngol"},{"key":"10.1016\/j.heares.2022.108518_bib0009","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.7150\/thno.49121","article-title":"Neutrophils infiltrate into the spiral ligament but not the stria vascularis in the cochlea during lipopolysaccharide-induced inflammation","volume":"11","author":"Bae","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.heares.2022.108518_bib0010","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1002\/ccr3.4019","article-title":"Sudden sensorineural hearing loss in COVID-19: a case report and literature review","volume":"9","author":"Beckers","year":"2021","journal-title":"Clin. Case Rep"},{"key":"10.1016\/j.heares.2022.108518_bib0011","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004774","article-title":"Murine CMV-induced hearing loss is associated with inner ear inflammation and loss of spiral ganglia neurons","volume":"11","author":"Bradford","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heares.2022.108518_bib0012","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1172\/JCI128867","article-title":"Exosomes mediate sensory hair cell protection in the inner ear","volume":"130","author":"Breglio","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.heares.2022.108518_bib0013","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3389\/fnmol.2017.00407","article-title":"Macrophage-mediated glial cell elimination in the postnatal mouse cochlea","volume":"10","author":"Brown","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.heares.2022.108518_bib0014","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.heares.2018.10.007","article-title":"Response of the inner ear to lipopolysaccharide introduced directly into scala media","volume":"370","author":"Brown","year":"2018","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0015","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1288\/00005537-198908000-00001","article-title":"An immunohistochemical study of the endolymphatic sac in patients with acoustic tumors","volume":"99","author":"Bui","year":"1989","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2022.108518_bib0016","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s12974-014-0173-8","article-title":"Molecular profile of cochlear immunity in the resident cells of the organ of Corti","volume":"11","author":"Cai","year":"2014","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.heares.2022.108518_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.816439","article-title":"Microglia and microglia-like cells: similar but different","volume":"16","author":"Cuadros","year":"2022","journal-title":"Front. Cell Neurosci"},{"key":"10.1016\/j.heares.2022.108518_bib0018","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/00016489950181666","article-title":"In vivo study of the electrochemical composition of luminal fluid in the guinea pig endolymphatic sac","volume":"119","author":"Couloigner","year":"1999","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0019","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1177\/000348949009901206","article-title":"Effects of cyclophosphamide on the pathogenesis of cytomegalovirus-induced labyrinthitis","volume":"99","author":"Darmstadt","year":"1990","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0020","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1288\/00005537-199206000-00015","article-title":"Effects of bacterial endotoxin applied to the guinea pig cochlea","volume":"102","author":"Darrow","year":"1992","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2022.108518_bib0021","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/imm.12451","article-title":"Tissue-resident macrophages: then and now","volume":"144","author":"Davies","year":"2015","journal-title":"Immunology"},{"key":"10.1016\/j.heares.2022.108518_bib0022","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1080\/00016489.2017.1293292","article-title":"Herpes simplex virus-1 and cytomegalovirus DNAs detection in the inner ear of implanted patients with non-congenital infection","volume":"137","author":"Di Nardo","year":"2017","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0023","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.heares.2018.05.010","article-title":"Differential fates of tissue macrophages in the cochlea during postnatal development","volume":"365","author":"Dong","year":"2018","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0024","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.heares.2016.11.003","article-title":"Dynamic activation of basilar membrane macrophages in response to chronic sensory cell degeneration in aging mouse cochleae","volume":"344","author":"Frye","year":"2017","journal-title":"Hear. Res"},{"key":"10.1016\/j.heares.2022.108518_bib0025","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jneuroim.2018.06.019","article-title":"Lower level noise exposure that produces only TTS modulates the immune homeostasis of cochlear macrophages","volume":"323","author":"Frye","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.heares.2022.108518_bib0026","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1121\/1.5132545","article-title":"Inflammation associated with noise-induced hearing loss","volume":"146","author":"Frye","year":"2019","journal-title":"J. Acoust. Soc. Am."},{"key":"10.1016\/j.heares.2022.108518_bib0027","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/jnr.20764","article-title":"Proinflammatory cytokines expression in noise-induced damaged cochlea","volume":"83","author":"Fujioka","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0028","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1288\/00005537-198804000-00017","article-title":"The development of endolymphatic hydrops following CMV inoculation of the endolymphatic sac","volume":"98","author":"Fukuda","year":"1988","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2022.108518_bib0029","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0196-0709(88)80019-X","article-title":"Experimental cytomegalovirus infection: viremic spread to the inner ear","volume":"9","author":"Fukuda","year":"1988","journal-title":"Am. J. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/0003489492101S1014","article-title":"Spiral modiolar vein: its importance in viral load of the inner ear","volume":"157","author":"Fukuda","year":"1992","journal-title":"Ann. Otol. Rhinol. Laryngol. Suppl."},{"key":"10.1016\/j.heares.2022.108518_bib0031","doi-asserted-by":"crossref","first-page":"15093","DOI":"10.1523\/JNEUROSCI.1709-12.2012","article-title":"Hair cell replacement in adult mouse utricles after targeted ablation of hair cells with diphtheria toxin","volume":"32","author":"Golub","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2022.108518_bib0032","doi-asserted-by":"crossref","first-page":"7698","DOI":"10.1523\/JNEUROSCI.0619-21.2021","article-title":"The glymphatic system: a novel component of fundamental neurobiology","volume":"41","author":"Hablitz","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2022.108518_bib0034","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/019459988309100105","article-title":"Immunology of the inner ear: response of the inner ear to antigen challenge","volume":"91","author":"Harris","year":"1983","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2022.108518_bib0035","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3109\/00016489009122560","article-title":"Spiral modiolar vein: its importance in inner ear inflammation","volume":"110","author":"Harris","year":"1990","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0036","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000082306","article-title":"Innate immunity contributes to cochlear adaptive immune responses","volume":"10","author":"Hashimoto","year":"2005","journal-title":"Audiol. Neurootol."},{"key":"10.1016\/j.heares.2022.108518_bib0037","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s10162-018-00691-2","article-title":"The stress response in the non-sensory cells of the cochlea under pathological conditions-Possible role in mediating noise vulnerability","volume":"19","author":"Herranen","year":"2018","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0038","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/cne.20619","article-title":"Mononuclear phagocytes migrate into the murine cochlea after acoustic trauma","volume":"489","author":"Hirose","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.heares.2022.108518_bib0039","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s10162-014-0458-8","article-title":"Systemic lipopolysaccharide induces cochlear inflammation and exacerbates the synergistic ototoxicity of kanamycin and furosemide","volume":"15","author":"Hirose","year":"2014","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0040","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s10162-014-0476-6","article-title":"Systemic lipopolysaccharide compromises the blood-labyrinth barrier and increases entry of serum fluorescein into the perilymph","volume":"15","author":"Hirose","year":"2014","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0041","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.heares.2017.04.006","article-title":"Two cell populations participate in clearance of damaged hair cells from the sensory epithelia of the inner ear","volume":"352","author":"Hirose","year":"2017","journal-title":"Hear. Res"},{"key":"10.1016\/j.heares.2022.108518_bib0042","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.heares.2019.01.006","article-title":"The role of monocytes and macrophages in the dynamic permeability of the blood-perilymph barrier","volume":"374","author":"Hirose","year":"2019","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0043","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.heares.2017.12.009","article-title":"Immune cells and nonimmune cells with immune function in mammalian cochleae","volume":"362","author":"Hu","year":"2018","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0044","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s10162-005-0021-8","article-title":"An interstitial network of podoplanin-expressing cells in the human endolymphatic duct","volume":"7","author":"Hultg\u00e5rd-Ekwall","year":"2006","journal-title":"Assoc. Res. Otolaryngol"},{"key":"10.1016\/j.heares.2022.108518_bib0045","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1177\/000348948909801211","article-title":"Immune response of the endolymphatic sac to horseradish peroxidase: immunologic route from the middle ear to the inner ear","volume":"98","author":"Ikeda","year":"1989","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0046","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1177\/000348949910801209","article-title":"T cells infiltrating from the systemic circulation proliferate in the endolymphatic sac","volume":"108","author":"Iwai","year":"1999","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0047","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/dvdy.24624","article-title":"Postnatal development of lymphatic vasculature in the brain meninges","volume":"247","author":"Izen","year":"2018","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.heares.2022.108518_bib0048","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3389\/fncel.2017.00362","article-title":"Potential mechanisms underlying inflammation-enhanced aminoglycoside-induced cochleotoxicity","volume":"11","author":"Jiang","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.heares.2022.108518_bib0049","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fncel.2017.00192","article-title":"Resolution of cochlear inflammation: novel target for preventing or ameliorating drug-, noise- and age-related hearing loss","volume":"11","author":"Kalinec","year":"2017","journal-title":"Front. Cell Neurosci"},{"key":"10.1016\/j.heares.2022.108518_bib0050","doi-asserted-by":"crossref","first-page":"15050","DOI":"10.1523\/JNEUROSCI.2325-15.2015","article-title":"Fractalkine signaling regulates macrophage recruitment into the cochlea and promotes the survival of spiral ganglion neurons after selective hair cell lesion","volume":"35","author":"Kaur","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2022.108518_bib0051","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fncel.2015.00150","article-title":"Macrophage recruitment and epithelial repair following hair cell injury in the mouse utricle","volume":"9","author":"Kaur","year":"2015","journal-title":"Front. Cell Neurosci"},{"key":"10.1016\/j.heares.2022.108518_bib0052","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/cne.24369","article-title":"Genetic disruption of fractalkine signaling leads to enhanced loss of cochlear afferents following ototoxic or acoustic injury","volume":"526","author":"Kaur","year":"2018","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.heares.2022.108518_bib0053","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3389\/fnins.2019.00620","article-title":"Lack of fractalkine receptor on macrophages impairs spontaneous recovery of ribbon synapses after moderate noise trauma in C57BL\/6 mice","volume":"13","author":"Kaur","year":"2019","journal-title":"Front. Neurosci"},{"key":"10.1016\/j.heares.2022.108518_bib0054","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/0003489492101S1009","article-title":"Distribution of immunocompetent cells in the endolymphatic sac","volume":"157","author":"Kawauchi","year":"1992","journal-title":"Ann. Otol. Rhinol. Laryngol. Suppl."},{"key":"10.1016\/j.heares.2022.108518_bib0055","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/00005537-199603000-00019","article-title":"Late sequelae of cochlear infection","volume":"106","author":"Keithley","year":"1996","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2022.108518_bib0056","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1097\/MAO.0b013e31818256a9","article-title":"Tumor necrosis factor alpha can induce recruitment of inflammatory cells to the cochlea","volume":"29","author":"Keithley","year":"2008","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.heares.2022.108518_bib0057","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3389\/fneur.2019.01115","article-title":"Early development of resident macrophages in the mouse cochlea depends on yolk sac hematopoiesis","volume":"10","author":"Kishimoto","year":"2019","journal-title":"Front Neurol"},{"key":"10.1016\/j.heares.2022.108518_bib0058","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fnmol.2019.00316","article-title":"Single cell and single nucleus RNA-Seq reveal cellular heterogeneity and homeostatic regulatory networks in adult mouse stria vascularis","volume":"12","author":"Korrapati","year":"2019","journal-title":"Front. Mol. Neurosci"},{"key":"10.1016\/j.heares.2022.108518_bib0059","doi-asserted-by":"crossref","first-page":"e01506","DOI":"10.1128\/JVI.01506-20","article-title":"Human cytomegalovirus interactions with the basement membrane protein nidogen 1","volume":"95","author":"Kuan","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.heares.2022.108518_bib0060","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.heares.2015.02.009","article-title":"Synaptopathy in the noise-exposed and aging cochlea: primary neural degeneration in acquired sensorineural hearing loss","volume":"330","author":"Kujawa","year":"2015","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0061","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/BF00171140","article-title":"Detection of viral antigen in the endolymphatic sac","volume":"253","author":"Kumagami","year":"1996","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0062","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/cne.20929","article-title":"Contribution of bone marrow hematopoietic stem cells to adult mouse inner ear: mesenchymal cells and fibrocytes","volume":"496","author":"Lang","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.heares.2022.108518_bib0063","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fneur.2019.00977","article-title":"Cytokine levels in inner ear fluid of young and aged mice as molecular biomarkers of noise-induced hearing loss","volume":"10","author":"Landegger","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.heares.2022.108518_bib0064","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuroscience.2020.11.041","article-title":"Scar formation and debris elimination during hair cell degeneration in the adult DTR mouse","volume":"453","author":"Lee","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2022.108518_bib0065","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3389\/fimmu.2018.00223","article-title":"Macrophages in the human cochlea: saviors or predators-A study using super-resolution immunohistochemistry","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.heares.2022.108518_bib0066","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3389\/fneur.2019.00728","article-title":"Human inner ear immune activity: a super-resolution immunohistochemistry study","volume":"10","author":"Liu","year":"2019","journal-title":"Front Neurol"},{"key":"10.1016\/j.heares.2022.108518_bib0067","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joto.2018.11.010","article-title":"Super-resolution immunohistochemistry study on CD4 and CD8 cells and the relation to macrophages in human cochlea","volume":"14","author":"Liu","year":"2019","journal-title":"J. Otol."},{"key":"10.1016\/j.heares.2022.108518_bib0068","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/s41593-018-0227-9","article-title":"CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature","volume":"21","author":"Louveau","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.heares.2022.108518_bib0069","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.immuni.2005.10.001","article-title":"Macrophage polarization comes of age","volume":"23","author":"Mantovani","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.heares.2022.108518_bib0070","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/(SICI)1097-0185(199710)249:2<153::AID-AR1>3.0.CO;2-Z","article-title":"Immunohistochemical and ultrastructural investigation of the human vestibular dark cell area: roles of subepithelial capillaries and T lymphocyte-melanophage interaction in an immune surveillance system","volume":"249","author":"Masuda","year":"1997","journal-title":"Anat. Rec."},{"key":"10.1016\/j.heares.2022.108518_bib0071","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.brainres.2005.11.020","article-title":"Nuclear factor-kappa B nuclear translocation in the cochlea of mice following acoustic overstimulation","volume":"1068","author":"Masuda","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.heares.2022.108518_bib0072","series-title":"Schuknecht's Pathology of the Ear Third Edition","first-page":"82","author":"Merchant","year":"2010"},{"key":"10.1016\/j.heares.2022.108518_bib0073","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109758","article-title":"A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma","volume":"36","author":"Milon","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.heares.2022.108518_bib0074","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1288\/00005537-196811000-00005","article-title":"Cytomegalic inclusion disease of the inner ear","volume":"78","author":"Myers","year":"1968","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2022.108518_bib0075","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2002574118","article-title":"An immunohistochemical study of lymphatic elements in the human brain","volume":"118","author":"Mezey","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heares.2022.108518_bib0076","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1097\/MLG.0b013e31817e2c27","article-title":"Acoustic trauma augments the cochlear immune response to antigen","volume":"118","author":"Miyao","year":"2008","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2022.108518_bib0077","doi-asserted-by":"crossref","first-page":"E269","DOI":"10.1002\/lary.25242","article-title":"Gene expression demonstrates an immunological capacity of the human endolymphatic sac","volume":"125","author":"M\u00f8ller","year":"2015","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2022.108518_bib0078","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s00405-014-2884-y","article-title":"Endolymphatic sac involvement in bacterial meningitis","volume":"272","author":"M\u00f8ller","year":"2015","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0079","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/joa.12559","article-title":"Innate immune defense in the inner ear - mucines are expressed by the human endolymphatic sac","volume":"230","author":"M\u00f8ller","year":"2017","journal-title":"J. Anat."},{"key":"10.1016\/j.heares.2022.108518_bib0080","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1038\/cdd.2015.48","article-title":"Live imaging the phagocytic activity of inner ear supporting cells in response to hair cell death","volume":"22","author":"Monzack","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.heares.2022.108518_bib0081","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.heares.2022.108518_bib0082","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.3390\/pathogens10081062","article-title":"Murine models of central nervous system disease following congenital human cytomegalovirus infections","volume":"10","author":"Moulden","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.heares.2022.108518_bib0083","doi-asserted-by":"crossref","first-page":"E7766","DOI":"10.1073\/pnas.1702946114","article-title":"NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy","volume":"114","author":"Nakanishi","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heares.2022.108518_bib0084","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3389\/fneur.2019.00895","article-title":"Age-related changes in immune cells of the human cochlea","volume":"10","author":"Noble","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.heares.2022.108518_bib0085","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1097\/MAO.0000000000002764","article-title":"Immune response of macrophage population to cochlear implantation: cochlea immune cells","volume":"41","author":"Noonan","year":"2020","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.heares.2022.108518_bib0086","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.3389\/fimmu.2018.03181","article-title":"The human endolymphatic sac and inner ear immunity: macrophage interaction and molecular expression","volume":"9","author":"Nordstr\u00f6m","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.heares.2022.108518_bib0087","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.4049\/jimmunol.1002183","article-title":"Activation of lipopolysaccharide-TLR4 signaling accelerates the ototoxic potential of cisplatin in mice","volume":"186","author":"Oh","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.heares.2022.108518_bib0088","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/jnr.21625","article-title":"Bone marrow-derived cells expressing Iba1 are constitutively present as resident tissue macrophages in the mouse cochlea","volume":"86","author":"Okano","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0089","doi-asserted-by":"crossref","first-page":"e774","DOI":"10.1097\/MAO.0000000000002313","article-title":"Density of macrophages immunostained with anti-iba1 antibody in the vestibular endorgans after cochlear implantation in the human","volume":"40","author":"Okayasu","year":"2019","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.heares.2022.108518_bib0090","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/MAO.0000000000000879","article-title":"Anti CD163+, Iba1+, and CD68+ Cells in the adult human inner ear: normal distribution of an unappreciated class of macrophages\/microglia and implications for inflammatory otopathology in humans","volume":"37","author":"O'Malley","year":"2016","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.heares.2022.108518_bib0091","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s41592-021-01200-9","article-title":"gEAR: gene expression analysis resource portal for community-driven, multi-omic data exploration","volume":"18","author":"Orvis","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.heares.2022.108518_bib0092","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/00016489850182053","article-title":"Intercellular adhesion molecule-1 expression in the inner ear of rats following secondary immune reaction in the endolymphatic sac","volume":"539","author":"Pawankar","year":"1998","journal-title":"Acta Otolaryngol. Suppl."},{"key":"10.1016\/j.heares.2022.108518_bib0093","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1749-6632.1999.tb08646.x","article-title":"Excitotoxicity, synaptic repair, and functional recovery in the mammalian cochlea: a review of recent findings","volume":"884","author":"Pujol","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.heares.2022.108518_bib0094","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/0194599813491712","article-title":"Effect of systemic lipopolysaccharide-induced inflammation on cytokine levels in the murine cochlea: a pilot study","volume":"149","author":"Quintanilla-Dieck","year":"2013","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2022.108518_bib0095","doi-asserted-by":"crossref","first-page":"15167","DOI":"10.1038\/s41598-020-72181-6","article-title":"The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells","volume":"10","author":"Rai","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.heares.2022.108518_bib0096","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0378-5955(91)90034-7","article-title":"Scar formation after drug-induced cochlear insult","volume":"51","author":"Raphael","year":"1991","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0097","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000275458","article-title":"Lymphocyte-macrophage activity in the endolymphatic sac. An ultrastructural study of the rugose endolymphatic sac in the guinea pig","volume":"41","author":"Rask-Andersen","year":"1979","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"key":"10.1016\/j.heares.2022.108518_bib0098","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/00016488009127140","article-title":"Immunodefence of the inner ear? Lymphocyte-macrophage interaction in the endolymphatic sac","volume":"89","author":"Rask-Andersen","year":"1980","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0099","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3109\/00016489109128039","article-title":"Lymphocyte-macrophage activity in the human endolymphatic sac","volume":"485","author":"Rask-Andersen","year":"1991","journal-title":"Acta Otolaryngol. Suppl."},{"key":"10.1016\/j.heares.2022.108518_bib0100","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1093\/hmg\/ddl022","article-title":"Cochlin immunostaining of inner ear pathologic deposits and proteomic analysis in DFNA9 deafness and vestibular dysfunction","volume":"15","author":"Robertson","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.heares.2022.108518_bib0101","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s10162-015-0512-1","article-title":"Perilymph kinetics of FITC-dextran reveals homeostasis dominated by the cochlear aqueduct and cerebrospinal fluid","volume":"16","author":"Salt","year":"2015","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0102","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10162-016-0562-z","article-title":"Scanning electron microscopic examination of the extracellular matrix in the decellularized mouse and human cochlea","volume":"17","author":"Santi","year":"2016","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0103","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/cne.21583","article-title":"Repopulation of cochlear macrophages in murine hematopoietic progenitor cell chimeras: the role of CX3CR1","volume":"506","author":"Sato","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.heares.2022.108518_bib0104","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10162-009-0198-3","article-title":"Expression of fractalkine receptor CX3CR1 on cochlear macrophages influences survival of hair cells following ototoxic injury","volume":"11","author":"Sato","year":"2010","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0105","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10162-002-3025-7","article-title":"Proinflammatory cytokine expression in the endolymphatic sac during inner ear inflammation","volume":"4","author":"Satoh","year":"2003","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0106","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/000348940611500112","article-title":"Transforming growth factor beta expression during an inner ear immune response","volume":"115","author":"Satoh","year":"2006","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0107","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10162-006-0051-x","article-title":"CC chemokine receptor 2 is protective against noise induced hair cell death: studies in CX3CR1+\/GFP mice","volume":"7","author":"Sautter","year":"2006","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0108","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.670013","article-title":"Cochlin deficiency protects against noise-induced hearing loss","volume":"14","author":"Seist","year":"2021","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.heares.2022.108518_bib0109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heares.2006.10.011","article-title":"Expression of adhesion molecular proteins in the cochlear lateral wall of normal and PARP-1 mutant mice","volume":"224","author":"Shi","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0110","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00441-010-1040-2","article-title":"Resident macrophages in the cochlear blood-labyrinth barrier and their renewal via migration of bone-marrow-derived cells","volume":"342","author":"Shi","year":"2010","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.heares.2022.108518_bib0111","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.heares.2016.01.010","article-title":"Pathophysiology of the cochlear intrastrial fluid-blood barrier (review)","volume":"338","author":"Shi","year":"2016","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0112","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neulet.2008.07.091","article-title":"Spatiotemporal expression of cochlin in the inner ear of rats during postnatal development","volume":"444","author":"Shindo","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.heares.2022.108518_bib0114","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0378-5955(91)90153-Z","article-title":"Differentiation of inner ear fibrocytes according to their ion transport related activity","volume":"56","author":"Spicer","year":"1991","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0115","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0378-5955(96)00106-2","article-title":"The fine structure of spiral ligament cells relates to ion return to the stria and varies with place-frequency","volume":"100","author":"Spicer","year":"1996","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0116","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1288\/00005537-199308000-00010","article-title":"Development of high endothelial venule-like characteristics in the spiral modiolar vein induced by viral labyrinthitis","volume":"103","author":"Stearns","year":"1993","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2022.108518_bib0117","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.128878","article-title":"Virus-induced cochlear inflammation in newborn mice alters auditory function","volume":"4","author":"Sung","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.heares.2022.108518_bib0118","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1177\/000348949510400111","article-title":"Expression of intercellular adhesion molecule-1 during inner ear inflammation","volume":"104","author":"Suzuki","year":"1995","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0119","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/00016488809122264","article-title":"Anatomic distribution and localization of immunocompetent cells in normal mouse endolymphatic sac","volume":"106","author":"Takahashi","year":"1988","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0120","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1288\/00005537-198810000-00018","article-title":"Analysis of immunocompetent cells following inner ear immunostimulation","volume":"98","author":"Takahashi","year":"1988","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2022.108518_bib0121","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3109\/00016489509139336","article-title":"Cell proliferation in the endolymphatic sac in situ after inner ear immunostimulation","volume":"115","author":"Takahashi","year":"1995","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0122","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1177\/000348949710601211","article-title":"Reduction of inner ear inflammation by treatment with anti-ICAM-1 antibody","volume":"106","author":"Takasu","year":"1997","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0123","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cne.21729","article-title":"Bone-marrow-derived cells that home to acoustic deafened cochlea preserved their hematopoietic identity","volume":"509","author":"Tan","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.heares.2022.108518_bib0124","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/dvdy.176","article-title":"Zika virus can directly infect and damage the auditory and vestibular components of the embryonic chicken inner ear","volume":"249","author":"Thawani","year":"2020","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.heares.2022.108518_bib0125","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1288\/00005537-198606000-00018","article-title":"The endolymphatic sac: its importance in inner ear immune responses","volume":"96","author":"Tomiyama","year":"1986","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2022.108518_bib0126","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3109\/00016488709107271","article-title":"The role of the endolymphatic sac in inner ear immunity","volume":"103","author":"Tomiyama","year":"1987","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0127","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/0003489492101S1010","article-title":"Endolymphatic hydrops induced by immune response of the endolymphatic sac: relation to perilymph antibody levels","volume":"157","author":"Tomiyama","year":"1992","journal-title":"Ann. Otol. Rhinol. Laryngol. Suppl."},{"key":"10.1016\/j.heares.2022.108518_bib0128","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.heares.2006.09.004","article-title":"Immune cell recruitment following acoustic trauma","volume":"222","author":"Tornabene","year":"2006","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0129","doi-asserted-by":"crossref","first-page":"e2245","DOI":"10.1038\/cddis.2016.156","article-title":"Toll-like receptor 4 modulates the cochlear immune response to acoustic injury","volume":"7","author":"Vethanayagam","year":"2016","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.heares.2022.108518_bib0130","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/000348948709600308","article-title":"Human endolymphatic sac: morphologic evidence of immunologic function","volume":"96","author":"Wackym","year":"1987","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0131","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neures.2009.12.008","article-title":"Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea","volume":"66","author":"Wakabayashi","year":"2010","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0132","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1113\/jphysiol.2006.112888","article-title":"Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential","volume":"576","author":"Wangemann","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.heares.2022.108518_bib0133","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a033555","article-title":"Interactions between macrophages and the sensory cells of the inner ear","volume":"9","author":"Warchol","year":"2019","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.heares.2022.108518_bib0134","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3389\/fncel.2017.00106","article-title":"The contribution of immune infiltrates to ototoxicity and cochlear hair cell loss","volume":"11","author":"Wood","year":"2017","journal-title":"Front. Cell Neurosci"},{"key":"10.1016\/j.heares.2022.108518_bib0135","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.anl.2016.10.007","article-title":"Toll-like receptor ligands induce cytokine and chemokine production in human inner ear endolymphatic sac fibroblasts","volume":"44","author":"Yamada","year":"2017","journal-title":"Auris. Nasus Larynx"},{"key":"10.1016\/j.heares.2022.108518_bib0136","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1002\/jnr.22018","article-title":"The influence of NF-kappaB signal-transduction pathways on the murine inner ear by acoustic overstimulation","volume":"87","author":"Yamamoto","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0137","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3109\/00016489309135786","article-title":"Evidence of direct communication of bone marrow cells with the endolymphatic sac in experimental autoimmune labyrinthitis","volume":"113","author":"Yamanobe","year":"1993","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0138","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1097\/00005537-200309000-00038","article-title":"Cell proliferation in the endolymphatic sac in situ after the rat Waldeyer ring equivalent immunostimulation","volume":"113","author":"Yan","year":"2003","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2022.108518_bib0139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2015.05.081","article-title":"Activation of the antigen presentation function of mononuclear phagocyte populations associated with the basilar membrane of the cochlea after acoustic overstimulation","volume":"303","author":"Yang","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2022.108518_bib0140","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1288\/00005537-199506000-00012","article-title":"Antigen diffusion from the perilymphatic space of the cochlea","volume":"105","author":"Yeo","year":"1995","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2022.108518_bib0141","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1097\/00005537-200109000-00026","article-title":"Connection between the inner ear and the lymphatic system","volume":"111","author":"Yimtae","year":"2001","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2022.108518_bib0142","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","article-title":"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis","volume":"38","author":"Yona","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.heares.2022.108518_bib0143","doi-asserted-by":"crossref","first-page":"10388","DOI":"10.1073\/pnas.1205210109","article-title":"Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid-blood barrier","volume":"109","author":"Zhang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heares.2022.108518_bib0144","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s10162-013-0403-2","article-title":"Characterization and inflammatory response of perivascular-resident macrophage-like melanocytes in the vestibular system","volume":"14","author":"Zhang","year":"2013","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2022.108518_bib0145","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.heares.2019.04.012","article-title":"The TLR-4\/NF-\u03baB signaling pathway activation in cochlear inflammation of rats with noise-induced hearing loss","volume":"379","author":"Zhang","year":"2019","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0146","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2020.107996","article-title":"New insights on repeated acoustic injury: augmentation of cochlear susceptibility and inflammatory reaction resultant of prior acoustic injury","volume":"393","author":"Zhang","year":"2020","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108518_bib0147","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.619189","article-title":"The immune system can hear noise","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.heares.2022.108518_bib0148","article-title":"Lipopolysaccharide-induced middle ear inflammation disrupts the cochlear intra-strial fluid-blood barrier through down-regulation of tight junction proteins","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS ONE"}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595522000879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595522000879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:00:52Z","timestamp":1759921252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595522000879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":146,"alternative-id":["S0378595522000879"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2022.108518","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inner ear immunity","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2022.108518","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108518"}}