{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:58:40Z","timestamp":1788778720487,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000738","name":"Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01RX002431"],"award-info":[{"award-number":["I01RX002431"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.heares.2022.108601","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T20:41:07Z","timestamp":1662410467000},"page":"108601","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Noise overstimulation of young adult UMHET4 mice accelerates age-related hearing loss"],"prefix":"10.1016","volume":"424","author":[{"given":"Richard A","family":"Altschuler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney E.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Kabara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Kanicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Kohrman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Dolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2022.108601_bib0001","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuroscience.2015.01.068","article-title":"Age-related changes in auditory nerve \u2013 inner hair cell connections, hair cell numbers, auditory brain stem response and gap detection in UM-HET4 mice","volume":"292","author":"Altschuler","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2022.108601_bib0002","doi-asserted-by":"crossref","first-page":"30821","DOI":"10.1038\/srep30821","article-title":"Treatment with piribedil and memantine reduces noise-induced loss of inner hair cell synaptic ribbons","volume":"6","author":"Altschuler","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.heares.2022.108601_bib0003","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.heares.2018.09.003","article-title":"Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse cochlea","volume":"370","author":"Altschuler","year":"2018","journal-title":"Hearing Res"},{"key":"10.1016\/j.heares.2022.108601_bib0004","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuroscience.2018.07.027","article-title":"Small arms fire-like noise: effects on hearing loss, gap detection and the influence of preventive treatment","volume":"407","author":"Altschuler","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.heares.2022.108601_bib0005","article-title":"Rapamycin added to diet in mid-life delays age-related hearing loss in UMHET4 mice","author":"Altschuler","year":"2021","journal-title":"Frontiers (Boulder)"},{"issue":"7","key":"10.1016\/j.heares.2022.108601_bib0006","first-page":"86","article-title":"Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss","volume":"15","author":"Alvarado","year":"2015","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.heares.2022.108601_bib0007","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3389\/fncel.2020.00226","article-title":"Antioxidants and vasodilators for the treatment of noise-induced hearing loss: are they really effective?","volume":"14","author":"Alvarado","year":"2020","journal-title":"Front Cell Neurosci"},{"issue":"1\u20132","key":"10.1016\/j.heares.2022.108601_bib0008","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.heares.2008.11.010","article-title":"Aging outer hair cells (OHC) in the Fischer 344 rat cochlea: function and morphology","volume":"248","author":"Chen","year":"2009","journal-title":"Hear. Res."},{"issue":"1","key":"10.1016\/j.heares.2022.108601_bib0009","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1044\/1059-0889(2013\/12-0062)","article-title":"Adult hearing screening: health policy issues-what happens next","volume":"22","author":"Davis","year":"2013","journal-title":"Am. J. Audiol"},{"issue":"5","key":"10.1016\/j.heares.2022.108601_bib0010","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10162-013-0396-x","article-title":"Classifying human audiometric phenotypes of age-related hearing loss from animal models","volume":"14","author":"Dubno","year":"2013","journal-title":"J. Assoc. Res. Otolaryngol."},{"issue":"19","key":"10.1016\/j.heares.2022.108601_bib0011","doi-asserted-by":"crossref","first-page":"7509","DOI":"10.1523\/JNEUROSCI.5138-14.2015","article-title":"Aging after noise exposure: acceleration of cochlear synaptopathy in \"recovered\" ears","volume":"13","author":"Fernandez","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2022.108601_bib0012","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1749-6632.2009.03931.x","article-title":"Age-related hearing loss: ear and brain mechanisms","volume":"1170","author":"Frisina","year":"2009","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"10.1016\/j.heares.2022.108601_bib0013","first-page":"9","article-title":"Auditory sensitivity and the outer hair cell system in the CBA model of age-related hearing loss","volume":"2","author":"Frisina","year":"2010","journal-title":"Anim. Physiol"},{"issue":"9491","key":"10.1016\/j.heares.2022.108601_bib0015","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0140-6736(05)67423-5","volume":"366","author":"Gates","year":"2005","journal-title":"Presbycusis. Lancet."},{"issue":"1","key":"10.1016\/j.heares.2022.108601_bib0016","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/01.aud.0000194512.51849.ab","article-title":"The effect of noise on cochlear aging","volume":"27","author":"Gates","year":"2006","journal-title":"Ear Hear."},{"issue":"4","key":"10.1016\/j.heares.2022.108601_bib0017","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/WNN.0b013e3181d748d7","article-title":"Executive dysfunction and presbycusis in older persons with and without memory loss and dementia","volume":"23","author":"Gates","year":"2010","journal-title":"Cogn. Behav. Neurol."},{"key":"10.1016\/j.heares.2022.108601_bib0018","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000393093","article-title":"Comparative otopathology: aging, noise and ototoxic drugs","volume":"20","author":"Hawkins","year":"1973","journal-title":"Advance in Oto-Rhino-Laryngology"},{"key":"10.1016\/j.heares.2022.108601_bib0019","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/00206098009070071","article-title":"Genotypic differences in behavior, physiological and anatomical expressions of age-related hearing loss in the laboratory mouse","volume":"19","author":"Henry","year":"1980","journal-title":"Audiology"},{"issue":"5","key":"10.1016\/j.heares.2022.108601_bib0020","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fnins.2018.00125","article-title":"Impact of aging on the auditory system and related cognitive functions: a narrative review","volume":"12","author":"Jayakody","year":"2018","journal-title":"Front Neurosci"},{"issue":"1\u20132","key":"10.1016\/j.heares.2022.108601_bib0021","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-5955(97)00155-X","article-title":"A major gene affecting age-related hearing loss in C57BL\/6J mice","volume":"114","author":"Johnson","year":"1997","journal-title":"Hear. Res."},{"issue":"2","key":"10.1016\/j.heares.2022.108601_bib0022","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/geno.2000.6377","article-title":"A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice","volume":"70","author":"Johnson","year":"2000","journal-title":"Genomics"},{"issue":"1","key":"10.1016\/j.heares.2022.108601_bib0023","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.brainres.2006.02.021","article-title":"Strain background effects and genetic modifiers of hearing in mice","volume":"1091","author":"Johnson","year":"2006","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.heares.2022.108601_bib0024","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1001\/archoto.2009.30","article-title":"Safety of ciprofloxacin and dexamethasone in the guinea pig middle ear","volume":"135","author":"Lemke","year":"2009","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2022.108601_bib0025","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/gerona\/glr002","article-title":"Hearing loss prevalence and risk factors among older adults in the United States","volume":"66A","author":"Lin","year":"2011","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"6","key":"10.1016\/j.heares.2022.108601_bib0026","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1037\/a0024238","article-title":"Hearing loss and cognition in the Baltimore Longitudinal Study of Aging","volume":"25","author":"Lin","year":"2011","journal-title":"Neuropsychology"},{"key":"10.1016\/j.heares.2022.108601_bib0027","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1289\/ehp.8244119","article-title":"Review of environmental factors affecting hearing","volume":"44","author":"Mills","year":"1982","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.heares.2022.108601_bib0028","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng1226","article-title":"Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss","volume":"35","author":"Noben-Trauth","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.heares.2022.108601_bib0029","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/01.moo.0000134450.99615.22","article-title":"Age-related hearing loss: the status 935 of Schuknecht's typology","volume":"12","author":"Ohlemiller","year":"2004","journal-title":"Curr. Opin. 936 Otolaryngol. Head Neck Surg"},{"issue":"1","key":"10.1016\/j.heares.2022.108601_bib0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainres.2006.03.017","article-title":"Contributions of mouse models to understanding age- and noise-related hearing loss","volume":"1091","author":"Ohlemiller","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.heares.2022.108601_bib0031","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/MAO.0b013e3182009d29","article-title":"OTO-104: a sustained release dexamethasone hydrogel for the treatment of otic disorder","volume":"32","author":"Piu","year":"2011","journal-title":"Otol. and Neurotol"},{"key":"10.1016\/j.heares.2022.108601_bib0032","first-page":"15","article-title":"Alleles that modulate late life hearing in genetically heterogeneous mice","volume":"1842","author":"Schacht","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heares.2022.108601_bib0033","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archotol.1964.00750040381003","article-title":"Further Observations on the Pathology of Presbycusis","volume":"80","author":"Schuknecht","year":"1964","journal-title":"Arch. Otolaryngol."},{"issue":"34","key":"10.1016\/j.heares.2022.108601_bib0034","doi-asserted-by":"crossref","first-page":"13686","DOI":"10.1523\/JNEUROSCI.1783-13.2013","article-title":"Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline","volume":"33","author":"Sergeyenko","year":"2013","journal-title":"J. Neurosci"},{"issue":"1\u20132","key":"10.1016\/j.heares.2022.108601_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(01)00224-6","article-title":"Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals","volume":"155","author":"Sha","year":"2001","journal-title":"Hearing Res"},{"key":"10.1016\/j.heares.2022.108601_bib0036","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.heares.2008.06.001","article-title":"Age-related auditory pathology in the CBA\/J mouse","volume":"243","author":"Sha","year":"2008","journal-title":"Hearing Res"},{"key":"10.1016\/j.heares.2022.108601_bib0037","series-title":"Principles of Tissue Engineering","article-title":"Protection and Repair of Hearing","author":"Sha","year":"2020"},{"key":"10.1016\/j.heares.2022.108601_bib0038","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1121\/1.418315","article-title":"Quantitative measures of hair cell loss in CBA and C57BL\/6 mice throughout their life spans","volume":"101","author":"Spongr","year":"1997","journal-title":"J. Acoust. Soc. Am."},{"issue":"1\u20132","key":"10.1016\/j.heares.2022.108601_bib0039","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.heares.2009.11.003","article-title":"The Fischer 344 rat as a model of presbycusis","volume":"264","author":"Syka","year":"2010","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2022.108601_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heares.2004.04.016","article-title":"The guide to plotting a cytocochleogram","volume":"197","author":"Viberg","year":"2004","journal-title":"Hear. Res."},{"issue":"3","key":"10.1016\/j.heares.2022.108601_bib0041","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/MAO.0000000000000261","article-title":"OTO-201: nonclinical assessment of a sustained-release ciprofloxacin hydrogel for the treatment of otitis media","volume":"35","author":"Wang","year":"2014","journal-title":"Otol. Neurotol."},{"issue":"1\u20132","key":"10.1016\/j.heares.2022.108601_bib0042","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0378-5955(95)00107-F","article-title":"Genetics of age-related hearing loss in mice. II. Strain differences and effects of caloric restriction on cochlear pathology and evoked response thresholds","volume":"88","author":"Willott","year":"1995","journal-title":"Hear. Res."},{"issue":"33","key":"10.1016\/j.heares.2022.108601_bib0043","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.1523\/JNEUROSCI.0937-20.2020","article-title":"Age-related hearing loss is dominated by damage to inner ear sensory cells, not the cellular battery that powers them","volume":"40","author":"Wu","year":"2020","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.heares.2022.108601_bib0044","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s00405-013-2622-x","article-title":"Impulse noise exposure in early adulthood accelerates age-related hearing loss","volume":"271","author":"Xiong","year":"2014","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.heares.2022.108601_bib0045","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.heares.2013.01.021","article-title":"Current concepts in age-related hearing loss: epidemiology and mechanistic pathways","volume":"303","author":"Yamasoba","year":"2013","journal-title":"Hear. Res."},{"issue":"9","key":"10.1016\/j.heares.2022.108601_bib0046","first-page":"276","article-title":"Age-related hearing impairment and the triad of acquired hearing loss","volume":"27","author":"Yang","year":"2015","journal-title":"Front Cell Neurosci"}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595522001691?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595522001691?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:03:20Z","timestamp":1759921400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595522001691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":45,"alternative-id":["S0378595522001691"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2022.108601","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Noise overstimulation of young adult UMHET4 mice accelerates age-related hearing loss","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2022.108601","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108601"}}