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Sci."},{"key":"10.1016\/j.heares.2022.108625_bib0149","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2017.00315","article-title":"Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity","volume":"11","author":"Yang","year":"2017","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.heares.2022.108625_bib0150","doi-asserted-by":"crossref","unstructured":"Yin, H.-.X., Zhang, P., Wang, Z., Liu, Y.-.F., Liu, Y., Xiao, T.-.Q., Yang, Z.-.H., Xian, J.-.F., Zhao, P.-.F., Li, J., Lv, H., Ding, H.-.Y., Liu, X.-.H., Zhu, J.-.M., Wang, Z.-.C., 2019. 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