{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:11:21Z","timestamp":1777871481693,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100019266","name":"Korea Medical Device Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.heares.2026.109598","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T16:04:18Z","timestamp":1772294658000},"page":"109598","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Translational framework combining machine learning and in vivo screening for aminoglycoside ototoxicity prevention"],"prefix":"10.1016","volume":"474","author":[{"given":"Eunjung","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Jae","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Hun","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saemi","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6330-279X","authenticated-orcid":false,"given":"June","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.heares.2026.109598_bib0001","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd1468","article-title":"Drug repositioning: identifying and developing new uses for existing drugs","volume":"3","author":"Ashburn","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.heares.2026.109598_bib0002","article-title":"Current techniques of water solubility improvement for antioxidant compounds and their correlation with its activity","volume":"12","author":"Budiman","year":"2023","journal-title":"Molecul. Pharmaceut. Antioxidant. (Basel)"},{"issue":"3","key":"10.1016\/j.heares.2026.109598_bib0003","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3390\/molecules28031057","article-title":"Structural features of small molecule antioxidants and strategic modifications to improve potential bioactivity","volume":"28","author":"Charlton","year":"2023","journal-title":"Molecules"},{"issue":"25","key":"10.1016\/j.heares.2026.109598_bib0004","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1056\/NEJMra1616601","article-title":"Hearing loss in adults","volume":"377","author":"Cunningham","year":"2017","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.heares.2026.109598_bib0005","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jhealeco.2016.01.012","article-title":"Innovation in the pharmaceutical industry: new estimates of R&D costs","volume":"47","author":"DiMasi","year":"2016","journal-title":"J. Health Econ."},{"key":"10.1016\/j.heares.2026.109598_bib0006","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.692762","article-title":"Mechanism and prevention of ototoxicity induced by aminoglycosides","volume":"15","author":"Fu","year":"2021","journal-title":"Front. Cell Neurosci."},{"issue":"7","key":"10.1016\/j.heares.2026.109598_bib0007","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1093\/jac\/dkae106","article-title":"Pharmacogenetics of aminoglycoside-related ototoxicity: a systematic review","volume":"79","author":"Gaafar","year":"2024","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.heares.2026.109598_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.eswa.2023.121496","article-title":"A comprehensive characterizations of zebrafish rheotactic behaviors and its application to otoprotective drug screening","volume":"237","author":"Han","year":"2024","journal-title":"Expert Syst. Appl."},{"key":"10.1016\/j.heares.2026.109598_bib0009","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuro.2020.03.005","article-title":"Analysis of behavioral changes in zebrafish (Danio rerio) larvae caused by aminoglycoside-induced damage to the lateral line and muscles","volume":"78","author":"Han","year":"2020","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.heares.2026.109598_bib0010","article-title":"Mechanisms and otoprotective strategies of programmed cell death on aminoglycoside-induced ototoxicity","volume":"11","author":"Han","year":"2023","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.heares.2026.109598_bib0011","article-title":"Using the zebrafish lateral line to understand the roles of mitochondria in sensorineural hearing loss","volume":"8","author":"Holmgren","year":"2020","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.heares.2026.109598_bib0012","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/937861","article-title":"Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection","volume":"2011","author":"Huth","year":"2011","journal-title":"Int. J. Otolaryngol."},{"key":"10.1016\/j.heares.2026.109598_bib0013","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3389\/fmicb.2013.00272","article-title":"Understanding biocatalyst inhibition by carboxylic acids","volume":"4","author":"Jarboe","year":"2013","journal-title":"Front Microbiol."},{"issue":"9","key":"10.1016\/j.heares.2026.109598_bib0014","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1097\/MAO.0000000000001192","article-title":"Role of STAT1 and oxidative stress in gentamicin-induced hair cell death in organ of corti","volume":"37","author":"Jiang","year":"2016","journal-title":"Otol. Neurotol."},{"issue":"15","key":"10.1016\/j.heares.2026.109598_bib0015","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1021\/acs.jmedchem.8b00077","article-title":"Lipophilic efficiency as an important metric in drug design","volume":"61","author":"Johnson","year":"2018","journal-title":"J. Med. Chem."},{"issue":"7270","key":"10.1016\/j.heares.2026.109598_bib0016","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nature08506","article-title":"Predicting new molecular targets for known drugs","volume":"462","author":"Keiser","year":"2009","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.heares.2026.109598_bib0017","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.2042-7158.2010.01216.x","article-title":"Does hydrophobicity always enhance antioxidant drugs? A cut-off effect of the chain length of functionalized chlorogenate esters on ROS-overexpressing fibroblasts","volume":"63","author":"Laguerre","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.heares.2026.109598_bib0018","doi-asserted-by":"crossref","DOI":"10.1097\/MAO.0000000000004074","article-title":"Cortisol sensitizes cochlear hair cells to gentamicin ototoxicity via endogenous apoptotic pathway","volume":"45","author":"Li","year":"2024","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.heares.2026.109598_bib0019","series-title":"Proceedings of the Twenty Third International Conference on Artificial Intelligence and Statistics","first-page":"4313","article-title":"Gradient descent with early stopping is provably robust to label noise for overparameterized neural networks","author":"Li","year":"2020"},{"key":"10.1016\/j.heares.2026.109598_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114792","article-title":"Protective effects of Y-27632 against cisplatin-induced ototoxicity: a zebrafish model Y-27632 and cisplatin-induced ototoxicity","volume":"190","author":"Lim","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.heares.2026.109598_bib0021","series-title":"Antioxidant Compounds and Their Antioxidant Mechanism","first-page":"Ch. 2","author":"Norma Francenia","year":"2019"},{"issue":"1\u20132","key":"10.1016\/j.heares.2026.109598_bib0022","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.heares.2012.01.009","article-title":"Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line","volume":"288","author":"Ou","year":"2012","journal-title":"Hear Res."},{"issue":"2","key":"10.1016\/j.heares.2026.109598_bib0023","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10162-009-0158-y","article-title":"Identification of FDA-approved drugs and bioactives that protect hair cells in the zebrafish (Danio rerio) lateral line and mouse (Mus musculus) utricle","volume":"10","author":"Ou","year":"2009","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2026.109598_bib0024","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.freeradbiomed.2015.11.007","article-title":"Ecabet sodium alleviates neomycin-induced hair cell damage","volume":"89","author":"Rah","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.heares.2026.109598_bib0025","doi-asserted-by":"crossref","DOI":"10.3390\/ph16101353","article-title":"Aminoglycosides-related ototoxicity: mechanisms, risk factors, and prevention in pediatric patients","volume":"16","author":"Rivetti","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.heares.2026.109598_bib0026","series-title":"Free Radicals in ENT Pathology","first-page":"195","article-title":"Aminoglycoside-induced oxidative stress: pathways and protection","author":"Rybak","year":"2015"},{"issue":"8","key":"10.1016\/j.heares.2026.109598_bib0027","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/sj.ki.5002434","article-title":"Ototoxicity","volume":"72","author":"Rybak","year":"2007","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.heares.2026.109598_bib0028","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/138161207779313731","article-title":"Aminoglycoside-induced ototoxicity","volume":"13","author":"Selimoglu","year":"2007","journal-title":"Curr. Pharm. Des."},{"issue":"1","key":"10.1016\/j.heares.2026.109598_bib0029","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-29174-3","article-title":"Compressing networks with super nodes","volume":"8","author":"Stanley","year":"2018","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.heares.2026.109598_bib0030","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cell.2020.01.021","article-title":"A deep learning approach to antibiotic discovery","volume":"180","author":"Stokes","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.heares.2026.109598_bib0031","unstructured":"Veli\u010dkovi\u0107, P., Cucurull, G., Casanova, A., Romero, A., Lio, P., Bengio, Y., 2017. Graph attention networks. ArXiv preprint arXiv:1710.10903."},{"issue":"2","key":"10.1016\/j.heares.2026.109598_bib0032","article-title":"Integrating artificial intelligence for drug discovery in the context of revolutionizing drug delivery","volume":"14","author":"Visan","year":"2024","journal-title":"Life (Basel)"},{"issue":"5","key":"10.1016\/j.heares.2026.109598_bib0033","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1097\/MOO.0b013e32833e05ec","article-title":"Cellular mechanisms of aminoglycoside ototoxicity","volume":"18","author":"Warchol","year":"2010","journal-title":"Curr. Opin Otolaryngol. Head Neck Surg."},{"issue":"1","key":"10.1016\/j.heares.2026.109598_bib0034","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1109\/TNNLS.2020.2978386","article-title":"A comprehensive survey on graph neural networks","volume":"32","author":"Wu","year":"2021","journal-title":"IEEE Trans. Neural Netw. Learn. Syst."},{"issue":"1\u20132","key":"10.1016\/j.heares.2026.109598_bib0035","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.heares.2011.05.008","article-title":"New developments in aminoglycoside therapy and ototoxicity","volume":"281","author":"Xie","year":"2011","journal-title":"Hear Res."},{"issue":"9","key":"10.1016\/j.heares.2026.109598_bib0036","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/s41587-019-0224-x","article-title":"Deep learning enables rapid identification of potent DDR1 kinase inhibitors","volume":"37","author":"Zhavoronkov","year":"2019","journal-title":"Nat. Biotechnol."},{"issue":"12","key":"10.1016\/j.heares.2026.109598_bib0037","doi-asserted-by":"crossref","first-page":"e667","DOI":"10.1016\/S2589-7500(20)30192-8","article-title":"Artificial intelligence in COVID-19 drug repurposing","volume":"2","author":"Zhou","year":"2020","journal-title":"Lancet Digit Health."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595526000742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595526000742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:17:37Z","timestamp":1777569457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595526000742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":37,"alternative-id":["S0378595526000742"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2026.109598","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Translational framework combining machine learning and in vivo screening for aminoglycoside ototoxicity prevention","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2026.109598","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109598"}}