{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T08:21:49Z","timestamp":1794558109804,"version":"4.9.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020172","name":"RNID","doi-asserted-by":"publisher","award":["G86"],"award-info":[{"award-number":["G86"]}],"id":[{"id":"10.13039\/501100020172","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["221769\/Z\/20\/Z"],"award-info":[{"award-number":["221769\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.heares.2026.109664","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:04:09Z","timestamp":1778601849000},"page":"109664","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A non-invasive test for stria vascularis dysfunction"],"prefix":"10.1016","volume":"477","author":[{"given":"Neil J.","family":"Ingham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisse H.","family":"Panganiban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn M.","family":"McClaskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly C.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8019-5359","authenticated-orcid":false,"given":"Karen P.","family":"Steel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heares.2026.109664_bib0001","doi-asserted-by":"crossref","first-page":"191","DOI":"10.15252\/emmm.201505523","article-title":"Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing","volume":"8","author":"Buniello","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.heares.2026.109664_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2024.109091","article-title":"A new mutation of Sgms1 causes gradual hearing loss associated with a reduced endocochlear potential","volume":"451","author":"Chen","year":"2024","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2026.109664_bib0003","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneumeth.2003.10.009","article-title":"EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis","volume":"134","author":"Delorme","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.heares.2026.109664_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2025.109259","article-title":"Middle-aged CBA\/CaJ mice exhibit auditory dysfunction in background noise","volume":"461","author":"Fabrizio-Stover","year":"2025","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2026.109664_bib0005","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0140-6736(11)61143-4","article-title":"Mental health of deaf people","volume":"379","author":"Fellinger","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.heares.2026.109664_bib0006","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1152\/jn.00638.2017","article-title":"Complementary metrics of human auditory nerve function derived from compound action potentials","volume":"119","author":"Harris","year":"2018","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.heares.2026.109664_bib0007","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3447","article-title":"Evoked potential recordings of auditory brainstem activity in the mouse: an optimized method for the assessment of hearing function of mice","volume":"9","author":"Ingham","year":"2019","journal-title":"Bio - Protoc."},{"key":"10.1016\/j.heares.2026.109664_bib0008","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/9780470942390.mo110059","article-title":"Using the auditory brainstem response (ABR) to determine sensitivity of hearing in mutant mice","volume":"1","author":"Ingham","year":"2011","journal-title":"Curr. Protoc. Mouse Biol."},{"key":"10.1016\/j.heares.2026.109664_bib0009","doi-asserted-by":"crossref","DOI":"10.1038\/srep28964","article-title":"S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse","volume":"6","author":"Ingham","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.heares.2026.109664_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0258158","article-title":"Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss","volume":"16","author":"Ingham","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.heares.2026.109664_bib0011","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-5955(97)00155-X","article-title":"A major gene affecting age-related hearing loss in C57BL\/6J mice","volume":"114","author":"Johnson","year":"1997","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2026.109664_bib0012","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.annepidem.2010.03.011","article-title":"Associations between hearing impairment and mortality risk in older persons: the blue mountains hearing study","volume":"20","author":"Karpa","year":"2010","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.heares.2026.109664_bib0013","doi-asserted-by":"crossref","first-page":"8801","DOI":"10.1523\/JNEUROSCI.1138-23.2023","article-title":"Predicting atrophy of the cochlear stria vascularis from the shape of the threshold audiogram","volume":"43","author":"Kaur","year":"2023","journal-title":"J. Neurosci."},{"key":"10.1016\/j.heares.2026.109664_bib0014","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/(SICI)1097-0193(1999)8:4<194::AID-HBM4>3.0.CO;2-C","article-title":"Measuring phase synchrony in brain signals","volume":"8","author":"Lachaux","year":"1999","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.heares.2026.109664_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2024.109109","article-title":"Two new mouse alleles of Ocm and Slc26a5","volume":"452","author":"Lachgar-Ruiz","year":"2024","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2026.109664_bib0016","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13073-024-01394-5","article-title":"Pathological mechanisms and candidate therapeutic approaches in the hearing loss of mice carrying human MIR96 mutations","volume":"16","author":"Lewis","year":"2024","journal-title":"Genome Med."},{"key":"10.1016\/j.heares.2026.109664_bib0017","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/S0140-6736(17)31363-6","article-title":"Dementia prevention, intervention, and care","volume":"390","author":"Livingston","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.heares.2026.109664_bib0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnhum.2014.00213","article-title":"ERPLAB: an open-source toolbox for the analysis of event-related potentials","volume":"8","author":"Lopez-Calderon","year":"2014","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.heares.2026.109664_bib0019","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1016\/S0140-6736(23)02874-X","article-title":"AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial","volume":"403","author":"Lv","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.heares.2026.109664_bib0020","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2307355120","article-title":"Reversal of an existing hearing loss by gene activation in Spns2 mutant mice","volume":"120","author":"Martelletti","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.heares.2026.109664_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2020.108937","article-title":"A multi-metric approach to characterizing mouse peripheral auditory nerve function using the auditory brainstem response","volume":"346","author":"McClaskey","year":"2020","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.heares.2026.109664_bib0022","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1177\/0194599813518021","article-title":"The association between hearing loss and social isolation in older adults","volume":"150","author":"Mick","year":"2014","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2026.109664_bib0023","article-title":"AAV-mediated gene therapy restores hearing in patients with DFNB9 deafness","volume":"11","author":"Qi","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.heares.2026.109664_bib0024","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neurobiolaging.2022.03.014","article-title":"Age-related central gain with degraded neural synchrony in the auditory brainstem of mice and humans","volume":"115","author":"Rumschlag","year":"2022","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heares.2026.109664_bib0025","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1177\/019459989411000610","article-title":"Auditory and cytocochlear correlates of inner ear disorders","volume":"110","author":"Schuknecht","year":"1994","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.heares.2026.109664_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/00034894931020S101","article-title":"Cochlear pathology in presbycusis","volume":"102","author":"Schuknecht","year":"1993","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.heares.2026.109664_bib0027","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10162-021-00826-y","article-title":"Metabolic and sensory components of age-related hearing loss","volume":"23","author":"Eckert","year":"2022","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.heares.2026.109664_bib0028","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1038\/s41591-024-03023-5","article-title":"Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results","volume":"30","author":"Wang","year":"2024","journal-title":"Na.t Med."}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595526001413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595526001413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T07:38:08Z","timestamp":1794555488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595526001413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":28,"alternative-id":["S0378595526001413"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2026.109664","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.07.18.665193","asserted-by":"object"}]},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A non-invasive test for stria vascularis dysfunction","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2026.109664","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"109664"}}