{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:15:37Z","timestamp":1788668137261,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012324","name":"University Hospitals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hearing Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.heares.2026.109713","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:23:34Z","timestamp":1782170614000},"page":"109713","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Clarin-1 mRNA expression in the central auditory system of Fischer Brown Norway rats"],"prefix":"10.1016","volume":"479","author":[{"given":"Laila S.","family":"Almassri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurveer","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian L.","family":"Barach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madelyne","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hager","family":"Hamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse W.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar N.","family":"Alagramam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4753-7326","authenticated-orcid":false,"given":"Jeffrey G.","family":"Mellott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.heares.2026.109713_bib0001","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/sj.ejhg.5200831","article-title":"USH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses","volume":"10","author":"Adato","year":"2002","journal-title":"Eur. J. Hum. Genet.: EJHG"},{"key":"10.1016\/j.heares.2026.109713_bib0002","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1626021","article-title":"Neuropeptide Y mRNA expression in the aging inferior colliculus of Fischer Brown Norway rats","volume":"17","author":"Almassri","year":"2025","journal-title":"Front. Aging Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.heares.2026.109713_bib0003","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.heares.2010.12.016","article-title":"Physiological differences between histologically defined subdivisions in the mouse auditory thalamus","volume":"274","author":"Anderson","year":"2011","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2026.109713_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J. Stat. Softw."},{"issue":"4","key":"10.1016\/j.heares.2026.109713_bib0006","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.ymthe.2024.03.020","article-title":"Otoferlin gene therapy restores hearing in deaf children","volume":"32","author":"Brigande","year":"2024","journal-title":"Mol. Ther."},{"issue":"2","key":"10.1016\/j.heares.2026.109713_bib0007","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuron.2010.10.011","article-title":"Hearing impairment: a panoply of genes and functions","volume":"68","author":"Dror","year":"2010","journal-title":"Neuron"},{"issue":"8","key":"10.1016\/j.heares.2026.109713_bib0008","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1172\/JCI94351","article-title":"Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome","volume":"128","author":"Dulon","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"15","key":"10.1016\/j.heares.2026.109713_bib0009","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddp210","article-title":"Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation","volume":"18","author":"Geng","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"28","key":"10.1016\/j.heares.2026.109713_bib0010","doi-asserted-by":"crossref","first-page":"9485","DOI":"10.1523\/JNEUROSCI.0311-12.2012","article-title":"The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene","volume":"32","author":"Geng","year":"2012","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.heares.2026.109713_bib0011","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13620-9","article-title":"Modeling and preventing progressive hearing loss in Usher Syndrome III","volume":"7","author":"Geng","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.heares.2026.109713_bib0013","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1086\/323610","article-title":"Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3","volume":"69","author":"Joensuu","year":"2001","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.heares.2026.109713_bib0014","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tma.2023.04.001","article-title":"Age-related changes of GAD1 mRNA expression in the Central inferior colliculus","volume":"7","author":"Koehler","year":"2023","journal-title":"Transl. Med. Aging"},{"issue":"13","key":"10.1016\/j.heares.2026.109713_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v082.i13","article-title":"lmerTest package: tests in linear mixed effects models","volume":"82","author":"Kuznetsova","year":"2017","journal-title":"J. Stat. Softw."},{"issue":"1","key":"10.1016\/j.heares.2026.109713_bib0016","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1073\/pnas.0907873107","article-title":"Topography and physiology of ascending streams in the auditory tectothalamic pathway","volume":"107","author":"Lee","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.heares.2026.109713_bib0017","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.21105\/joss.03139","article-title":"performance: an R package for assessment, comparison and testing of statistical models","volume":"6","author":"L\u00fcdecke","year":"2021","journal-title":"J. Open Source Softw."},{"key":"10.1016\/j.heares.2026.109713_bib0018","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-1-4419-0074-6_9","article-title":"Descending connections of auditory cortex to the midbrain and brain stem","author":"Malmierca","year":"2011","journal-title":"Audit. Cortex"},{"issue":"2","key":"10.1016\/j.heares.2026.109713_bib0019","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/cne.25226","article-title":"Tonotopic distribution and inferior colliculus projection pattern of inhibitory and excitatory cell types in the lateral superior olive of Mongolian gerbils","volume":"530","author":"Mellott","year":"2022","journal-title":"J. Comp. Neurol."},{"issue":"3\u20134","key":"10.1016\/j.heares.2026.109713_bib0020","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00439-021-02339-3","article-title":"Central auditory deficits associated with genetic forms of peripheral deafness","volume":"141","author":"Michalski","year":"2022","journal-title":"Hum. Genet"},{"issue":"10","key":"10.1016\/j.heares.2026.109713_bib0021","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1136\/jmg.40.10.767","article-title":"Genetic homogeneity and phenotypic variability among Ashkenazi Jews with Usher syndrome type III","volume":"40","author":"Ness","year":"2003","journal-title":"J. Med. Genet"},{"issue":"4","key":"10.1016\/j.heares.2026.109713_bib0023","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0166-2236(97)01192-2","article-title":"How well do we understand the cochlea?","volume":"21","author":"Nobili","year":"1998","journal-title":"Trends. Neurosci."},{"key":"10.1016\/j.heares.2026.109713_bib0024","series-title":"Neuronal Organization in the Inferior colliculus. The Inferior Colliculus","first-page":"69","author":"Oliver","year":"2005"},{"issue":"6","key":"10.1016\/j.heares.2026.109713_bib0025","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1288\/00005537-199506000-00010","article-title":"Usher's syndrome type 3 in Finland","volume":"105","author":"Pakarinen","year":"1995","journal-title":"Laryngoscope"},{"key":"10.1016\/j.heares.2026.109713_bib0026","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.heares.2026.109713_bib0027","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev.genom.2.1.271","article-title":"Usher syndrome: from genetics to pathogenesis","volume":"2","author":"Petit","year":"2001","journal-title":"Annu Rev Genom. Hum Genet"},{"issue":"2","key":"10.1016\/j.heares.2026.109713_bib0028","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000083363","article-title":"Serial audiometry and speech recognition findings in Finnish Usher syndrome type III patients","volume":"10","author":"Plantinga","year":"2005","journal-title":"Audiol. Neurootol"},{"key":"10.1016\/j.heares.2026.109713_bib0029","unstructured":"R. Core Team. (2025). R: a language and environment for statistical computing. 4.5.2, \u201c[Not] Part of a Rumble\u201d ed. Vienna, Austria: R Foundation for Statistical Computing (https:\/\/www.R-project.org\/)."},{"key":"10.1016\/j.heares.2026.109713_bib0030","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.heares.2018.07.008","article-title":"Detection of single mRNAs in individual cells of the auditory system","volume":"367","author":"Salehi","year":"2018","journal-title":"Hear. Res."},{"key":"10.1016\/j.heares.2026.109713_bib37","series-title":"The Inferior Colliculus","first-page":"132","article-title":"Superior olivary complex and lateral lemniscal connections of the auditory midbrain","author":"Schofield","year":"2005"},{"key":"10.1016\/j.heares.2026.109713_bib0032","series-title":"Age-related Changes in the Auditory Brainstem and Inferior Colliculus","first-page":"67","author":"Syka","year":"2020"},{"issue":"28","key":"10.1016\/j.heares.2026.109713_bib0033","doi-asserted-by":"crossref","first-page":"18980","DOI":"10.1074\/jbc.M109.003160","article-title":"Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton","volume":"284","author":"Tian","year":"2009","journal-title":"J. Biol. Chem"},{"issue":"4","key":"10.1016\/j.heares.2026.109713_bib0034","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1152\/physrev.00053.2017","article-title":"Toward Cochlear therapies","volume":"98","author":"Wang","year":"2018","journal-title":"Physiol. Rev"},{"issue":"43","key":"10.1016\/j.heares.2026.109713_bib0035","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.21105\/joss.01686","article-title":"Welcome to the Tidyverse","volume":"4","author":"Wickham","year":"2019","journal-title":"J. Open Source Softw."},{"key":"10.1016\/j.heares.2026.109713_bib0036","series-title":"The Inferior Colliculus","article-title":"The Central auditory system: a functional analysis","author":"Winer","year":"2005"}],"container-title":["Hearing Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595526001905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378595526001905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:03:54Z","timestamp":1788667434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378595526001905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":33,"alternative-id":["S0378595526001905"],"URL":"https:\/\/doi.org\/10.1016\/j.heares.2026.109713","relation":{},"ISSN":["0378-5955"],"issn-type":[{"value":"0378-5955","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clarin-1 mRNA expression in the central auditory system of Fischer Brown Norway rats","name":"articletitle","label":"Article Title"},{"value":"Hearing Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heares.2026.109713","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"109713"}}