{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:12:00Z","timestamp":1756462320783},"reference-count":40,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T00:00:00Z","timestamp":1470182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["heliyon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.heliyon.2016.e00153","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T03:23:14Z","timestamp":1473391394000},"page":"e00153","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["RON kinase isoforms demonstrate variable cell motility in normal cells"],"prefix":"10.1016","volume":"2","author":[{"given":"Alissa","family":"Greenbaum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwani","family":"Rajput","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghua","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.heliyon.2016.e00153_bib0005","doi-asserted-by":"crossref","DOI":"10.1245\/ASO.2005.08.013","article-title":"RON, a tyrosine kinase receptor involved in tumor progression and metastasis","volume":"12","author":"Camp","year":"2005","journal-title":"Ann. Surg. Oncol."},{"issue":"2","key":"10.1016\/j.heliyon.2016.e00153_bib0010","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.canlet.2007.08.007","article-title":"Multiple variants of the RON receptor tyrosine kinase: Biochemical properties, tumorigenic activities, and potential drug targets","volume":"257","author":"Lu","year":"2007","journal-title":"Cancer Letters"},{"key":"10.1016\/j.heliyon.2016.e00153_bib0015","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0014-4827(03)00280-5","article-title":"Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor","volume":"289","author":"Peace","year":"2003","journal-title":"Exp. Cell Res."},{"issue":"12","key":"10.1016\/j.heliyon.2016.e00153_bib0020","doi-asserted-by":"crossref","first-page":"7072","DOI":"10.1128\/MCB.16.12.7072","article-title":"Constitutive activation of the RON gene promotes invasive growth but not transformation","volume":"16","author":"Santoro","year":"1996","journal-title":"Mol. Cell. Biol."},{"issue":"6","key":"10.1016\/j.heliyon.2016.e00153_bib0025","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/sj.onc.1201994","article-title":"Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor","volume":"17","author":"Santoro","year":"1998","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.heliyon.2016.e00153_bib0030","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1093\/carcin\/bgg089","article-title":"Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinase","volume":"24","author":"Wang","year":"2003","journal-title":"Carcinogenesis"},{"issue":"27","key":"10.1016\/j.heliyon.2016.e00153_bib0035","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1038\/sj.onc.1203620","article-title":"Cross-talk between the proto-oncogenes Met and Ron","volume":"19","author":"Follenzi","year":"2000","journal-title":"Oncogene"},{"issue":"5182","key":"10.1016\/j.heliyon.2016.e00153_bib0040","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1126\/science.7939629","article-title":"Identification of the ron gene product as the receptor for the human macrophage stimulating protein","volume":"266","author":"Wang","year":"1994","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.heliyon.2016.e00153_bib0045","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/1568009033333745","article-title":"Oncogenic signaling pathways activated by RON receptor tyrosine kinase","volume":"3","author":"Danilkovitch-Miagkova","year":"2003","journal-title":"Curr. Cancer Drug Targets"},{"issue":"15","key":"10.1016\/j.heliyon.2016.e00153_bib0050","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1002\/j.1460-2075.1994.tb06659.x","article-title":"RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP","volume":"13","author":"Gaudino","year":"1994","journal-title":"EMBO J."},{"issue":"43","key":"10.1016\/j.heliyon.2016.e00153_bib0055","doi-asserted-by":"crossref","first-page":"6142","DOI":"10.1038\/sj.onc.1204836","article-title":"Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis","volume":"20","author":"Peace","year":"2001","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.heliyon.2016.e00153_bib0060","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1006\/excr.1999.4429","article-title":"Macrophage stimulating protein-induced epithelial cell adhesion is mediated by a PI3-K-dependent, but FAK-independent mechanism","volume":"248","author":"Danilkovitch","year":"1999","journal-title":"Exp. Cell Res."},{"issue":"7","key":"10.1016\/j.heliyon.2016.e00153_bib0065","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1177\/1947601911421924","article-title":"Short-Form Ron Promotes Spontaneous Breast Cancer Metastasis through Interaction with Phosphoinositide 3-Kinase","volume":"2","author":"Liu","year":"2011","journal-title":"Genes Cancer"},{"issue":"16","key":"10.1016\/j.heliyon.2016.e00153_bib0070","doi-asserted-by":"crossref","first-page":"10912","DOI":"10.1074\/jbc.M809551200","article-title":"Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma","volume":"284","author":"Wang","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.heliyon.2016.e00153_bib0075","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1006\/excr.2000.5012","article-title":"Overexpression and activation of the RON receptor tyrosine kinase in a panel of human colorectal carcinoma cell lines","volume":"261","author":"Chen","year":"2000","journal-title":"Exp. Cell Res."},{"issue":"22","key":"10.1016\/j.heliyon.2016.e00153_bib0080","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1038\/sj.onc.1201812","article-title":"Overexpression of the RON gene in human breast carcinoma","volume":"16","author":"Maggiora","year":"1998","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.heliyon.2016.e00153_bib0085","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1038\/sj.onc.1207282","article-title":"Collaborative activities of macrophage-stimulating protein and transforming growth factor-beta1 in induction of epithelial to mesenchymal transition: roles of the RON receptor tyrosine kinase","volume":"23","author":"Wang","year":"2004","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.heliyon.2016.e00153_bib0090","doi-asserted-by":"crossref","first-page":"495","DOI":"10.4161\/rna.7.4.12744","article-title":"Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: Therapeutic potential of bifunctional oligonucleotides and indole derivatives","volume":"7","author":"Ghigna","year":"2014","journal-title":"RNA Biol."},{"issue":"7","key":"10.1016\/j.heliyon.2016.e00153_bib0095","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1177\/1947601911421924","article-title":"Short-Form Ron Promotes Spontaneous Breast Cancer Metastasis through Interaction with Phosphoinositide 3-Kinase","volume":"2","author":"Liu","year":"2011","journal-title":"Genes Cancer"},{"issue":"2","key":"10.1016\/j.heliyon.2016.e00153_bib0100","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/sj.onc.1206075","article-title":"Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential","volume":"22","author":"Zhou","year":"2003","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.heliyon.2016.e00153_bib0105","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S1470-2045(07)70104-3","article-title":"Alternative splicing: an emerging topic in molecular and clinical oncology","volume":"8","author":"Pajares","year":"2007","journal-title":"Lancet Oncol."},{"issue":"7-8","key":"10.1016\/j.heliyon.2016.e00153_bib0110","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.biocel.2007.02.016","article-title":"Alternative splicing in cancer: Noise, functional, or systematic?","volume":"39","author":"Skotheim","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.heliyon.2016.e00153_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pcbi.1000011","article-title":"Entropy measures quantify global splicing disorders in cancer","volume":"4","author":"Ritchie","year":"2008","journal-title":"PLoS Comput. Biol."},{"issue":"10","key":"10.1016\/j.heliyon.2016.e00153_bib0120","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1128\/MCB.16.10.5518","article-title":"A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype","volume":"16","author":"Collesi","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.heliyon.2016.e00153_bib0125","first-page":"1551","article-title":"Inhibition of MSP-RON signaling pathway in cancer cells by a novel soluable form of RON comprising the entire sema sequence","volume":"36","author":"Ma","year":"2010","journal-title":"Int. J. Oncol."},{"issue":"8","key":"10.1016\/j.heliyon.2016.e00153_bib0130","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1093\/carcin\/21.8.1507","article-title":"Identification of a novel splicing product of the RON receptor tyrosine kinase in human colorectal carcinoma cells","volume":"21","author":"Wang","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.heliyon.2016.e00153_bib0135","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1015>3.0.CO;2-N","article-title":"Gene structure of the human receptor tyrosine kinase RON and mutation analysis in lung cancer samples","volume":"29","author":"Angeloni","year":"2000","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.heliyon.2016.e00153_bib0140","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.1158\/0008-5472.CAN-06-4128","article-title":"The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression","volume":"67","author":"Thomas","year":"2007","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.heliyon.2016.e00153_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0069992","article-title":"Ron Knockdown and Ron Monoclonal Antibody IMC-RON8 Sensitize Pancreatic Cancer to Histone Deacetylase Inhibitors (HDACi)","volume":"8","author":"Zou","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.heliyon.2016.e00153_bib0150","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3322\/caac.21254","article-title":"Cancer statistics","volume":"65","author":"Siegel","year":"2015","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.heliyon.2016.e00153_bib0155","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/gim.2012.184","article-title":"Recommendations from the EGAPP Working Group: can testing of tumor tissue for mutations in EGFR pathway downstream effector genes in patients with metastatic colorectal cancer improve health outcomes by guiding decisions regarding anti-EGFR therapy?","volume":"15","author":"Calonge","year":"2013","journal-title":"Genet. Med."},{"issue":"7","key":"10.1016\/j.heliyon.2016.e00153_bib0160","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1158\/2159-8290.CD-12-0480","article-title":"Inhibition of Ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity","volume":"3","author":"Eyob","year":"2013","journal-title":"Cancer Discov."},{"issue":"8","key":"10.1016\/j.heliyon.2016.e00153_bib0165","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1007\/s10350-008-9297-1","article-title":"The Prognostic Significance of RON and MET Receptor Coexpression in Patients with Colorectal Cancer","volume":"51","author":"Lee","year":"2008","journal-title":"Dis. Colon Rectum"},{"issue":"3","key":"10.1016\/j.heliyon.2016.e00153_bib0170","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/carcin\/21.3.497","article-title":"Tumor progression and metastasis","volume":"21","author":"Yokota","year":"2000","journal-title":"Carcinogenesis"},{"issue":"4","key":"10.1016\/j.heliyon.2016.e00153_bib0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060299","article-title":"Intra-tumoral heterogeneity in metastatic potential and survival signaling between iso-clonal HCT116 and HCT116b human colon carcinoma cell lines","volume":"8","author":"Chowdhury","year":"2013","journal-title":"PloS One"},{"issue":"11","key":"10.1016\/j.heliyon.2016.e00153_bib0180","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.bbagrm.2014.09.003","article-title":"SRSF2 promotes splicing and transcription of exon 11 included isoform in Ron proto-oncogene","volume":"1839","author":"Moon","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.heliyon.2016.e00153_bib0185","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.molcel.2005.10.026","article-title":"Cell motility is controlled by SF2\/ASF through alternative splicing of the Ron protooncogene","volume":"20","author":"Ghigna","year":"2005","journal-title":"Mol. Cell."},{"issue":"6","key":"10.1016\/j.heliyon.2016.e00153_bib0190","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1745-7254.2006.00361.x","article-title":"Oncogenesis of RON receptor tyrosine kinase: a molecular target for malignant epithelial cancers","volume":"27","author":"Wang","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.heliyon.2016.e00153_bib0195","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1476-4598-10-82","article-title":"The monoclonal antibody Zt\/f2 targeting RON receptor tyrosine kinase as potential therapeutics against tumor growth-mediated by colon cancer cells","volume":"10","author":"Yao","year":"2011","journal-title":"Mol. Cancer"},{"issue":"9","key":"10.1016\/j.heliyon.2016.e00153_bib0200","doi-asserted-by":"crossref","first-page":"21138","DOI":"10.3390\/ijms160921138","article-title":"PI3 K and AKT: unfaithful partners in cancer","volume":"16","author":"Faes","year":"2015","journal-title":"Int. J. Mol. Sci."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844016310064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844016310064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T05:01:10Z","timestamp":1568350870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844016310064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S2405844016310064"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2016.e00153","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RON kinase isoforms demonstrate variable cell motility in normal cells","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2016.e00153","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e00153"}}