{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:23:34Z","timestamp":1758709414056},"reference-count":24,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["heliyon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.heliyon.2017.e00350","type":"journal-article","created":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T10:22:01Z","timestamp":1499682121000},"page":"e00350","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["New anthrarobin acyl derivatives as butyrylcholinesterase inhibitors: synthesis, in vitro and in silico studies"],"prefix":"10.1016","volume":"3","author":[{"given":"Mehreen","family":"Lateef","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abid","family":"Azhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bina S.","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shamshad","family":"Zarina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizam","family":"uddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad F.","family":"Anwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kauser","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaniz F.","family":"Azhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubna","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashad","family":"Mehmood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shagufta","family":"Perveen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.heliyon.2017.e00350_bib0005","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1212\/WNL.48.5_Suppl_6.35S","article-title":"The search for disease-modifying treatment for Alzheimer\u2019s Disease","volume":"48","author":"Aisen","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.heliyon.2017.e00350_bib0010","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0025-7125(16)30280-2","article-title":"Reversible dementias","volume":"77","author":"Arnold","year":"1993","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0015","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1212\/WNL.42.1.115","article-title":"Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham study","volume":"42","author":"Bachman","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.heliyon.2017.e00350_bib0020","first-page":"54","article-title":"Butyrylcholiesterase: structure and physiological importance","volume":"28","author":"\u00c7oku\u011fra\u015f","year":"2003","journal-title":"Turk. J. Biochem."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0025","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1021\/jm049510k","article-title":"Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase BuChE; Rational design of novel, selective, and highly potent BuChE inhibitors","volume":"48","author":"Campiani","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0030","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0035","doi-asserted-by":"crossref","first-page":"891","DOI":"10.2165\/00002512-200118120-00001","article-title":"Selective inhibitors of butyrylcholinesterase: a valid alternative for therapy of Alzheimer's disease?","volume":"18","author":"Giacobini","year":"2001","journal-title":"Drugs Aging"},{"key":"10.1016\/j.heliyon.2017.e00350_bib0040","doi-asserted-by":"crossref","first-page":"17213","DOI":"10.1073\/pnas.0508575102","article-title":"Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent","volume":"102","author":"Greig","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0045","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1185\/03007990152673800","article-title":"A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase","volume":"17","author":"Greig","year":"2001","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0050","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1001\/jama.1995.03520410048025","article-title":"Age-specific incidence of Alzheimer\u2019s disease in a community population","volume":"273","author":"Hebert","year":"1995","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0055","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S0006-2952(02)00848-1","article-title":"Structure-activity relationships for inhibition of human 5\u03b1-reductases by polyphenols","volume":"63","author":"Hiipakka","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0060","first-page":"63","article-title":"Exploring the Active Sites of Cholinesterases by Inhibition with Bambuterol and Haloxon","volume":"76","author":"Kovarik","year":"2003","journal-title":"Croatica Chemica Acta"},{"key":"10.1016\/j.heliyon.2017.e00350_bib0065","first-page":"1015","article-title":"Antioxidant potential of anthrarobin (1, 2, 10-trihydroxyanthracene) and its acyl derivatives","volume":"37","author":"Lateef","year":"2015","journal-title":"J. Chem. Soc. Pak."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0070","doi-asserted-by":"crossref","first-page":"7046","DOI":"10.1021\/bi300955k","article-title":"Probing the peripheral site of human butyrylcholinesterase","volume":"51","author":"Macdonald","year":"2012","journal-title":"Biochem."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0075","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0167-4838(99)00115-6","article-title":"Interaction between the peripheral site residues of human butyrylcholinesterase, D70 and Y332, in binding and hydrolysis of substrates","volume":"1433","author":"Masson","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.heliyon.2017.e00350_bib0080","doi-asserted-by":"crossref","first-page":"41141","DOI":"10.1074\/jbc.M210241200","article-title":"Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products","volume":"278","author":"Nicolet","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0085","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"Open Babel: An open chemical toolbox","volume":"3","author":"O'Boyle","year":"2011","journal-title":"J. Cheminf."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0090","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1136\/bmj.2.6150.1457","article-title":"Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia","volume":"2","author":"Perry","year":"1978","journal-title":"Br. Med. J."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0095","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1021\/cr00081a005","article-title":"Acetylcholinesterase: enzyme structure, reaction dynamics and virtual transition states","volume":"87","author":"Quinn","year":"1987","journal-title":"Chem. Rev."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0100","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1006\/jmbi.1996.0477","article-title":"A fast flexible docking method using an incremental construction algorithm","volume":"261","author":"Rarey","year":"1996","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0105","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0749-0690(05)70072-0","article-title":"Treatment of Alzheimer\u2019s disease with cholinesterase inhibitors","volume":"17","author":"Schneider","year":"2001","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0110","first-page":"3293","article-title":"Inhibition of xanthine oxidase by hydroxylated anthraquinones and related compounds","volume":"17","author":"Sheu","year":"1997","journal-title":"Anticancer Res."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0115","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.5012\/bkcs.2011.32.8.2593","article-title":"Selective butyrylcholinesterase inhibitors using polyphenol-polyphenol hybrid molecules","volume":"32","author":"Woo","year":"2011","journal-title":"Bull. Korean Chem. Soc."},{"key":"10.1016\/j.heliyon.2017.e00350_bib0120","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/ana.410340312","article-title":"Neurological cholinesterases in the normal brain and in Alzheimer\u2019s disease: relationship to plaques, tangles, and patterns of selective vulnerability","volume":"34","author":"Wright","year":"1993","journal-title":"Annals Neurol."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844017305881?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844017305881?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T07:50:40Z","timestamp":1535615440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844017305881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S2405844017305881"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2017.e00350","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New anthrarobin acyl derivatives as butyrylcholinesterase inhibitors: synthesis, in vitro and in silico studies","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2017.e00350","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e00350"}}