{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:42:12Z","timestamp":1784882532335,"version":"3.55.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["heliyon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.heliyon.2017.e00405","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T23:47:35Z","timestamp":1506642455000},"page":"e00405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Paclitaxel induces Stathmin 1 phosphorylation, microtubule stability and apoptosis in acute lymphoblastic leukemia cells"],"prefix":"10.1016","volume":"3","author":[{"given":"Jo\u00e3o Agostinho","family":"Machado-Neto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Nunes","family":"Rodrigues Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline Cristina","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luiz","family":"Coelho-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Scopim-Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Alves","family":"Fenerich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Borges","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Santos","family":"Scheucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda Pinto","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Magalh\u00e3es","family":"Rego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Traina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heliyon.2017.e00405_bib0005","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.mayocp.2016.09.010","article-title":"Adult acute lymphoblastic leukemia","volume":"91","author":"Paul","year":"2016","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.heliyon.2017.e00405_bib0010","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1517\/14728222.2011.620951","article-title":"Stathmin: a protein with many tasks. New biomarker and potential target in cancer","volume":"15","author":"Belletti","year":"2011","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.heliyon.2017.e00405_bib0015","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s12967-016-1000-z","article-title":"Stathmin-dependent molecular targeting therapy for malignant tumor: the latest 5 years' discoveries and developments","volume":"14","author":"Biaoxue","year":"2016","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.heliyon.2017.e00405_bib0020","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.leukres.2013.11.013","article-title":"Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells","volume":"38","author":"Machado-Neto","year":"2014","journal-title":"Leuk. Res."},{"key":"10.1016\/j.heliyon.2017.e00405_bib0025","first-page":"569","article-title":"Quantitative analysis of the expression and regulation of an activation-regulated phosphoprotein (oncoprotein 18) in normal and neoplastic cells","volume":"7","author":"Brattsand","year":"1993","journal-title":"Leukemia"},{"key":"10.1016\/j.heliyon.2017.e00405_bib0030","first-page":"1538","article-title":"Expression of oncoprotein 18 in human leukemias and lymphomas","volume":"7","author":"Roos","year":"1993","journal-title":"Leukemia"},{"key":"10.1016\/j.heliyon.2017.e00405_bib0035","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF00243911","article-title":"Immunohistochemical detection of oncoprotein 18 (Op18) in malignant lymphomas","volume":"27","author":"Nylander","year":"1995","journal-title":"Histochem. J."},{"key":"10.1016\/j.heliyon.2017.e00405_bib0040","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3892\/or.2012.2157","article-title":"Expression and phosphorylation of stathmin correlate with cell migration in esophageal squamous cell carcinoma","volume":"29","author":"Liu","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.heliyon.2017.e00405_bib0045","doi-asserted-by":"crossref","first-page":"29573","DOI":"10.18632\/oncotarget.4998","article-title":"Stathmin 1 inhibition amplifies ruxolitinib-induced apoptosis in JAK2V617F cells","volume":"6","author":"Machado-Neto","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.heliyon.2017.e00405_bib0050","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.heliyon.2017.e00405_bib0055","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1038\/sj.leu.2400792","article-title":"Quantitative analysis of Op18 phosphorylation in childhood acute leukemia","volume":"11","author":"Melhem","year":"1997","journal-title":"Leukemia"},{"key":"10.1016\/j.heliyon.2017.e00405_bib0060","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.euprot.2014.01.002","article-title":"2DGE and DIGE based proteomic study of malignant B-cells in B-cell acute lymphoblastic leukemia","volume":"3","author":"Saha","year":"2014","journal-title":"EuPA Open Proteom."},{"key":"10.1016\/j.heliyon.2017.e00405_bib0065","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc1317","article-title":"Microtubules as a target for anticancer drugs","volume":"4","author":"Jordan","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.heliyon.2017.e00405_bib0070","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1126\/scitranslmed.3007965","article-title":"Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles","volume":"6","author":"Zasadil","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.heliyon.2017.e00405_bib0075","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1200\/JCO.1995.13.1.180","article-title":"Nonlinear pharmacokinetics and metabolism of paclitaxel and its pharmacokinetic\/pharmacodynamic relationships in humans","volume":"13","author":"Gianni","year":"1995","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.heliyon.2017.e00405_bib0080","doi-asserted-by":"crossref","first-page":"6316","DOI":"10.1074\/jbc.M410598200","article-title":"Global effects of BCR\/ABL and TEL\/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR\/ABL","volume":"280","author":"Unwin","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.heliyon.2017.e00405_bib0085","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1002\/pmic.200600307","article-title":"Proteomic analysis of acute promyelocytic leukemia: PML-RARalpha leads to decreased phosphorylation of OP18 at serine 63","volume":"6","author":"Zada","year":"2006","journal-title":"Proteomics"},{"key":"10.1016\/j.heliyon.2017.e00405_bib0090","article-title":"The role of stathmin, a regulator of mitosis, in hematopoiesis","volume":"120","author":"Ramlogan-Steel","year":"2012","journal-title":"Blood (ASH Ann. Meet. Abstr.)"},{"key":"10.1016\/j.heliyon.2017.e00405_bib0095","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1242\/jcs.114.5.909","article-title":"Effects of stathmin inhibition on the mitotic spindle","volume":"114","author":"Iancu","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.heliyon.2017.e00405_bib0100","doi-asserted-by":"crossref","first-page":"e577","DOI":"10.1038\/bcj.2017.53","article-title":"Acute lymphoblastic leukemia: a comprehensive review and 2017 update","volume":"7","author":"Terwilliger","year":"2017","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.heliyon.2017.e00405_bib0105","first-page":"1307","article-title":"Induction of stathmin expression during erythropoietic differentiation","volume":"6","author":"Rabilloud","year":"1995","journal-title":"Cell Growth Differ."},{"key":"10.1016\/j.heliyon.2017.e00405_bib0110","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0301-472X(03)00043-2","article-title":"Stathmin expression and megakaryocyte differentiation: a potential role in polyploidy","volume":"31","author":"Rubin","year":"2003","journal-title":"Exp. Hematol."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844017314664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844017314664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T17:22:01Z","timestamp":1659547321000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844017314664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S2405844017314664"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2017.e00405","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paclitaxel induces Stathmin 1 phosphorylation, microtubule stability and apoptosis in acute lymphoblastic leukemia cells","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2017.e00405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e00405"}}