{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:27:48Z","timestamp":1792114068580,"version":"4.4.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T00:00:00Z","timestamp":1511222400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["heliyon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.heliyon.2017.e00464","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T04:30:48Z","timestamp":1512102648000},"page":"e00464","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Leukotriene D 4 induces chemotaxis in human eosinophilc cell line, EoL-1 cells via CysLT1 receptor activation"],"prefix":"10.1016","volume":"3","author":[{"given":"Hideaki","family":"Shirasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuko","family":"Kanaizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Himi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heliyon.2017.e00464_bib0005","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1517\/14728222.12.4.415","article-title":"Cysteinyl leukotriene receptor CysLT1 as a novel therapeutic target for allergic rhinitis","volume":"12","author":"Shirasaki","year":"2008","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.heliyon.2017.e00464_bib0010","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0014-2999(90)94159-U","article-title":"Eosinophil-eicosanoid interactions; inhibition of eosinophil chemotaxis in vivo by a LTD4-receptor antagonist","volume":"191","author":"Chan","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.heliyon.2017.e00464_bib0015","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/0140-6736(93)91073-U","article-title":"Leukotriene E4 and granulocytic infiltration into asthmatic airways","volume":"341","author":"Laitinen","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.heliyon.2017.e00464_bib0020","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1136\/thx.53.10.835","article-title":"Effect of the leukotriene receptor antagononist pranlukast on cellular infiltration in the bronchial mucosa of patients with asthma","volume":"53","author":"Nakamura","year":"1998","journal-title":"Thorax"},{"key":"10.1016\/j.heliyon.2017.e00464_bib0025","first-page":"541","article-title":"Compoment receptor enhancement and chemotaxis of human neutrophils and eosinophils by leukotriene and other lipoxygenase products","volume":"47","author":"Nagy","year":"1982","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.heliyon.2017.e00464_bib0030","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/jlb.55.2.183","article-title":"Comparison of leukotriene B4 and D4 effects on human eosinophil and neutrophil mobility in vitro","volume":"55","author":"Spada","year":"1994","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.heliyon.2017.e00464_bib0035","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.4049\/jimmunol.164.2.1055","article-title":"Molecular analysis of CCR-3 events in eosinophilic cells","volume":"164","author":"Zimmerman","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.heliyon.2017.e00464_bib0040","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000115891","article-title":"Human eosinophils show chemotaxis to lymphoid chemokines and exhibit antigen-presenting\u2013cell-like propertyes upon stimulation with IFN-\u03b3, IL-3 and GM-CSF","volume":"146","author":"Jung","year":"2008","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.heliyon.2017.e00464_bib0045","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000236418","article-title":"Effect of butyric acid on induction of differetiation into eosinophil-like cells in human eosinophilic leukemia cells, EoL-1 cell line: possible role granulocyte-macrophage colony-stimulating factor as an autocrine differetiating factor","volume":"100","author":"Saito","year":"1993","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.heliyon.2017.e00464_bib0050","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0165-2478(99)00064-4","article-title":"Differentiation of a human eosinophilic leukemic cell line, EoL-1: characterization by the expression of cytokine receptors, adhesion molecule. CD95 and eosinophilic cationic protein (ECP)","volume":"68","author":"Wong","year":"1999","journal-title":"Immunol. Lett."},{"issue":"Suppl. 1","key":"10.1016\/j.heliyon.2017.e00464_bib0055","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000101401","article-title":"Mechanism for the differentiation of EoL-1 cells into eosinophils by histone deacetylase inhibitors","volume":"143","author":"Kaneko","year":"2007","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.heliyon.2017.e00464_bib0060","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1042\/bj3050829","article-title":"Expression of human platelet-activatinf factor gene in EoL-1 cells following butyrate-induced differentiation","volume":"305","author":"Izumi","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.heliyon.2017.e00464_bib0065","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1016\/j.intimp.2011.07.017","article-title":"IFN-(and TNF-\u03b1 potentiate prostaglandin D2-induced human eosinophil chemotaxis through up-regulation of CRTH2 surface receptor","volume":"11","author":"El-Shazly","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.heliyon.2017.e00464_bib0070","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1164\/ajrccm.155.4.9105062","article-title":"The effect of inhalated leukotriene D4 and methacholine on sputum cell differentials in asthma","volume":"155","author":"Diamant","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.heliyon.2017.e00464_bib0075","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1164\/ajrccm.164.2.2101105","article-title":"Pulmonary gas exchange and sputum cellular responses to inhalated leukotriene D4 in asthma","volume":"164","author":"Echazarreta","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.heliyon.2017.e00464_bib0080","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1164\/ajrccm.159.5.9810095","article-title":"Effect of inhaled leukotriene D4 on airway eosinophilia and airway hyperresponsiveness in asthmatic subjects","volume":"159","author":"Mulder","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.heliyon.2017.e00464_bib0085","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1164\/ajrccm.164.8.2102033","article-title":"Inhalaed leukotriene E4, but not leukotriene D4, increased airway inflammatory cells in subjects with atopic asthma","volume":"164","author":"Gauvreau","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.heliyon.2017.e00464_bib0090","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1398-9995.2006.00993.x","article-title":"Cysteinyl-leukotrienes contribute to sputum eosinophil chemotactic activity in asthmatics","volume":"61","author":"Hemelaers","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.heliyon.2017.e00464_bib0095","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1046\/j.1365-2222.2002.01384.x","article-title":"Cysteinyl leukotrienes induce human eosinophil locomotion and adhesion molecule expression via a CysLT1 receptor-mediated mechanism","volume":"32","author":"Fregonese","year":"2002","journal-title":"Clin. Exp. Allergy"}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844017319746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844017319746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T16:00:59Z","timestamp":1535212859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844017319746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S2405844017319746"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2017.e00464","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leukotriene D4 induces chemotaxis in human eosinophilc cell line, EoL-1 cells via CysLT1 receptor activation","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2017.e00464","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e00464"}}