{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:21:50Z","timestamp":1792045310362,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T00:00:00Z","timestamp":1515456000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["heliyon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.heliyon.2018.e00511","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T10:06:48Z","timestamp":1517479608000},"page":"e00511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mutations in the \u03b2-amyloid precursor protein in familial Alzheimer\u2019s disease increase A\u03b2 oligomer production in cellular models"],"prefix":"10.1016","volume":"4","author":[{"given":"Yoichi","family":"Ohshima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutoshi","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Mizuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takami","family":"Tomiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyuki","family":"Kametani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Yabe-Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Tokuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.heliyon.2018.e00511_bib0005","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0014-5793(99)00685-7","article-title":"Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration","volume":"453","author":"Alvarez","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0010","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nchem.247","article-title":"Amyloid-beta protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer\u2019s disease","volume":"1","author":"Bernstein","year":"2009","journal-title":"Nat. Chem."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0015","doi-asserted-by":"crossref","first-page":"11993","DOI":"10.1073\/pnas.91.25.11993","article-title":"Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation","volume":"91","author":"Citron","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0020","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1093\/hmg\/10.16.1665","article-title":"Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability","volume":"10","author":"De Jonghe","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0025","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1096\/fj.09-150359","article-title":"High-molecular-weight beta-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients","volume":"24","author":"Fukumoto","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0030","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1073\/pnas.1834302100","article-title":"Alzheimer\u2019s disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss","volume":"100","author":"Gong","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0035","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer\u2019s amyloid beta-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0040","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.heliyon.2018.e00511_bib0045","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2013.06.029","article-title":"Correlation of Abeta oligomer levels in matched cerebrospinal fluid and serum samples","volume":"551","author":"Kasai","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0050","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.bbrc.2012.04.146","article-title":"Utilization of a multiple antigenic peptide as a calibration standard in the BAN50 single antibody sandwich ELISA for Abeta oligomers","volume":"422","author":"Kasai","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0055","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.stem.2013.01.009","article-title":"Modeling Alzheimer\u2019s disease with iPSCs reveals stress phenotypes associated with intracellular Abeta and differential drug responsiveness","volume":"12","author":"Kondo","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.heliyon.2018.e00511_bib0060","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.neuropharm.2010.07.012","article-title":"ADDLs and the signaling web that leads to Alzheimer\u2019s disease","volume":"59","author":"Krafft","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.heliyon.2018.e00511_bib0065","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1074\/jbc.271.8.4077","article-title":"Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains","volume":"271","author":"Kuo","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0070","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature04533","article-title":"A specific amyloid-beta protein assembly in the brain impairs memory","volume":"440","author":"Lesne","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.heliyon.2018.e00511_bib0075","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/brain\/awt062","article-title":"Brain amyloid-beta oligomers in ageing and Alzheimer\u2019s disease","volume":"136","author":"Lesne","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.heliyon.2018.e00511_bib0080","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1046\/j.1471-4159.2003.02196.x","article-title":"Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression","volume":"88","author":"Liu","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0085","doi-asserted-by":"crossref","first-page":"a006338","DOI":"10.1101\/cshperspect.a006338","article-title":"Neurotoxicity of amyloid beta-protein: synaptic and network dysfunction","volume":"2","author":"Mucke","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"7","key":"10.1016\/j.heliyon.2018.e00511_bib0090","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1021\/cn500105p","article-title":"New Mouse Model of Alzheimer\u2019s","volume":"5","author":"Nilsson","year":"2014","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0095","doi-asserted-by":"crossref","first-page":"32895","DOI":"10.1074\/jbc.M109.000208","article-title":"Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains","volume":"284","author":"Noguchi","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0100","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.neurobiolaging.2003.08.012","article-title":"Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer\u2019s disease","volume":"24","author":"Oddo","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.heliyon.2018.e00511_bib0105","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.heliyon.2018.e00511_bib0110","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2183\/pjab.89.321","article-title":"Metabolism of amyloid beta peptide and pathogenesis of Alzheimer\u2019s disease","volume":"89","author":"Saido","year":"2013","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0115","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nn.3697","article-title":"Single App knock-in mouse models of Alzheimer\u2019s disease","volume":"17","author":"Saito","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0120","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1111\/j.1742-4658.2010.07568.x","article-title":"Amyloid oligomers: formation and toxicity of Abeta oligomers","volume":"277","author":"Sakono","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0125","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nm0896-864","article-title":"Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer\u2019s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer\u2019s disease","volume":"2","author":"Scheuner","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0130","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1126\/science.275.5300.630","article-title":"Alzheimer\u2019s disease: genotypes, phenotypes, and treatments","volume":"275","author":"Selkoe","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.heliyon.2018.e00511_bib0135","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0896-6273(91)90052-2","article-title":"The molecular pathology of Alzheimer\u2019s disease","volume":"6","author":"Selkoe","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/j.heliyon.2018.e00511_bib0140","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm1782","article-title":"Amyloid-beta protein dimers isolated directly from Alzheimer\u2019s brains impair synaptic plasticity and memory","volume":"14","author":"Shankar","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0145","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.8191290","article-title":"An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants","volume":"264","author":"Suzuki","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.heliyon.2018.e00511_bib0150","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0168-0102(98)00061-3","article-title":"Activation of tau protein kinase I\/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons","volume":"31","author":"Takashima","year":"1998","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0155","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.0953-816X.2003.03135.x","article-title":"Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2","volume":"19","author":"Takeda","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.heliyon.2018.e00511_bib0160","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo","volume":"416","author":"Walsh","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.heliyon.2018.e00511_bib0165","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.expneurol.2011.10.020","article-title":"Transendocytosis is impaired in CADASIL-mutant NOTCH3","volume":"233","author":"Watanabe-Hosomi","year":"2012","journal-title":"Exp. Neurol."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844017332048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844017332048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T10:20:20Z","timestamp":1535106020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844017332048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S2405844017332048"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2018.e00511","relation":{},"ISSN":["2405-8440"],"issn-type":[{"value":"2405-8440","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mutations in the \u03b2-amyloid precursor protein in familial Alzheimer\u2019s disease increase A\u03b2 oligomer production in cellular models","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2018.e00511","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e00511"}}