{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T15:30:44Z","timestamp":1748964644820,"version":"3.40.5"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:00:00Z","timestamp":1522108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI70955","R01 AI99125"],"award-info":[{"award-number":["R01 AI70955","R01 AI99125"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["heliyon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.heliyon.2018.e00591","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T15:25:14Z","timestamp":1522769114000},"page":"e00591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Molecular characterization of two sub-family specific monoclonal antibodies to meningococcal Factor H binding protein"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5531-6748","authenticated-orcid":false,"given":"C.","family":"Lo Passo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Zippilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0158-3039","authenticated-orcid":false,"given":"A.","family":"Angiolillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Pernice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Galbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2205-5195","authenticated-orcid":false,"given":"F.","family":"Felici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.T.","family":"Beernink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.heliyon.2018.e00591_bib1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.molimm.2005.06.016","article-title":"Complement escape of human pathogenic bacteria by acquisition of complement regulators","volume":"43","author":"Kraiczy","year":"2006","journal-title":"Mol. Immunol."},{"issue":"Suppl. 8","key":"10.1016\/j.heliyon.2018.e00591_bib2","doi-asserted-by":"crossref","first-page":"I113","DOI":"10.1016\/j.vaccine.2008.11.058","article-title":"Microbial complement inhibitors as vaccines","volume":"26","author":"Meri","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.heliyon.2018.e00591_bib3","doi-asserted-by":"crossref","first-page":"501","DOI":"10.4049\/jimmunol.177.1.501","article-title":"The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance","volume":"177","author":"Madico","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.heliyon.2018.e00591_bib4","first-page":"608","article-title":"Use of serogroup B meningococcal vaccines in persons aged >\/=10 years at increased risk for serogroup B meningococcal disease: recommendations of the Advisory Committee on Immunization Practices, 2015","volume":"64","author":"Folaranmi","year":"2015","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.heliyon.2018.e00591_bib5","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1084\/jem.20021911","article-title":"Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870","volume":"197","author":"Masignani","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.heliyon.2018.e00591_bib6","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1128\/IAI.72.4.2088-2100.2004","article-title":"Vaccine potential of the Neisseria meningitidis 2086 lipoprotein","volume":"72","author":"Fletcher","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.heliyon.2018.e00591_bib7","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.4049\/jimmunol.172.9.5606","article-title":"Protective activity of monoclonal antibodies to genome-derived neisserial antigen 1870, a Neisseria meningitidis candidate vaccine","volume":"172","author":"Welsch","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.heliyon.2018.e00591_bib8","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1086\/528994","article-title":"Complement-dependent synergistic bactericidal activity of antibodies against factor H-binding protein, a sparsely distributed meningococcal vaccine antigen","volume":"197","author":"Welsch","year":"2008","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.heliyon.2018.e00591_bib9","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1128\/IAI.05182-11","article-title":"Complement-mediated bactericidal activity of anti-factor H binding protein monoclonal antibodies against the meningococcus relies upon blocking factor H binding","volume":"79","author":"Giuntini","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.heliyon.2018.e00591_bib10","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1016\/j.vaccine.2009.01.075","article-title":"Detection of LP2086 on the cell surface of Neisseria meningitidis and its accessibility in the presence of serogroup B capsular polysaccharide","volume":"27","author":"McNeil","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.heliyon.2018.e00591_bib11","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1016\/j.vaccine.2009.12.027","article-title":"Frequency of factor H-binding protein modular groups and susceptibility to cross-reactive bactericidal activity in invasive meningococcal isolates","volume":"28","author":"Pajon","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.heliyon.2018.e00591_bib12","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1128\/IAI.00367-08","article-title":"Fine antigenic specificity and cooperative bactericidal activity of monoclonal antibodies directed at the meningococcal vaccine candidate factor H-binding protein","volume":"76","author":"Beernink","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.heliyon.2018.e00591_bib13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/srep00341","article-title":"A broadly cross-reactive monoclonal antibody against an epitope on the N-terminus of meningococcal fHbp","volume":"2","author":"Vu","year":"2012","journal-title":"Sci. Rep."},{"key":"10.1016\/j.heliyon.2018.e00591_bib14","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.molimm.2009.02.021","article-title":"A region of the N-terminal domain of meningococcal factor H-binding protein that elicits bactericidal antibody across antigenic variant groups","volume":"46","author":"Beernink","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.heliyon.2018.e00591_bib15","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1042\/BCJ20160806","article-title":"Neisseria meningitidis factor H-binding protein bound to monoclonal antibody JAR5: implications for antibody synergy","volume":"473","author":"Malito","year":"2016","journal-title":"Biochem. J."},{"key":"10.1016\/j.heliyon.2018.e00591_bib16","doi-asserted-by":"crossref","first-page":"e34272","DOI":"10.1371\/journal.pone.0034272","article-title":"Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity","volume":"7","author":"Giuntini","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.heliyon.2018.e00591_bib17","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1073\/pnas.1222845110","article-title":"Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen","volume":"110","author":"Malito","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heliyon.2018.e00591_bib18","doi-asserted-by":"crossref","first-page":"7566","DOI":"10.4049\/jimmunol.176.12.7566","article-title":"Functional significance of factor H binding to Neisseria meningitidis","volume":"176","author":"Schneider","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.heliyon.2018.e00591_bib19","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1073\/pnas.1019751108","article-title":"Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination","volume":"108","author":"Budroni","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heliyon.2018.e00591_bib20","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1128\/IAI.00849-10","article-title":"Effect of factor H-binding protein sequence variation on factor H binding and survival of Neisseria meningitidis in human blood","volume":"79","author":"Dunphy","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.heliyon.2018.e00591_bib21","doi-asserted-by":"crossref","first-page":"10834","DOI":"10.1073\/pnas.0603940103","article-title":"A universal vaccine for serogroup B meningococcus","volume":"103","author":"Giuliani","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.heliyon.2018.e00591_bib22","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1016\/j.vaccine.2010.06.083","article-title":"Broad vaccine coverage predicted for a bivalent recombinant factor H binding protein based vaccine to prevent serogroup B meningococcal disease","volume":"28","author":"Jiang","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.heliyon.2018.e00591_bib23","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0022-2836(91)90213-P","article-title":"Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector","volume":"222","author":"Felici","year":"1991","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.heliyon.2018.e00591_bib24","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1046\/j.1365-2958.1998.01008.x","article-title":"Codon usages in different gene classes of the Escherichia coli genome","volume":"29","author":"Karlin","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.heliyon.2018.e00591_bib25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0378-1119(93)90152-S","article-title":"Mimicking of discontinuous epitopes by phage-displayed peptides, I. Epitope mapping of human H ferritin using a phage library of constrained peptides","volume":"128","author":"Luzzago","year":"1993","journal-title":"Gene"},{"key":"10.1016\/j.heliyon.2018.e00591_bib26","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/nature07769","article-title":"Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates","volume":"458","author":"Schneider","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.heliyon.2018.e00591_bib27","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1128\/IAI.00033-08","article-title":"Bactericidal antibody responses induced by meningococcal recombinant chimeric factor H-binding protein vaccines","volume":"76","author":"Beernink","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.heliyon.2018.e00591_bib28","series-title":"Protein Identification and Analysis Tools on the ExPASy Server","first-page":"571","author":"Gasteiger","year":"2005"},{"key":"10.1016\/j.heliyon.2018.e00591_bib29","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.4049\/jimmunol.1003470","article-title":"A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination","volume":"186","author":"Beernink","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.heliyon.2018.e00591_bib30","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1086\/597806","article-title":"Meningococcal factor H-binding protein variants expressed by epidemic capsular group A, W-135, and X strains from Africa","volume":"199","author":"Beernink","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.heliyon.2018.e00591_bib31","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1099\/mic.0.029876-0","article-title":"The modular architecture of meningococcal factor H-binding protein","volume":"155","author":"Beernink","year":"2009","journal-title":"Microbiology"},{"key":"10.1016\/j.heliyon.2018.e00591_bib32","first-page":"271","article-title":"Selection of phage-displayed peptides mimicking an extracellular epitope of human MDR1-P-glycoprotein","volume":"27","author":"Poloni","year":"1995","journal-title":"Physiol. Chem. Phys. Med. NMR"},{"key":"10.1016\/j.heliyon.2018.e00591_bib33","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/ijc.2910610522","article-title":"Isolation of antigenic mimics of MDR1-P-glycoprotein by phage-displayed peptide libraries","volume":"61","author":"Poloni","year":"1995","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.heliyon.2018.e00591_bib34","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1515\/BC.2003.014","article-title":"Identification by phage display of the linear continuous MRPr1 epitope in the multidrug resistance-associated protein (MRP1)","volume":"384","author":"Flego","year":"2003","journal-title":"Biol. Chem."},{"key":"10.1016\/j.heliyon.2018.e00591_bib35","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1086\/600141","article-title":"Sequence diversity of the factor H binding protein vaccine candidate in epidemiologically relevant strains of serogroup B Neisseria meningitidis","volume":"200","author":"Murphy","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.heliyon.2018.e00591_bib36","doi-asserted-by":"crossref","first-page":"e1002981","DOI":"10.1371\/journal.ppat.1002981","article-title":"Design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules","volume":"8","author":"Johnson","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.heliyon.2018.e00591_bib37","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1128\/IAI.01491-15","article-title":"Meningococcal Factor H binding protein vaccine antigens with increased thermal stability and decreased binding of human Factor H","volume":"84","author":"Rossi","year":"2016","journal-title":"Infect. Immun."},{"key":"10.1016\/j.heliyon.2018.e00591_bib38","doi-asserted-by":"crossref","first-page":"91ra62","DOI":"10.1126\/scitranslmed.3002234","article-title":"Rational design of a meningococcal antigen inducing broad protective immunity","volume":"3","author":"Scarselli","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.heliyon.2018.e00591_bib39","doi-asserted-by":"crossref","first-page":"e1302","DOI":"10.1371\/journal.pntd.0001302","article-title":"Meningococcal factor H binding proteins in epidemic strains from Africa: implications for vaccine development","volume":"5","author":"Pajon","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.heliyon.2018.e00591_bib40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1073\/pnas.69.1.65","article-title":"Ultrastructure of the human complement component, Clq (negative staining-glutamine synthetase-biologically active Clq)","volume":"69","author":"Shelton","year":"1972","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844017339282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844017339282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T14:54:21Z","timestamp":1534949661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844017339282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S2405844017339282"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2018.e00591","relation":{},"ISSN":["2405-8440"],"issn-type":[{"type":"print","value":"2405-8440"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular characterization of two sub-family specific monoclonal antibodies to meningococcal Factor H binding protein","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2018.e00591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e00591"}}