{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:04:39Z","timestamp":1759341879191,"version":"3.40.5"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T00:00:00Z","timestamp":1524528000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["JP15K08467"],"award-info":[{"award-number":["JP15K08467"]}]}],"content-domain":{"domain":["heliyon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heliyon"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.heliyon.2018.e00616","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T14:18:26Z","timestamp":1525097906000},"page":"e00616","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Leptospiral 3-hydroxyacyl-CoA dehydrogenase as an early urinary biomarker of leptospirosis"],"prefix":"10.1016","volume":"4","author":[{"given":"Claudia","family":"Toma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-535X","authenticated-orcid":false,"given":"Nobuo","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Kakita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idam","family":"Hermawan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Higa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsu","family":"Yamashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.heliyon.2018.e00616_bib1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrmicro.2017.5","article-title":"Virulence of the zoonotic agent of leptospirosis: still terra incognita?","volume":"15","author":"Picardeau","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"issue":"4","key":"10.1016\/j.heliyon.2018.e00616_bib2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1620\/tjem.238.287","article-title":"Development of point-of-care testing for disaster-related infectious diseases","volume":"238","author":"Hattori","year":"2016","journal-title":"Tohoku J. Exp. Med."},{"issue":"4","key":"10.1016\/j.heliyon.2018.e00616_bib3","doi-asserted-by":"crossref","first-page":"652","DOI":"10.4269\/ajtmh.2005.73.652","article-title":"Leptospirosis after recreational exposure to water in the Yaeyama islands, Japan","volume":"73","author":"Narita","year":"2005","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"1","key":"10.1016\/j.heliyon.2018.e00616_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/SHK.0b013e3182594ad7","article-title":"Early identification of leptospirosis as an ignored cause of multiple organ dysfunction syndrome","volume":"38","author":"Yang","year":"2012","journal-title":"Shock"},{"issue":"11\u201312","key":"10.1016\/j.heliyon.2018.e00616_bib5","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.vaccine.2003.10.007","article-title":"Leptospiral immunoglobulin-like proteins elicit protective immunity","volume":"22","author":"Koizumi","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.heliyon.2018.e00616_bib6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12941-014-0060-2","article-title":"Current immunological and molecular tools for leptospirosis: diagnostics, vaccine design, and biomarkers for predicting severity","volume":"14","author":"Rajapakse","year":"2015","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"issue":"1","key":"10.1016\/j.heliyon.2018.e00616_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diagmicrobio.2013.09.012","article-title":"Rapid tests for diagnosis of leptospirosis: current tools and emerging technologies","volume":"78","author":"Picardeau","year":"2014","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.heliyon.2018.e00616_bib8","article-title":"Addressing barriers to the development and adoption of rapid diagnostic tests in global health","volume":"2","author":"Miller","year":"2015","journal-title":"Nanobiomedicine (Rij)"},{"issue":"6","key":"10.1016\/j.heliyon.2018.e00616_bib9","doi-asserted-by":"crossref","first-page":"e2289","DOI":"10.1371\/journal.pntd.0002289","article-title":"Sensitivity and specificity of a new vertical flow rapid diagnostic test for the serodiagnosis of human leptospirosis","volume":"7","author":"Goarant","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"5","key":"10.1016\/j.heliyon.2018.e00616_bib10","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1128\/CVI.00756-12","article-title":"Development of immunochromatography-based methods for detection of leptospiral lipopolysaccharide antigen in urine","volume":"20","author":"Widiyanti","year":"2013","journal-title":"Clin. Vaccine Immunol."},{"issue":"1","key":"10.1016\/j.heliyon.2018.e00616_bib11","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1038\/s41598-017-03658-0","article-title":"Peptide specific monoclonal antibodies of Leptospiral LigA for acute diagnosis of leptospirosis","volume":"7","author":"Kanagavel","year":"2017","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.heliyon.2018.e00616_bib12","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.1371\/journal.ppat.0030097","article-title":"The OmpA-like protein Loa22 is essential for leptospiral virulence","volume":"3","author":"Ristow","year":"2007","journal-title":"PLoS Pathog."},{"issue":"10","key":"10.1016\/j.heliyon.2018.e00616_bib13","doi-asserted-by":"crossref","first-page":"e26046","DOI":"10.1371\/journal.pone.0026046","article-title":"Comparative proteomic analysis of differentially expressed proteins in the urine of reservoir hosts of leptospirosis","volume":"6","author":"Nally","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.heliyon.2018.e00616_bib14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1471-2180-14-132","article-title":"Identification of leptospiral 3-hydroxyacyl-CoA dehydrogenase released in the urine of infected hamsters","volume":"14","author":"Segawa","year":"2014","journal-title":"BMC Microbiol."},{"issue":"9","key":"10.1016\/j.heliyon.2018.e00616_bib15","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1111\/cmi.12296","article-title":"Leptospiral outer membrane protein LMB216 is involved in enhancement of phagocytic uptake by macrophages","volume":"16","author":"Toma","year":"2014","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.heliyon.2018.e00616_bib16","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1099\/mic.0.072439-0","article-title":"High virulence in hamsters of four dominant Leptospira serovars isolated from rats in the Philippines","volume":"160","author":"Villanueva","year":"2014","journal-title":"Microbiology"},{"issue":"4","key":"10.1016\/j.heliyon.2018.e00616_bib17","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00882-15","volume":"3","author":"Satou","year":"2015","journal-title":"Genome Announc."},{"key":"10.1016\/j.heliyon.2018.e00616_bib18","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3389\/fcimb.2017.00362","article-title":"Pathogenic leptospires modulate protein expression and post-translational modifications in response to mammalian host signals","volume":"7","author":"Nally","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"10.1016\/j.heliyon.2018.e00616_bib19","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4269\/ajtmh.16-0033","article-title":"Redefining gold standard testing for diagnosing leptospirosis: further evidence from a well-characterized, flood-related outbreak in Sri Lanka","volume":"95","author":"Agampodi","year":"2016","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"9","key":"10.1016\/j.heliyon.2018.e00616_bib20","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/prca.200800243","article-title":"Sources of urinary proteins and their analysis by urinary proteomics for the detection of biomarkers of disease","volume":"3","author":"Julian","year":"2009","journal-title":"Proteonomics Clin. Appl."},{"issue":"2","key":"10.1016\/j.heliyon.2018.e00616_bib21","first-page":"201","article-title":"Development of an immunochromatographic test with anti-LipL32-coupled gold nanoparticles for Leptospira detection","volume":"37","author":"Chirathaworn","year":"2014","journal-title":"New Microbiol."},{"issue":"6","key":"10.1016\/j.heliyon.2018.e00616_bib22","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1128\/JCM.00481-12","article-title":"A new loop-mediated isothermal amplification method for rapid, simple, and sensitive detection of Leptospira spp. in urine","volume":"50","author":"Koizumi","year":"2012","journal-title":"J. Clin. Microbiol."},{"issue":"3","key":"10.1016\/j.heliyon.2018.e00616_bib23","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10096-018-3187-9","article-title":"Pathogen-specific leptospiral proteins in urine of patients with febrile illness aids in differential diagnosis of leptospirosis from dengue","volume":"37","author":"Chaurasia","year":"2018","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."}],"container-title":["Heliyon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844017340045?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405844017340045?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T03:40:52Z","timestamp":1571283652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405844017340045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S2405844017340045"],"URL":"https:\/\/doi.org\/10.1016\/j.heliyon.2018.e00616","relation":{},"ISSN":["2405-8440"],"issn-type":[{"type":"print","value":"2405-8440"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leptospiral 3-hydroxyacyl-CoA dehydrogenase as an early urinary biomarker of leptospirosis","name":"articletitle","label":"Article Title"},{"value":"Heliyon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.heliyon.2018.e00616","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e00616"}}